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Cita Rosita SP
Departemen/Staf Medik Fungsional Ilmu Kesehatan Kulit dan Kelamin Fakultas Kedokteran Universitas Airlangga/Rumah Sakit Umum Daerah Dr. Soetomo Surabaya
Immunology & microbiology Public Health

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Open Oral Food Challenge in Adult with Food Allergy to Chicken Meat Yosi Charly; Cita Rosita SP; Trisniartami Setyaningrum
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 2 (2016): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (309.282 KB) | DOI: 10.20473/bikk.V28.2.2016.96-103

Abstract

Background: Food allergy is a hypersensitivity of the body's response to food. Food allergies are divided into three groups: immunoglobulin E (IgE) mediated, non-IgE mediated, and mixed IgE mediated with non-IgE mediated. Food allergies can be life threatening, causing malnutrition, eating disorders, and psychosocial problems. The gold standard for the diagnosis of food allergy is double-blind placebo-controlled food challenge (DBPCFC), but time consuming, costly, and a resuming specialist to perform it. Open oral food challenge (OFC), commonly used as screening in the clinic, with food suspected of being in its true form, in particular to look for symptoms. Objective: To evaluate specific IgE and open OFC in adult patients with a history of food allergies to chicken. Methods: Descriptive cross-sectional study involving 28 adult patients with history of food allergies to chicken were diagnosed as urticaria, angioedema, and atopic dermatitis. Specific IgE chicken meat was performed  and patients were asked to eliminate chicken for 1 week before open OFC. Results: Twenty eight samples, specific IgE within normal limit. Positive results of open OFC were found in 9 people and 19 negative result. Conclusion: The specific IgE chicken does not always correlate with clinical reactivity and open the OFC can be used for the diagnosis of food allergy to chicken meat. Key words: food allergies, spesific Ig E, open oral food challenge.
Severe Cutaneous Adverse Drug Reaction Damayanti Damayanti; Sylvia Anggraeni; Cita Rosita SP; Marsudi Hutomo; Hari Sukanto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 2 (2017): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (356.379 KB) | DOI: 10.20473/bikk.V29.2.2017.151-157

Abstract

Background: Cutaneous adverse drug eruption (CADR) are frequently found. A systematic review showed, the incidence of severe CADR (SCADR) ranging from 0-8%. Few studies have assessed the severe form of CADR, which has high mortality rate. The epidemiological study was needed to show the profile of SCADR, especially in the setting of general hospital. Purpose: To evaluate clinical and epidemiological profile of SCADR in Dermatology and Venereology Ward Dr. Soetomo Hospital Surabaya. Methods: All SCADR patients in the period of January 2015–January 2016 was evaluated clinically and epidemiologically. Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic reaction (DRESS) cases were included in the study. Results: There were 14 patients in this study, consist of 10 SJS cases (71.4%), 2 TEN patients, and 2 AGEP patients. The highest frequency of age group was 25-29 years old (57.1%). Man to woman ratio was 3:4. The most common offending drug was paracetamol (50%), followed by amoxicillin (28.6%). Antibiotic was the highest frequent offending drug-group (64.3%), followed by antipiretics (50%). In this study, all patients got systemic corticosteroid and the mortality was 0%. Conclusion: The most common type of SCADR was SJS. The most common offending drug was paracetamol, and antibiotic was the highest frequent offending drug-group. Systemic corticosteroid therapy showed good result in severe CADR management.
Co-Authors Anggraeni, Sylvia Damayanti Damayanti Hari Sukanto, Hari Marsudi Hutomo Trisniartami Setyaningrum Yosi Charly