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All Journal Jurnal Farmasi Udayana Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Farmasi Indonesia Poltekita: Jurnal Pengabdian Masyarakat Jurnal Insan Farmasi Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian Medical Sains : Jurnal Ilmiah Kefarmasian
Dina Yuspitasari
Akademi Farmasi Yarsi Pontianak
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health

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UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN BUAS-BUAS (Premna serratifolia L.) ASAL KABUPATEN MELAWI PROVINSI KALIMANTAN BARAT DENGAN METODE DPPH Weni Puspita; Dina Yuspita Sari; Ika Ristia Rahman
Jurnal Insan Farmasi Indonesia Vol 3 No 2 (2020): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v3i2.532

Abstract

Buas Buas (Premna serratifolia L.) contains secondary metabolites of flavonoids, saponins, tannins and triterpenoids/steroids, where flavonoids are known to have antioxidant properties and counteract free radicals. Antioxidants are compounds that can fight toxic hazards and reduce cell damage to the body caused by free radical oxidation. The purpose of this study was to determine the antioxidant activity of ethanol extracts of buas-buas leaves was carried out by DPPH (2,2-diphenyl-1-picrylhydrazyl), using UV-Vis spectrophotometry at wavelength 518.40 nm with various concentrations of 10 ppm, 20 ppm, 30 ppm, 40 ppm and 50 ppm. The results showed that Buas Buas leaves (Premna serratifolia L.) had an antioxidant activity with IC50 values ??of 20.66 ug / mL.
PENETAPAN KADAR FLAVONOID TOTAL EKSTRAK ETANOL KULIT BATANG SAWO (Manilkara zapota (L.)) SECARA SPEKTROFOTOMETRI UV-VISIBEL Ratna Widyasari; Dina Yuspita Sari
Jurnal Insan Farmasi Indonesia Vol 4 No 2 (2021): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v4i2.828

Abstract

Sawo (Manilkara zapota (L.)) is one of the plants that can be used in traditional medicine. Sawo bark contains secondary metabolites of flavonoids, saponins, tannins, and phenolics. This study aims to determine the total flavonoid content in the ethanol extract of sapodilla stem bark. Determination of total flavonoid content using a colorimetric method using AlCl3 reagent. Determination of total flavonoid using UV Visible Spectrophotometry at a maximum wavelength of 417.50 nm and total flavonoid expressed in QE (Quercetin Equivalent).. The results showed that the total flavonoid content contained in the ethanol extract of the Sawo Bark (Manilkara zapota (L.)) was 1,095 mgQE/g.
Penentuan Kadar Flavonoid Total Ekstrak Etanol Jamur Susu Harimau (Lignosus rhinocerus) Dina Yuspita Sari; Widyasari R; Taslima AN
Jurnal Farmasi Udayana Vol. 10, No 1, Tahun 2021
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2021.v10.i01.p03

Abstract

ABSTRAK Jamur susu harimau (Lignosus rhinocerus) merupakan tanaman yang digunakan dalam pengobatan tradisional di pedalaman Kalimantan Barat terutama di Kapuas Hulu. Salah satu konstituen fitokimia yang terkandung adalah flavonoid (flavon dan flavanon). Penelitian ini bertujuan untuk menentukan kadar flavonoid total pada ekstrak etanol jamur susu harimau. Simplisia jamur susu harimau dimaserasi menggunakan etanol 96 %. Skrining fitokima terhadap keberadaan flavonoid dalam ekstrak menggunakan serbuk magnesium dan amil alkohol. Penentuan kadar flavonoid total pada ekstrak etanol jamur susu harimau dilakukan secara spektrofotometri UV-Vis dengan metode kolorimetri (AlCl3) pada ? 410 nm dan dinyatakan sebagai flavonoid total dalam ekuivalen kuersetin (EQ). Kadar flavonoid total pada ekstrak etanol jamur susu harimau adalah sebesar 33,041 mgEQ/g ekstrak. Ekstrak etanol jamur susu harimau yang mengandung flavonoid berpotensi sebagai sumber antiooksidan alami dan potensial untuk dikembangkan dalam produk obat dan kosmetik. Kata kunci: Jamur susu harimau, kadar flavonoid total, kolorimetri.
Keamanan Hair Tonic Ekstrak Etanol, Fraksi Etanol, dan Fraksi Kloroform-Metanol dari Kayu Secang (Caesalpinia sappan L.) dengan Metode Uji Iritasi Primer dan HET-CAM Dina Yuspita Sari; Ika Ristia Rahman
Jurnal Farmasi Udayana Vol. 10, No 2, Tahun 2021
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2021.v10.i02.p08

Abstract

Hair tonic is a hair care cosmetic to reduce hair loss, stimulate, and increase hair volume. Secang wood (Caesalpinia sappan L.) has the potential to be developed as an active substance in hair tonic products because it contains flavonoids, polyphenols, including brazilin which are used to treat damage hair. To ensure the safety of hair tonic products, safety tests are required, including skin and eye irritation tests. This study aims to determine the safety of hair tonic formula of ethanol extract, ethanol fraction, and chloroform-methanol fraction from sappan wood. Ethanol extract, ethanol fraction, and chloroform-methanol fraction of sappan wood were formulated into hair tonic preparations. The hair tonic safety test includes: primary irritation test and eye irritation test using HET-CAM method. Based on the primary irritation test, the score of erythema and edema on the skin obtained a PII value of 0 (non-irritating category). The HET-CAM test on the three hair tonic formulas, positive control and negative control, showed that the positive control (lactic acid) resulted in an irritation score of 9.51 (strong irritation category); negative control (NaCl 0.9%) and the three hair tonic formulas had an irritation score of 0 (no irritation category). This indicates that the hair tonic formula from ethanol extract, ethanol fraction, and chloroform-methanol fraction of sappanwood is not irritating and safe to use. Keywords: HET-CAM, primary irritation test, sappan wood
FORMULASI SEDIAAN SHAMPOO CAIR EKSTRAK ETANOL DAUN ALAMANDA (Allamanda cathartica L.) DENGAN CARBOPOL 940 SEBAGAI PENGENTAL Dian Kartikasari; Dina Yuspitasari; Lindasari .
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 1 No 2 (2017)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (68.804 KB) | DOI: 10.37874/ms.v1i2.19

Abstract

ABSTRAK Telah dilakukan penelitian formulasi sediaan shampoo cair ekstrak etanol daun alamanda (Allamanda cathartica L.) dengan carbopol 940 sebagai pengental. Penelitian ini bertujuan untuk membuat formulasi dan menentukan konsentrasi carbopol 940 sebagai pengental yang dapat menghasilkan sediaan shampoo yang baik. Penelitian menggunakan 3 formula shampoo, dengan variasi konsentrasi carbopol 1%, 1,5%, dan 2%. Evaluasi yang dilakukan meliputi uji organoleptis, pH, ketahan busa, bobot jenis, dan viskositas. Hasil dari evaluasi organpleptis didapatkan shampoo ekstrak etanol daun alamanda berbau khas alamanda, berwarna hijau dan berbentuk cair. Hasil pengukuran pH didapatkan formula I dan II 4,2 dan formula III 6,8. Pada pengukuran tinggi busa didapatkan formula I tinggi busanya 6,1 cm, formula II tinggi busanya 4,5 cm, dan formula III tinggi busanya 4 cm. pengukuran bobot jenis didapatkan formula I dan II adalah 1,03 dan formula III adalah 1. Pada pengukuran viskositas didapatkan s formula I 0,43 dPa’s, formula II 0,96 dPa’s, dan formula III 1,5 dPa’s.
Uji Toksisitas Akut Ekstrak Metanol Kulit Buah Jeruk Sambal (Citrus microcarpa Bunge) Terhadap Larva Artemia salina L. Dengan Metode Brine Shrimp Lethality Test (BSLT) Ratna Widyasari; Dina Yuspitasari; Wilda Wildaniah; Rosi Cahayuni Wahida
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 3 No 1 (2018)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (783.893 KB) | DOI: 10.37874/ms.v3i1.64

Abstract

Tanaman jeruk sambal (Citrus microcarpa Bunge) merupakan salah satu tanaman yang banyak terdapat di Kalimantan Barat. Kulit buah jeruk sambal mempunyai aktivitas antioksidan kuat dan aktivitas antimikroba, hal ini berkaitan erat dengan kandungan senyawa metabolit sekunder yaitu flavonoid, alkaloid dan polifenol, dimana senyawa ini berpotensi sitotoksik. Tujuan dari penelitian ini adalah untuk mengetahui apakah ekstrak metanol kulit jeruk sambal bersifat sitotoksik dengan metode Brine Shrimp Lethality Test (BSLT) dan mengetahui nilai LC50 yang dihasilkan. Penelitian eksperimental ini menggunakan ekstrak metanol kulit jeruk sambal dengan pembagian konsentrasi 1000 µg/ml, 750 µg/ml, 500 µg/ml, 250 µg/ml, 100 µg/ml, dan 0 µg/ml dimana pada masing-masing konsentrasi diletakkan 10 ekor larva Artemia salina L. Data kematian larva dikumpulkan dan dianalisis dengan metode analisis probit. Berdasarkan hasil dari analisis regresi linier menunjukkan nilai LC50 dari ekstrak metanol kulit jeruk sambal adalah 234,42 µg/ml.. Hasil penelitian ini menunjukan bahwa ekstrak metanol kulit jeruk sambal bersifat sitotoksik yang ditunjukkan dengan harga LC50 < 1000 µg/ml.
Formulasi Hair Tonic dari Ekstrak Etanol, Fraksi Etanol, dan Fraksi Kloroform-Metanol Kayu Secang (Caesalpinia sappan L.) Dina Yuspita Sari; Ratna Widyasari; Weni Puspita
Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i2.954

Abstract

Secang wood (Caesalpinia sappan L.) has been used as an antioxidant in cosmetic products. The bioactive compound contained in secang wood are brazilin, brazilein, 3´-O-methylbrazilin, sappanone, chalcone, and sappankalkon as secondary metabolite components. This study aims to formulating hair tonic from extracts and fractions of secang wood and to determine the quality of hair tonic formulas using ethanol extract (Eet), ethanol fraction (Fen), and chloroform-methanol fraction (Fkm) of secang wood. The extraction process was carried out using maceration with 96% ethanol as ellent, after that extact partitioned using n-hexane. Fen was then applied using vacuum column chromatography using chloroform, chloroform: methanol (5:1), and methanol as eluent. Eet, Fen, and Fkm of secang wood were then formulated. Hair tonic evaluation includes organoleptic test, determination of pH value, viscosity determination, homogeneity test, and hair growth activity. The results showed that the three hair tonic formulas produced red-orange color, smelled aromatic in solution form, had a pH of 7, were homogeneous, had a viscosity of 3 cps, and showed activity on hair growth and hair weight of rabbits. FIII gave significantly different results from negative control (p <0.05) on rabbit hair length data on day 30, so ii can be concluded that FIII shows the best activity. All three formulas were qualify according to standard requirements and has activity on hair growth.
UJI AKTIVITAS ANTIPIRETIK EKSTRAK DAUN SISIK NAGA(Pyrrosia piloselloides (L.) M.G. Price) TERHADAP TIKUS PUTIH (Rattus norvegicus) JANTAN GALUR WISTAR YANG DIINDUKSI PEPTON 5% Ratna Widyasari; Dina Yuspitasari; Fadli Fadli; Athiah Masykuroh; Winda Tahuhiddah
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 1 Juni 2018
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (270.672 KB) | DOI: 10.31942/jiffk.v15i01.2169

Abstract

INTISARI  Demam adalah keadaan ketika suhu tubuh meningkat melebihi suhu tubuh normal. Demam terjadi karena pelepasan  pirogen  dari dalam leukosit yang sebelumnya telah terangsang oleh pirogen  eksogen yang dapat berasal dari mikroorganisme atau merupakan suatu hasil reaksi imunologik yang tidak berdasarkan suatu infeksi. Sementara itu, banyak  negara telah mengembangkan pengobatan menggunakan herbal. Salah satu usaha yang dilakukan adalah dengan penggunaan obat tradisional. Penelitian ini bertujuan untuk membuktikan bahwa daun Sisik Naga (Pyrrosia piloselloides  (L.) M.G Price) dengan konsentrasi 0,062%, 0,125% dan 0,25% memiliki aktivitas antipiretik dengan menggunakan penginduksi demam  Pepton  5%. Penelitian ini merupakan penelitian eksperimental dengan Rancang Acak Lengkap (RAL). Pengukuran suhu rektal tikus menggunakan termometer  infra red. Hewan uji dibagi menjadi 5 kelompok yaitu kelompok kontrol negatif (suspensi Na-CMC 1%), kelompok kontrol positif (suspensi parasetamol) dan kelompok uji yaitu pemberian ekstrak daun sisik naga 0,062%, 0,125% dan 0,25%. Data yang diperoleh dianalisis dengan  menggunakan uji anova dan uji LSD (Least Significant Different). Hasil dari penelitian ini bahwa ekstrak daun sisik naga (Pyrrosia piloselloides  (L.) M.G Price) konsentrasi 0,25% mempunyai aktivitas antipiretik pada tikus putih (Rattus norvegicus) jantan galur wistar. Kata kunci: Antipiretik, Daun Sisik Naga (Pyrrosia piloselloides (L.) M.G Price), Pepton 5%   ABSTRACT  A fever is a condition when the body temperature rises beyond the normal body temperature. Fever occurs due to the release of pyrogytes from within leukocytes that have previously been stimulated by exogenous pyrogens that may originate from microorganisms or are a result of immunologic reactions that are not based on an infection. Meanwhile, many countries have developed treatments using herbs. One of the efforts done is with the use of traditional medicine. This study aims to prove that the leaves of the Dragon Scales (Pyrrosia piloselloides (L.) M.G Price) with concentrations of 0.062%, 0.125% and 0.25% have antipyretic activity using Pepton fever induction 5%. This research is an experimental research with Completely Random Design (RAL). Rectal temperature measurements of mice using infra red thermometer. Test animals were divided into 5 groups: negative control group (1% Na-CMC suspension), positive control group (paracetamol suspension) and the test group were 0.062%, 0.125% and 0.25%. The data obtained were analyzed using anova test and LSD (Least Significant Different) test. The results of this study showed that the extract of leaf scales (Pyrrosia piloselloides (L.) M.G Price) concentrations of 0.25% had antipyretic activity in white rats (Rattus norvegicus) male wistar strain. Keywords: Antipyretics, Leaf Scales Dragon (Pyrrosia piloselloides (L.) M.G Price), Pepton 5%
Edukasi Potensi Kayu Secang (Caesalpinia sappan L.) terhadap Kesehatan Reproduksi dengan Metode Webinar Dina Yuspita Sari
Poltekita: Jurnal Pengabdian Masyarakat Vol. 3 No. 3 (2022): Juli - September
Publisher : Pusat Penelitian & Pengabdian Masyarakat Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (841.376 KB) | DOI: 10.33860/pjpm.v3i3.1051

Abstract

The tropical rain forests of West Kalimantan are rich in medicinal plant species, one of which is sappanwood and has been used for reproductive health. Sappanwood can be used as a supplement during pregnancy, after birth, and as antifertility. The role of sappanwood in reproductive health needs to be socialized to the public, especially pharmacists through webinar education activities. The purpose of this webinar is to introduce and educate the public and pharmacists in knowing the potential of sappanwood for reproductive health. Based on the results of the webinar activity, it was found that there was an increase in the average score before giving the webinar, from 34.1 to 78.1. This shows that PkM activities carried out through webinars are able to provide understanding, introduction, and education to the public and pharmacists in knowing the potential of sappanwood for reproductive health. Utilization of sappanwood for reproductive health can be done by brewing or making syrup products from sappanwood or by formulating sappanwood extract in traditional medicinal preparations. ABSTRAK Hutan hujan tropis di Kalimantan Barat kaya akan jenis tanaman obat, salah satunya kayu secang dan telah dimanfaatkan masyarakat untuk Kesehatan reproduksi. Kayu secang dapat digunakan sebagai suplemen saat hamil, setelah melahirkan, dan sebagai antifertilitas. Peranan kayu secang ini perlu disosialisasikan kepada masyarakat khususnya farmasis melalui kegiatan edukasi webinar. Webinar ini bertujuan untuk memperkenalkan dan mengedukasi masyarakat dan farmasis dalam mengetahui potensi kayu secang untuk kesehatan reproduksi. Berdasarkan hasil kegiatan pengabdian kepada masyarakat yang telah dilakukan, didapatkan bahwa terdapat peningkatan nilai rata-rata sebelum pemberian materi webinar yaitu 34,1 menjadi 78,1. Hal tersebut menunjukkan bahwa kegiatan PkM yang dilaksanakan melalui webinar mampu memberikan pemahaman, pengenalan, dan edukasi kepada masyarakat dan farmasis dalam mengetahui potensi bahan alam untuk kesehatan reproduksi. Pemanfaatan kayu secang untuk kesehatan reproduksi dapat dilakukan dengan menyeduh atau membuat produk sirup dari kayu secang atau dengan memformulasikan ekstrak kayu secang dalam sediaan obat tradisional.
Pencegahan Stunting Melalui Pelatihan Pembuatan Sirup Kayu Secang dan Jeruk Sambal Kepada Ibu PKK Desa Pal IX, Kalimantan Barat Dina Yuspita Sari; Ratna Widyasari
Poltekita: Jurnal Pengabdian Masyarakat Vol. 4 No. 3 (2023): Juli-September
Publisher : Pusat Penelitian & Pengabdian Masyarakat Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/pjpm.v4i3.1818

Abstract

Desa Pal IX is one of the villages in Kecamatan Sungai Kakap, Kubu Raya Regency which is affected by stunting cases with a stunting case percentage of around 12.7 percent. Sappan wood and limau citrus contain micronutrient compounds in the form of bioactive phenolic compounds and flavonoids, as well as macronutrients in the form of fats and carbohydrates. The aim of implementing this PkM is to provide education and training in making syrup from processed sappan wood and limau citrus as a macro and micro nutrient intake for handling stunting cases in Pal IX village. In general, the stages and planned activities that carried out at this PkM are preparation for activities, implementation of activities, monitoring and evaluation. The method used is the material explanation followed by training on making syrup and how to pack it to produce syrup. The results obtained are processed syrup products from sappan wood and limau citrus. In addition, there was an increase in the average score before and after the workshop, namely an increase in knowledge from a score of 30 to 68.4. Meanwhile, the results of the activity evaluation gave an index value of 86.5%, in the very satisfied category. The workshop activities were able to provide education and skills for PKK organisation in Pal IX Village in recognizing the potential of processed sappan wood and limau citrus syrup in preventing and treating stunting and making syrup product that is rich in macro-micro nutrients.
Co-Authors Athiah Masykuroh Dian Kartikasari Fadli Fadli Lindasari . Puspita, Weni Rahman, Ika Ristia Ratna Widyasari Rosi Cahayuni Wahida Taslima AN Widyasari R Wilda Wildaniah Winda Tahuhiddah