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All Journal Dental Journal (Majalah Kedokteran Gigi) Denta: Jurnal Kedokteran Gigi JPMP
Endah Wahjuningsih
Biologi Oral Fakultas Kedokteran Gigi Universitas Hang Tuah
Humanities Dentistry Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Social Sciences

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Modulation of FGF2 after topical application of Stichopus hermanii gel on traumatic ulcer in Wistar rats Rima Parwati Sari; Endah Wahjuningsih; isidora Karsini Soeweondo
Dental Journal (Majalah Kedokteran Gigi) Vol. 47 No. 3 (2014): September 2014
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (357.902 KB) | DOI: 10.20473/j.djmkg.v47.i3.p126-129

Abstract

Background: stichopus hermanii (golden sea cucumber) is one of the many types of marine organisms containing glycosaminoglycans (GAGs), a polysaccharide that promote wound healing. The content of this GAGs, mainly dermatan sulfate, chondroitin sulfate and heparan sulfate has the ability to modulate FGF2. FGF2 many found in the oral mucosa to activate fibroblast proliferation. Purpose: The study was aimed to determine the modulation of FGF2after topical application of stichopus hemanii gel on traumatic ulcers in wistar rat. Methods: The sample was 36 male Wistar rats which were divided into 6 groups. C1 and C2 group was placebo gel, sC1 and sC2 group was stichopus hermanii gel, HA1 and HA2 was hyaluronic acid A gel. The gel was given shortly after the traumatic ulcer (TU) formed and 24 hour later. Then all rats were sacrificed lips mucosa were taken and ELIsA examination was done. Results: All data were analyzed by ANOVA test followed by Tukey HsD. Test results show significant differences between sC1-sC2 with C1- C2 group, while the HA1-HA2 with C1-C2 group showed no significant difference. Conclusion: The study showed that modulation of FGF2 increased after topical application of stichopus hermanii gel on traumatic ulcers in wistar rats.Latar belakang: stichopus hermanii (teripang emas) merupakan salah satu jenis biota laut yang banyak mengandung GAG, suatu polisakarida yang sangat bermanfaat dalam proses penyembuhan luka. Kandungan GAG ini, terutama dermatan sulfat, chondroitin sulfat dan heparan sulfat memiliki kemampuan untuk memodulasi FGF2. FGF2 banyak didapatkan pada mukosa rongga mulut untuk mengaktifkan proliferasi fibroblas. Tujuan: studi ini bertujuan meneliti modulasi FGF2setelah pemberian aplikasi topikal gel stichopus hermanii pada ulkus traumatikus pada tikus wistar. Metode: sampel penelitian ini adalah 36 ekor tikus wistar jantan yang dibagi dalam 6 kelompok. Kelompok C1 dan C2 merupakan kelompok kontrol negatif (gel plasebo), Kelompok sC1 dan sC2 merupakan kelompok pemberian gel stichopus hermanii (sC), serta kelompok asam hyaluronat HA1 dan HA2 merupakan kelompok pemberian gel asam hialuronat (AH). Pemberian gel dilakukan sesaat setelah pembuatan ulkus traumatikus dan 24 jam kemudian. Kemudian semua tikus dikorbankan untuk diambil mukosa bibirnya dan dilakukan pemeriksaan ELIsA. Hasil: semua data dilakukan analisa dengan uji Anova dan dilanjutkan dengan uji Tukey HsD yang hasilnya menunjukkan adanya perbedaan bermakna antara kelompok sC1-sC2 dengan kelompok C1-C2, sedangkan kelompok HA1-HA2 dengan kelompok C1-C2 tidak menunjukkan perbedaan yang bermakna. Simpulan: Modulasi FGF2 meningkat setelah pemberian aplikasi topikal gel stichopus hermanii pada ulkus traumatikus tikus wistar.
Expression of bone morphogenetic protein-2 after using chitosan gel with different molecular weight on wound healing process of dental extraction Sularsih Sularsih; Endah Wahjuningsih
Dental Journal (Majalah Kedokteran Gigi) Vol. 48 No. 2 (2015): June 2015
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1399.431 KB) | DOI: 10.20473/j.djmkg.v48.i2.p53-58

Abstract

Background: Bone morphogenetic protein-2 (BMP-2) is bone stimulator which capable of inducing differentiation of mesenchymal cells into osteoblast, stimulating bone formation in wound healing process of dental extraction. Chitosan is polymer composed N-acetylD-glucosamine unit that has been used in various applications in wound healing process and bone tissue engineering. Purpose: The objective of this research was to analyzed expressions of BMP-2 for 7,14 and 21 days after using chitosan gel with different molecular weight on wound healing process of dental extraction. Method: The research was an experimental laboratory study. Rattus nornegicus strain wistar male, aged 8-16 weeks, divided into 3 treatment groups namely group 1 and II which given chitosan gel 1 % with high and low molecular weight and group III as control which were not given chitosan gel. Chitosan gel were applied into the socket of dental extraction. Rat was decaputated 7,14 and 21 days after chitosan gel application and the jaw in the treated regions and control group were cut for immunohistochemical examination to observe BMP-2. Data were analyzed using ANOVA test. Result: The result of this research showed significant differences on BMP-2 for 7,14 and 21 days observation (p<0,05). The increasing of BMP-2 were found in the group which given chitosan gel with high molecular weight. Conclusion: It may be concluded that chitosan gel with high molecular weight can enhance the expresion of BMP-2 on wound healing process ofdental extraction.
Perbandingan Hasil Penilaian Ketebalan Korteks dengan Menggunakan Mental Index pada Pasien Wanita Berdasarkan Kelompok Umur 30-70 Tahun Edward Perdana Putra; Sarianoferni; Endah Wahjuningsih
Denta Journal Kedokteran Gigi Vol 9 No 2 (2015): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: The osteoporosis risk can be detected through the width of cortical mandible and porosity which can be seen in panoramic radiography. One of measurement methods using panoramic radiography in assessing the quality of bone and observing symptom of resorption and osteoporosis by utilizing Mental Index. Mental Index is a method in counting the average width of cortex under foramen mentale because thin mandible might correlates with decreasing of bone density. Purpose: To compare the assessment result of the cortex thickness by using Mental Index on women patient based on age of group (aged 30-70) at RSGM FKG Hang Tuah University, Surabaya. Materials and Methods: In this research, panoramic radiography of women patients aged 30 to 70 were used with utilizing radiomorfometri Mental Index to assess the mandibular cortical thickness manually using adigital caliper (accuracy of 0,01mm). Result: Based on One Way ANOVA assessment, p=0.000 value was found in which it means that there was a significant difference from the result of cortical thickness assessment in age of groups using Mental Index based onpanoramic radiography of women patients aged 30-70 at RSGM FKG Hang Tuah University, Surabaya. Conclusion: The assessment of cortical thickness by using Mental Index on women patients who experienced a decrease bone density in the age of 56-70 years old and which is compared with previous three groups of age, 30-35 years old, 36-45 years old and 46-55 years old and out of 93 panoramic radiographies, 11 panoramic radiographies were detected osteoporosis or the percentage of osteoporosis occurance based on Mental Index was 12%.
KNOWLEDGE AND INDEPENDENCE IN THE CARE OF COMMUNITY DENTAL AND ORAL HEALTH TO TEACHERS AND PARENTS OF ELEMENTARY SCHOOL STUDENTS Restika Pinasti; Agni Febrina; Kristanti Parisihni; Linda Rochyani; Meinar Nur; Chaterina Dyah Nanik; Onge Victoria; Vivin Ariestania; Arifzan Razak; Yoifah Rizka; Eddy Hermanto; Nafiah; Endah Wahjuningsih
Jurnal Pengabdian Masyarakat Pesisir VOLUME 2 NOMOR 1
Publisher : Universitas Hang Tuah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/jpmp.v2i1.89

Abstract

Kesehatan gigi dan mulut di Indonesia masih merupakan masalah kesehatan yang perlu diperhatikan. Berdasarkan Riskesdas 2018, dilaporkan bahwa prevalensi masalah gigi dan mulut di Indonesia masih sangat tinggi. Sebanyak 57,6 persen orang Indonesia memiliki masalah gigi dan mulut. Hal yang paling memperhatinkan adalah sebanyak 93% anak-anak usia sekolah mengalami masalah gigi dan mulut. Kegiatan ini ditujukan sebagai program sekolah yang komprehensif di Indonesia, yang terdiri dari program 21 hari kesehatan gigi dan mulut pada anak di sekolah. Pelaksanaan Program Kesehatan Sekolah ini mengunakan sistem online melalui aplikasi zoom. Target peserta adalah 5 orang tua dan 5 guru di SD Hangtuah 6 Surabaya. Untuk lokasi dan waktu pelaksanaan adalah Sabtu, 5 November 2022, pukul 08.30 – 11.00 WIB dengan pelaksanaan menggunakan zoom meeting. Hasil analisis statistik menggunakan paired sample t-test nilai signifikansi 0.000, hal ini berarti bahwa terdapat perbedaan yang signifikan pada tingkat pengetahuan menjaga kesehatan gigi dan mulut pada guru pengajar dan orang tua murid di SD Hangtuah 6 sebelum diberi materi DHE dan sesudah diberi DHE melalui “Training of Trainer”. Guru dan orang tua dapat menjadi pioner dalam menyebarluaskan ilmu dan cara menjaga kesehatan gigi dan mulut bagi anak tingkat sekolah, juga untuk mengubah perilaku menjaga kesehatan gigi dan mulut menjadi lebih baik.
Co-Authors Agni Febrina Amelia Elizabeth Pranoto Anindita Apsari ariestania, Vivin Arifzan Razak Chaterina Dyah Nanik Dyah Ayu Eddy Hermanto Eddy Hermanto Edward Perdana Putra isidora Karsini Soeweondo Istien Wardhani Juniar, Eriza Kristanti Parisihni Linda Rochyani Meinar Nur Mohammad Basroni Rizal Nafiah Noengki Prameswari Nur Tsurayya Onge Victoria Pambudi Rahardjo Paulus Budi Teguh Restika Pinasti sari, Rima parwati Sarianoferni Sinta Puspita Sularsih Sularsih Sutarto, Ayulistya Paramita Yoifah Rizka