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All Journal Jurnal Tumbuhan Obat Indonesia Indonesian Journal of Cancer Chemoprevention
Fitriana Hayyu Arifah
Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology Public Health

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EFEK REBUSAN RIMPANG SEGAR, REBUSAN RIMPANG KERING, MINYAK ATSIRI DAN KURKUMIN Curcuma xanthorriza Roxb. TERHADAP KADAR BILIRUBIN PADA TIKUS WISTAR JANTAN YANG DIINDUKSI PARASETAMOL Fitriana Hayyu Arifah; Suwijiyo Pramono; Agung Endro Nugroho
Jurnal Tumbuhan Obat Indonesia Vol 11 No 2 (2018): Jurnal Tumbuhan Obat Indonesia
Publisher : Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1170.339 KB) | DOI: 10.22435/jtoi.v11i2.572

Abstract

Javanese turmeric (Curcuma xanthorrhiza Roxb.) is a medicinal plant that can be developed for the treatment of liver disease. The aim of this study is to evaluate the decoction of fresh rhizome, decoction of dried rhizome, essential oils, and curcumin of Curcuma xanthorrhiza Roxb. against bilirubin level on paracetamol-induced male Wistar rats. Male Wistar rats were divided into 10 groups including group I and II were normal control and negative control, groups III, IV, and V received pretreatment of decoction of fresh rhizome 0,75 g/kgBW, 2,25 g/kgBW, and 6,75 g/kgBW, respectively for 9 days, Groups VI, VII, and VIII received pretreatment of decoction of dried rhizome 0,45 g/kgBW, 1,35 g/kgBW, and 4,05 g/kgBW, respectively for 9 days, group IX received pretreatment of essential oils 1,01 μl/kgBW for 9 days, group X received pretreatment of curcumin 75 μg/kgBW for 9 days. Groups II, III, IV, V, VI, VII, VIII, IX, and X on days 7, 8, and 9 induced paracetamol 3 g/kgBW. The blood was drained on day 0 and 4 after induction of paracetamol for bilirubin parameter study. Data were analyzed statistically using One-Way ANOVA test followed by LSD test with a 95% confidence level. The results showed that pretreatment of decoction of fresh rhizome 0,75 g/kgBW decrease the bilirubin level significantly (p<0,05) against the negative control. It can be concluded that pretreatment of decoction of fresh rhizome 0,75 g/kgBW was the best effect of decrease the bilirubin level.
Estrogenic Activity of Ethanolic Extract of Papaya Peels (Carica Papaya L.) on Uterine Weight and Mammae Gland Proliferation on Ovariectomy Rats Dhania Novitasari; Devyanto Hadi Triutomo; Fitriana Hayyu Arifah; Anselma Ivanawati; Zahrotul Ulum; Retno Murwanti
Indonesian Journal of Cancer Chemoprevention Vol 9, No 2 (2018)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev9iss2pp86-91

Abstract

Papaya bark is one of Indonesia's natural wealth that contains flavonoid compounds such as myricetin and kaempferol that included in the phytoestrogen compounds. The aim of this study is to examine the estrogenic effects of ethanolic extract of papaya peels (EEPP) on the development of mammae gland and the increasing of uterine weight. The in vivo test was performed in ovariectomized Sprague Dawley female rats. After 30 days of treatment, animals were sacrificed to take the uterus and mammae glands. Measurement of uterine weight and mammae gland was observed by hematoxylin-eosin staining method to know the lobulus development and AgNOR staining to determine the proliferation level of mammae gland epithelial cells. The results showed that EEPP at the concentrations of 500 and 1000 mg/kgBW were able to increase uterine weight and proliferation of mammae gland. In conclusion, papaya bark has the potential as phytoestrogen compound to maintain female reproductive health and woman beauty.Keywords : Ethanolic extract of papaya peels (EEPP), phytoestrogen, ovariectomized rats, uterine weight, mammae proliferation
Co-Authors Agung Endro Nugroho Anselma Ivanawati Devyanto Hadi Triutomo Dhania Novitasari Retno Murwanti Suwijiyo Pramono Zahrotul Ulum