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Studi In silico Potensi Anti Hipertensi dan Prediksi Profil Farmakokinetika Daun Jati Belanda (Guazuma ulmifolia. Lamk) Andri Tilaqza; Merlita Herbani
Jurnal Kesehatan Islam : Islamic Health Journal Vol 10, No 2 (2021): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v10i2.13821

Abstract. Hypertension is a disease that is often occurred in every country, including Indonesia. Hypertension is one of the risk factors that lead to cardiovascular disease. Guazuma ulmifolia Lamk are one of the plants used empirically as antihypertensive in Indonesia, but research on the antihypertensive potential of its leaves has never been done before.The purpose of this study was to predict the potential activity and predict the pharmacokinetic of several compounds contained in Guazuma ulmifolia leaves. The Guazuma ulmifolia leaves compounds and captopril were docked to the Angiotensin-Converting Enzyme protein (PDB ID: 1O86). Molecular docking tests were performed using PyRx software while the visualization analysis of molecular anchoring results was performed using Biovia Discovery Studio Visualizer software. Prediction of pharmacokinetic and physicochemical properties of the tested compounds was carried out using the pkCSM web page. Based on the molecular docking test, all compounds in Guazuma ulmifolia leaves have lower energy than the captopril. Kaempferitrin (-9.9 k/mol) and beta-sitosterol (-9.2 kcal/mol) had the lowest energy among other test compounds compared to captopril (-5.5 kcal/mol). Quercetin, kaempferol, and beta-caryophyllene were compounds that had similar interactions to the captopril based on the chemical interaction. All compounds had varied pharmacokinetic profiles but still had a fairly good profile.

Pengaruh Stadium HIV terhadap Infeksi Oportunistik, Penggunaan Antiretroviral dan Antibiotik pada Pasien HIV di Rumah Sakit X Kota Malang Nurma Puspita Asis; Andri Tilaqza; Hardadi Airlangga
Jurnal Kedokteran Komunitas Vol 8, No 2 (2020)
Publisher : Jurnal Kedokteran Komunitas (Journal of Community Medicine)

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Introduction: Human Immunodeficiency Virus (HIV) is a retrovirus group in the family Retroviridae, a genus of lentiviruses that attack white blood cells that cause a decrease in immunity in humans.The immunity of HIV patients can be assessed based on CD4 levels and clinical symptoms which are divided into four clinical stages of HIV. Each level of HIV stage can affect the use patterns of antiretrovirals and antibiotics used by HIV patients during treatment. This study aims to determine the relationship between the effect of HIV staging on antiretroviral profiles, types of opportinistic infections that accompany, antibiotics used for opportunistic infections and the duration of antibiotic administration used by HIV patients in one hospital in Malang.Method: Non-experimental research was carried out in a Analytic Observational Cross Sectional Retrospective study using a Descriptive Analytic design, using a total sampling method by taking secondary data or medical records on HIV patients at Hospital X Malang in 2015-2018.Results: The total population are 112 medical records and data that inclusion criteria are 73 medical records obtained by the HIV stadium did not affect the use of ARVs HIV stage did not affect the use of antiretroviral drugs (p = 0.473) (p> 0.05), opportunistic infections (p = 0.135) (p> 0.05), antibiotic use (p = 0.175) (p> 0.05) and duration of antibiotic administration (p = 0.864) (p> 0.05).Conclusion: HIV stage does not affect the pattern of ARV use, opportunistic infections that accompany patients, patterns of antibiotic use and duration of antibiotic administration of HIV patients at VCT Hospital X Malang in 2015-2018.Keywords: HIV stage, ARVs, opportunistic infections, antibiotics

AKTIVITAS ANALGESIK INFUSA DAN DEKOKTA DAUN PULUTAN (Urena lobata) Yudi Purnomo; Andri Tilaqza
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 9, No 1 (2022)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/wiyata.v9i1.586

Latar belakang: Pulutan (Urena lobata) merupakan tanaman obat yang digunakan secara tradisional untuk pengobatan radang, infeksi dan rematik. Studi in silico menunjukkan potensi anti inflamasi dan analgetik dengan menghambat siklooksigenase-2 (COX-2) tetapi penelitian secara in vivo belum banyak dilaporkan. Tujuan: Penelitian ini bertujuan untuk mengetahui potensi analgesik infusa dan dekokta daun U.lobata pada tikus. Metode: Desain penelitian ini control group post test design menggunakan tikus wistar jantan yang dibagi menjadi 5 kelompok. Simplisia daun U. lobata dilakukan penyarian dengan metode infudasi dan dekoktasi. Dosis infusa dan dekokta U. lobata yang digunakan masing-masing 250, 500 dan 1000 mg/kg BB. Pengujian aktivitas analgesik menggunakan analgesimeter beban geser selama 4 jam. Data dianalisa menggunakan one way ANOVA dan dilanjutkan dengan uji LSD (p<0.05). Hasil: Pemberian infusa U. lobata 250, 500 dan 1000 mg/kg BB meningkatkan Area Under Curve (AUC) ambang nyeri berturut-turut sekitar 8 %, 10 % dan 12 % dibandingkan kelompok kontrol (p<0.05), sementara bentuk dekokta meningkatkan kurang lebih 1 %, 3 % dan 3 % (p> 0.05). Simpulan: Infusa daun U. lobata memiliki aktifitas analgesik lebih kuat dibandingkan dekokta U.lobata

Studi Docking Molekuler Penghambatan Reseptor Neprilysin Bunga Lawang (Illicium verum) sebagai Anti Hipertensi dan Prediksi Profil Farmakokinetikanya Andri Tilaqza; Merlita Herbani; Zaenab Aqilah
Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) Vol 9 No 1 (2023): Agustus 2023
Publisher : Fakultas Matematika & Ilmu Pengetahuan Alam - Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/e-jbst.v9i1.529

Evaluation of Analgesic Effect of Corn Silk Infusion (Zea mays L.) Nidaan Khafiya; Andri Tilaqza; Reza Hakim
Nusantara Science and Technology Proceedings 1st International Conference on Health and Medicine
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2023.3503

Corn silk (Zea mays L.) is a plant that is widely found in Indonesia but is still unexplored. In silico studies show that corn silk contains compounds that have the potential as analgesics by inhibiting the work of the enzyme cyclooxygenase (COX) which can reduce the production of prostaglandins by arachidonic acid, but these studies have not been proven in vivo. This study aims to evaluate the analgesic effect of corn silk infusion. Corn silk was extracted by the infundation method. A phytochemical screening test was conducted to determine the content of corn silk infusion. Analgesic effect was evaluated using analgesimeter rendal-selitto in 30 male wistar rats. The negative control group was given distilled water, the treatment groups were given 125, 250, and 500 mg/kgBW of corn silk infusion, and the positive control group was given mefenamic acid suspension of 45 mg/kgBW. Corn silk infusion contains flavonoid, saponin, and alkaloid compounds based on phytochemical screening tests. The administration of corn silk infusion with doses of 125, 250, and 500 mg/kgBW produced a percentage of pain inhibition at 13.2%, 13.89%, and 20.42% compared to mefenamic acid at 25.11%. The greater analgesic activity was observed by the maximum dose of the infusion (500 mg/kgBW). The effect of the infusion was also statistically significant (p<0.05) only in the maximum dose. The result obtained from this study shows that the Corn silk infusion contained phytochemical constituents with analgesic activities, therefore could be used in the management of pain conditions. Further research is needed regarding the toxicity test and its mechanism of action.

Formulasi dan Uji Stabilitas Sediaan Krim Natrium Diklofenak dengan Perbandingan Konsentrasi Cera Alba Hidayanti, Nurul; Tilaqza, Andri; Maulita, Arina Swastika; Widyaningrum, Ike
Prosiding Seminar Nasional Universitas Ma Chung (Informatika & Sistem Informasi Bahasa dan Seni
Publisher : Ma Chung Press

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Abstrak. NSAID (nonsteroidal antiinflamasi) adalah obat yang memberikan efek analgesik, antipiretik, dan anti-inflamasi dengan menghambat kerja enzim siklooksigenase. Natrium diklofenak termasuk salah satu obat NSAID, digunakan untuk meringankan nyeri, inflamasi otot rangka dan penyakit sendi Anggraeni, (2012). Krim adalah sediaan setengah padat yang mengandung satu atau lebih bahan obat yang terdispersi dengan baik dalam bentuk emulsi air dalam minyak (a/m) atau minyak dalam air (m/a), mengandung air tidak kurang dari 60 % dan itujukan untuk pemakaian topikal pada kulit Haerani, (2017). Penelitian ini bertujuan untuk memformulasikan dan mengetahui stabilitas fisik krim natrium diklofenak yang dibuat dalam 3 formula dengan perbedaan kosentrasi pada cera alba yang berperan sebagai basis. Pengujian yang dilakukan meliputi uji organoleptik (bau, warna dan konsistensi), homogenitas, pH, daya sebar dan uji tipe krim. Hasil penelitian uji organoleptik menunjukan bahwa bentuk sediaan yang didapat berupa setengah cair ( F1 dan F2) dan setengah padat (F3), berwarna putih dan memiliki bau khas pada ke 3 formula. Uji homogenitas menunjukan bahwa ke 3 formula memiliki homogenitas yang baik, uji pH krim menunjukkan pH 7, pH tersebut memenuhi standar pH krim yang baik. Uji daya sebar krim berkisar 3,93-6,56 cm, yang memenuhi syarat (F1 dan F2). Uji tipe krim menunjukan bahwa ke 3 formula memiliki tipe (m/a). Formulasi krim yang di buat dengan variasi konsentrasi cera alba sebagai basis menunjukkan terdapat perbedaan terhadap stabilitas fisik dan kimia.

Formulasi dan Evaluasi Sediaan Serum dari Ekstrak Kental Kunyit (Curcuma longa L.) dan Pati Bengkoang (Pachyrhizus erosus) dengan Variasi Konsentrasi Xanthan Gum Kamila, Clarissa Rahmaini; Husnawiyah, Nurul; Aminah, Sita; Tilaqza, Andri; Maulita, Arina Swastika; Widyaningrum, Ike
Prosiding Seminar Nasional Universitas Ma Chung (Informatika & Sistem Informasi Bahasa dan Seni
Publisher : Ma Chung Press

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Ekstrak kunyit dan pati bengkuang diketahui memiliki berbagai kandungan yang memiliki aktifitas salah satunya adalah antioksidan. Penelitian ini dilakukan untuk mengetahui pengaruh perbedaan konsentrasi xanthan gum terhadap evaluasi mutu fisik dan kimia sediaan serum. Dalam sediaan Serum yang dibuat adalah rute topikal Ekstrak kunyit diekstraksi dengan metode UAE (UItrasonic Assisted Extraction) dengan pelarut etanol 70%. Pati Bengkuang didapatkan dengan mengendapkan air hasil perasan benkuang kemudian diformulasikan dalam bentuk serum wajah. Ekstrak kental kunyit mengandung senyawa Alkaloid, Saponin, Tanin, dan Flavonoid. Bahan yang digunakan adalah ekstrak kental kunyit (Curcuma longa L.), pati bengkuang (Pachyrhizus erosus), Butylated Hydroxytoluene (BHT), gliserin, xanthan gum, Fenoksietanol, akuades. larutan amoniak, FeCl3, HCl pekat, asam sulfat 2N, pereaksi meyer, anhidra asam asetat, H2SO4 pekat dan Pereaksi dragendrof. Formulasi serum yang menggunakan metode skrining fitokimia menunjukkan hasil skrining fitokimia yang dilakukan terhadap ekstrak kental kunyit mengandung senyawa Alkaloid, Saponin, Tanin, dan Flavonoid. Pengujian skrining fitokimia yang dilakukan pada Pati bengkuang terdapat mengandung senyawa Alkaloid, Saponin, dan Tanin. Selanjutnya serum diuji mutu fisik berdasarkan pengujian organoleptis, pH, viskositas, daya sebar, homogenitas, dan uji hedonik. Berdasarkan penelitian yang dilakukan diketahui bahwa konsentrasi xanthan gum memiliki pengaruh terhadap kekentalan, daya sebar, dan pH. Dari hasil pengujian didapatkan formula yang paling baik yaitu formula 2 didasari oleh pengujian hedonik dan pengujian lainnya.

In Silico Study of Pulutan (Urena lobata) Leaf Extract as Anti Inflammation and their ADME Prediction Doti Wahyuningsih; Yudi Purnomo; Andri Tilaqza
Journal of Tropical Pharmacy and Chemistry Vol. 6 No. 1 (2022): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v6i1.323

Inflammation is the basic for the pathogenesis of several diseases both of degenerative and non-degenerative disease. Urena lobata is a medicinal plant that can be found in Indonesia and has been used traditionally to cure influenza, inflammation and fever. However, there have been few reports about their anti-inflammatory activity and their mechanism action are still unclear. The aim of study to evaluate the anti-inflammatory activities of active substances from U.lobata leaf and their pharmacokinetic property through in silico study. lobata leaf was extracted by digeration methods using ethanol solvent. Therefore, the active substances in the extract was analyzed by Liquid Chromatography-Mass Spectra (LC-MS). Pharmacokinetic property and physicochemical of active compounds were evaluated using pkCSM online tool. Anti-inflammatory activity of U. lobata active compound on phospholipase-A2 (PLA-2), cyclooxygenase-2 (COX-2) and lipoxygenase-5 (LOX-5) were evaluated by in silico study. Ethanolic extract of U. lobata contained five active compound, there are stigmasterol, ?-sitosterol mangiferin, gossypetin and chrysoeriol. Molecular docking study indicated stigmasterol and ?-sitosterol of U. lobata have a strong activity as anti-inflammatory based on the estimation of inhibition constant (Ki) value against PLA2 and COX-2. Meanwhile, mangiferin and gossypetin have a stronger anti-inflammatory effect on LOX-5 among others compound. U. lobata has anti-inflammatory activity through inhibition on COX-2 greater than on PLA2 and LOX-5.

Evaluation of Analgesic Effect of Corn Silk Infusion (Zea mays L.) Nidaan Khafiya; Andri Tilaqza; Reza Hakim
Nusantara Science and Technology Proceedings 1st International Conference on Health and Medicine
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2023.3503

Corn silk (Zea mays L.) is a plant that is widely found in Indonesia but is still unexplored. In silico studies show that corn silk contains compounds that have the potential as analgesics by inhibiting the work of the enzyme cyclooxygenase (COX) which can reduce the production of prostaglandins by arachidonic acid, but these studies have not been proven in vivo. This study aims to evaluate the analgesic effect of corn silk infusion. Corn silk was extracted by the infundation method. A phytochemical screening test was conducted to determine the content of corn silk infusion. Analgesic effect was evaluated using analgesimeter rendal-selitto in 30 male wistar rats. The negative control group was given distilled water, the treatment groups were given 125, 250, and 500 mg/kgBW of corn silk infusion, and the positive control group was given mefenamic acid suspension of 45 mg/kgBW. Corn silk infusion contains flavonoid, saponin, and alkaloid compounds based on phytochemical screening tests. The administration of corn silk infusion with doses of 125, 250, and 500 mg/kgBW produced a percentage of pain inhibition at 13.2%, 13.89%, and 20.42% compared to mefenamic acid at 25.11%. The greater analgesic activity was observed by the maximum dose of the infusion (500 mg/kgBW). The effect of the infusion was also statistically significant (p<0.05) only in the maximum dose. The result obtained from this study shows that the Corn silk infusion contained phytochemical constituents with analgesic activities, therefore could be used in the management of pain conditions. Further research is needed regarding the toxicity test and its mechanism of action.

PELATIHAN PEMBUATAN HERBAL INHALER UNTUK MEREDAKAN GEJALA COMMON COLD DI SMP WAHID HASYIM KOTA MALANG Tilaqza, Andri; Anwar, Anwar; Wahyu Melani, Dina; Endjelia, Dinna; Salwa Kinarsyahranie, Naomira; Amartya Mumtaz, Ajeela; Tarisa Anwar, Andiny; Cherril Aisyah, Chandan; Agnesia Sukmawardani, Daffany; Medinah Arrosyad, Fara; Arum Arrizqi, Sinta; Kartika Danisyahputri, Widya
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 7, No 12 (2024): MARTABE : JURNAL PENGABDIAN MASYARAKAT
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v7i12.5186-5191

Common cold adalah salah satu contoh penyakit yang termasuk dalam ISPA non spesifik Common cold paling sering disebabkan oleh Rhinovirus. Penyakit ini dapat diderita oleh bayi hingga lansia, berdasarkan CDC 2024 menyebutkan bahwa orang dewasa menderita Common cold sekitar 2-3 kali per tahunnya. Anak anak dan individu yang memiliki imunitas rentan lebih sering menderita Common cold (lebih dari 3 kali per tahun). Terapi suportif yang dapat diberikan adalah terapi inhalasi menggunakan herbal inhaler, penggunaan inhaler ini dapat meringankan gejala karena mengandung bahan aktif dan mudah digunakan tanpa menimbulkan risiko luka iritasi pada pasien. Kegiatan ini bertujuan untuk meningkatkan pemahaman dan keterampilan siswa SMP Wahid Hasyim Kota Malang mengenai manfaat herbal inhaler dan teknik pembuatan herbal inhaler sebagai upaya meredakan gejala common cold. Metode yang digunakan dalam penelitian ini meliputi penyuluhan dan pelatihan pembuatan inhaler. Pada kegiatan ini juga dilakukan pre-test dan post test untuk menilai pemahaman siswa-siswi, Berdasarkan hasil nilai rata-rata pre test dan post test peserta mengalami peningkatan dari 68,3 menjadi 85,3 pada 30 siswa-siswi SMP Wahid Hasyim Malang. Hasil dari kegiatan ini diharapkan dapat meningkatkan pengetahuan siswa tentang pengobatan alami dan mempraktikkan keterampilan pembuatan inhaler, sehingga mereka dapat lebih mandiri dalam mengatasi gejala common cold.

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