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Trigona sp. Propolis Ethanolic Extract Decreased Chloramphenicol-induced Serum Glutamic Oxaloacetic Transaminase and Alkaline Phosphatase Levels of Rats (Rattus novergicus) Chanif Mahdi; Anna Zukiaturrahmah; Dyah Ayu Oktavianie Ardhiana Pratama; Putranty Widha Nugraheni
Indonesian Journal of Cancer Chemoprevention Vol 9, No 3 (2018)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev9iss3pp110-117

Abstract

Liver has an important role in detoxification of toxins such as xenobiotic which could interfere the function of liver. Chloramphenicol is an antibiotic widely used,despite of its toxicity potentials. The enhancement of free radicals in the body could suppress antioxidant activity. Propolis of Trigona sp. has been known to contain very high amount of antioxidants. The enhanced serum glutamic oxaloacetic transaminase (SGOT) and alkaline phosphatase (ALP) levels in serum is used as marker of liver damage due to the increase of free radicals. The purpose of this study was to observe the effect of Trigona sp. propolis ethanolic extract on SGOT and ALP levels in rats (Rattus novergicus) pretreated by chloramphenicol to induce liver damage. Test animals used for this research were male rats aged 8-12 weeks divided into five treatment groups: negative controlgroup (normal), positive control group (induced by 400 mg/kgBW chloramphenicol), first therapy group, second therapy group, third therapy group induced by chloramphenicol with and propolis extract with the dose of 8 mg, 16 mg, and 24 mg, respectively. Chloramphenicol was injected subcutaneously for 14 days, whereas propolis extract were administered orally for 21 days. The level of SGOT and ALP was determined using spectophotometry. The results showed that propolis extract could reduce levels of SGOT and ALP. Dose of 24 mg/kg was the effective dose to decrease levels of SGOT and ALP significantly (p<0.01). Hence, it may be concluded that the ethanol extract of propolis could be used as herbal therapy in rats model of liver damage.Keywords : ALP, liver, chloramphenicol, propolis, SGOT
Case report: Demodicosis in a Chow-chow dog at Yours Veterinary Clinic in Padang Panjang City Ridho Gelagar, Ario; Sukmawati, Yofa; Ramadhan, Juliadi; Aulia, Usma; Zukiaturrahmah, Anna
Basic and Applied Nursing Research Journal Vol 4 No 2 (2023): Basic and Applied Nursing Research Journal (BANRJ)
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/banrj.04.02.07

Abstract

Demodecosis, also known as Red Mange, Acarus Mange, and Follicular Mange, is a skin disease caused by the mite Demodex canis. Demodecosis infection can occur in dogs of all ages. This study aims to diagnose and treat the infection of Demodex sp in chow-chow dogs. Clinical signs include generalized alopecia, scales, and crusts found on the body's surface, followed by dehydration symptoms, poor skin turgor, and long CRT. Supporting examinations to determine demodecosis infection are carried out using the deep skin scrapping test method. Next, a hematological exam was carried out. The hematology examination interpreted the blood analysis results to indicate that the dog had normochromic microcytic anemia. A decrease in RBC, hemoglobin, and hematocrit indicates anemia. A low MCV indicates Microcytic, and normochromic is due to a normal MCHC. Treatment is carried out by administering ivermectin, diphenhydramine HCl, and longamox.
Enucleation of Bulbus Oculi in Domestic Cats Patients with Orbital Tumors Ramadhan, Juliadi; Nafis S, Muhammad; Ridho Gelagar, Ario; Aulia, Usma; Zukiaturrahmah, Anna; Sukmawati, Yofa
Basic and Applied Nursing Research Journal Vol 4 No 2 (2023): Basic and Applied Nursing Research Journal (BANRJ)
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/banrj.04.02.06

Abstract

The eye is an essential organ for living things, as one of the five senses of the eye is very vulnerable to infectious or non-infectious diseases. The orbital tumor is one of the disorders in the cat's eye that can attack the eye muscles, nerves, and lacrimal glands. This study aims to diagnose and treat the enucleation of bulbus oculi in domestic cats and patients with orbital tumors. This activity was carried out at the Veterinary Practice "Drh. Juliadi Ramadhan, M.Si." Jl. Payakumbuh-Lintau No. 12 Regency 50 City, West Sumatra Province. The results showed that one of the treatments for orbital tumor cases can be done by enucleation of the oculi bulk. This operation uses a subconjunctival method to remove the eye, the nictitating membrane, and a little eyelid by minimizing the removal of extraocular muscle tissue. After surgery, intense treatment is carried out by maintaining the sanitation of the cage and administering anti-inflammatory drugs, antibiotics, and vitamins.