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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) Jurnal Aplikasi Teknologi Pangan Jurnal Aplikasi Teknologi Pangan JIMR - Journal of Islamic Medicine Research Jurnal Kesehatan Islam : Islamic Health Journal Jurnal Klinik dan Riset Kesehatan Jurnal Kedokteran Komunitas (Journal of Community Medicine)
Merlita Herbani
Fakultas Kedokteran, Universitas Islam Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Journal : Jurnal Kedokteran Komunitas (Journal of Community Medicine)

 1 
PENGARUH FREKUENSI AKTIVITAS FISIK TERHADAP KADAR TRIGLISERIDA SERUM DAN SKOR NON ALCOHOLIC STEATO HEPATITIS (NASH) TIKUS BETINA DENGAN DIET HIPERLIPIDEMIA Desy Amalia Wulandari; Dini Sri Damayanti; Merlita Herbani
Jurnal Kedokteran Komunitas Vol 9, No 2 (2021)
Publisher : Jurnal Kedokteran Komunitas (Journal of Community Medicine)

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Pendahuluan: Hiperlipidemia ialah kondisi peningkatan kadar kolesterol, trigliserida dan LDL dalam darah di atas batas normal disertai penurunan kadar HDL, mapun kombinasi dari ketiganya. Hiperlipidemia dapat terjadi akibat, obesitas, diet tinggi lemak (diet hiperlipidemia), jarang olahraga, penggunaan alkohol, merokok, diabetes yang tidak terkontrol dan hipotiroidisme. Penelitian ini akan menguji aktivitas fisik dengan berenang dengan variasi frekuensi yang berbeda guna menguji pengaruhnya terhadap kadar kadar trigliserida dan skor NASH.Metode: Penelitian ini dilakukan secara eksperimental laboratorium menggunakan desain penelitian Control Group Post Test Only secara In Vivo, untuk mengetahui pengaruh frekuensi aktivitas fisik yang berbeda pada tiap kelompok tikus betina dengan diet hiperlipidemia. Penelitian ini membagi lima kelompok kelompok perlakuan fisik (berenang), yaitu kontrol negatif (KN), kelompok kontrol positif (KP), kelompok dua kali seminggu (KDS), kelompok tiga kali seminggu (KTS), dan kelompok setiap hari (KSH). Analisis data ini menggunakan uji one-way anova dan diteruskan dengan analisis post hoc LSD (Least Significantly Difference) untuk mengetahui kelompok yang paling berpengaruh.Hasil dan Pembahasan: Nilai rata-rata kadar trigliserida tertinggi pada perlakuan KP sebesar 183.40 ± 27.56 yang diikuti dengan KDS 163±23.30, KTS 151.40±23.53, KSH 126.80±20.36 dan KN 74.00 ± 6.52. Penurunan kadar trigliserida KTS dan KSH lebih besar dibandingkan KDS. Skor NASH pada KP lebih besar secara signifikan dibandingkan KSH, dan KP namun tidak berbeda secara signifikan dibandingkan KDS dan KTS. Hal tersebut menunjukkan bahwa terdapat pengaruh frekuensi aktivitas fisik terhadap Skor NASH.Simpulan: Perlakuan KSH merupakan perlakuan paling baik untuk menurunkan kadar trigliserida dan menurunkan skor NASH pada tikus yang diinduksi diet hiperlipidemia.
Pengaruh Kombinasi Dekokta Rimpang Zingiber officinale var rubrum dan Imperata cylindrica Terhadap Kadar MMP-9 Serum Tikus Wistar Jantan Model Osteoartritis Adam Bregas Regowo; Merlita Herbani; Doti Wahyuningsih
Jurnal Kedokteran Komunitas Vol 8, No 1 (2020)
Publisher : Jurnal Kedokteran Komunitas (Journal of Community Medicine)

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Introduction: Osteoarthritis is a damage chronic disorder caused by degenerative process and inflammation that lead to the joint cartilage. Previous research showed that red ginger rhizome (Zingiber officinale var rubrum) and cogon grass rhizome (Imperata Cylindrica) had anti-inflammation and antioxidant effects. This research aimed to know the potencial of the combination of red ginger rhizome (Zingiber officinale var rubrum) and cogon grass rhizome (Imperata Cylindrica) (CRGCG) by measuring the OA rats serum Matrix Metalloproteinase-9 (MMP-9). Matrix Metalloproteinase-9 is an enzyme that plays a role in joint cartilage destruction.Methods: 25 male Wistar rats age 4 months divided into 5 groups namely positive control group (PC), negative control group (NC), treatment group 1 recieved dose 9+40 mg/rat/day (T1), treatment group 2 recieve dose 18+40 mg/rat/day (T2), and treatment group 3 recieve dose 36+40 mg/rat/day(T3). Rats were induced with Complete Freund’s Adjuvant (CFA) by 0.1 ml/rat on right knee intraarticular to induce. The administration of CRGCG is given for 10 days. The serum MMP-9 level was assessed by MMP-9 ELISA Kit. Data analyzed using One Way Anova followed by Post Hoc test. The result is significant if p<0.05.Result: The Combination of Red Ginger Rhizome and Cogon Grass Rhizome (CRGCG) on the first treatment (0,85±0,03), second treatment (0,86±0,02) and third treatment (0,84±0,02) able to decrease the serum MMP-9 level significantly (p<0,05).Conclusion: The optimal dose from Combination of Red Ginger Rhizome and Cogon Grass Rhizome (CRGCG) to reduce serum MMP-9 level is  dose 9+40 mg/rat/day.Keywords: Cogon Grass, Matrix Metalloproteinase-9, Osteoarthritis, Red Ginger
PERBANDINGAN EFEK PERASAN DAGING DAUN LIDAH BUAYA (Aloe vera L.) DAN POVIDONE IODINE TERHADAP EKSPRESI VEGF DAN JUMLAH LUMEN PEMBULUH DARAH TIKUS WISTAR DENGAN LUKA SAYAT Moch. Saifudin; Merlita Herbani; Diah Andriana
Jurnal Kedokteran Komunitas Vol 8, No 1 (2020)
Publisher : Jurnal Kedokteran Komunitas (Journal of Community Medicine)

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Introduction: Incision wound is disorders of skin structure that causes sensory dysfunction and the delay in this process may cause increasing the patient’s morbidity. Some alternative treatment to increase wound healing is by using herb such as Aloe vera. Therefore, the study to know the effect of Aloe vera on wound healing process by measuring the VEGF expression and number of blood vessels is needed.Method: 24 male Wistar rats aged 2-3 months divided into 4 groups, (1). K + (povidone iodine) group, (2). The treatment group given the taste of aloe with 20% concentration (KP1), (3). 40% concentration (KP2) and (3). 80% concentration (KP3) at a dose of 0.5 gr/rat/day topically for 6 days. VEGF expressions are measured using immunohistochemistry (IHK) staining and blood vessels using Hematoxylin Eosin (HE). Data obtained by statistical analysis using SPSS version 17 with a signification level p < 0.05Result: Effect of Aloe vera juice on VEGF expression in KP+, KP1, KP2, KP3 goup were (1.41±1.79), (1.40±2.09), (1.42±1.24), and (1.44±1.52) with signification value (p>0,05). Effect of Aloe vera juice on the number of  blood vessel lumen in KP+, KP1, KP2, KP3 goup were (14.7±4,94), (17.16±4,67), (25.53±5.54), dan (33.9±11.82) with signification value (p<0,05).Conclusion: Aloe vera juice affect on the number of blood vessel lumen. Further research in need to know the active compound in Aloe vera that has wound healing effectKeywords: Incision Wound, Aloe vera L., vascular endoothelial growth factor (VEGF), Blood vessels
Co-Authors Adam Bregas Regowo Andri Tilaqza Aris Widodo Damayanti, Dini Sri Desy Amalia Wulandari Diah Andriana Doti Wahyuningsih Heni Pujiastuti Hidayat Suyuti Hidayat Suyuti Kurnianingsih , Novi Moch. Saifudin Oktavia Rahayu Puspitarini Yoni Rina Bintari Zaenab Aqilah