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Susceptibility test of Griseofulvin, Ketoconazole, Itraconazole, and Terbinafine to Dermatophyte Species Using Microdilution Method Anggarini, Dyah Ratri; Sukanto, Hari; Astari, Linda; Endraswari, Pepy Dwi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Backgroud: Dermatophytosis is common disease in tropical countries such as Indonesia. The prevalence of dermatophytosis in general population also high (20%). The dermatophyte fungi are the etiologic agents that cause this disease, some of them had already reported to be resistant to some anti-fungi. Purpose: To determine dermatophyte species causing dermatophytosis and the resistancy of griseofulvin, ketoconazole, itraconazole, dan terbinafine to dermatophyte species. Methods: Isolates of dermatophyte from patient who met the inclusion criteria in outpatient clinic of dermato-venereology Dr. Soetomo Hospital Surabaya during October until December 2014 were analyzed with respect to their susceptibility to four anti-fungal agents (griseofulvin, ketoconazole, itraconazole, and terbinafine) using microdilution methode. Results: Thirthy patients were included in inclusion criteria, with T. mentagrophytes var. Interdigitale was the most common cause of dermatophytoses. According to MIC all 30 isolates were already resistant to all anti-fungal agent, except T. rubrum that still sensitive to ketoconazole and 80,Â itraconazole.Â Conclusion: According to MIC 16.7% isolates sensitive to griseofulvin, 23.3% to ketoconazole, 16.7% to 80 itraconazole and 20% to terbinafine.Key word: dermatophyte species, susceptibility test of anti-fungal, microdilution.

Uji Tempel Pasien Dengan Riwayat Dermatitis Kontak Alergi Kosmetik di URJ Kesehatan Kulit Dan Kelamin RSUD Dr. Soetomo Surabaya Miftah, Antoni; Prakoeswa, Cita Rosita Sigit; Sukanto, Hari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 1 (2014): BIKKK APRIL 2014
Publisher : Faculty Of Medicine Airlangga University

Latar belakang: Kasus dermatitis kontak alergi kosmetik (DKAK) relatif signifikan, diperkirakan 10% dari seluruh kasus dermatitis kontak di RSUD Dr. Soetomo Surabaya cenderung meningkat. Tahun 2008 ditemukan 24 (6%) penderita DKAK dari 267 pasien DKA, sedangkan tahun 2009 ditemukan 36 (15%) dari 230 pasien DKA yang datang berobat. Tujuan: Mengetahui bahan kosmetik penyebab dermatitis kontak akibat kosmetik dan mengetahui relevansi klinis hasil uji tempel. Metode: Penelitian retrospektif terhadap 30 sampel dengan riwayat DKAK periode November 2010 â November 2011 di Divisi Alergi Imunologi URJ Kulit dan Kelamin RSUD Dr. Soetomo. Uji tempel menggunakan 12 bahan standar alergen kosmetik. Hasil: Enam belas pasien dari 30 sampel (53,33%) didapatkan hasil positif dengan satu atau lebih alergen dan 14 pasien (46,67%) negatif terhadap alergen yang ditempelkan. Hasil uji tempel positif terbanyak dari 16 pasien tersebut adalah alergen pewarna rambut yaitu 13 pasien (43,3%), diikuti pewangi 6 pasien (20%) dan pengawet 5 pasien (16,7%). Simpulan: Uji tempel alergen standar kosmetik dapat digunakan sebagai pemeriksaan penunjang terhadap penderita dermatitis kontak alergi kosmetik di Divisi Alergi Imunologi URJ Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya. Kata kunci: dermatitis kontak alergi, alergen kosmetik, uji tempel, relevansi klinis.

Occupational Contact Dermatitis: Retrospective Study Witasari, Dinar; Sukanto, Hari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Background: Occupational skin disease is the second largest occupational disease in Europe after musculoskeletal injury.Most common occupational skin disease is contact dermatitis as many as 70-90%. Determining the cause of contact dermatitis in occupational environment is very important to avoid causing substances and to establish healing as well as reducing the recurrence rate. Purpose: To evaluate the management of new patients with occupational contact dermatitis in Allergy Immunology Division, Dermatology and Venerology outpatient clinic Dr. Soetomo General Hospital Surabaya in period of 2010-2012. Methods: Retrospective study of new patients with occupational contact dermatitis in Allergy Immunology Division during 2010-2012. Results: New patient of occupational contact dermatitis during the period of 2010-2012 were 50 new persons, predominantly occured in male in reproductive age (25-44 year old), irritant contact dermatitis (ICD) occured more frequent than allergic contact dermatitis (ACD). The majority of subjects were factory workers, with the most suspected ingredients was chemicals. About 21.7% patients underwent patch test. The therapy mostly given were antihistamines and topical steroids. There were 46% of patients who did not visit outpatient clinic again. Conclusions: New patients of occupational contact dermatitis in Allergy Immunology Division during the period of 2010-2012 were as many as 50 new patients. Patch test should be performed to establish the diagnosis and determine the cause of contact dermatitis materials.Key words: occupational contact dermatitis, patch test, retrospective study.

Drug Patch Test as a Diagnostic Test to Determine the Culprit Drug of Cutaneous Adverse Drug Reaction (CADR) Damayanti; Hari Sukanto; Marsudi Hutomo; Sylvia Anggraeni; Menul Ayu Umborowati; Cita Rosita Sigit Prakoeswa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15739

Background: Cutaneous Adverse Drug Reaction (CADR) is a frequent problem in clinical practice since there were new drugs or drug misuse, which leads to high morbidity and mortality rate. It is often difficult to determine the offending drug only from the history. Provocation test, intradermal test or skin prick test are of significant value, but having higher risk to re-precipitate life-threatening reaction. Drug patch test (DPT) is a test, which is performed to CADR patient to determine the culprit drug. The main advantages of DPT are, it gives rarely adverse reaction and any commercialized form of drugs can be used.Methods: This is a retrospective study, aimed to analize the clinical relevance between anamnesis and DPT result in patient with history of CADR. All patient, who were performed with DPT in one year period in Dr. Soetomo General Academic Hospital Surabaya Indonesia, were evaluated in this study. Results: There were 14 patients with history of CADR, who performed DPT; consist of 7 maculopapular eruption cases, 4 Stevens-Johnson Syndrome (SJS) cases, 1 Fixed Drug Eruption (FDE) case, 1 Acute Generalized Exanthematous Pustulosis (AGEP) case and 1 Drug Reaction with Eosinophilia and Systemic Reaction (DRESS) case. There were 9 patients (64.3 %), who got positive result of DPT. The relevance between anamnesis and positive result of DPT were shown in 8 patient (88.9%) of 9 patient with positive DPT result. Conclusion: DPT has important role in identifying the culprit drug in CADR, especially when multiple drugs are involved.

Uji Tempel Pasien Dengan Riwayat Dermatitis Kontak Alergi Kosmetik di URJ Kesehatan Kulit Dan Kelamin RSUD Dr. Soetomo Surabaya Antoni Miftah; Cita Rosita Sigit Prakoeswa; Hari Sukanto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 26 No. 1 (2014): BIKKK APRIL 2014
Publisher : Faculty of Medicine, Universitas Airlangga

Latar belakang: Kasus dermatitis kontak alergi kosmetik (DKAK) relatif signifikan, diperkirakan 10% dari seluruh kasus dermatitis kontak di RSUD Dr. Soetomo Surabaya cenderung meningkat. Tahun 2008 ditemukan 24 (6%) penderita DKAK dari 267 pasien DKA, sedangkan tahun 2009 ditemukan 36 (15%) dari 230 pasien DKA yang datang berobat. Tujuan: Mengetahui bahan kosmetik penyebab dermatitis kontak akibat kosmetik dan mengetahui relevansi klinis hasil uji tempel. Metode: Penelitian retrospektif terhadap 30 sampel dengan riwayat DKAK periode November 2010 – November 2011 di Divisi Alergi Imunologi URJ Kulit dan Kelamin RSUD Dr. Soetomo. Uji tempel menggunakan 12 bahan standar alergen kosmetik. Hasil: Enam belas pasien dari 30 sampel (53,33%) didapatkan hasil positif dengan satu atau lebih alergen dan 14 pasien (46,67%) negatif terhadap alergen yang ditempelkan. Hasil uji tempel positif terbanyak dari 16 pasien tersebut adalah alergen pewarna rambut yaitu 13 pasien (43,3%), diikuti pewangi 6 pasien (20%) dan pengawet 5 pasien (16,7%). Simpulan: Uji tempel alergen standar kosmetik dapat digunakan sebagai pemeriksaan penunjang terhadap penderita dermatitis kontak alergi kosmetik di Divisi Alergi Imunologi URJ Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya. Kata kunci: dermatitis kontak alergi, alergen kosmetik, uji tempel, relevansi klinis.

Occupational Contact Dermatitis: Retrospective Study Dinar Witasari; Hari Sukanto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 26 No. 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Occupational skin disease is the second largest occupational disease in Europe after musculoskeletal injury.Most common occupational skin disease is contact dermatitis as many as 70-90%. Determining the cause of contact dermatitis in occupational environment is very important to avoid causing substances and to establish healing as well as reducing the recurrence rate. Purpose: To evaluate the management of new patients with occupational contact dermatitis in Allergy Immunology Division, Dermatology and Venerology outpatient clinic Dr. Soetomo General Hospital Surabaya in period of 2010-2012. Methods: Retrospective study of new patients with occupational contact dermatitis in Allergy Immunology Division during 2010-2012. Results: New patient of occupational contact dermatitis during the period of 2010-2012 were 50 new persons, predominantly occured in male in reproductive age (25-44 year old), irritant contact dermatitis (ICD) occured more frequent than allergic contact dermatitis (ACD). The majority of subjects were factory workers, with the most suspected ingredients was chemicals. About 21.7% patients underwent patch test. The therapy mostly given were antihistamines and topical steroids. There were 46% of patients who did not visit outpatient clinic again. Conclusions: New patients of occupational contact dermatitis in Allergy Immunology Division during the period of 2010-2012 were as many as 50 new patients. Patch test should be performed to establish the diagnosis and determine the cause of contact dermatitis materials.Key words: occupational contact dermatitis, patch test, retrospective study.

Susceptibility test of Griseofulvin, Ketoconazole, Itraconazole, and Terbinafine to Dermatophyte Species Using Microdilution Method Dyah Ratri Anggarini; Hari Sukanto; Linda Astari; Pepy Dwi Endraswari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 1 (2015): BIKKK APRIL 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Backgroud: Dermatophytosis is common disease in tropical countries such as Indonesia. The prevalence of dermatophytosis in general population also high (20%). The dermatophyte fungi are the etiologic agents that cause this disease, some of them had already reported to be resistant to some anti-fungi. Purpose: To determine dermatophyte species causing dermatophytosis and the resistancy of griseofulvin, ketoconazole, itraconazole, dan terbinafine to dermatophyte species. Methods: Isolates of dermatophyte from patient who met the inclusion criteria in outpatient clinic of dermato-venereology Dr. Soetomo Hospital Surabaya during October until December 2014 were analyzed with respect to their susceptibility to four anti-fungal agents (griseofulvin, ketoconazole, itraconazole, and terbinafine) using microdilution methode. Results: Thirthy patients were included in inclusion criteria, with T. mentagrophytes var. Interdigitale was the most common cause of dermatophytoses. According to MIC all 30 isolates were already resistant to all anti-fungal agent, except T. rubrum that still sensitive to ketoconazole and 80, itraconazole. Conclusion: According to MIC 16.7% isolates sensitive to griseofulvin, 23.3% to ketoconazole, 16.7% to 80 itraconazole and 20% to terbinafine.Key word: dermatophyte species, susceptibility test of anti-fungal, microdilution.

C-Reactive Protein in Various Degrees Severity of Psoriasis Vulgaris Lita Setyowatie; Hari Sukanto; Dwi Murtiastutik
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 2 (2016): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Psoriasis vulgaris is an inflammatory, chronic, recurrent, and, non-contangious skin disease. The severity grade of psoriasis is measured with psoriasis area and severity index (PASI) score. C-reactive protein (CRP) is a sensitive, but not specific indicator of inflammation. In the active stage of psoriasis, highly increased CRP levels were found, whereas at remission they present a decrease level. Purpose: To evaluate the profile of CRP level in psoriasis vulgaris patients with various degress of psoriasis vulgaris severity in Dr. Soetomo Hospital Surabaya. Methods: Blood samples were collected in 16 patients to measure the CRP level in psoriasis vulgaris patients with various degrees of severity. Results: There were 16 patients (10 male and 6 female) with various degrees of psoriasis vulgaris severity (5 patients with mild severity, 8 patients with moderate severity, and 3 patients with severe severity). All CRP results were within normal limits. Conclusion: Many factors can influence the CRP levels, CRP can not be as single indicator of inflammation in psoriasis vulgaris. Key words: psoriasis vulgaris, c-reactive protein, PASI score.

Profile of Serum Insulin-like Growth Factor-1 Levels in Patients with Acne Vulgaris I G.A. Kencana Wulan; Afif Nurul Hidayati; Hari Sukanto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 2 (2016): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Acne vulgaris (AV) is a skin disease that is commonly found in adolescence. In addition to causing physical disorders, acne vulgaris affects the quality of life of patients that cause social disorder, psychological, and emotional. Based on the observations of the experts, AV is rarely found in non-westernized populations, indicates an underlying environmental factors including diet. Excessive sebum production has an important role in the pathogenesis of AV. One of the factors which allegedly associated with the production of sebum and diet is IGF-1 in serum. Purpose: To evaluate the levels of IGF-1 serum in patients with AV with varying degrees of severity. Methods: This study is an observational cross-sectional study in 38 AV patients aged 15-24 years at the Outpatient Clinic of Dermatovenereology Department of Dr. Soetomo Hospital Surabaya as many as 38 people. The severity of AV are grouped according to the method of Combined Acne Severity Classification (CASC). Anamnesis of diet based on the table of load and glycemic index foods. Subjects has been collected through consecutive sampling. Results: Serum IGF-1 levels in the mild AV group was 155,000 (SD±23,381) µg/ml, in the moderate AV group was 211,052 (SD±85,498) µg/ml and in severe AV group was 150,000 (SD±45,826) µg/ml. Serum IGF-1 levels in male group was higher than female, was 199,230 (SD±85,582) µg/ml and in female group was 174,000 (SD±58,238) µg/ml. Serum IGF-1 levels in the aged group of 15-20 years was 192,270 (SD±80,766) µg/ml, higher than the aged group of 21-24 years, was 169,380 (SD±46,829) µg/ml. Conclusion: The mean levels of IGF-1 in patients with moderate degrees of AV was higher than mild or severe. IGF-1 levels can vary influenced by many factors. Key words: acne vulgaris, serum IGF-1, severity degrees of acne vulgaris.

Increase of Serum Zinc Levels in Patients with Vitiligo Dinar Witasari; Hari Sukanto; Trisniartami Setyaningrum
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Vitiligo is a common acquired depigmentary disease characterized by depigmented patches of the skin, hair, and mucous membranes due to selective destruction of melanocytes. Zinc is one of the trace element that suspected to play an important role in pathogenesis of vitiligo. Previous research showed a controversial result in zinc level of vitiligo. Purpose: To compare serum zinc between vitiligo and control in Dermatology and Venereology Outpatient Clinic in Dr. Soetomo General Hospital Surabaya. Methods: Analitic observational case control research was conducted, with 19 vitiligo patients in Dermatology and Venereology Outpatient Clinic Dr. Soetomo hospital and 19 age-sex matched controls (non-vitiligo subjects) that were qualified with inclusion and exclusion criteria. Serum zinc level was measured in both groups using atomic absorbtion spectrophotometer. Results: Mean serum zinc in vitiligo groups were 254.53 µg/dL and 109.53 µg/dL in control groups. This results showed that mean serum zinc in vitiligo group significantly higher compared to control group (p<0,05). There was a statistically significant association between serum zinc level and progressivity of the lesion as patient with active vitiligo lesion showed higher values of serum zinc. Stress is the most common predisposing factors (36%), meanwhile stress can also induce the increasing of serum zinc. Conclusion: Serum zinc in vitiligo patient is higher than control and showed correlation with course of the disease. It is required further research to reveal the role of zink in vitiligo and the connection between the degree of stress and serum zinc.

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