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All Journal Dental Journal (Majalah Kedokteran Gigi) Journal of Dentomaxillofacial Science Denta: Jurnal Kedokteran Gigi
Hansen Kurniawan
Department Of Periodontics, Faculty Of Dentistry, Hang Tuah University, Surabaya, Indonesia
Dentistry

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The effects of Anadara granosa shell-Stichopus hermanni on bFGF expressions and blood vessel counts in the bone defect healing process of Wistar rats Rima Parwati Sari; Sri Agus Sudjarwo; Retno Pudji Rahayu; Widyasri Prananingrum; Syamsulina Revianti; Hansen Kurniawan; Aisah Faiz Bachmid
Dental Journal (Majalah Kedokteran Gigi) Vol. 50 No. 4 (2017): December 2017
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (578.577 KB) | DOI: 10.20473/j.djmkg.v50.i4.p194-198

Abstract

Background: Bone damage can be caused by various factors with treatment usually involving graft materials being applied to the defective area. Moreover, in the bone defect healing process, blood vessels are also considered to be an important energy source for cell proliferation. One of the angiogenic factors playing an important role in blood vessel formation is basic fibroblast growth factor (bFGF). Furthermore, synthesized hydroxyapatite derived from Anadara granosa (AG) shells constitutes one of the potential materials for use in bone graft. The gold sea cucumber genus Stichopus hermanni (SH) possesses the ability to stimulate endothelial progenitor cells inducing bFGF. Purpose: This study aims to investigate the effects of AG shells and SH on bFGF expressions and blood vessel counts within the bone healing process. Methods: Twenty four male Wistar rats were divided into three groups, namely: a control group (C), a treatment group was administered with blood cockle shell (AG), and a treatment group with blood cockle shell and golden sea cucumber (AG+SH). Defects were made on their femurs measuring half the diameter of a circular, no. 018. bur These rats were subsequently sacrificed on day 7 after surgery. The expressions of bFGF were measured by means of IHC technique, while the number of blood vessels was quantified using HE technique. The resulting data was subjected to statistical analysis using an Anova test followed by an LSD test (p < 0.05). Results: The one-way Anova test results combined with those of an LSD test showed there to be significant differences in bFGF expressions and blood vessel counts between the control group (K) and the treatment group (AG) as well as between the treatment group (AG) and the treatment group (AG+SH). Conclusions: A combination of Anadara granosa shell and Stichopus hermanni can increase the expression of bFGF and the number of blood vessels on day 7 during the bone healing process in Wistar rats.
Effectiveness of Anadara granosa shell-Stichopus hermanni granules at accelerating woven bone formation fourteen days after tooth extraction Rima Parwati Sari; Hansen Kurniawan
Dental Journal (Majalah Kedokteran Gigi) Vol. 52 No. 4 (2019): December 2019
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v52.i4.p177-182

Abstract

Background: Post-extraction complications can cause alveolar bone resorption. Hydroxyapatite-tricalcium phosphate (HA-TCP) is one potential bone graft material that can be synthesized from Anadara granosa shell. Another biomarine, Stichopus hermanni, contains hyaluronic acid which can accelerate bone formation on the fourteenth day. Purpose: This study aims to prove the effectiveness of Anadara granosa shell-Stichopus hermanni granules in weaving bone formation fourteen days after tooth extraction. Methods: Twenty-five male Wistar rats were divided into five groups. Their lower left incisor was extracted with gelatin being administered to the control group (C) and granule scaffold derived from Anadara granosa (AG) shell and Anadara granosa shell-Stichopus hermanni at concentrations of 0.4%-0.8%-1.6% (AGSH1-AGSH2-AGSH3) to the treatment group. This study developed a HA-TCP synthesized from Anadara granosa combined with whole Stichopus hermanni to create granule scaffolds by means of a freeze-dried method. The jaw was removed on the fourteenth day post-tooth extraction. Observation of HPA involved the use of an Image Raster®. The resulting data was subjected to analysis by ANOVA and tukey-HSD tests (p<0.05). Results: Data showed the mean of C=0.157±0.078; AG=1.139±0.371; AGSH1=1.595±0.291; AGSH2=1.740±0.308; and AGSH3=1.638±0.286. Statistical analyses showed significant differences in the woven bone area (mm2) between C and the treatment groups AG;AGSH1;AGSH2; AGSH3; and between AG and the AGSH2 groups. Conclusions: Scaffold granules from Anadara granosa shells and Stichopus hermanni effectively accelerate the bone formation process with the most effective being Stichopus hermanni at a concentration of 0.8%.
The effectiveness of the combination of Moringa oleifera extract and propolis on Porphyromonas gingivalis biofilms compared to 0.7% tetracycline Hansen Kurniawan; W. Widyastuti; Mery Esterlita Hutapea
Dental Journal (Majalah Kedokteran Gigi) Vol. 54 No. 2 (2021): June 2021
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v54.i2.p63-67

Abstract

Background: Periodontitis is an inflammatory disease that occurs in periodontal tissues. Porphyromonas gingivalis is also known as a bacterium commonly associated with the pathogenesis of periodontitis. Tetracycline is one of the antibiotics often used in periodontal tissue treatment. Propolis and Moringa oleifera are also known to have certain compounds assumed to be able to inhibit biofilm growth. Purpose: This study aims to understand the effectiveness of the combination of Moringa oleifera and propolis on porphyomonas gingivalis biofilms compared to 0.7% tetracycline. Methods: A biofilm inhibition activity test was performed using the broth micro dilution method. First, bacteria were prepared by making a suspension in brain heart infusion media and adjusting it to 0.5 McFarland I standard. Second, fifteen samples were divided into five groups; group K as control group (0.1% sodium carboxymethyl cellulose), T (0.7% tetracycline), and treatment groups with the combination of propolis and Moringa oleifera in various concentrations, such as P1(10%+20%), P2(10%+40%), and P3(10%+80%). Third, the result data obtained in the form of optical density (OD) was read by using an ELISA reader. Next, statistical analysis using analysis of the variance test was conducted (p<0.05. Results: There was no significant difference between group T and group P1 (0.075). Nevertheless, there were significant differences between group T and group P2 as well as between group T and group P3 (0.00) (p=< 0.05). Conclusion: The combination of 10% propolis and 40% Moringa oleifera as well as the combination of 10% propolis and 80% Moringa oleifera have better antibacterial effectiveness against Porphyromonas gingivalis biofilm than 0.7% tetracycline.
Efek Pemberian PRF dengan Xenograft dan Alloplast terhadap Jumlah Osteoblas Hansen Kurniawan
Denta Journal Kedokteran Gigi Vol 9 No 1 (2015): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Bone graft materials have been widely used to regenerate bone defects, which are caused by trauma, tumor resection, pathological processes, and congenital bone defects. Type of bone graft is classified into several types, autograft, allograft, xenograft, and alloplast PRP and PRF derived from autologous blood which sends a high concentration of growth factors on bone defect area. Purpose: The aim of this study is to investigate the effect of PRF with xenograft and alloplast to osteoblast in bone New Zealand rabbits. Materials and Methods: The experiment was held by Post Test Group design. Twenty seven male New Zealand Rabbits were divided into three group. The first group performed the treatment on the right hind limb be treated with Alloplast and PRF treated, The second group performed the treatment on the right hind limb be treated with xenograft and PRF, and The third group was the control group performed the treatment on the right hind limb was given PRF. After treatment the rabbits were sacrificed. Osteoblast of each group was measured by EDTA method All data experiment were analyzed by ANOVA and LSD test (p<0,01). Results: The result of this study showed that the results of osteoblasts between PRF with alloplast compared with prf with xenografts, significant differences as a result of the process of bone formation to see the results of better bone formation. Conclusion: In PRF with alloplast has better results compared with PRF with xenografts from to increase osteoblasts expression.
Effectivity of lemuru fish oil (sardinella longiceps) protection in periodontal tissue wistar rats induced by diabetes mellitus Rizka SA. Putri; Dian W. Damaiyanti; Hansen Kurniawan
Journal of Dentomaxillofacial Science Vol. 7 No. 3 (2022): (Available online: 1 December 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v7i3.1418

Abstract

Objective: To determine the effect of lemuru fish oil extract (Sardinella longiceps) on the number of fibroblasts in periodontal tissue of Wistar rats induced by diabetes mellitus using streptozotocin. Material and Methods: Thirty-two Wistar rats male, were divided into 4 groups, group K0 (negative control), K1 (4ml/kgBB), K2 (8ml/kgBB), and K3 (4ml/kgBB). Rats were induced with nicotinamide and streptozotocin to create a state of diabetes. The experiment of giving lemuru fish oil extract was carried out for 21 days.The number of fibroblast cells in periodontal tissue with HE staining was performed. The data were analyzed by One-Way ANOVA and Post-Hoc LSD test. Results: The LSD test showed a significant difference between the group without treatment and the group using treatment lemuru fish oil. Group with Lemuru fish oil can increase the number of fibroblasts and the most effective dose is 8ml/kgBB. Conclusion: Lemuru fish oil extract (Sardinella longiceps) can increase the number of fibroblasts in periodontal tissue of Wistar rats induced by diabetes mellitus.
Co-Authors Aisah Faiz Bachmid Dian W. Damaiyanti Mery Esterlita Hutapea Retno Pudji Rahayu Rizka SA. Putri sari, Rima parwati Syamsulina Revianti W, Widyastuti Widyasri Prananingrum