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All Journal Medical Journal of Indonesia Jurnal Penyakit Dalam Indonesia
Ginova Nainggolan
Faculty of Medicine Universitas Indonesia, Jakarta
Medicine & Pharmacology

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Qualitative work overload and other risk factors related to hypertension risk among Indonesian Police Mobile Brigade (Brimob) Kanam, Riri N.; Basuki, Bastaman; Nainggolan, Ginova
Medical Journal of Indonesia Vol 17, No 3 (2008): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (404.428 KB) | DOI: 10.13181/mji.v17i3.322

Abstract

Members of the Police Mobile Brigade (Brimob) can suffer from hypertension which is related to work stressors and other risk factors. This study aimed to identify the relationship between work stressors and other hypertensive risk factors. The subjects of this cross-sectional study were members of the Brimob undergoing their periodic medical check-up during July-October 2007. A subject was hypertensive if systolic blood pressure (SBP) was 140 mmHg or higher, or diastolic (DBD) 90 mmHg, or higher or taking antihypertensive drugs. Normal subjects were those who had SBP less than 120 mmHg and DBP less than 80 mmHg, and have never been diagnosed with hypertension. A number of 336 Brimobs aged 21 to 51 years participated in this study, 111 had high blood pressure and 79 had normal blood pressure. Hypertension was found to be related to excessive body weight and qualitative work overload. Age, work, lifestyle, history of diabetes, hypertension in the family, and other work stressors were not found to increase the risk of hypertension. Medium to high level qualitative work overload had a two-fold risk for hypertension [relative risk adjusted (RRa) = 2.00; 95% confidence interval (CI) = 0.97-4.14; p = 0.060]. Overweight subjects had 48% increased risk to hypertension (RRa = 1.48; 95% CI = 0.98-2.22). Obese subjects had a two-fold risk of being hypertensive (RRa = 2.21; 95%CI = 1.51 - 3.14). Qualitative work overload and obesity increased the risk of hypertension. These risk factors should therefore be controlled. (Med J Indones 2008; 17: 188-96)Keywords: hypertension, qualitative work overload, overweight, obese
Job stressors and other risk factors related to the risk of hypertension among selected employees in Jakarta Krisnawati, Feni; Basuki, Bastaman; Nainggolan, Ginova
Medical Journal of Indonesia Vol 15, No 3 (2006): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (151.386 KB) | DOI: 10.13181/mji.v15i3.236

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Almost everyone, including employees, may develop hypertension. Several risk factors, including stresses in the work environment, are related to hypertension. The aim of this study is to identify these work-related risk factors in hypertension. A nested case-control study was conducted among office employees in Jakarta during May 2004. Employees with stage 1 or stage 2 hypertension (based on the United States of America Joint National Committee on high blood pressure 2003), or those taking antihypertensive drugs were designated as cases. As controls were employees with no history of hypertension. One case was randomly matched by gender with two controls. All risk factors for cases and controls were counted as of the reference date of diagnosis for cases. There were 70 cases and 140 controls aged 25 to 65 years. Hypertension was found to be related to the qualitative and quantitative increase in the workload, career development, age, obesity, current and past smoking habits, and a family history of hypertension. However, it was noted that role of ambiguity, role of conflict, and personal responsibility did not increase the risk of hypertension. Compared to those with low qualitative job stressor, those who had moderate or high qualitative job stressor had a seven-fold risk to be hypertensive [adjusted odds ratio (ORa) = 7.47; 95% confidence interval (CI) = 1.40-39.76]. In addition, relative to those who had low quantitative job stressor, those with moderate or high stressors were four times at risk to be hypertensive (ORa = 4.10; 95% CI = 1.06-15.90). In conclusion moderate or high qualitative and quantitative job stressors as well as career development increased risk hypertension. Therefore these stressors need to be prevented. (Med J Indones 2006; 15:177-84) Keywords: hypertension, qualitative job stressor, quantitative job stressor, career development
Pengembangan Model Prediksi Mortalitas 3 Bulan Pertama pada Pasien Penyakit Ginjal Kronik yang Menjalani Hemodialisis Umami, Vidhia; Lydia, Aida; Nainggolan, Ginova; Setiati, Siti
Jurnal Penyakit Dalam Indonesia Vol. 2, No. 3
Publisher : UI Scholars Hub

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Pendahuluan: Mortalitas pasien yang menjalani hemodialisis (HD) paling tinggi pada tiga bulan pertama. Data mengenai insidens dan prediktor mortalitas dini pada pasien HD sangat terbatas. Suatu model prediksi dapat menjadi alat bantu yang sederhana untuk mengetahui pasien yang berisiko tinggi sehingga pada akhirnya upaya pencegahan dapat dilakukan. Penelitian ini bertujuan untuk mengetahui insidens dan prediktor mortalitas 3 bulan pada pasien hemodialisis baru dan membuat suatu model prediksi. Metode: Penelitian dengan disain kohort retrospektif terhadap 246 pasien PGTA yang baru menjalani HD di Unit HD RSCM antara Januari 2011-Januari 2012. Dilakukan analisis chi-square untuk mendapatkan nilai OR (Odds Ratio) terhadap variabel usia, pembiayaan, jenis HD, akses pembuluh darah, anemia, hipoalbuminemia, kelainan EKG, kardiomegali, komorbid, waktu rujukan ke nefrologis, dan kepatuhan. Prediktor yang bermakna kemudian dimasukkan pada model regresi logistik untuk mendapatkan sistem skor. Hasil: Sebanyak 78 (31,7%) dari 246 pasien meninggal dalam 3 bulan pertama. Terdapat 5 variabel yang berhubungan dengan terjadinya mortalitas 3 bulan yaitu usia > 60 tahun, hemoglobin/dl, albumin serum Simpulan: Insidens mortalitas 3 bulan pada pasien HD baru sebesar 31,7%. Usia > 60 tahun, hemoglobin/dl, albumin serum
Nilai Diagnostik Rerata Tekanan Darah Pre dan Post Hemodialisis pada Pasien yang Menjalani Hemodialisis Kronik Purba, Ferry Tigor P.; Siregar, Parlindungan; Nainggolan, Ginova; Shatri, Hamzah
Jurnal Penyakit Dalam Indonesia Vol. 1, No. 2
Publisher : UI Scholars Hub

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Pendahuluan. Penyebab utama morbiditas dan mortalitas pada pasien PGK (penyakit ginjal kronik) yang menjalani HD (hemodialisis) kronik adalah penyakit kardiovaskuler. Faktor utama penyebab kejadian kardiovaskuler pada pasien PGK yang menjalani HD adalah hipertensi. Diagnosis hipertensi pada pasien PGK yang menjalani HD tidaklah mudah. Hal ini dikarenakan adanya efek retensi cairan, office hypertension, dan proses ultrafiltrasi setelah HD. Baku emas diagnosis hipertensi pada pasien HD adalah pemeriksaan tekanan darah interdialitik dengan menggunakan alat ambulatory blood pressure monitoring (ABPM). Namun alat ini memiliki banyak kendala dalam pemeriksaannya. Studi sebelumnya yang meneliti tekanan darah pre dan post dialisis dibandingkan dengan tekanan darah ABPM memberikan hasil yang masih kontroversial. Penelitian ini bertujuan untuk mengetahui korelasi dan nilai diagnostik rerata tekanan darah pre dan post hemodialisis dengan baku emas tekanan darah interdialisis yang diukur dengan metode ABPM. Metode. Dilakukan studi diagnostik dan uji korelasi dengan desain penelitian potong lintang pada tiga puluh lima pasien dewasa dengan penyakit ginjal kronik yang menjalani hemodialisis kronik. Pasien yang memenuhi kriteria penelitian dilakukan pengukuran ABPM selama 24 jam dan tekanan darah saat pre dan post dialisis. Hasil. Uji korelasi Pearson menunjukkan korelasi rerata TD sistolik pre-post dialisis dan sistolik ABPM sebesar r = 0,669 dan p= 0,000 dengan AUC sebesar 84,4% (95% IK, 71,5% - 97,3%) dengan p = 0,001 serta nilai sensitivitas 82,14%, spesifisitas 71.43%, nilai duga positif 92%, dan nilai duga negatif 50%. Uji korelasi Pearson mendapatkan korelasi antara rerata TD diastolik prepost dialisis dan diastolik ABPM sebesar r = 0,359 dan p = 0,034 dengan AUC sebesar 67,6 % (95% IK, 49,3 % - 86,0%) dengan p= 0,075 serta nilai sensitivitas 82,14%, spesifisitas 85,71%, nilai duga positif 95,83%, dan nilai duga negatif 54,55%. Simpulan. Rerata tekanan darah sistolik pre-post hemodialisis dapat digunakan untuk diagnosis hipertensi pada pasien penyakit ginjal kronik yang menjalani hemodialisis kronik.
Peran Prediktif IL-6, IL-10, dan TNF-α Plasma terhadap Gagal Ginjal Akut pada Pasien dengan COVID-19 Derajat Sedang dan Berat Gathmyr, Dewi; Bonar, Maruhum Bonar H; Susilo, Adityo; Harimurti, Kuntjoro; Nainggolan, Ginova; Tagor, Alvin; Shatri, Hamzah; Lesmana, Cosmas Rinaldi Adithya; Amin, Zulkifli
Jurnal Penyakit Dalam Indonesia
Publisher : UI Scholars Hub

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Introduction. Acute kidney injury (AKI) is associated with higher mortality rate in COVID-19 patients due to inflammation and immune dysregulation. This study aimed to correlate serum levels of IL-6, IL-10, and TNF-α with serum creatinine changes and their roles to predict incidence of acute kidney injury (AKI) in patients with moderate and severe COVID-19. Methods. This prospective cohort study was conducted among patients with moderate to severe COVID-19 in Pertamina Central Hospital Jakarta, Indonesia during November 2020 to January 2021. All serum levels of cytokines (IL-6, IL-10, and TNF-α) and creatinine were collected on the first day and seventh day of hospitalization. They might be collected earlier if the patients died or discharged early. AKI was defined as deterioration in serum creatinine or urine output based on Kidney Disease Improving Global Outcomes (KDIGO) guideline. The correlation between cytokine and creatinine serum level changes were analyzed using Spearman test. Receiver operator characteristic curve was calculated to explore predictive roles of cytokines on AKI incidence. Results. A total of 43 patients were included in the study, with a mean age of 59.3 years (SD 12.59), and the majority were male (74%). The incidence of AKI was 7%. Serum creatinine changes were correlated with serum levels changes IL-10 (r= -0.343; p=0.024), but not for IL-6 (r=-0.198; p=0.202) and TNF-α (r=-0.129, p=0.409). Meanwhile, serum TNF-α level on the first day was able to predict AKI incidence on the seventh day of hospitalization (AUC 85%; p=0.045; 95% CI=0.737 to 0.963). Conclusions. TNF-α on the first day is potential to be predictor on AKI incidence on the seventh day in moderate and severe COVID-19 patients.
Co-Authors Adityo Susilo, Adityo Aida Lydia, Aida Ari Fahrial Syam Bastaman Basuki Bonar, Maruhum Bonar H C Rinaldi A Lesmana Chudahman Manan Dewi Gathmyr E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Feni Krisnawati Ferry Tigor P Purba, Ferry Tigor P Kuntjoro Harimurti Lusy Erawati Ni Made Hustrini, Ni Made Parlindungan Siregar Purba, Ferry Tigor P. Riri N. Kanam Sayid Ridho Siti Setiati Tagor, Alvin Vidhia Umami, Vidhia Zulkifli Amin