Garuda - Garba Rujukan Digital

p-Index From 2020 - 2025

0.882

P-Index

This Author published in this journals

All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin ISM (Intisari Sains Medis) : Jurnal Kedokteran

Iskandar Zulkarnain

Departemen/Staf Medik Fungsional Ilmu Kesehatan Kulit Dan Kelamin Fakultas Kedokteran Universitas Airlangga, Rumah Sakit Umum Daerah Dr. Soetomo

Author-ID : 3287371

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

Published : 17 Documents Claim Missing Document

Claim Missing Document

Articles

1 2

Serum Level of Vitamin D (25[OH]D) in Patient with Atopic Dermatitis Meidyta Sinantryana Widyaswari; Iskandar Zulkarnain; Diah Mira Indramaya
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 2 (2016): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Atopic Dermatitis (AD) is a chronic inflammatory relapsing skin disorder along with itchy sensation. Etiopathogenesis DA remains unclear, however in common are caused by impaired epidermal barrier function of the skin and immune system that tend to ensue infection. Vitamin D is an immunomodulator and plays an important role in the pathogenesis of DA through improving the integrity of skin barrier permeability, expression of antimicrobial peptide (AMP), which inhibit infection, and reduce inflammation. Deficiency of vitamin D may increase the development risk of DA lesion. Purpose: To evaluate the serum levels of vitamin D (25[OH]D) in patients with DA. Methods: A descriptive observational cross-sectional study, in 34 DA patients at Dermatology and Venereology Outpatient Clinic of Dr. Soetomo Hospital Surabaya. Subjects were enrolled through consecutive sampling, serum vitamin D levels were measured using enzyme-linked immunosorbent assay (ELISA) method. Results: Serum levels of vitamin D (25[OH]D) in DA patients was 22.72±14.55 ng/mL. Serum levels of vitamin D based on the severity DA: mild (30.86±22.66 ng/mL); moderate (20.42±10.13 ng/mL); and severe (18.84±8.22 ng/mL). Conclusion: Deficiency of vitamin D can occur in DA patient with low level of serum vitamin D (25[OH]D), but the relationship with the severity of DA remains to be done further research. Key words: atopic dermatitis, vitamin D (25[OH]D).

A Retrospective Study: Incidence and Management of Genodermatoses Dwi Ratna Adisty; Iskandar Zulkarnain
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 2 (2016): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Genodermatoses are rare congenital diseases of the skin especially genetically determined. Genodermatoses can be grouped into three categories: chromosomal, single gene, and multifactorial. Skin condition in the genodermatoses patients not only important to start the right therapy but also to detect the other system diorders including malignancy. Objective: To evaluate the incidence of genodermatoses and to know the management of each patients. Methods: A retrospective study of genodermatoses patients in Kemuning Ward Dr. Soetomo Hospital Surabaya in 5 years period 2010-2014. Results: The incidence of genodermatoses among patients in Kemuning Ward was 10 of 1912 (0.52%).They are five males and five females (1:1). This study had shown that the diagnosis of genodermatoses were ichthyosis in 3 patients, epidermolysis bullosa (EB), and xeroderma pigmentosum (XP) each in 2 patients, neurofibromatosis (NF) type 1 in 1 patient, lymphangioma circumscriptum in 1 patient, and verrucous epidermal nevi in 1 patient. Positive family history of the same disease was obtained in one patients with xeroderma pigmentosum. No data of consanguinity found in ten patients. Conclusion: Small number of patients with genodermatoses due to the small incidence of the disease. The management vary depends on the clinical manifestations observed in each patient. Key words: genodermatoses, incidence, management, retrospective.

Increasing of Urinary 8-Hydroxydeoxyguanosine (8-OHdG) Levels in Children with Atopic Dermatitis Shakti Indraprasta; Iskandar Zulkarnain; Evy Ervianti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Atopic dermatitis (AD) is a chronic inflammation of the skin occurring in individuals with allergic diathesis. Reactive oxygen species (ROS) is assumed to be involved in the pathogenesis of allergic inflammation. 8-Hydroxydeoxyguanosine (8-OHdG) is a marker of oxidative DNA base damage. Previous research showed a various result in urinary 8-OHdG levels of AD in children. Purpose: To evaluate urinary 8-OHdG level of children with AD in Dermatology and Venereology Outpatient Clinic at Dr. Soetomo general hospital Surabaya. Methods: This is a descriptive observational cross sectional research in children with AD at Dermatology and Venereology Outpatient Clinic Dr. Soetomo hospital who qualified inclusion and exclusion criteria in three months period (March to June 2016). Urine sampling for 8-OhdG examination were underwent from all subjets. Results: Mean urinary 8-OHdG level of children with AD was 17.236 ± 13.596 ng/mL. Mean urinary 8-OHdG level of AD in children with mild, moderate, and severe based on grade of severity were 7.892 ± 5.596 ng/mL, 16.006 ± 13.662 ng/mL, and 27.321 ± 12.668 ng/mL respectively. Conclusion: There is a tendency of increased levels of urinary 8-OHdG in accordance with increasing grade of severity in children with AD which possibly caused by the role of oxidative stress in the pathogenesis of AD. Further research is needed to reveal the role of antioxidant in AD and the connection between the severity of AD and urinary 8-OHdG levels.

The Profile of Interferon-ɣ and BCG Scar as an Immune Response Reflection in Children with Leprosy Renata Mayangsari; Iskandar Zulkarnain; Trisniartami Setyaningrum
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Leprosy in children are commonly found in Madura, Indonesia. Bacillus Calmette-Guerin (BCG) vaccination and interferon--γ (IFN-γ) level associated with severity of leprosy. Purpose: To evaluate IFN-γ level and BCG scar due to leprosy in child. Methods: A descriptive observational cross sectional research, with leprosy in patients in Bangkalan, Madura as subjects. Subjects has been collected through consecutive sampling, then BCG scars were observed and blood vein samples were taken to measure IFN-γ level. Results: IFN-γ level were below normal range in almost all subjects. Mean level in patients with BCG scar (10,07 pg/ml) were higher than patients with non-scar (6,9 pg/ml). Seventy percents patients without BCG scar tend to be MB type based on percentage BCG scar due to type of leprosy. Conclusion: Immunity status as a result of BCG vaccination measured from IFN-γ level has many confounding factor. BCG vaccination seems to have an important role in severity of leprosy. Patients with BCG scar tend to be PB type. BCG vaccination can be benefits to make milder symptoms of leprosy.

Profile of Superficial Mycoses in Pediatric Dermatology Patient Maria Ulfa Sheilaadji; Iskandar Zulkarnain
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Superficial mycoses in children is a fungal infection of the skin, hair and nails that affected children aged 14 years and below. The superficial mycoses common in children are tinea capitis, pityriasis versicolor and diaper candidiasis. Purpose: To evaluate the distribution of superficial mycoses in pediatric patients in Pediatric Dermatology Division of Dermatology and Venereology Outpatient Clinic in Dr. Soetomo General Hospital Surabaya. Methods: Retrospective study using new patient’s medical record during the period of January 1 2013 until December 31 2015. Results: In period year 2013-2015 the total new superficial mycoses’s pediatric patients is 320 with the precentage in 2013 is 0.4%, in 2014 is 0.5%, and in 2015 is 0.4%. The proportion in male is more than female, and most frequent at aged 5-14 that 54.6%. Most common complain is itchy with the most common diagnosed is pitiriasis versicolor 28.3%. Potasium hydroxide is the most common additional examination in 70.3% and frequent use therapies are ketoconazole and griseofulvin orally. Conclusion: Superficial mycoses especially pitiriasis versicolor in pediatric is still a common issues in Indonesia, specially in Surabaya.

Bilateral Nevus of Ota Treated with Combination of CO2 Fractional Laser and 1064 nm Nd:YAG Laser Dewi Nurasrifah; Iskandar Zulkarnain
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 1 (2017): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Ota’s nevus (nevus fuscocaeruleus ophthalmomaxillaris) was first described by Ota in 1939. It is characterized by blue–black or gray–brown dermal melanocytic pigmentation and typically occurs in areas innervated by the first and second branches of the trigeminal nerve. Mucosal pigmentation may occur involving conjunctiva, sclera, and tympanic membrane (oculodermal melanocytosis), or other sites. Purpose: Describe the clinical manifestation and therapy of bilateral nevus of Ota. Case: A 20-year-old female patient, complaint about dark patches in both of her cheek and forehead since birth. Histopathology has not been done because patient refused to do the biopsy. Diagnosis of bilateral nevus of Ota is made based on anamnesis and clinical manifestations. Discussion: Pasien has undergo Nd:YAG laser session for Ota’s nevus and the result was not satisfactory. Now patient was given combination laser of CO2 fractional laser and 1064 nm Nd:YAG laser for 4 sessions with 3 months interval. After four laser sessions, there has been an improvement in the lesions as the lesions is getting lighter. The purpose of CO2 fractional laser is to increase light delivery into the tissue and for extruding material out of the skin. This laser combination aimed to increase the ability to remove pigment as an alternative method without inducing a systemic allergic reaction. Conclusion: Nevus of Ota is diagnosed based on clinical finding. Combination therapy of CO2 fractional laser and1064 nm Nd:YAG is the mode of choice because of excellent results.

Comparison of Malassezia Colonization on Atopic Dermatitis Patients and Control Ardsari Azminingrum; Iskandar Zulkarnain; Dwi Murtiastutik
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Atopic dermatitis (AD) is a chronic skin disease that often occurs in infancy and children. Skin barrier defect in atopic dermatitis causes the skin susceptible to bacterial, fungal, and viral infection. Antifungal therapy can improve atopic dermatitis by reducing the number of Malassezia colonization on the skin. Purpose: To compare Malassezia colonization of children with AD and non-AD children in Dermato-venereology Outpatient Clinic in Dr. Soetomo general hospital Surabaya. Methods: This was an analitic observational study, 25 atopic dermatitis and 25 non-atopic children (controls) that qualify inclusion and exclusion criteria were eligibled. Skin specimens were obtained by skin scraping and then planted in the culture medium ChromAgar Malassezia. Results: Positive culture of Malassezia in AD group was fewer than the control group, while the average number colony of Malassezia sp.in atopic dermatitis was higher than the control group; but statistic analysis showed the difference was not significant (p>0.05), except in seborrheic area. Conclusions: The average number colony of Malassezia sp. was higher in AD patient than control group in this study. Statistic analysis showed the difference was not significant, except in seborrheic area. This results differ with previous study can be possible due to the difference of using culture medium and methods of skin specimen collection, as well as the influence of tropical climate that occurred in Indonesia.

Perbandingan Kadar 8-Hydroxydeoxyguanosine (8-OhdG) Urin pada Dermatitis Atopik Anak dan Non-Dermatitis Atopik Anak Shinta Dewi Rahmadhani Soetojo; Iskandar Zulkarnain; Trisniartami Setyaningrum
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 3 (2018): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Latar belakang: Etiologi dan patogenesis dermatitis atopik (DA) masih belum jelas hingga saat ini. Banyak faktor diduga dapat memengaruhi terjadinya DA, salah satunya adalah peningkatan Reactive Oxygen Species (ROS) yang dapat dinilai dengan mengukur konsentrasi 8-hydroksi-2’-deoksiguanosine (8-OHdG) urin.Penelitian analitik mengenai hubungan 8-OHdG urin pasien DA dan non-DA masih jarang ditemukan dan sampai saat ini belum ada publikasi yang serupa di Indonesia. Tujuan: Membandingkan kadar 8-OHdG urin pada pasien DA anak yang sedang eksaserbasi dan non-DA anak. Metode: Desain penelitian adalah analitik observasional dengan membandingkan kadar 8-OHdG sebagai penanda urin pada pasien DA dan non-DA anak sebagai kontrol. Populasi penelitian adalah semua pasien anak (£12 tahun) dengan diagnosis DA yang sedang mengalami eksaserbasi dan non-DA yang dikonfirmasi melalui anamnesis, manifestasi klinis, dan kriteria diagnosis Hanfin Rajka di Divisi Dermatologi Anak Unit Rawat Jalan (URJ) Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya pada November 2017 sampai Februari 2017. Hasil: Nilai rerata kadar 8-OHdG urin pada pasien DA adalah 79,77 ± 31,79 ng/mg kreatinin. Nilai rerata kadar 8-OHdG urin pada pasien kontrol adalah 16,92 ± 11,18 ng/mg kreatinin. Kadar 8-OHdG urin pada pasien DA lebih besar daripada kelompok kontrol. Simpulan: Pasien DA mengalami stress oksidatif. 8-OHdG merupakan produk yang banyak ditemukan di dalam tubuh dan mudah terdeteksi akibat kerusakan DNA oksidatif, karena itu dianggap sebagai penanda yang berguna dan relevan untuk stress oksidatif.

Pengaruh Vitamin D3 pada Dermatitis Atopik Anak di Indonesia Yuli Wahyu Rahmawati; Iskandar Zulkarnain; M Yulianto Listiawan; Trisniartami Setyaningrum; Irmadita Citrashanty; Lisa Aditama; Christina Avanti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 2 (2019): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Latar Belakang: Vitamin D berperan pada homeostasis dan metabolisme kalsium. Selain fungsi tersebut, vitamin D juga berperan penting pada sistem kekebalan tubuh. Peran vitamin D terhadap sistem kekebalan tubuh telah diteliti akhir–akhir ini dengan penemuan reseptor vitamin D (VDR) pada jenis sel yang berbeda. Reseptor vitamin D telah diidentifikasi pada hampir semua sel sistem kekebalan termasuk sel T, sel B, neutrofil, makrofag, dan dendritic cell (DC). Penelitian yang menghubungkan kekurangan vitamin D dengan peningkatan risiko keganasan (terutama kolorektal), dermatitis atopik (DA), autoimun, infeksi, dan kardiovaskular banyak dilakukan pada dekade terakhir ini. Di antara faktor-faktor yang terlibat dalam patogenesis DA, kekurangan vitamin D pada pasien DA menjadi topik yang penting saat ini. Tujuan: Mengetahui pengaruh vitamin D3 pada pasien DA anak. Metode: Penelitian cohort pada pasien DA anak yang memenuhi kriteria inklusi yang diberikan sirup vitamin D3 selama 28 hari, kemudian dilakukan pengukuran kolonisasi Staphylococcus aureus sebelum dan sesudah pemberian vitamin D3. Hasil: Terdapat perbedaan yang signifikan penurunan kolonisasi Staphylococcus aureus sebelum dan setelah pemberian vitamin D3 pada pasien DA anak, dengan nilai p=0,0001. Simpulan: Vitamin D3 dapat menurunkan kolonisasi Staphylococcus aureus pada pasien DA anak.

Uji Kepekaan Antibiotik Oral terhadap Bakteri Propionilbacterium acnes Pasien Akne Vulgaris Derajat Sedang Berat Alfrid Asditya; Iskandar Zulkarnain; Rahmadewi Rahmadewi; Afif Nurul Hidayati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 3 (2019): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Latar Belakang: Akne vulgaris (AV) merupakan penyakit kulit yang sering terjadi terutama pada usia remaja dan dapat berlanjut pada usia dewasa. Peningkatan penggunaan antibiotik menyebabkan pola bakteri Propionilbacterium acnes yang berubah, sehingga dilaporkan adanya resistensi terhadap beberapa antibiotik Tujuan: Mengevaluasi kepekaan antibiotik oral doksisiklin, klindamisin, azitromisin, dan eritromisin yang digunakan pada akne vulgaris derajat sedang-berat terhadap bakteri Propionilbacterium acnes. Metode: Deskriptif observasional, dengan 37 pasien AV baru dan lama yang memenuhi kriteria inklusi dan eksklusi. Sampel diambil dari lesi pustula akne vulgaris kemudian ditanam di media kultur anaerob, diidentifikasi dengan VITEK® 2, dan tes kepekaan antibiotik dengan metode disk difusi. Hasil: Akne vulgaris derajat sedang-berat terbanyak pada laki-laki usia 18-25 tahun dengan tingkat pendidikan sekolah lanjutan tingkat atas (SLTA), hasil uji kultur dan identifikasi menunjukkan terbanyak adalah bakteri Propionilbacterium acnes. Tiga puluh tujuh sampel isolat menunjukkan antibiotik yang memiliki kepekaan terhadap Propionilbacterium acnes adalah sebagai berikut: doksisiklin (100%), azitromisin (86%), klindamisin (76%), dan eritromisin (73%). Simpulan: Kepekaan antibiotik terhadap bakteri Propionilbacterium acnes menunjukkan yang pertama adalah doksisiklin, azitromisin, klindamisin, dan kepekaan paling rendah adalah eritromisin.

Co-Authors Afif Nurul Hidayati Alfrid Asditya Ardsari Azminingrum Arisia Fadila Bernadya Yogatri Anjuwita Budi Utomo Chesia Christiani Liuwan Christina Avanti Christina Avanti Cita Rosita Sigit Prakoeswa Damayanti Damayanti Dewi Nurasrifah Dewi Nurasrifah Diah Mira Indramaya Dwi Murtiastutik Dwi Ratna Adisty Endang Wahyu Fitriani Erwin Astha Triyono Eva Lydiawati Eva Lydiawati Evy Ervianti Farhat Surya Ningrat Icha Aisyah Irmadita Citrashanty Irmadita Citrashanty Kurniati Kurniati Linda Astari, Linda Lisa Aditama, Lisa M. Yulianto Listiawan Maria Ulfa Sheilaadji Meidyta Sinantryana Widyaswari, Meidyta Sinantryana Menul Ayu Umborowati Pepy Dwi Endraswari, Pepy Dwi Rahmadewi Rahmadewi Regitta Indira Agusni Renata Mayangsari Sawitri Sawitri Sawitri Shakti Indraprasta Shinta Dewi Rahmadhani Soetojo Trisniartami Setyaningrum Yuli Wahyu Rahmawati

Title

Found 17 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 17 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 17 Documents
Search