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All Journal Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Sari Pediatri
Aridamuriany Dwiputri Lubis
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Sumatera Utara
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Vasoactive-inotropic Score for Early Detection and Mortality Prediction of Sepsis in Children Aileen Clarissa Dauhan; Aridamuriany Dwiputri Lubis; Munar Lubis
The Indonesian Biomedical Journal Vol 13, No 1 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i1.1323

Abstract

BACKGROUND: Early detection and treatment of sepsis can prevent septic shock and reduce mortality rate. Troponin can become a prognostic factor in sepsis. However, not all health facilities are equipped to assess troponin levels. Vasoactive-inotropic score (VIS) is a simpler and more accessible method to describe hemodynamic status. The aim of this study was to assess the suitability of VIS score as early prognosis and mortality predictor of sepsisMETHODS: A retrospective study was conducted to determine the correlation between VIS and troponin levels for sepsis cases in Pediatric Intensive Care Unity (PICU) Haji Adam Malik Hospital, Medan from January 2018 to December 2019. VIS score at 48 hours, maximum VIS score, pediatric logistic organ dysfunction-2 (PELOD-2) score, cardiac troponin levels at 48 hours were taken from medical records.RESULTS: There were 54 samples analyzed. VIS scores were positively correlated (p<0.001) to troponin T and troponin I levels at 48 hours (r=0.670 and r=0.606, respectively). VIS at 48 hours and maximum VIS were related to mortality (p=0.001 and p<0.001, respectively). VIS score at 48 hours could be used as a predictive factor for mortality (area under the curve (AUC): 79.7%, p<0.001) with a cut-off point at 11 (74.4% sensitivity and 80% specificity). High VIS at 48 hours indicated poor outcomes of sepsis in children with odd ratio (OR) value: 1.99 (95% confidence interval (CI): 1.25-3.19).CONCLUSION: Vasoactive-inotropic score was suitable as an alternative to cardiac troponin T and troponin I levels at 48 hours to early detect myocardial dysfunctions and mortality in children.KEYWORDS: troponin, vasoactive-inotropic score, sepsis, children, mortality
The Usefulness of C-Reactive Protein, Procalcitonin, and PELOD-2 Score as a Predictive Factor of Mortality in Sepsis Munar Lubis; Aridamuriany Dwiputri Lubis; Badai Buana Nasution
The Indonesian Biomedical Journal Vol 12, No 2 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i2.1073

Abstract

BACKGROUND: Sepsis in children is a significant cause of morbidity and mortality in the pediatric intensive care unit (PICU). Assessment of pediatric sepsis using serial Pediatric Logistic Organ Dysfunction (PELOD)-2 score can be used as a prognostic factor. The use of biomarkers of sepsis is also used for diagnosis and predicting outcomes. Many studies have suggested that C-reactive protein (CRP) and procalcitonin (PCT) can be used to predict mortality.METHODS: A prospective cohort study was conducted to evaluate CRP, PCT, PELOD-2 score and its combination as a predictive factor of mortality in sepsis. All patients admitted to PICU Haji Adam Malik General Hospital, Medan, from April to November 2019 with suspected sepsis were included in this study. Blood examination and PELOD-2 scores were examined in the first 24 hours.RESULTS: A total of 79 children were included with a mortality rate 55.7%. The CRP, PCT, and PELOD-2 score were higher in nonsurvivor (2.8 (0.5-22.4) mg/dL; 9.36 (0.13-79.8) ng/mL; 9 (3-21), respectively). In multivariate logistic regression analysis, neither CRP nor PCT values could be independent predictors of mortality. The PELOD-2 score can be an independent predictor for mortality at a cut-off score of 7 (OR: 3.47 (95% CI: 1.68-7.19)). The combination of PELOD-2 and CRP scores as predictors of mortality showed lower values than PELOD-2 and PCT scores (0.80 vs. 0.95). The combination of all parameters only adds 1% of the predicted mortality value.CONCLUSION: PELOD-2 score with PCT value are recommended to predict mortality children with sepsis.KEYWORDS: sepsis, mortality, C-reactive protein, procalcitonin, PELOD-2 score
Hubungan Prokalsitonin dan Rasio Neutrofil Limfosit dengan Mortalitas Pneumonia di Ruang Rawat Intensif Anak Rumah Sakit Umum Pusat Haji Adam Malik Medan Nadya Riqqoh Adilla; Aridamuriany Dwiputri Lubis
Sari Pediatri Vol 23, No 6 (2022)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp23.6.2022.390-4

Abstract

Latar belakang. Pneumonia merupakan penyebab kematian 808.694 anak dibawah 5 tahun pada tahun 2017 di dunia. Rerata jumlah kematian harian balita akibat pneumonia pada tahun 2007 adalah 83 anak. Peningkatan kadar prokalsitonin (PCT) secara signifikan berhubungan dengan peningkatan mortalitas, begitu pula dengan rasio neutrofil limfosit (NLR) yang merupakan parameter sederhana untuk menilai status inflamasi subjek dan dapat memperkirakan mortalitas 30 hari pasien Community Acquired Pneumonia (CAP) khususnya pada pasien pediatri.Tujuan. Studi ini bertujuan untuk mengetahui hubungan PCT dan NLR dengan angka mortalitas pneumonia anak di PICU RSUP Haji Adam Malik Medan tahun 2018-2019. Metode. Penelitian analitik desain cross sectional dengan pengambilan sampel data rekam medis PICU pasien pneumonia anak di RSUP H Adam Malik Medan tahun 2018-2019 yang disesuaikan dengan kriteria inklusi dan ekslusi. Analisis data menggunakan uji Mann-Whitney menggunakan program pengolahan data SPSS.Hasil. Hasil uji Mann-Whitney menunjukkan hasil yang tidak signifikan antara PCT dengan angka mortalitas pasien pneumonia anak dengan nilai p=0,996. Sebaliknya, ditemukan hasil yang signifikan, tetapi relatif lemah pada analisis NLR dengan angka mortalitas pasien pneumonia anak dengan nilai p=0,049.Kesimpulan. Terdapat hubungan antara NLR dengan angka mortalitas pasien pneumonia anak di PICU. Namun didapati hasil sebaliknya pada hubungan PCT dengan variable yang sama.
Abnormal Uterine Bleeding (AUB) at Haji Adam Malik General Hospital, Medan, North Sumatera, Indonesia Putri Ardina Sari Nainggolan; Muhammad Rusda; Dwi Faradina; Aridamuriany Dwiputri Lubis
Majalah Obstetri & Ginekologi Vol. 31 No. 1 (2023): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V31I12023.30-35

Abstract

HIGHLIGHTS Leiomyoma is still the most common case in women aged 41–50 years. Women who have an obese BMI are the main risk factor for abnormal uterine bleeding, so it is urged for women to maintain an ideal weight because it can be bad for health.   ABSTRACT Objective: This study identified the incidence of Abnormal Uterine Bleeding (AUB) at Haji Adam Malik General Hospital, Medan, Indonesia, in 2020-2021. Materials and Methods: This was a descriptive study with a cross-sectional design. Sampling was taken using total sampling and using retrospective data in the form of medical records with a diagnosis of AUB at Haji Adam Malik General Hospital Medan in 2020–2021. Results: There were 197 cases of AUB, with the highest distribution in the age group of 41–50 years with 84 people (42.6%). The most cases of AUB with an obese BMI were 91 people (46.2%), married status as many as 176 people (89.3%), had the last education level of senior high school as many as 99 people (50.3%), 144 people (73.1%) got their first menstruation when they were >12 years old, 80 people (40.6%) had multiparity, 90 people (45.7%) received medical therapy. Based on the PALM-COEIN classification, the most AUB cases were AUB-L with 99 people (50.3%). Based on the classification of AUB-L locations, most locations were submucosa with 38.6%. Conclusion: AUB-L cases were still the most common cases at Haji Adam Malik General Hospital, Medan, Indonesia, in 2020–2021.
Co-Authors Aileen Clarissa Dauhan Dwi Faradina Muhammad Rusda Munar Lubis Nadya Riqqoh Adilla Nasution, Badai Buana Putri Ardina Sari Nainggolan