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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin
Endang Wahyu Fitriani
Faculty of Pharmacy, Universitas Surabaya, Surabaya
Immunology & microbiology Public Health

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The Effectiveness of 5% Tea Tree Oil cream, 10% Tea Tree Oil cream, and 5% Permethrin Cream for Scabies Treatment in Pediatric Patients Chesia Christiani Liuwan; Muhammad Yulianto Listiawan; Dwi Murtiastutik; Evy Ervianti; Sawitri Sawitri; Cita Rosita Sigit Prakoeswa; Linda Astari; Farhat Surya Ningrat; Kurniati Kurniati; Endang Wahyu Fitriani; Irmadita Citrashanty; Regitta Indira Agusni; Iskandar Zulkarnain
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 3 (2020): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.3.2020.200-205

Abstract

Background: Scabies, an infectious disease caused by Sarcoptes scabiei mites, is still one of the most common skin diseases found in developing countries, including Indonesia. The 5% permethrin cream for scabies treatment has been investigated as having 2–3 time to cure scabies. Tea Tree Oil (TTO) is one of the agents that has been proven to have acaricidal potential as an anti-inflammatory, antibacterial, and antipruritic agent. It has minimal side effects in topical use. Purpose: To evaluate the effectiveness of 5% TTO cream and 10% TTO cream in scabies treatment of pediatric patients. Methods: This was an experimental, analytical study with controlled clinical trial methods, and a double-blind, parallel design comparing 5% TTO cream (treatment 1), 10% TTO cream (treatment 2), with 5% permethrin cream (control) to children with scabies. Result: The 5% TTO cream gave a cure rate of 61.5% and was significantly different from the 5% permethrin cream groups with a p-value = 0.044 in the first week of the study. The 5% permethrin cream gave a cure rate of 15.4%, and the cure rate of 10% TTO cream was 53.8% in the first week of the study. Conclusion: There was a significant difference between the 5% TTO cream and 5% permethrin cream in the first week of the study. The highest and fastest cure rates were found in the 5% TTO cream treatment group.
In Vitro Antifungal Susceptibility Testing of Tea Tree Oil (TTO) 5% Compared with Nystatin against Candida sp. as Important Agent of Oral Candidiasis in HIV/AIDS Patients Eva Lydiawati; Muhammad Yulianto Listiawan; Dwi Murtiastutik; Rahmadewi Rahmadewi; Cita Rosita Sigit Prakoeswa; Christina Avanti; Endang Wahyu Fitriani; Erwin Astha Triyono; Linda Astari; Iskandar Zulkarnain
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 3 (2020): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.3.2020.189-194

Abstract

Background: Oral candidiasis is the most common clinical manifestation in a person infected with HIV which has been linked with the severity of the disease. Candida albicans responsible for most oral candidiasis. The increased resistance to the available antifungal drugs can reduce the efficacy of therapy. Therefore, it will be crucial to discover novel antifungal agents. One of them is tea tree oil (TTO) or Melaleuca alternifolia which has a potent antifungal effect to inhibit the growth of Candida sp.  Purpose: To evaluate the antifungal susceptibility of TTO 5% compared with nystatin against Candida sp. taken from HIV/AIDS patients. Methods: The study assessed the antifungal effect of TTO 5% and nystatin against 33 isolates of Candida sp. that was isolated from the oral cavity of 30 HIV/AIDS patients in Dr. Soetomo General Academic Teaching Hospital Surabaya, Indonesia. Antifungal susceptibility was evaluated by the disc diffusion method. The diameter of the inhibition zone was determined as the result of this study. Result: The most strains found in this study was Candida albicans (84.8%). The mean inhibition zone of nystatin against all strains was 23.24 mm whether it was 17.55 mm for TTO 5%. The inhibition zone of both TTO 5% and nystatin in Candida non-albicans were tended to be higher than in Candida albicans. It revealed that the inhibition zone of TTO 5% significantly lower than nystatin (P = 0.00; P < 0.05).Conclusion: Therefore, the antifungal susceptibility of nystatin was significantly higher than TTO 5% against Candida albicans and non-albicans.
Co-Authors Chesia Christiani Liuwan Christina Avanti Cita Rosita Sigit Prakoeswa Dwi Murtiastutik Erwin Astha Triyono Eva Lydiawati Evy Ervianti Farhat Surya Ningrat Irmadita Citrashanty Iskandar Zulkarnain Kurniati Kurniati Linda Astari, Linda M. Yulianto Listiawan Rahmadewi Rahmadewi Regitta Indira Agusni Sawitri Sawitri