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Pattern of Prostate Specific Antigen and Gleason Score in Relation to Imunohistochemistry Features in Prostate Adenocarcinoma Patients in Dr. Hasan Sadikin General Hospital Azela Glady; Endah Hamidah; Rahmat Budi Prasetyo; Agung Budi Sutiono
International Journal of Integrated Health Sciences Vol 4, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Objective: To review the correlation between prostate specific antigen (PSA) and Gleason score and Cav-1 for diagnosing prostate adenocarcinoma.Methods: Data were collected from one hundred fifty-nine patients with prostate adenocarcinoma at the Department of Urology, Dr. Hasan Sadikin General Hospital in the period of January 2008–December 2010. The PSA levels were measured and classified into <4 ng/ml, 4–10 ng/ml, and >10 ng/ml. The results were then analyzed and compared to the imunohistochemistry (caveolin-1) staining in the literature. The Gleason score was also noted and analyzed. Results: This study confirmed that positive caveolin-1 expression was related to the clinical markers of disease progression and was predictive of poor clinical outcome after surgery. The PSA results showed that one hundred fourty-one adenocarcinoma patients had a PSA level of >10 ng/ml with Gleason score of gleason 5–6 as the most common score. However, there was no correlation between PSA and Gleason score and caveolin-1 for diagnosing prostate adenocarcinoma.Conclusions: Caveolin-1 cannot be used to measure Gleason and PSA score due to different markers that have various advantages and disadvantages to predict carcinoma prostate. Therefore, further studies are needed. Keywords: Gleason score, imunohistochemistry, prostate adenocarcinoma, prostate specific antigen DOI: 10.15850/ijihs.v4n1.679

Morphometric Analysis of the Corpus, Spinal Canal and Torg Ratio Using Midsagittal Cervical Vertebrae Computed Tomography Scan: Indonesian Population Rully Hanafi Dahlan; Priandana Adya Eka Saputra; Farid Farid Yudoyono; Sevline Esthetia Ompusunggu; Muhammad Zafrullah Arifin; Agung Budi Sutiono; Ahmad Faried
International Journal of Integrated Health Sciences Vol 2, No 1 (2014)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Objective: To determine the normal ranges of cervical spinal canal morphometry in Indonesian population and to compare the acquired data collected from other populationsMethods: Computed tomography measurements on the diameter of midsagital spinal canal and corpus of cervical vertebrae and its Torg ratio from the lower cervical (C3-C7) canal from 24 normal Indonesian adults were performed at the Radiology Department of Dr. Hasan Sadikin General Hospital. Patients who had cervical spine disorders and those under 20 years old were exluded. We used computed tomography scan midsagittal view to measure the aforementioned parameters. Results: The average diameter for the cervical spinal canals for the Indonesian population is comparable with those of other Asian populations such as Hongkong and India, albeit with smaller Torg ratio. Conclusions: This study reports the normal radiological anatomy of the midsagital spinal canal and corpus of cervical vertebrae as well as Torg ratio from the lower cervical vertebrae among Indonesian population. The measurements result of this study shows that, although slightly smaller, the measurement results for those parameters are identical with other Asian populations. Keywords: Corpus cervical vertebrae, midsagittal cervical spinal canal, Torg ratio DOI: 10.15850/ijihs.v2n1.285

Anterior Interhemispheric Approach for Olfactory Groove Meningioma Imam Hidayat; Agung Budi Sutiono; Ahmad Faried; Muhammad Zafrullah Arifin
International Journal of Integrated Health Sciences Vol 4, No 2 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Objective: To evaluate the surgical technique with bifrontal interhemispheric approach for total removal of tumor in olfactory groove meningioma (OGM). Methods: This study described a case of a 38-year-old woman with bilateral blindness, anosmia, and behaviour changes. Imaging studies show a tumor mass in midfrontal base. Surgery using a bifrontal interhemispheric approach was performed and total removal was achieved and postoperative computed tomography (CT) scan was performed to confirm the result. Histopathological findings established a diagnosis of meningioma.Results: A coronal skin incision behind the hairline was utilized. The scalp was elevated, taking care to reserve the vascularized pericranium medial to the linea temporalis of each side, and preserving the 2 supraorbital nerves. Eight burr holes were used, with the two initial holes made on each side of the orbitotemporal region, and the other four holes at the midline. A bifrontal craniotomy was performed. The tumor was first detached from its attachment with bipolar cautery and debulked. During this step, the main tumor feeder arteries from the anterior and posterior ethmoidal artery were interrupted, and the tumor devascularized. Total tumor removal through surgical intervention was achieved and confirmed by head CT-scan postoperatively.Conclusions: This case report supports the suitability of the bifrontal interhemispheric approach for OGM resection with additional radiation therapy.Keywords: Anterior interhemispheric approach, olfactory groove meningioma DOI: 10.15850/ijihs.v4n2.838

Cystic Meningioma in the Inter-Hemisferic Space Location Muhammad Zafrullah Arifin; Firman Priguna Tjahjono; Agung Budi Sutiono; Ahmad Faried
International Journal of Integrated Health Sciences Vol 4, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Objective: The presentation of cystic meningioma in the inter-hemispheric near the falx cerebri is uncommon. It is difficult to differentiate it from intra-axial tumors, such as gliomas. Therefore, it is likely that it is misdiagnosed as other types of brain tumors.Methods: In this study, we reported a cystic meningioma case in the inter-hemispheric location, showing an intramural nodule on magnetic resonance imaging scans.Results: Patient underwent surgical treatment and pathological section confirmation revealing meningioma. The patient was a middle-age woman and had been misdiagnosed as suffering from glioma followed by slight hemipharesis on the right extremities.Conclusions: Although this is a rare case, it will be good if we always consider cystic meningioma in inter-hemispheric space when diagnosing this type of cystic lesion if the magnetic resonance imaging (MRI) shows a cystic lesion mimicking glioma image presentation.Keywords: Cystic meningioma, interhemispheric space, magnetic resonance imaging, diagnosis DOI: 10.15850/ijihs.v4n1.686

Fetus inside Brain - Mature Cystic Teratoma in Posterior Fossa Farid Yudoyono; Mirna Sobarna; Agung Budi Sutiono; Muhammad Zafrullah Arifin
International Journal of Integrated Health Sciences Vol 4, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Objective: To describe a rare case of posterior fossa cystic teratoma in central nervous system. Methods: A 2-year old boy was admitted with a chief complaint of decreased consciousness with tonic clonic seizure. Non-Contrast Head Computed Tomography (NCCT) scan showed acute hydrocephalus and a well-defined extra-axial cystic lesion mass, 3.4x3.9x4.2 cm in size, in the posterior fossa.Results: Patient underwent a total resection of the tumor. No systemic complication was found in ten days following the surgery. There was no evidence of tumor recurrence one year after the surgery. The histopathologycal diagnosis of the tumor was cystic teratoma.Conclusions: Mature cyst teratoma located in the posterior fossa is a rare case. Total resection and long-term follow up is the treatment of choice for mature teratoma.Keywords: Hydrocephalus, posterior fossa, teratoma DOI: 10.15850/ijihs.v4n1.687

Anterior Transpetrosal Untuk Lesi pada Fosa Kranialis Media dan Posterior: Review Literatur dan Diseksi Kadaver Muhammad Zafrullah Arifin; Agung Budi Sutiono; Ahmad Faried; Takeshi Kawase; Beny Atmadja Wirjomartani; Kahdar Wiriadisastra
Majalah Kedokteran Bandung Vol 42, No 2
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Reseksi selektif pada bagian anterior piramid os petrosus (segitiga Kawase), dengan terlebih dahulu melakukan kraniotomi pada dinding lateral fosa kranialis media, dapat memberikan lapang pandang bedah yang cukup luas dari parasellar, clivus dan cerebellopontine angle (CPA), tanpa mengorbankan struktur organ pendengaran dalam (internal acoustics organ). Keuntungan utama teknik anterior transpetrosal ini adalah dapat langsung mengakses tumor yang melekat pada klivus melalui rongga kecil yang dibuat pada apeks os petrosus. Pengangkatan tumor dengan perdarahan yang minimal dapat dicapai dengan melakukan koagulasi pada arteri tentorium dan akses langsung ke arah anterior kanalis auditorius internus, juga dapat mengurangi cedera pada nervus fasialis dan vestibulokoklearis. Keuntungan lainnya, yaitu, rendahnya risiko komplikasi perdarahan vena, karena teknik ini tidak mengekspos sinus sigmoid ataupun vena Labbe. [MKB. 2010;42(2):86-91].Kata kunci: Anterior transpetrosal, fosa media dan posterior, diseksi kadaverAnterior Transpetrosal for Lession in Middle and Posterior Fossa: Literature Review and Cadaver DissectionResection of the anterior part of pyramid through the middle fossa craniotomy will give us a surgical field of the parasellar, clivus and cerebellopontine angle without sacrificing the auditory structure. The advantage of the anterior transpetrosal approach is the direct access to tumors that attached to the clivus via a keyhole created on the petrosus apex. Bloodless tumor removal can be achieved by detachment of the tentorial artery and direct access of the anterior internal auditory canal also can minimize the injury of the cranial nerve facialis and vestibulocochlearis. Another advantage is the low risk of venous damages since this approach is not exposing the sigmoid sinus and the vein of Labbe. [MKB. 2010;42(2):86-91].Key words: Anterior transpetrosal, middle and posterior fossa, cadaver dissection DOI: http://dx.doi.org/10.15395/mkb.v42n2.219

Analisis Faktor Prediksi Keberhasilan Traksi Servikal Berdasarkan Tercapainya Realignment Tulang Servikal Pada Evaluasi Foto Polos Servikal Lateral Serial Pasien Dengan Cedera Tulang Servikal Subaksial Ahmad Faried; Muhammad Zafrullah Arifin; Rully Hanafi Dahlan; Firman Priguna Tjahjono; Agung Budi Sutiono
Jurnal llmu Bedah Indonesia Vol. 43 No. 1 (2014): September 2014
Publisher : Ikatan Ahli Bedah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46800/jibi-ikabi.v43i1.72

Pendahuluan. Cedera tulang servikal merupakan cedera tulang belakang yang paling ditakuti, baik bagi dokter, pasien dan keluarganya. Semua pasien dengan cedera tulang servikal subaksial yang tidak stabil, harus segera dilakukan fiksasi menggunakan traksi servikal. Foto polos servikal lateral masih merupakan standar dalam menganalisis stabilitas stuktur tulang servikal dan masih memiliki nilai diagnostik tinggi dalam menge- valuasi keberhasilan traksi servikal pasien cedera tulang servikal. Keberhasilan traksi servikal dapat diprediksi dengan melihat tercapainya realignment tulang servikal berdasarkan evaluasi foto polos servikal lateral serial pada pasien cedera tulang servikal subaksial. Metode. Penelitian ini merupakan studi retrospektif yang dilakukan terhadap 30 pasien cedera tulang servikal subaksial yang masuk Unit Gawat Darurat (UGD) Rumah Sakit dr. Hasan Sadikin Bandung (RSHS) periode 2009–2013. Studi ini menggunakan metode statistik logistik regresi dengan kemaknaan berdasarkan nilai p < 0,05 dan confidence interval sebesar 95%. Hasil. Studi ini menunjukkan bahwa dari semua karakteristik pasien cedera servikal subaksial yang dilakukan traksi servikal (closed reduction), didapatkan interval kedatangan ke rumah sakit dan facet lock (FL) merupakan faktor utama suatu kegagalan traksi servikal. Interval kedatangan pasien ke RSHS pada keberhasilan traksi servikal bermakna signifikan secara statistik (p=0.015; 2–sided tail dengan Pearson's chi–square) dan distribusi FL pada keberhasilan traksi servikal bermakna signifikan secara statistik (p=0,001; 2 sided tail dengan fisher's exact test). Odds ratio untuk ada atau tidak adanya FL adalah 3,8 dengan 95% confidence interval 0.5–27.1; dengan p=0,001. Kesimpulan. Disimpulkan bahwa dalam penanganan dan terapi cedera servikal subaksial > 24 jam perlu di–informed concent–kan akan kegagalan upaya traksi, serta bilamana terdapat FL tidak perlu dilakukan suatu upaya traksi servikal (closed reduction) percobaan, melainkan harus langsung dilakukan terapi definitif (opened reduction) serta stabilisasi

Hubungan Gejala Klinis Dengan Tekanan Intraventrikuler Pada Hidrosefalus Akut Donny Argie; Muhammad Zafrullah Arifin; Achmad Adam; Akhmad Imron; Mirna Sobana; Agung Budi Sutiono
Jurnal llmu Bedah Indonesia Vol. 43 No. 1 (2014): September 2014
Publisher : Ikatan Ahli Bedah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46800/jibi-ikabi.v43i1.73

Latar Belakang. Penelitian tentang gejala klinis atau tekanan intrakranial pasien pediatrik yang menderita hidrosefalus akut telah banyak dilakukan, tetapi penelitian yang menghubungkan antara gejala klinis dan tekanan intrakranial pasien pediatrik yang menderita hidrosefalus akut belum banyak dilakukan. Tujuan. Mengetahui hubungan antara gejala klinis dengan tekanan intraventrikuler pada pasien pediatrik penderita hidrosefalus akut. Metode. Penelitian prospektif analitik, dimana data diambil dari tanggal 1 Januari 2010 sampai dengan 17 Agustus 2013 di Departemen/ SMF Ilmu Bedah Saraf Fakultas Kedokteran Universitas Padjadjaran/ RSUP Dr. Hasan Sadikin Bandung. Hasil. Jumlah sampel pasien hidrosefalus akut, sebanyak 27 laki–laki (53%) dan 24 perempuan (47%). Penyebab hidrosefalus akut pada penelitian ini adalah neoplasma yaitu sebanyak 24 kasus (47%), dan infeksi 23 kasus (45%). Hasil uji secara statistik menunjukkan bahwa gejala klinis muntah dan penurunan kesadaran memiliki nilai yang bermakna dengan p<0.05 sedangkan nyeri kepala memiliki nilai yang tidak bermakna terhadap peningkatan tekanan intraventrikuler dengan nilai p >0.05. Kesimpulan. Gejala klinis muntah dan penurunan kesadaran mempunyai hubungan dengan tekanan tinggi intrakranial sehingga dapat digunakan sebagai deteksi dini pada pasien pediatrik penderita hidrosefalus akut yang dis- ebabkan oleh neoplasma maupun infeksi.

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