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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin BIOEDUKASI JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indian Journal of Forensic Medicine & Toxicology INTERNATIONAL JOURNAL OF EDUCATION, INFORMATION TECHNOLOGY, AND OTHERS Prosiding International Conference on Sustainable Innovation (ICoSI)

Anggraeni, Sylvia

Departemen/Staf Medik Fungsional Ilmu Kesehatan Kulit Dan Kelamin Fakultas Kedokteran Universitas Airlangga/Rumah Sakit Umum Daerah Dr. Soetomo Surabaya

Author-ID : 3287451

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Neuroscience Public Health Social Sciences

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The Gloves as Effective Personal Protective Equipment (PPE) of Indonesian Batik Workers Cita Rosita Sigit Prakoeswa; Damayanti; Sylvia Anggraeni; Menul Ayu Umborowati; Sri Awalia Febriana
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16832

Background: Batik substances may increase the risk of biological function disruption to batik workers.Objective: To Determine the effectiveness of using test gloves in transepidermal water loss (TEWL), skinhydration level, and skin acidity (pH).Methods: This study was one group pretest-posttest design of 16 batik workers. Subjects use test glovesmade from neoprene on right hands and personal gloves made from thermoplastic polymer of vinyl chlorideon left hands in first and second week. Washed out for 2 weeks, last 2 weeks use test gloves on left handand personal gloves on right hand. TEWL, skin hydration level, and pH was examined by Cutometer dualMP-580Result: First and second week using test gloves on the right hand, significantly differences of TEWL levelon extensor and dorsum manus; skin hydration level on flexor, extensor, palmar, and dorsum manus; pHon extensor, palmar and dorsum manus (p<0.05; CI 95%). Fifth and sixth week using test gloves in theleft hand, significantly difference of TEWL level on dorsum manus, all area of skin hydration level and pHresults (p<0.05; CI 95%). No significant differences of comparison right and left hand in the first, second,fifth, and sixth week, that showed any types of gloves can protect batik workers from skin barrier disruption.Conclusion: Personal gloves and test gloves usage for protection doesn’t have much significant difference.Wearing gloves may also give risk to trigger contact dermatitis if not used properly or using incompatiblematerial.

The Role of Aloe vera and Centella asiatica to the Improvement of Skin Barrier Function in Indonesian Batik Workers Damayanti; Menul Ayu Umborowati; Sylvia Anggraeni2; Cita Rosita Sigit Prakoeswa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15731

Background: The batik industry uses dyes and candles, that can disrupt the skin barrier function and may precipitate skin disease. Objective: To determine the role of Aloe vera and Centella asiatica to the improvement of the skin barrier function in Indonesian batik workersMethods: This was a double blind clinical trial of 30 Indonesian batik workers were divided into 2 group and given Aloe vera or Centella asiatica topical randomly was applied twice a day. Transepidermal water loss (TEWL) level, stratum corneum hydration level, and pH level, were examined using Cutometer dual MP-580. Result: Sensitivity (Sn) of new local compared with imported allergen extracts in this study was between 15.38%-84.61%, the highest point was house dust mite extract. Specificity (Sp) was ranged from 81.48%-93.75%, the highest rank was shrimp extract. Compared with IgE results, the Sn of new local and imported house dust mite extracts was good (85.7%; 92.9%). The Sp was good for egg white and cow’s milk new local extracts (86.4%; 84.4%). Conclusion: Aloe vera topical gave significant improvement on palm area of TEWL level (P=0.033; CI 95%), stratum corneum hydration (P=0.000; CI 95%), and pH level (P=0.004; CI 95%); while on dorsal hand area of stratum corneum hydration (P=0.002; CI 95%). Centella asiatica topical gave significant improvement on palm area of stratum corneum hydration (P=0.007; CI 95%); while on dorsal hand area of stratum corneum hydration (P=0.001; CI 95%) and pH level (P=0.17; CI 95%). No significant differences of Aloe vera compared to Centella asiatica in the improvement of skin barrier function.

Drug Patch Test as a Diagnostic Test to Determine the Culprit Drug of Cutaneous Adverse Drug Reaction (CADR) Damayanti; Hari Sukanto; Marsudi Hutomo; Sylvia Anggraeni; Menul Ayu Umborowati; Cita Rosita Sigit Prakoeswa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15739

Background: Cutaneous Adverse Drug Reaction (CADR) is a frequent problem in clinical practice since there were new drugs or drug misuse, which leads to high morbidity and mortality rate. It is often difficult to determine the offending drug only from the history. Provocation test, intradermal test or skin prick test are of significant value, but having higher risk to re-precipitate life-threatening reaction. Drug patch test (DPT) is a test, which is performed to CADR patient to determine the culprit drug. The main advantages of DPT are, it gives rarely adverse reaction and any commercialized form of drugs can be used.Methods: This is a retrospective study, aimed to analize the clinical relevance between anamnesis and DPT result in patient with history of CADR. All patient, who were performed with DPT in one year period in Dr. Soetomo General Academic Hospital Surabaya Indonesia, were evaluated in this study. Results: There were 14 patients with history of CADR, who performed DPT; consist of 7 maculopapular eruption cases, 4 Stevens-Johnson Syndrome (SJS) cases, 1 Fixed Drug Eruption (FDE) case, 1 Acute Generalized Exanthematous Pustulosis (AGEP) case and 1 Drug Reaction with Eosinophilia and Systemic Reaction (DRESS) case. There were 9 patients (64.3 %), who got positive result of DPT. The relevance between anamnesis and positive result of DPT were shown in 8 patient (88.9%) of 9 patient with positive DPT result. Conclusion: DPT has important role in identifying the culprit drug in CADR, especially when multiple drugs are involved.

The Accuracy of Indonesian New Local Skin Prick Test (SPT) Allergen Extracts as Diagnostic Tool of IgE-mediated Atopic Dermatitis Sylvia Anggraeni; Menul Ayu Umborowati; Damayanti; Anang Endaryanto; Cita Rosita Sigit Prakoeswa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15965

Background: Skin Prick Test (SPT) is good diagnostic tool of allergic disease such as Atopic Dermatitis (AD). Imported allergen extracts are expensive and not always available in Indonesia. New local SPT allergen extracts are potential as substitute. Objective: To compare SPT results of new local and imported allergen extracts (house dust mite, chicken, egg white, cow’s milk, and shrimp), and specific IgE in AD patients. Methods: This was clinical trial of 45 non lesional AD patients. The SPT of imported allergen extracts was performed in the first week, followed by the new local and specific IgE examination in the next one week. Result: Sensitivity (Sn) of new local compared with imported allergen extracts in this study was between 15.38%-84.61%, the highest point was house dust mite extract. Specificity (Sp) was ranged from 81.48%-93.75%, the highest rank was shrimp extract. Compared with IgE results, the Sn of new local and imported house dust mite extracts was good (85.7%; 92.9%). The Sp was good for egg white and cow’s milk new local extracts (86.4%; 84.4%). Conclusion: New local allergen extracts should be considered as a substitute of the imported diagnostic tool.

Significant Different Level of Malondialdehyde (MDA) as Oxydative Stress Marker in Severity Groups of Acne Vulgaris Sylvia Anggraeni; Trisniartami Setyaningrum; M Yulianto Listiawan
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 1 (2017): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Acne vulgaris (AV) is a common chronic inflammatory disease of sebaceous gland that may decrease patient’s quality of life. Oxidative stress is suggested to play role in the pathogenesis of AV. Purpose: To evaluate the differences of malondialdehyde (MDA) level as oxidative stress marker in AV severity. Method: This is an analytic observational cross sectional research of AV patients in Cosmetic Division of Dermatology and Venereology Outpatient Clinic of Dr. Soetomo hospital Surabaya. Subjects were collected through consecutive sampling since May-August 2015. Total samples were 42 patients, classified into 3 severity groups (mild, moderate, severe). Samples were taken from blood vein, examined with Enzyme-linked immunosorbent assay (ELISA) then analyzed statistically. Results: There were differences of MDA mean level among AV severity groups: mild 58.371 ng/ml (SD±25.2141); moderate 99.121 ng/ml (SD±8.5172); and severe 171.779 ng/ml (SD±49.9694). Post hoc analytic revealed that there were statistically differences of MDA level in all stages (mild-moderate p=0.002; mild-severe p=0.000; moderate-severe p=0.000). Conclusions: This research revealed that oxidative stress plays a role in AV pathogenesis. Lipid peroxidation process in sebum produced lipid oxidant that could induce inflammatory process in sebaseous gland via Peroxisome Proliferator-Activated Receptor (PPAR).

Severe Cutaneous Adverse Drug Reaction Damayanti Damayanti; Sylvia Anggraeni; Cita Rosita SP; Marsudi Hutomo; Hari Sukanto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 2 (2017): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Cutaneous adverse drug eruption (CADR) are frequently found. A systematic review showed, the incidence of severe CADR (SCADR) ranging from 0-8%. Few studies have assessed the severe form of CADR, which has high mortality rate. The epidemiological study was needed to show the profile of SCADR, especially in the setting of general hospital. Purpose: To evaluate clinical and epidemiological profile of SCADR in Dermatology and Venereology Ward Dr. Soetomo Hospital Surabaya. Methods: All SCADR patients in the period of January 2015–January 2016 was evaluated clinically and epidemiologically. Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic reaction (DRESS) cases were included in the study. Results: There were 14 patients in this study, consist of 10 SJS cases (71.4%), 2 TEN patients, and 2 AGEP patients. The highest frequency of age group was 25-29 years old (57.1%). Man to woman ratio was 3:4. The most common offending drug was paracetamol (50%), followed by amoxicillin (28.6%). Antibiotic was the highest frequent offending drug-group (64.3%), followed by antipiretics (50%). In this study, all patients got systemic corticosteroid and the mortality was 0%. Conclusion: The most common type of SCADR was SJS. The most common offending drug was paracetamol, and antibiotic was the highest frequent offending drug-group. Systemic corticosteroid therapy showed good result in severe CADR management.

Faktor Risiko Kandidiasis Vulvovaginalis (KVV) Dewi Puspitorini; Linda Astari; Yuri Widya; Sylvia Anggraeni; Evy Ervianti; Cita Rosita Sigit Prakoeswa; Sunarso Suyoso
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 3 (2018): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Latar Belakang: Kandidiasis vulvovaginalis (KVV) merupakan penyakit inflamasi vulva dan vagina yang disebabkan oleh spesies Candida. Penyakit ini menyerang hampir tiga per empat wanita usia subur. Terdapat berbagai faktor yang berpengaruh terhadap kejadian penyakit ini. Penanganan yang baik terhadap faktor-faktor tersebut diharapkan dapat menurunkan angka kejadian KVV. Tujuan: Mengevaluasi faktor-faktor yang memengaruhi KVV. Metode: Penelitian ini bersifat deskriptif cross-sectional untuk mengamati faktor-faktor predisposisi KVV pada 12 April 2017 hingga 11 Juli 2017 di Unit Rawat Jalan RSUD Dr Soetomo Surabaya. Hasil: Didapatkan 25 pasien KVV dengan distribusi usia terbanyak adalah usia 15-24 tahun, lama keluhan terbanyak adalah 1-9 bulan, riwayat predisposisinya antara lain diabetes melitus, kondisi penurunan sistem imun, dan yang terbanyak adalah pemakai douching vagina. Hasil pemeriksaan klinis didapatkan semua pasien dengan vulva dan vagina eritema dan edema. Hasil pemeriksaan sediaan basah didapatkan blastospora positif dengan pseudohifa negatif sebesar 20%, blastospora positif dengan pseudohifa positif sebesar 48%, blastospora negatif dengan pseudohifa negatif sebesar 32%, dan tidak didapatkan blastospora negatif dengan pseudohifa positif. Pemeriksaan mikroskopis pengecatan Gram didapatkan blastospora positif dengan pseudohifa negatif sebesar 16%, blastospora negatif dengan pseudohifa positif sebesar 4%, blastoposra positif dengan pseudohifa positif sebesar 52%, dan blastospora negatif dengan pseudohifa negatif sebesar 28%. Didapatkan 100% sampel tumbuh koloni pada media Saboroud Dextrose Agar (SDA). Simpulan: KVV disebabkan oleh spesies Candida, yang tumbuh 100% pada media SDA. Terdapat faktor-faktor predisposisi yang sangat berpengaruh terhadap kejadian KVV.

Clinicoepidemiological Profile of Severe Cutaneous Adverse Drug Reaction: A Retrospective Study Damayanti Damayanti; Menul Ayu Umborowati; Sylvia Anggraeni; Cita Rosita Sigit Prakoeswa; Marsudi Hutomo; Hari Sukanto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 1 (2019): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Drug eruption were varied from mild to severe reaction. Few studies have assessed the severe cutaneous adverse drug reaction (SCADR), especially in the setting of general hospital. Purpose: To evaluate clinicoepidemiological profile of SCADR at Dermatology and Venereology Ward Dr. Soetomo Hospital, Surabaya, Indonesia. Methods: All SCADR patients at Dr. Soetomo Hospital, Surabaya, Indonesia in the period of January 2016 – June 2017 was evaluated. Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), Acute Generalized Exanthematous Pustulosis (AGEP), Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) and exfoliative dermatitis cases were included in the study. Results: There were 24 patients in this study, consisted of 11 SJS cases, 1 TEN case, 2 SJS/TEN-overlap cases, 10 exfoliative dermatitis cases. The mean of latent period between drug intake and onset of symptoms was 15.8 days. The most common offending drug was mefenamic acid (20.9%), followed by cefadroxil and phenytoin (each 16.7%). Antibiotics was the highest frequent offending drug-groups (62.5%), followed by non-steroid anti-inflammatory drugs (NSAIDs). Prompt withdrawal of the offending drugs, systemic corticosteroid, and supported therapy were given to all patients, which gave good results in 21/24 patients (87.5%). Conclusion: Antibiotics were the most common offending drug-groups. SCADR might give high mortality rate, but early diagnosis, prompt withdrawal of the suspected drugs, closed monitoring to evaluate complications can improve the prognosis of SCADR.

Management of Eumycetoma Tjokorde Istri Nyndia Vaniari; Sunarso Suyoso; Linda Astari; Yuri Widia; Sylvia Anggraeni; Evy Ervianti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 3 (2020): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.3.2020.232-238

Background: Mycetoma is a chronic inflammatory disease of the skin that can extend to the fascia, tendons, muscles, and bones. Caused by a bacterium called actinomycetoma and a fungus called eumycetoma are responsible for mycetoma, both of which must be distinguished because they require different medical therapy. Eumycetoma is a localized disease, chronic, and growing slowly. Most of eumycetoma patients had delays in seeking medical care. Purpose: To provide an overview and discuss various aspects of eumycetoma, including its epidemiology, etiology, pathogenesis, classification, clinical picture, diagnosis, differential diagnosis, and therapy. Review: Eumycetoma infection begins as infectious agents enter through the skin with a minor trauma caused by objects contaminated with fungi, forming granular or granulomatous lesions with tract and sinus in there. The infection can spread from the site of inoculation into the muscles and bones. The diagnosis is based on anamnesis (chronic and painless), the triad of tumefaction, draining sinuses and grains, and laboratory investigation. It’s a difficult case, often recur and difficult to be surgical excisison, so that the best first option therapy is the combination of itraconazole and terbinafine itself as an alternative to surgical therapy at least 6 months. Conclusion: Eumycetoma is an infection caused by a fungus with granulomatous lesions with sinus formation and grains in it. The best first option therapy is the combination of itraconazole and terbinafine although it’s still an early case.

Secukinumab Therapy in Psoriasis Management Ira Yunita; Sylvia Anggraeni
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 1 (2022): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.1.2022.59-65

Background : In recent years, use of biological therapy in psoriasis has increased as a result of advances in understanding the pathophysiology of psoriasis disease. Biological agents currently approved for the treatment of moderate to severe plaque psoriasis including inhibitor TNF-α (adalimumab, etanercept, infliximab), inhibitor IL-17 (ixekizumab, brodalumab, secukinumab), inhibitor IL-12/IL-23 (ustekinumab), and inhibitor IL-23 (guselkumab, tildrakizumab). Secukinumab is a human monoclonal antibody that selectively neutralizes IL-17A, a cytokine involved in the development of psoriasis. Review: Psoriasis is a chronic skin inflammation with the characteristic form of erythematous plaque firmly, thick scale, layered, and silvery-white. The trigger factors cause damage to the skin and produce cytokines IFN-γ, TNF-α, IL-17, and IL-22. This proinflammatory cytokine induces the proliferation of keratinocytes and subsequently causes skin inflammation, leading to plaque psoriasis formation. Biologic agents are utilized to block those cytokines. There are three main classes of biological agents in the treatment of psoriasis: inhibitor TNFα, inhibitor IL-17, and inhibitor IL-23. Secukinumab is a fully human antibody that selectively binds and neutralizes IL-17A. Conclusion: Biological agents targeting IL-17 receptors are more effective and safer than biological agents that target TNF-α and IL-23 receptors for moderate to severe plaque psoriasis treatment. Secukinumab has been approved for plaque psoriasis therapy in adults, psoriasis arthritis (PsA), and ankylosing spondylitis.

Co-Authors Afif Nurul Hidayati, Afif Nurul Anang Endaryanto Axelia, Presstisa Gifta Ayu Umborowati, Menul Bella Ayu Paramitha Bramantono Bramantono, Bramantono Budi Utomo Cita Rosita Sigit Prakoeswa Cita Rosita SP Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Devi, Aprilin Krista Dewi Puspitorini Evy Ervianti Farah Adiba, Asmahan Gabriel Rio Widipriyatama Hadiwidjaja, Farsha Naufal Hari Sukanto, Hari Harningtyas, Citra Dwi I Ketut Mahardika INDROPO AGUSNI Ira Yunita Irmadita Citrashanty, Irmadita Jastika, Faradistiani Rakhmawati Jekti Prihatin Karimatul Aini Kathrin Kezia Henry Linda Astari, Linda Linda Dewanti M. Yulianto Listiawan Made Putri Hendaria Mappamasing, Hasnikmah Marsudi Hutomo Marsudi Hutomo Marsudi Hutomo Maylita Sari, Maylita Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati, Menul Ayu Ngesti Kumalasari, Diah Puspowati, Erindah Putri, Melati Adinda Rahmadewi Rahmadewi Rahmadewi Ridlo Firmansyah Sadiyah, Nurhalimatus Sari, Desiana Widityaning Sheilaadji, Maria Ulfa Sri Awalia Febriana Sri Suwartini Sulaksanaswastho Suyoso Sunarso Suyoso Sunarso Suyoso Sunarto, Olivia Awwalin Suratno Suratno Tanojo, Natalia Tjokorde Istri Nyndia Vaniari Trisniartami Setyaningrum Wisnu Triadi Nugroho Yuri Widia, Yuri Yuri Widya

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