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All Journal International Journal of Integrated Health Sciences Jurnal EduHealth
Endah Hamidah
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Health Professions Public Health Veterinary

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Pattern of Prostate Specific Antigen and Gleason Score in Relation to Imunohistochemistry Features in Prostate Adenocarcinoma Patients in Dr. Hasan Sadikin General Hospital Azela Glady; Endah Hamidah; Rahmat Budi Prasetyo; Agung Budi Sutiono
International Journal of Integrated Health Sciences Vol 4, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To review the correlation between prostate specific antigen (PSA) and Gleason score and Cav-1 for diagnosing prostate adenocarcinoma.Methods: Data were collected from one hundred fifty-nine patients with prostate adenocarcinoma at the Department of Urology, Dr. Hasan Sadikin General Hospital in the period of January 2008–December 2010. The PSA levels were measured and classified into <4 ng/ml, 4–10 ng/ml, and >10 ng/ml. The results were then analyzed and compared to the imunohistochemistry (caveolin-1) staining in the literature. The Gleason score was also noted and analyzed. Results: This study confirmed that positive caveolin-1 expression was related to the clinical markers of disease progression and was predictive of poor clinical outcome after surgery. The PSA results showed that one hundred fourty-one adenocarcinoma patients had a PSA level of >10 ng/ml with Gleason score of gleason 5–6 as the most common score. However, there was no correlation between PSA and Gleason score and caveolin-1 for diagnosing prostate adenocarcinoma.Conclusions: Caveolin-1 cannot be used to measure Gleason and PSA score due to different markers that have various advantages and disadvantages to predict carcinoma prostate. Therefore, further studies are needed. Keywords: Gleason score, imunohistochemistry, prostate adenocarcinoma, prostate specific antigen DOI: 10.15850/ijihs.v4n1.679
Characterisctics, Clinical Features, And Management Of Fibroadenoma Mammae Patients At Dustira Hospital Cimahi Ris Kristiana; Salsha Regina Syakyra; Endah Hamidah; Endry Septiadi; Fitriardi Sejati; Tatang Bisri
Jurnal EduHealth Vol. 16 No. 01 (2025): Jurnal EduHealt, Edition January - March, 2025
Publisher : Sean Institute

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Fibroadenoma mammae (FAM) is the most common benign breast tumor that occurs at the age of 14-35 years. About 10% of the female population has FAM. FAM manifests as solitary masses that are easily movable, well-defined, with a smooth surface. The aim of this study was to determine the characteristics, clinical features, and management of FAM patients at Dustira Hospital using secondary data from medical records. A total of 68 FAM patients were selected as samples during the period 2018-2023. The research variables consisted of the number of cases, age, body mass index(BMI), location, topography, size, quantity, and management of FAM. Univariate analysis was used in this study and the results were presented in narrative and tabular forms. The results of the study showed that the highest number of FAM cases occurred in 2018, reaching 28 (41.1%). Characteristics of FAM patients included 49 individuals (72%) in the 16-30 age group, 32 individuals (47%) with normal body mass index. Clinical features of FAM were found in 31 individuals (45.6%) on the right breast, 24 individuals (35.3%) in the upper medial quadrant, with a size of 3-5 cm in 24 individuals (35.3%), and 49 individuals ( 72.1%) limited solitary masses. Management included surgery in all 68 individuals (100%), with 67 individuals (98.5%) underwent excision, while 1 individual (1.5%) underwent incision. Age and BMI are suspected to play a role in FAM formation related to estrogen hypersensitivity and mutations in the mediator complex subunit 12 (MED12). Lesion size is influenced by estrogen exposure. Management of fibroadenoma depends on the patient's preferences and clinical conditions. Women at risk or suspecting breast masses are advised to perform self-breast examination (BSE) and efficiently consult with healthcare professionals.
Co-Authors Agung Budi Sutiono Azela Glady Endry Septiadi Fitriardi Sejati Rahmat Budi Prasetyo Ris Kristiana Salsha Regina Syakyra Tatang Bisri