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All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian JURNAL FARMASI GALENIKA
Achmad Mursyidi
Dept. Pharmaceutical Chemistry, Faculty of Pharmacy, Gadjah Mada University Yogyakarta
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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The determination of metal content, microbial contamination and dissolution assessment of the ethanol extract of pasak bumi root Nurani, Laela Hayu; Kumalasari, Eka; Zainab, Zainab; Mursyidi, Achmad; Widyarini, Sitarina; Rohman, Abdul
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (315.452 KB) | DOI: 10.12928/pharmaciana.v7i2.6751

Abstract

 The Eurycoma longifoliais bitter therefore, to address this problem, it is prepared in a capsule form. The capsule dosage form  must has  the parameters of good quality, thus expected to increase the potential use of biodiversity and the interest of the community in consuming the medicine from the natural materials. The purpose of this research is to get the capsule product of ethanol extract of the Eurycoma longifolia root of quality through the test of total plate value and yeast yeast contamination, the determination of the metal content of Pb, Hg, Cd and the level of flavonoids released in the capsule dissolution test of ethanol extract Eurycoma longifolia root. The result of this research shows that the dissolution efficiency (DE120) capability of ethanol extract of Eurycoma longifolia root is 81,04±2,38%. Test of heavy metal content in capsule of  of ethanol extract of Eurycoma longifolia root found level of Pb equal to 4,132 ppm and not detected content of Cd and Hg in capsule. This indicates that the capsule meets the requirements set by BPOM RI. Tests for total plate numbers (ALT) and yeast capsule ethanol extract of the E. longifolia root were each obtained data of 70 x 102 colonies / g and 4 x 102 colonies / g. It also shows that the capsules meet the requirements by BPOM RI.
PENGARUH PEMBERIAN KOMBINASI FRAKSI ETIL ASETAT AKAR PASAK BUMI DAN DOXORUBICIN TERHADAP BERAT BADAN DAN JUMLAN NODUL TIKUS SPRAGUE DAWLEY BETINA YANG DIINDUKSI 7,12 DIMETILBENZ(α) ANTRASEN (DMBA) Nurani, Laela Hayu; Mursyidi, Achmad; Widyarini, Sitarina
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (458.079 KB) | DOI: 10.12928/pharmaciana.v6i1.3093

Abstract

Pasak Bumi roots contain quasinoid compounds that have carcinogenesis inhibitory, imunomudulator, antiulcer, and antimalaria effects. This study aims to determine the effect of a combination of ethyl acetate fraction of Pasak Bumi roots and doxorubicin on DMBA-induced white mice by weight and palpation observation. The mice were divided into 8 groups. Each group consisted of 7 female Sprague Dawley mice. Group 1 (normal) was only given food and drink, Group 2 was given fraction of ethyl acetate of Pasak Bumi roots (100 mg/kg body weight, Group 3 (positive control) was given doxorubicin (1.17 mg/kg body weight) 1 times a week for 5 weeks, Group 4 was given DMBA (20 mg/kg) two times a week for 5 weeks, Groups 5 was given DMBA (20 mg/kg) + doxorubicin (1.17 mg/kg), Group 6 was given DMBA (20 mg / kg) + ethyl acetate fractions of Pasak Bumi roots (100 mg / kg), Group 7 was given DMBA (20 mg / kg) + doxorubicin (1.17 mg / kg) + ethyl acetate fraction of Pasak Bumi roots (100 mg / kg) and Group 8 doxorubicin ( 1.17 mg / kg body weight) + ethyl acetate fraction of Pasak Bumi roots (100 mg / kg). Observations were made on the basis of body weight of mice and tumor incidence by palpation at week 6 of treatment. The result of  this research shows that the administration of ethyl acetate fraction of Pasak Bumi roots and doxorubicin combination can increase body weight of the mice and decrease the number of tumors compared to single doxorubicin.
UJI TOKSISITAS SUBKRONIS FRAKSI KLOROFORM DAUN PANDAN (Pandanus amaryllifolius ROXB) SEBAGAI AGEN KOKEMOTERAPI DOKSORUBISIN TERHADAP FUNGSI JANTUNG Ismiyati, Nur; Mardiyaningsih, Ana; Trilestari, Trilestari; Mursyidi, Achmad; Yuwono, Tedjo
JURNAL FARMASI GALENIKA Vol 4 No Edisi Khus (2017): Jurnal Farmasi Galenika Volume 4 Edisi Khusus SemNas Tanaman Obat Indon
Publisher : Sekolah Tinggi Farmasi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (254.611 KB)

Abstract

Fraksi kloroform daun pandan (Pandanus amaryllifolius) diketahui memiliki efek sinergis sebagai kokemoterapi doksorubisin pada sel kanker payudara MCF-7 dan T47D. Penelitian ini untuk mengetahui efek toksik subkrosis fraksi kloroform daun pandan dikombinasi dengan doksorubisin. Penelitian dilakukan dengan menggunakan tikus Sprague Dawly 1-2 bulan sebanyak 40 ekor dibagi dalam 8 kelompok yang terdiri dari kelompok sehat, kelompok pelarut, kelompok doksorubisin, dan empat kelompok perlakuan kombinasi doksorubisin dan fraksi kloroform. Setelah 30 hari dilakukan pemeriksaan biokimiawi darah  trigliseride, LDL, HDL dan kolesterol. Hasil penelitian menunjukkan kombinasi doksorubisin dengan fraksi kloroform daun pandan tidak menyebabkan toksisitas terhadap jantung dan mampu menurunkan efek toksik doksorubisin terhadap jantung.
The Role of Chemical Analysis in the Halal Authentication of Food and Pharmaceutical Products Mursyidi, Achmad
Journal of Food and Pharmaceutical Sciences Vol 1, No 1 (2013): J.Food Pharm.Sci (January-April)
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.851 KB) | DOI: 10.14499/jfps

Abstract

Food and pharmaceutical products (drugs and cosmetics) are one of the essential human needs since the human civilization. It is an obligation for Muslim to consume and use the halal consumer goods. Currently, there are numerous food and pharmaceutical products available in the market supplied to consumers in which the actual contents of these products are not clear; consequently, the halal verification and authentication of these are highly required. Non-halal items commonly found are pig derivatives such as pork, lard, and gelatin as well as alcohol (khamr), blood, dead meats, and the allowed animals to be consumed which are not slaughtered according to Syariah law. One of the ways to authenticate the halalness of the food and pharmaceutical products is chemical analysis which is relied to find the specific markers present or absent in the products they contain. Currently, some analytical techniques have been proposed and continuously developed for the authentication of halal products such as Fourier transform infrared (FTIR), chromatography-based methods, differential scanning calorimetry, electronic nose, and DNA-based methods. However, these methods can not verify the non-halal items which are not physical, chemical, or biological in nature like dead animal. Consequently, another method should be performed, i.e. direct and monitoring the production step (from farm to table). Besides, to succed the verification and authentication of halal products, passing the legislation of “Halal products assurance” by Indonesian parliament is urgently needed. Keyword: chemical analysis, food, pharmaceutical, halal authentication
Co-Authors Ana Mardiyaningsih Eka Kumalasari Laela Hayu Nurani Lestari, Tri Nur Ismiyati Rohman, Abdul Sitarina Widyarini Tedjo Yuwono Widyarini, Sitarina Zainab Zainab