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All Journal Jurnal Kartika Kimia Jurnal Ilmu Kefarmasian Indonesia Journal of Natural Product for Degenerative Diseases
Anny Victor Purba
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Medicine & Pharmacology Public Health

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Analisis Perencanaan dan Pengendalian Obat di Rumah Sakit Pluit Tahun 2015 Endang Setiawati; Anny Victor Purba; Wahyudi Uun Hidayat
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (426.09 KB) | DOI: 10.35814/jifi.v18i1.782

Abstract

Drug planning at Pluit Hospital is carried out using a consumption method that is based on previous use. The purpose of this study was to determine the investment value and use of drug supplies based on a combination of consumption methods with ABC, VEN and Reorder Point (ROP) analysis. This research is a qualitative and quantitative descriptive study with retrospective data collection during the period May-October 2016 at Pluit Hospital. ABC analysis results based on the investment value of the total group A drug items have a percentage of 69.90%; group B 20.07% and group C 10.03%. ABC analysis results based on the use of group A 69.95%; group B 20.04% and group C 10.01%. VEN analysis results for group V 3.24% absorbed investment of 5.15%; group E 60.10% absorbed investment 76.56% and group N 36.66% absorbed investment 18.29%. Analysis of drug planning based on ABC and VEN methods has high, medium and low investment values, usage values ​​and NIK. While the analysis of drug control based on the method of Lead Time, Safety stock and Reorder Point guarantees the availability of drugs on an ongoing basis.
Formulasi Sediaan Gel Etosom Ekstrak Lamun (Enhalus acoroides) Sebagai Pencerah dan Pelembab Pada Kulit Muhammad Arif; Faizatun Faizatun; Anny Victor Purba
Jurnal Kartika Kimia Vol 4 No 1 (2021): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v4i1.75

Abstract

Lamun adalah tanaman berbunga yang hidup di laut yang ditemukan hampir di seluruh wilayah pesisir. Tanaman Lamun (Enhalus acoroides) mengandung senyawa fenol dan flavonoid yang berpotensi sebagai agen dipigmentasi melalui penghambatan tirosinase. Ekstrak etanol tanaman lamun diformulasikan ke dalam bentuk etosom untuk meningkatkan kemampuan penetrasi senyawa melalui stratum korneum. Penelitian ini bertujuan untuk memformulasi sediaan gel pelembab dari etosom ekstrak tanaman lamun (E. acoroides) pada kulit serta memiliki aktivitas menghambat enzim tirosinase sehingga dapat mencerahkan kulit. Etosom dibuat dengan menggunakan metode dingin sehingga dihasilkan formula yang baik dengan hasil karakterisasi ukuran partikel sebesar 216,1 nm yang diukur menggunakan Particle Size Analyzer (PSA). Etosom ekstrak lamun diformulasikan ke dalam bentuk gel dan dilakukan karakteristik, indeks iritasi, dan uji aktivitas gel. Pengujian karakteristik meliputi: organoleptik, homogenitas, pH, viskositas, dan daya sebar. Pengujian tersebut dilakukan terhadap gel yang disimpan pada suhu 4oC, 27oC, dan suhu 40oC selama dua bulan. Uji iritasi dilakukan secara topikal pada kelinci putih jantan. Hasil penelitian menunjukkan bahwa semua formula memiliki penampilan homogen yang baik dan berada pada rentang pH 5,38 – 5,80. Hasil uji aktivitas menunjukkan gel etosom ekstrak lamun memiliki aktivitas melembabkan sebesar 17% selama satu bulan pemakaian sediaan, serta memiliki aktivitas menghambat enzim tirosinase dengan nilai IC50 175,91 µg/mL. Kata kunci : Enhalus acoroides, etosom, enzim tirosinase, gel pelembab
Development of Gel Preparations from a Combination of Iler Leaf Extract and Patchouli Oil as a Repellent Against Aedes aegypti Mosquitoes Wahyuni, Ayu Nuki; Anny Victor Purba; Ratna Djamil
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 1 (2023): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i1.4676

Abstract

Dengue Hemorrhagic Fever (DHF) is an abnormal health condition caused by the dengue virus through the bite of the Aedes aegypti mosquito. The use of repellent to prevent mosquito bites can provide protection against DHF. DEET, a synthetic repellent with usage that has spread throughout the world, is reported to have toxic effects and cause irritation. Leaves of iler and patchouli oil are plants of the Lamiaceae family with repellent activity. This study aimed to obtain a repellant gel combination of iler leaf extract and patchouli oil. Gel preparations are made with a combination of Iler Leaf Extract and Patchouli Oil at concentrations of 12.5%, and 2%. Physical and chemical quality parameter test, stability test, acute dermal irritation test, and repel effectiveness test were tested on Aedes aegypti mosquitoes. Gel preparations showed a homogeneous physical appearance, greenish-brown color with an aromatic distinctive odor, a viscosity value of 16000 cPs, pH 6.32, and thixotropic flow properties. Gel preparations are effective as a mosquito repellent for 3 hours with a protection power of 56.82%. The gel preparation storage temperature, besides the resulting gel, does not irritate, and it is physically stable at 4 ± 2oC and 25 ± 2oC and is slightly less stable at 40 ± 2oC.
Co-Authors Endang Setiawati Faizatun Faizatun Leni Nurlina Yanti Muhammad Arif Ratna Djamil Wahyudi Uun Hidayat Wahyuni, Ayu Nuki