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All Journal International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Althea Medical Journal Jurnal Riset Kesehatan Journal of Medicine and Health Indonesian Journal of Rheumatology Jurnal Ilmu Bedah Indonesia Tunas Medika Jurnal Kedokteran & Kesehatan Jurnal Keperawatan Klinis dan Komunitas (Clinical and Community Nursing Journal) Jurnal Neuroanestesi Indonesia Journal of Medicine and Health Jurnal Widya Medika
Muhammad Zafrullah Arifin
Department Of Neurosurgery Faculty Of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung, Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Myelopathy caused by Ossification of Thoracic Ligamentum Flavum Yudoyono, Farid; Dahlan, Rully Hanafi; Ompusunggu, Sevline Esthetia; Hamijoyo, Laniyati; Arifin, Muhammad Zafrullah
Indonesian Journal of Rheumatology Vol 8, No 1 (2016)
Publisher : Indonesian Rheumatology Association

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Abstract

Hypertrophy of the posterior spinal elements leading to compromise of the spinal canal and its neural elements is a well-recognized pathological entity affecting the lumbar or cervical spine. Such stenosis of the thoracic spine in the absence of a generalized rheumatological,metabolic, or orthopedic disorder, or a history of trauma is generally considered to be rare. Spinal ligaments, such as the ligamentum flavum (LF), are prone to degeneration and can lead to back pain and nerve dysfunction. Ossification of ligamentum flavum (OLF) is a pathological condition that cause neurological symptoms and usually occurs in the thoracic spine and less frequently in the cervical spine. However the disease is now being increasingly recognized as acause of thoracic myelopathy. We report a rare case of thoracic myelopathy caused by OLF. A 48-year-old male presented with a chief complaint of weakness of bilateral lower extremities. Neurological examination revealed sensory deficit at Th 11 level below. Magnetic resonance imaging and computed tomography demonstrated OLF at the right T9–11 level. Thoracicmyelopathy caused by OLF was consider and surgical intervention was performed. Posterior decompression and laminoplasty has been performed for this patient. Keywords: ossification of ligamentum flavum, thoracic myelopathy, laminoplasty
Cognitive and Functional Outcome among Hospitalized Intracerebral Haemorrhage Patients in West Java’s Top Referral Hospital Setyawan, Ilham Bagas; Ong, Paulus Anam; Arifin, M. Zafrullah
Althea Medical Journal Vol 5, No 1 (2018)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (579.092 KB) | DOI: 10.15850/amj.v5n1.1331

Abstract

Background: Stroke is the highest cause of disability in adults. Disability and cognitive function impairment cause dependency and decreasing quality of life. The objectives of this study was to describe the outcome of functional and cognitive function among intracerebral haemorrhage patients admitted to Dr. Hasan Sadikin General Hospital Bandung in 2013.Methods: This study was a quantitative descriptive study, conducted from October 2016 to August 2017. Data were collected retrospectively with total sampling method from medical records of intracerebral haemorrhage patients admitted to Dr. Hasan Sadikin General Hospital in 2013 assessed with the Montreal Cognitive Assessment-Indonesian Version (MoCA-INA) and Barthel Index. Patients with incomplete medical records , severe aphasia, severe sensoric-motoric impairment, and decreased consciousness were excluded in this study. Data were analyzed using Microsoft Office Excel 2010 and presented in percentage.Results: Out of the 26 subjects, 11 were men and 15 women , who were in the age range of 45–54 years (42.3%), with low education level (61.5%), and unemployed (61.5%) had the highest prevalence on subjects studied. Hypertension was the most common risk factor (78%). Most subjects had cognitive function impairment (69.2%) with delayed memory function as the most common impairment domain found (84.6%), followed by visuospatial/executive function (69.2%). Most subjects had a high score of dependence according to the Barthel test (61.5%).Conclusions: Two third of intracerebral haemorrhage patients have cognitive function impairment and functional dependence. Memory function is the most common impaired cognitive functional domain. 
CRANIAL CHARACTERISTICS, MAXILLOFACIAL, AND SKULL BASE STRUCTURE OF NON-HUMAN PRIMATE (ADULT MACACA FASCICULARIS): A PRELIMINARY STUDY FOR CRANIAL CRANIOTOMY MODEL Bolly, Hendrikus Masang Ban; Indah, Astrina Rosaria; Faried, Ahmad; Noverina, Rachmawati; Arifin, Muhammad Zafrullah; Wirakusumah, Firman Fuad
Majalah Kedokteran Bandung Vol 51, No 2 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v51n2.1650

Abstract

The use of non-human primate (NHP) animal models, which anatomical and physiological similarities to human, is important for the sake of learning the anatomical properties. This study aimed to characterize the cranial, maxillofacial, and skull base structures of non-human primates as a potential model suitable for a cranial craniotomy model. Adult Macaca fascicularis (MF) skulls classified asspecificpathogen-free for TB, SIV, SV40, Polio, Foamy virus and Herpes B virus from PT Bio Farma (Persero) Animal Lab. Library were used to represent the anatomical model.The open access database from Mammalian Crania Photographic Archive 2nd Edition (MCPA2) was used for cranial characterization analysis. This study was performed at the Department of Neurosurgery, Dr. Hasan Sadikin General Hospital and the Animal Laboratory of PT. Biofarma (Persero) from November 2018 to January 2019. The skull base structures were assessed for its analogies with its human counterpart. Comparison by t-student analysis between male and female skulls shows the mean male cranial length (CL) is greater than in female (116.68 vs 102.50 mm), with p=0.000; the mean male bizygomatic width (BZB) is greater than in female (79.30 vs 69.70 mm) with p=0.001; the mean male posterior cranial breadth (CBN) is greater than in female (63.40 vs 58.79 mm) with p=0.019; and the mean male cranial base length (CBL) is greater than in female (63.32 vs 57.55 mm), with p=0.001. The skull of MF is suitable for Neurosurgery and Neuroscience study since the MF cranial characterization and structure are similar to that of human. Its structure is ideal for performing craniotomy since it has several characteristics such as cranial vault, maxillofacial structure with huge temporal muscle, and skull base structure.  Karakteristik Kranium, Maksilofasial, dan Struktur Dasar Tengkorak Non-human Primate Macaca fascicularis dewasa: Studi Pendahuluan untuk Model Craiotomi Kranium Penggunaan hewan model berasal dari primata bukan-manusia (NHP), dimana secara anatomis dan fisiologis mirip dengan manusia, sangat penting untuk dapat mempelajari struktur anatominya. Penelitian ini bertujuan untuk karakterisasi struktur kranium, maksilofasial dan dasar tengkorak primata (Non-human Primate) yang berpotensi sebagai model penelitian kraniotomi. Tengkorak dewasa Macaca fascicularis (MF) dari  Laboratorium Hewan PT Biofarma (Persero), bebas infeksi TBC, SIV, SV40, Polio, Foamy Virus,  dan Herpes B digunakan sebagai model anatomi. Basis data terbuka Mammalian Cranial Photographic Archive 2nd Edition (MCPA2) digunakan untuk analisis kranium. Penelitian dilakukan di Departmen Bedah Saraf RSHS dan Laboratorium Hewan  PT. Biofarma  pada November 2018?Januari 2019. Struktur tengkorak MF dipelajari analogi seperti pada struktur tengkorak manusia. Analisis uji-t tengkorak jantan dan betina menunjukan rerata panjang kranial (Cranial length, CL) jantan lebih panjang dibanding betina (116.68 vs 102.50 mm, p=0.000); rerata bizygomatic width (BZB) jantan lebih panjang dibanding betina (79.30 vs 69.70 mm, p=0.001); rerata posterior cranial breadth (CBN) jantan lebih panjang dibanding betina (63.40 vs 58.79 mm, p=0.019);dan rerata cranial base length (CBL) jantan lebih panjang dibanding betina (63.32 vs57.55 mm, p=0.001). Tengkorak MF sesuai untuk berbagai penelitian bidang bedah saraf dan neurosains. Karakterisasi kranial dan strukturnya sama dengan yang dimiliki manusia. Struktur kranium MF merupakan model ideal untuk kraniotomi berdasar karakteristik tulang tengkorak, otot temporal besar pada maksilofasial, dan struktur dasar tengkorak.
Incidence of Cavum Septum Pellucidum and Cavum Vergae in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia Faried, Ahmad; Soeprajogo, Adolf Setiabudi; Melia, Regina; Arifin, Muhammad Zafrullah
International Journal of Integrated Health Sciences Vol 5, No 1 (2017)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To describe the cavum septum pellucidum (CSP) and cavum vergae (CV) findings. Methods: Thirteen samples were recruited in the study. The study was conducted at the Department of Neurosurgery, Dr. Hasan Sadikin Hospital, Bandung, Indonesia in the period of 2015–2016. Thirteen samples were recruited for the study. Cavum septum pellucidum and CV spaces are relatively rare. During neurology and neurosurgery examination of patients with head computed tomography (CT) scan and magnetic resonance imaging (MRI), CSP and CV were discovered accidentally. The incidence of these unique spaces reported from many countries, but have never been reported from Indonesia.Results: This is the first-time reported incidental finding of CSP and CV from Indonesia, 13 cases in one-year period. Since the presence of CSP and CV is usually asymptomatic, clinician seem don’t really care to put it in their report.Conclusions: The presence of CSP and CV as a common incidental finding can be more revealed in our country in years to come and hopefully can be more studied in term of anatomical landmark on neurosurgical field.Keywords: Cavum septum pellucidum, cavum vergae, incidental finding DOI: 10.15850/ijihs.v5n1.964
COMPARISON OF HISTOLOGICAL CHARACTERISTICS OF DRIED AND FRESH AMNION MEMBRANES AND DURA MATER IN NON-HUMAN PRIMATE (MACACA FASCICULARIS) Indah, Astrina Rosaria; Bolly, Hendrikus Masang B.; Faried, Ahmad; Arifin, Muhammad Zafrullah; Achadiyani, Achadiyani; Wirakusumah, Firman Fuad
Majalah Kedokteran Bandung Vol 51, No 1 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.785 KB) | DOI: 10.15395/mkb.v51n1.1651

Abstract

This study aimed to characterize the histological properties of dry-lyophilized amniotic membrane, fresh amniotic membrane (AM), and duramater membrane in search for a biologically-derived material suitable for meninges surface reconstruction. This descriptive study was conducted at the Unit-3 Laboratory of Animal Test of PT. Bio Farma (Persero), Bandung and Cell Biology Laboratory of the Faculty of Medicine, Universitas Padjadjaran Bandung. This study was conducted from 2018-2019. Fresh Macacafascicularis placenta from healthy donors,classified as specific pathogen-free for TB, SIV, SV40, Polio type 1,2,3, Foamy virus and Herpes B virus, were obtained from selected caesarean sections.The harvested dried and fresh AM and duramater membrane were stained with hematoxylin-eosin and prepared for characterization. Histological examination of dry-lyophilized and fresh AM showed similar results. Histologically, AM is represented by a single layer of metabolically-active cuboidal to columnar epithelium with microvilli firmly attached to a basement membrane and an avascular and relatively sparsely populated stroma. Meninges layers consists of 3 layers: duramater, arachnoid membrane, and piamater. Most of these cells have the same characteristics as fibroblasts, including long organelles and nuclei with various levels of fibril formation. The histological study of amniotic membrane and duramater membrane shows comparable results. The AM is a biologically-derived material suitable for meninges surface reconstruction since its histological structure is somewhat similar to that of the duramater. Its structure is ideal for replacing duramater since it has several characteristics, such as having hygroscopic properties, good biocompatibility, relatively easy to apply, and inexpensive. Key words: Dried and fresh amnion membranes, duramater membranes, non-human primate Karakteristik Histologis Membran Amnion Jenis Kering dan Segar dengan Membran Duramater pada Primata Non-Human Macaca fascicularisPenelitian ini bertujuan mengetahui karakteristik histologis membran amnion kering yang diliofilisasi, membran amnion segar, dan duramater, dalam rangka mencari bahan biologis yang cocok untuk rekonstruksi permukaan meninges. Penelitian deskriptif dilakukan di Laboratorium Hewan Uji PT. Bio Farma dan Laboratorium Biologi Sel FK Universitas Padjadjaran periode 2018-2019. Plasenta Primata non-human Macaca fascicularis segar dari donor sehat, yang bebas dari pathogen spesifik TB, SIV, SV40, Polio tipe 1, 2, 3, virus Foamy dan virus Herpes B, diperoleh dari seksio sesarea. Kemudian, dilakukan pewarnaan dengan hematoxylin-eosin untuk membran amnion kering dan segar, serta membran duramater untuk mengetahui karakterisasi histologisnya. Pemeriksaan histologis membran amnion kering-yang aktif bermetabolisme hingga kolumnar dengan mikrovili; melekat kuat pada membran basal dan stroma yang avaskular dan relatif jarang. Lapisan Meninges terdiri dari 3 lapisan: duramater, arachnoid dan piamater. Sebagian besar sel-sel ini memiliki karakteristik yang sama dengan fibroblas. Studi histologis membran amnion dan membran duramater memiliki struktur yang relatif serupa. Membran amnion adalah material yang secara biologis cocok untuk rekonstruksi permukaan meningen, karena struktur histologinya agak mirip dengan duramater. Oleh karena itu secara struktur, membran amnion ideal untuk menggantikan duramater karena memiliki beberapa karakteristik seperti sifat higroskopis, biokompatibilitas baik, mudah diterapkan, dan murah.Kata kunci: Membran amnion segar dan kering, membran duramater, primate non-human
MODIFIKASI METODE ISOLASI SEL ENDOTEL PEMBULUH DARAH OTAK (EPDO) TIKUS: TEKNIK DASAR KULTUR SEL PRIMER DI BIDANG NEUROSAINS Faried, Ahmad; Zafrullah Arifin, Muhammad; Sutiono, Agung Budi; Halim, Danny; Djuwantono, Tono; Achmad, Tri Hanggono
Majalah Kedokteran Bandung Vol 42, No 4
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Metode konvensional isolasi sel endotel pembuluh darah otak (EPDO) masih tergolong sulit, sehingga upaya mendapatkan populasi murni sel ini adalah tantangan. Pada penelitian ini dilakukan isolasi endotel dari tikus Wistar dan mencit C57/Bl6, berdasarkan protokol the care and use of laboratory animals, Universitas Gunma, Jepang. Modifikasi metode isolasi adalah menggunakan gradasi bovine serum albumin (BSA), bukan Dextran-70 yang umumnya dipakai, untuk memisahkan sel EPDO yang bersatu menjadi sel EPDO tunggal. Penelitian ini dilakukan di laboratorium sel kultur, Universitas Padjadjaran bekerjasama dengan Universitas Gunma, Jepang, Januari 2008?Juni 2009. Uji hasil isolasi dan karakteristik sel EPDO dilakukan dengan teknik imunofloresen. Ekspresi tight junction ZO-1, menunjukkan sel EPDO membentuk selapis sel utuh, rapat, tidak bertumpuk dan kompak, sesuai dengan karakteristik dinding EPDO. Fenotip sel EPDO dikonfirmasi dengan acethylated LDL, faktor von Willebrand dan CD31. Penghancuran kapiler dengan collagenase/dispase masih menghasilkan populasi sel yang terkontaminasi perisit. Kontaminasi dimurnikan dengan menggunakan puromycin, tingkat pemurnian sel EPDO mencapai 98,3%. Simpulan, teknik modifikasi berhasil mengisolasi sel EPDO tikus dan mencit, tanpa melakukan intervensi genetik. Puromycin dapat digunakan untuk memurnikan sel EPDO. [MKB. 2010;42(4):161?8].Kata kunci: Metode modifikasi isolasi sel EPDO, pembuluh sawar otak, teknik pemurnian Isolation Modified-Method of Mouse-Brain Microvessel Endothelial Cells: Primary Cell Culture Technique in NeuroscienceIsolation method to obtain pure BMVECs is hard to be done consistently and remains a challenge. In this study, we isolated BMVECs from Wistar rat and C57/Bl6 mouse from Japan SLC. All procedures performed according to guidelines for the care and use of laboratory animals of Gunma University, Japan. The modification of isolation method was using bovine serum albumin (BSA) gradation, not Dextran-70 in which generally used, to separate clusters of BMVECs into single cell. This study was done at Universitas Padjadjaran, in colaboration with Gunma University, Japan, January 2008?June 2009. Further,characteristic and purification results were proven by imunofluorescene staining. The results showed that staining of tight junction, ZO-1, formed a monolayer, tightly packed, non-overlapping and contact-inhibited BMVECs, as expected for a vessel wall endothelial. ECs phenotype confirmed by acethylated LDL, von Willebrand and CD31. The digestion of capillaries generated contaminating pericytes. Contamination was purified using puromycin and the results considered satisfactory (98.3%). In conclusion, our modification procedure allows the isolation of primary rat and mouse BMVECs, which form an endothelial-like monolayer in few days. Puromycin can be used for purification of primary rat and mouse BMVECs. [MKB. 2010;42(4):161?8].Key words: Blood brain barrier, isolation modified-method of mouse-BMVECs, purification methods DOI: http://dx.doi.org/10.15395/mkb.v42n4.30
Functional Independence Measure Penderita Cedera Servikal Arifin, Muhammad Zafrullah; Henky, Jefri
Majalah Kedokteran Bandung Vol 45, No 3 (2013)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Cedera servikal merupakan salah satu cedera tulang belakang terbanyak pada penderita trauma. Di Amerika Serikat tahun 2008 dari 100.000 kasus cedera tulang belakang, 2/3 merupakan kasus cedera servikal. Penilaian awal dilakukan berdasarkan American Spinal Cord Injury Association (ASIA) Impairment Score, sedangkan hasil setelah penatalaksanaannya sering diabaikan untuk evaluasi keberhasilan ahli di rumah sakit. Tujuan penelitian untuk mengetahui nilai functional independence measure (FIM) penderita cedera servikal dengan manajemen konservatif dan korelasinya dengan usia, jenis kelamin, jenis trauma, onset trauma, abnormalitas tulang servikal, lesi cervical spine, dan ASIA Impairment Score. Dilakukan studi kohor prospektif pada semua pasien cedera servikal yang memenuhi kriteria inklusi di Departemen Bedah Saraf Rumah Sakit (RS) Dr. Hasan Sadikin Bandung. Subjek dikelompokkan berdasarkan usia, jenis kelamin, trauma tunggal/multipel, akut/kronik, abnormalitas tulang servikal, lesi komplet/inkomplet, ASIA Impairment Score, dan komplikasi awal cedera. Pada penderita dilakukan penilaian FIM di Poliklinik Bedah Saraf. Data dianalisis menggunakan uji-t dan uji chi-kuadrat dengan p<0,05. Terdapat 17 penderita cedera servikal yang dirawat di Departemen Bedah Saraf RS Dr. Hasan Sadikin Bandung periode April 2009–April 2010. Observasi kohor prospektif nilai FIM rata-rata penderita cedera servikal adalah 4+1,63. Analisis chi-kuadrat menyatakan bahwa tidak terdapat hubungan usia (p=0,064), jenis kelamin (p=0,144), jenis trauma penyerta (p=0,959), onset cedera (p=0,220), abnormalitas tulang servikal (p=0,869) dengan besarnya nilai FIM pasien cedera servikal. Terdapat hubungan jenis lesi cervical spine (p=0,037), ASIA Impairment Score (p<0,001) dengan besarnya nilai FIM penderita cedera servikal. Simpulan, jenis lesi cervical spine dan ASIA Impairment Score memiliki hubungan bermakna dengan besarnya nilai FIM penderita 3 bulan pascacedera servikal. [MKB. 2013;45(3):180–6]Functional Independence Measure in Patients with Cervical Spine InjuryCervical spine injury is one of the most common spinal cord injuries in trauma patients. From 100,000 spinal cord injury cases reported in the United States of America (2008), 2/3 involved cervical spine injury. American Spinal Cord Injury Association (ASIA) Impairment Score is used as an initial assessment but further prognostic outcome of these patients is often not paid enough attention. The objective of this study was to find the value of functional independence measure (FIM) cervical spine injury patients with conservative management and correlation with age, sex, type of trauma, onset of trauma, cervical bone abnormalities, type of spinal lesion and ASIA Impairment Score. A prospective cohort study was performed to all patients with cervical spine injury which fullfil the inclusion criteria treated in Neurosurgery Department of Dr. Hasan Sadikin Hospital Bandung. The subjects were classified based on age, sex, single/multiple trauma, acute/chronic, cervical bone abnormalities, complete/incomplete lesion, ASIA impairment score and initial complication. The patients were performed to FIM examination in Outpatient clinic of Neurosurgery. T-test and chi-square test with p<0.05 were done to analyze the data. There were 17 cervical spine injury patients treated in Neurosurgery Department of Dr. Hasan Sadikin Hospital Bandung during April 2009–April 2010. The average FIM value of cervical spine injury in those patients was 4+1.63 by cohort prospective study. There were no correlation between FIM value with age (p=0.064), sex (p=0.144), type of trauma (p=0.959), onset of trauma (p=0.220) and cervical bone abnormalities (p=0.869). We found a significant correlation between FIM value with type of cervical spine lesion (p=0.037) and ASIA Impairment Score (p<0.001) in cervical spine patients. In conclusion, type of cervical spine lesion and ASIA impairment score have significant correlation with FIM value of patients in 3 months after cervical injury.[MKB. 2013;45(3):180–6] DOI: http://dx.doi.org/10.15395/mkb.v45n3.15
KADAR PROTEIN S-100 SERUM PENDERITA FRAKTUR OROMAKSILOFASIAL YANG DISERTAI CEDERA KEPALA RINGAN Miguna, Hayana; Arifin, Muhammad Zafrullah
Majalah Kedokteran Bandung Vol 44, No 4 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Penderita fraktur oromaksilofasial sering disertai dengan cedera kepala karena letak dan strukturnya yang berdekatan. Penilaian kemungkinan untuk lesi intrakranial setelah cedera kepala ringan merupakan tantangan utama dalam mendiagnosisnya. Salah satu metode yang dapat digunakan yaitu dengan menggunakan biomarker (petanda biokimia) protein S-100 serum yang merupakan protein neuron-spesifik. Tujuan penelitian adalah untuk menilai peningkatan kadar protein S-100 serum dan melihat perbedaannya berdasarkan lokasi fraktur oromaksilofasial pada cedera kepala ringan. Penelitian ini menggunakan metode studi kasus kontrol yang dilakukan di RS Dr. Hasan Sadikin Bandung pada bulan November 2010?Januari 2011. Sampel berjumlah 76 orang yang terdiri atas 38 penderita dewasa fraktur oromaksilofasial disertai dengan cedera kepala ringan dan 38 orang dewasa sehat sebagai kontrol. Hasil penelitian menunjukkan bahwa pada penderita fraktur oromaksilofasial dengan cedera kepala ringan diperoleh kadar protein S-100 serum rata-rata meningkat sebanyak dua kali lipat, yang secara statistik signifikan dengan t hitung=2,26 atau nilai p=0,0135. Bila kelompok penderita yang satu dibandingkan dengan kelompok penderita lainnya, maka didapatkan hasil yang tidak signifikan secara statistik atau dapat dikatakan mempunyai kadar protein S-100 serum yang sama. Simpulan, pada penderita dewasa fraktur oromaksilofasial disertai cedera kepala ringan terdapat peningkatan kadar protein S-100 serum dan tidak terdapat perbedaan kadar protein S-100 serum berdasarkan lokasi fraktur oromaksilofasial. [MKB. 2012;44(4):233?39].Kata kunci: Cedera kepala ringan, fraktur oromaksilofasial, protein S-100 serumSerum Levels of S-100 Protein in Oromaxillofacial Fracture Patients with Mild Head InjuryOromaxillofacial fracture is often accompanied by head injury due to its adjacent location and structure. Risk estimation for clinically relevant intracranial lesions after minor head injury remains a major diagnostic challenge. One possible method to evaluate the possibility of intracranial lesion is by using biomarkers (biochemical marker) protein S-100. Protein S-100 is a neuron-specific protein. The aim of present study was to assess the elevated levels of S-100 protein serum and to investigate whether there was any difference in the S-100 protein serum concentrations depending on the location of the oromaxillofacial fractures in mild head injury. This study was performed using analytic observational method with case control research design conducted at Dr. Hasan Sadikin General Hospital Bandung between November 2010 and January 2011. There were 76 samples, comprised of 38 adult patients with oromaxillofacial and mild head injury and 38 healthy adults as a control group. The result showed that there was an increase level of S-100 protein serum concentrations in patients having oral and maxillofacial fractures with mild head injury. The concentration increased on average twice as much, which was statistically significant at t test=2.26 with p-value=0.0135. If one group of patients was compared with other patient groups, however, the results were not statistically significant, or it can be stated to have the same level of S-100 protein serum concentrations. In conclusion, oral and maxillofacial fractures in adult patients with mild head injury have elevated levels of S-100 protein serum concentrations and there is no difference in S-100 protein serum concentrations based on the location of oromaxillofacial fractures in mild head injury. [MKB. 2012;44(4):233?39].Key words: Mild head injury, oromaxillofacial fracture, S-100 protein serum DOI: http://dx.doi.org/10.15395/mkb.v44n4.178
Hubungan Cedera Servikal dengan Fraktur Depresi Tulang Frontal pada Cedera Kepala Ringan Arifin, Muhammad Zafrullah; Gunawan, Wienorman
Majalah Kedokteran Bandung Vol 43, No 3
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Pemahaman mekanisme cedera kepala penting dalam menentukan pola cedera secara anatomis. Fraktur depresi tulang frontal terjadi bila terdapat gaya mekanis yang cukup kuat pada kepala. Dalam hal ini pada aksis fleksi dan ekstensi. Gerakan fleksi ekstensi berlebihan dilaporkan berhubungan dengan cedera servikal. Penelitian analitik retrospektif di Departemen Bedah Saraf RS Dr. Hasan Sadikin Bandung periode Januari 2008–Desember 2009 ini bertujuan untuk melihat hubungan cedera servikal dengan fraktur depresi tulang frontal pada penderita cedera kepala ringan. Uji statistik menggunakan chi-kuadrat dan Pearson correlation. Didapatkan 354 kasus cedera kepala ringan dengan 17 (4,8%) kasus fraktur depresi tulang frontal, 14 (3,9%) kasus cedera servikal termasuk satu kasus dengan keduanya. Mekanisme cedera kepala terbanyak adalah kecelakaan bermotor, terjatuh dari ketinggian, dan benturan benda tumpul di bagian kepala. Hasil analisis statistik menunjukkan hubungan signifikan fraktur depresi tulang frontal dengan cedera servikal (p=0,000). Tidak didapatkan hubungan penggunaan helm dengan risiko cedera servikal (p=0,157). Simpulan, fraktur depresi tulang frontal pada kasus cedera kepala ringan merupakan indikator adanya cedera servikal. [MKB. 2011;43(3):122–7].Kata kunci: Cedera kepala ringan, cedera servikal, fraktur depresi tulang frontalCorrelation of Cervical Injury to Frontal Depressed Fracture in Mild Head InjuryAn understanding of head injury mechanism has a major role in predicting the anatomical injury. Frontal depressed fracture occurs if a substantial force is applied to the head. In this case, the flexion and extension axis. Overflexion and over-extension movement was reported to have correlation with cervical injury. This study was to find out the correlation cervical injury and frontal depresses fracture in mild head injury cases. A retrospective analytic study was carried out, chi-square and Pearson correlation test were performed using records of patients consulted to Neurosurgery Department of Dr. Hasan Sadikin Hospital in January 2008–December 2009. There were 354 cases of mild head injury with 17 (4.8%) cases of frontal depressed fracture, 14 (3.9%) cervical injuries, included one with both. The cause of the trauma were riding motorcycle, fell from height, and blunt trauma to the head. The statistical analysis showed a significant correlation between cervical injury and frontal depressed fracture (p=0.000). There was no correlation between helmet utilization and risk of cervical injury (p=0.157). In conclusion, fracture in mild head injury cases is an indicator of cervical injury. [MKB. 2011;43(3):122–7].Key words: Cervical injury, mild head injury, frontal depressed fracture DOI: http://dx.doi.org/10.15395/mkb.v43n3.57
Cognitive and Functional Outcome among Hospitalized Intracerebral Haemorrhage Patients in West Java’s Top Referral Hospital Ilham Bagas Setyawan; Paulus Anam Ong; M. Zafrullah Arifin
Althea Medical Journal Vol 5, No 1 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Stroke is the highest cause of disability in adults. Disability and cognitive function impairment cause dependency and decreasing quality of life. The objectives of this study was to describe the outcome of functional and cognitive function among intracerebral haemorrhage patients admitted to Dr. Hasan Sadikin General Hospital Bandung in 2013.Methods: This study was a quantitative descriptive study, conducted from October 2016 to August 2017. Data were collected retrospectively with total sampling method from medical records of intracerebral haemorrhage patients admitted to Dr. Hasan Sadikin General Hospital in 2013 assessed with the Montreal Cognitive Assessment-Indonesian Version (MoCA-INA) and Barthel Index. Patients with incomplete medical records , severe aphasia, severe sensoric-motoric impairment, and decreased consciousness were excluded in this study. Data were analyzed using Microsoft Office Excel 2010 and presented in percentage.Results: Out of the 26 subjects, 11 were men and 15 women , who were in the age range of 45–54 years (42.3%), with low education level (61.5%), and unemployed (61.5%) had the highest prevalence on subjects studied. Hypertension was the most common risk factor (78%). Most subjects had cognitive function impairment (69.2%) with delayed memory function as the most common impairment domain found (84.6%), followed by visuospatial/executive function (69.2%). Most subjects had a high score of dependence according to the Barthel test (61.5%).Conclusions: Two third of intracerebral haemorrhage patients have cognitive function impairment and functional dependence. Memory function is the most common impaired cognitive functional domain. 
Co-Authors Aan Nuraeni Achadiyani Achmad Adam Agung Budi Sutiono Agung Budi Sutiono Agung Budi Sutiono Agung Budi Sutiyono Ahmad Faried Ajid Risdianto Akhmad Imron Avrina, Rossa Avrina, Rossa Bayu Fandhi Achmad Benny Atmadja Wirjomartani Beny Atmadja Wirjomartani Bilzardy Ferry Danny Halim Dhuha, Alief Donny Argie Eldy Muhammad Noor Farid Yudoyono Firman Fuad Wirakusumah Firman P Tjahjono Firman Priguna Firman Priguna T Firman Priguna Tjahjono Ha Yoon Hayana Miguna Hellena Deli Hendrikus Masang Ban Bolly Ilham Bagas Setyawan Indah, Astrina Rosaria Jefri Henky Jefri Henky Jefri Henky Julius July Kahdar Wiriadisastra Kim Keung Nyun Laniyati Hamijoyo, Laniyati Melia, Regina Mirna Sobana Mirna Sobarna Noverina, Rachmawati Ong, Paulus Anam Paulus Anam Ong Petra Octavian Perdana Wahjoepramono Priandana Adya Eka Saputra Priandana Adya Eka Saputra Rully Hanafi Dahlan Sari Fatimah Setyawan, Ilham Bagas Sevline Estethia Ompusunggu Sevline Estethia Ompusunggu Sevline Esthetia Ompusunggu Sevline Esthetia Ompusunggu Sevline Esthetia Ompusunggu Shin Dong Ah Soeprajogo, Adolf Setiabudi Solly Aryza SS, Subrady Leo Subrady Leo SS T, Firman Priguna Takayuki Ohira Takeshi Kawase Tara M Mulyawan Tono Djuwantono Trajanus Laurens Yembise Tri Hanggono Achmad Wienorman Gunawan Yi Seong Yoon Do Heum