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All Journal Jurnal NERS Jurnal Keperawatan Padjadjaran Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Molekul: Jurnal Ilmiah Kimia Journal Of Bionursing Riset Informasi Kesehatan International Journal of Biomedical Nursing Review (IJBNR)

Saryono Saryono

Fakultas Ilmu-Ilmu Kesehatan Universitas Jenderal Soedirman Purwokerto

Author-ID : 3291085

Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Articles

The Effect of Orlistat, Green Coffee Bean Extract, and Its Combinations on Lipid Profi le and Adiponectin Levels Joko Setyono; Dwi Adi Nugroho; Mustofa Mustofa; Saryono Saryono
Jurnal Ners Vol. 9 No. 1 (2014): April 2014
Publisher : Universitas Airlangga

Introduction: Obesity prevalence is estimated increases, reached 19.1% of the population aged 15 years and over. This study aimed to determine the differences of the anti- obesity effect of orlistat, an extract of green coffee beans (Coffea canephora robusta), and its combination to the adiponectin levels and lipid profile.Method: This research was true experimental post -test only with control group design with completely randomized design (CRD). Experimental animals (Rattus novergicus) were divided into 6 group, group 1 ( negative control ), group 2 ( positive control ), group 3 was group of obese rats fed orlistat dose of 15.9 mg/kg, group 4 was the group of obese rats were fed ethanol extract of green coffee beans dose of 400 mg/kg, group 5 was the group of obese rats were given water extract of green coffee beans dose of 400 mg/kg, and group 6 was group of obese rats were fed a combination of orlistat dose of 15.9 mg/kg and ethanol extract of green coffee beans at a dose of 400 mg/kg. Lipid profi les and adiponectin levels were measured with a spectrophotometer at 500nm absorbance. The data were analyzed by one-way ANOVA, and then post hoc Least Significant Difference (LSD) with α = 0.05.Results: Ethanol extract of green coffee is more effi cient in lowering LDL cholesterol, increasing HDL cholesterol, and lowering the total cholesterol levels on HFD diet-induced mice, but there was no difference in lowering triglycerides . The combination of ethanol extract of green coffee with orlistat showedthe increasing of adiponectin levels were highest than the other treatment groups.Conclusion: The ethanol extract of green coffee readily diffuses through the digestive tract epithelium. Green coffee contains chlorogenic acid active compounds that can increase the body’s metabolism, increase fatty acid oxidation, reduce levels of triglycerides in the liver, and working to inhibit lipase and amylase pancreaticenzymes. In addition to chlorogenic acid, polyphenol content in coffee is also potentially reduce visceral fat accumulation. Preparations extract by ethanol allows the absorption process is done effi ciently and quickly.

Anti-inflammatory Test of Centella Asiatica Extract on Rat Induced by Cadmium Hernayanti Hernayanti; Sri Lestari; Saryono Saryono; Puji Lestari
Molekul Vol 16, No 3 (2021)
Publisher : Universitas Jenderal Soedirman

Cadmium is a toxic heavy metal. The present of cadmium caused inflammation in liver. This study aims to know the anti inflammatory of Centella asiatica extract on rat induced by cadmium. This research was an experimental study using post test only control group design. Twenty four rats divided into six groups with four replications, i.e group of healthy control (C1), negative control induced by CdSO4 with dosage 56 mg/kg for 14 days and treatment (C3-C6) with dosage of 100, 200 ,300 and 400 mg/kg of C. asiatica. The blood Cd, GST, GSH, TNF- α and COx2 were measured after a 21 days administration of C. asiatica. The data were analyzed by ANOVA test followed by Duncan test with a significance level of 5%. The result showed that administrating C.asiatica can neutralized cadmium, improve inflammation in liver.The conclusion of our research that C.asiatica extract can decrease Cd level, TNF-α and COx2 levels and increase GST and GSH level in rat induced by cadmium. A 200 mg/kg was the effective dosage to reduce Cd, TNF-α and COx2 levels and increase GST and GSH levels. Key words : anti inflammatory, Cd, Centella asiatica, GST, COX2

Potensi Jus Buah Pepaya (Carica Papaya L.) Mencegah Nefrotoksisitas pada Tikus Wistar yang Terpapar Pb Asetat Devi Etivia Purlinda; Sorta Basar Ida Simanjuntak; Saryono Saryono
Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Vol 37, No 2 (2020)
Publisher : Fakultas Biologi | Universitas Jenderal Soedirman

Lead is a heavy metal with hazardous toxicity causing dysfunction, especially the kidneys as excretion organs. Pb pollution in Indonesia is mostly derived from transportation emissions such as Tetraetillead, which can change into trietillead, a free radical that can reduce endogenous enzyme activity, one of which is SOD pollution. (Superoxide dismutase) which is in various organs, especially the kidneys. A decrease in SOD activity in the kidneys indicates oxidative stress because the enzyme is unable against superoxide anions and causes renal glomerular damage. Kidney damage can increase serum creatinine levels. Papaya juice contains flavonoids, vitamins C, E, and beta-carotene can prevent nephrotoxicity of Pb. The study aimed to obtain the best dose of papaya juice on the SOD activity of Wistar rats kidney tissue and serum creatinine level that exposed by lead acetate. The experiment was conducted experimentally with Completely Randomized Design, which was divided into 6 treatments, P1, P2, P3, of papaya juice, Lead ace with dose: 3.6; 7.2; 14.4 g / 200g of weight and exposed to Pb acetate 50 mg/kg weight. Treatment P4 (rats were given vitamin E 400 IU/kg weight and exposure to Pb acetate 50 mg/kg weight), P5 (rat exposed Pb acetate 50 mg/kg weight), P6 (normal mice) for 28 days. The results showed that papaya juice was the best dose of 14.4 g / 200g weight because the SOD activity of renal tissue was increased, and serum creatinine level decreased significantly. The conclusion is papaya juice can be used to prevent Pb acetate nephrotoxicity.

Maternal and paternal Age and Risk of Autism Spectrum Disorder (ASD) in Banyumas District, Central Java, Indonesia Desiyani Nani; Saryono Saryono; Arif Imam Hidayat; Dyla Annisa Putri; Lantip Rujito
Journal of Bionursing Vol 2 No 2 (2020): Journal Of Bionursing
Publisher : Fakultas Ilmu-ilmu Kesehatan Universitas Jenderal Soedirman

Introduction: The prevalence of autism spectrum disorders has increased in the last three decades. The genetic etiological component of ASD is quite strong and complex. Although genetic factors clearly contribute to ASD risk, environmental, prenatal and post-natal factors are also involved. Father's age and mother's age at the conception of children contribute to the occurrence of autism spectrum disorders in children.Objective: To explore the association between maternal and paternal age and risk of autis, spectrum disorders (ASD) in Banyumas district, Central Java, IndonesiaMethods: An analytical study with case control approach was conducted. This study used case control method that include 43 children with ASD as case group and 189 normal children as control group. Consecutive cases were selected over 4 months, with every weekend allocated to visit the school of children with special needs. Controls were selected from normal children who came with their parents and were also visited by our team at local schools, until the required sample size was reached.Results: This study showed that paternal and maternal age at conception onset were not associate with the occurence of asutism spectrum disorders in children based on the statistical annalyzes in every range of paternal and maternal age results p value > 0,05.Conclusion: Paternal and maternal age were not related with the occurence of autism spectrum disorders

Kesehatan mental masyarakat selama pandemi covid-19: Literatur review Aan Febriani; Yollanda Ardhitya Putri; Sharah Ayuni; Saryono Saryono
Riset Informasi Kesehatan Vol 10 No 1 (2021)
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Latar Belakang: Pandemi Covid-19 berpengaruh terhadap perubahan rasa khawatir, takut, panik, tertekan, dan depresi pada kalangan masyarakat. Tujuan dari penulisan ini yaitu mengetahui tingkat kesehatan mental masyarakat akibat pandemi Covid-19. Metode: yang digunakan berupa pencarian database pada Science Direct, PubMed, dan Google Scholar dengan kata kunci Covid-19, kesehatan mental pada masyarakat dan pandemi. Systematic review ini menggunakan 16 artikel dengan kriteria yaitu terbit pada tahun 2020-2021 dengan naskah lengkap, berbahasa Indonesia dan bahasa Inggris. Hasil: penelitian menunjukan bahwa terdapat perubahan kesehatan mental masyarakat akibat pandemi Covid-19. Masyarakat berisiko tinggi terkena depresi akibat pemberlakuan pembatasan fisik, pembatasan sosial dan karantina. Kesimpulan: Penatalaksanaan pandemi covid-19 hendaknya memperhatikan aspek kesehatan mental, sehingga kebutuhan manusia secara holistik terpenuhi.

The trend of research on oral hygiene in intubated patient based on bibliometric analysis Titis Wening Setyoharsih; Saryono Saryono; Latifah Jehloh
Jurnal Keperawatan Padjadjaran Vol. 12 No. 1 (2024): Jurnal Keperawatan Padjadjaran
Publisher : Faculty of Nursing Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkp.v12i1.2402

Background: ICU patients with critical conditions are generally intubated due to their inability to breathe independently. These patients require assistance from nurses in meeting their basic needs, one of which is oral hygiene. ICU nurses use several protocols when doing oral hygiene in intubated patients. Purpose: This study was conducted to reveal the trend of research on oral hygiene in intubated patients in the last two decades through bibliometric analysis. Methods: This study is a quantitative research. The research publications were collected from the Scopus and PubMed databases through the Publish or Perish application. Then, for further analysis, the VOSViewer application was used to create visualization maps of co-occurring terms that include the research themes. Results: There were a total of 88 publications from two databases in the last two decades that discussed oral hygiene in intubated patients. Visualization in VOSViewer illustrates five main clusters on oral hygiene-intubated patients. Most of the publication themes were oral hygiene protocols and the relationship between the oral hygiene and VAP incidence. However, suction toothbrush as one of the oral hygiene protocol did not appear in the co-occurring terms in the first search; therefore, the researchers conducted a separate search about this term. Conclusions: Based on the analysis, the most common themes used are oral hygiene protocols and the relationship between oral hygiene and VAP in the last two decades. However, research on suction toothbrush as one of the protocols is still lacking, so it can be used as a novelty in conducting further research.

The Utilization of Aloe Vera (Aloe barbadensis Miller) in Reducing Glucose Levels in Patients with Diabetes Mellitus Diah Dwi Astuti; Fahmi Romdhoni; Saryono Saryono
International Journal of Biomedical Nursing Review Vol 2 No 3 (2023): International Journal of Biomedical Nursing Review (IJBNR)
Publisher : Fakultas Ilmu-ilmu Kesehatan Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.ijbnr.2023.2.3.8417

ABSTRACT Background: Diabetes mellitus is a disease characterized by chronic hyperglycemia and glucose intolerance caused by metabolic disturbances in insulin production, insulin action, or both. Herbal plants might be used to cure this disease. Previous research discovered that herbal plants, such as aloe vera, are more effective at decreasing the risk of diabetes because they have hypoglycemia features and can reduce blood glucose levels. Objective: This systematic review aims to investigate the potential of aloe vera as a dietary additive that can minimize the risk of diabetes, especially diabetes mellitus. Methods: The study's design was a systematic review utilizing the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) technique, which searched for articles published between 2013 and 2023 in electronic databases such as Google Scholar, Pubmed, and Science Direct. These articles were then extracted by analyzing the titles and abstracts for topical relevance. Results: The five articles selected indicate that aloe vera has the potential as an additional food ingredient to reduce blood glucose levels by utilizing aloe vera's hypoglycemic content and maintaining endurance in the body to prevent diabetes. Aloe vera's aloe-emodin content activates insulin and improves the rate of glycogen synthesis, proving it effective for lowering blood sugar levels. In addition to aloe-emodin, aloe vera contains chromium, which helps in the activation of insulin secretion by pancreatic cells and the increased supply chain of glucose into cells by the insulin hormone. As an outcome, it will increase the number of insulin receptors on the cell membrane, enabling insulin to bind to cells. While insulin production increases, glucose production by the liver reduces, and blood glucose drops. Conclusion: As a result, it can be concluded that consuming aloe vera can lower blood glucose levels and thus minimize the risk of diabetes, especially diabetes mellitus. Keywords: Blood sugar levels, aloe vera, type II diabetes mellitus.

The Effect of Using Monosodium Glutamate (MSG) in Food On Body Health Reko Alya Gita Prawadya; Satrio Budi Utomo; Saryono Saryono
International Journal of Biomedical Nursing Review Vol 2 No 2 (2023): International Journal of Biomedical Nursing Review (IJBNR)
Publisher : Fakultas Ilmu-ilmu Kesehatan Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.ijbnr.2023.2.2.8550

Background: Monosodium glutamate (MSG) is a food additive that is often used as a flavor and aroma enhancer in processed foods. Several studies have shown that consuming high amounts of MSG can affect body health and cause symptoms such as headaches, nausea, vomiting, excessive sweating, and high blood pressure in some sensitive people. In addition, several studies have also found that MSG consumption can increase the risk of obesity, type 2 diabetes, cardiovascular disease, and metabolic disorders. Objective: This systematic review aims to determine the effect of using monosodium glutamate (MSG) in food on the health of the body so that readers can make wise decisions in choosing foods that are healthy and safe for consumption. Method: Using the PRISMA method, search for journals in electronic databases published on Google Scholar, PubMed, and ScienceDirect that were published from 2013 to 2023. These articles were then extracted, taking into account the titles and abstracts to determine their suitability for the topics discussed. Results: Of the 8 selected articles, it shows that monosodium glutamate used in food has a bad influence on body health. Glutamic acid contained in MSG can increase body weight and damage liver and kidney function if consumed above the safe limit, which is 30 mg/kg/day of body weight. When MSG is used every day, it can cause symptoms of headache (85.8 mg/kg), increased insulin (> 143 mg/kg), and increased blood pressure (150 mg/kg). Conclusion: Monosodium glutamate (MSG) is an additive commonly used as a flavor enhancer in food. Consuming excessive MSG can increase the risk of various health problems, but the use of MSG in moderate and controlled amounts does not have a negative impact on the health of the body.

The Effectiveness of Honey Consumption on Increasing Hemoglobin Levels in Young Women: A Systematic Review Bella Christa; Hanifa Intan Khairunnisa; Saryono Saryono
International Journal of Biomedical Nursing Review Vol 2 No 3 (2023): International Journal of Biomedical Nursing Review (IJBNR)
Publisher : Fakultas Ilmu-ilmu Kesehatan Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.ijbnr.2023.2.3.8606

ABSTRACT Background: Adolescents are one of the groups with a high risk of developing anemia. One of the causes of anemia is a lack of hemoglobin in the blood, so iron intake is vital for the body to make hemoglobin. Previous studies have shown that honey consumption has a positive impact on increasing hemoglobin levels. However, more research is required to determine whether honey eating can raise hemoglobin levels in female adolescents. Objective: This systematic review's objective is to determine the effectiveness of honey as a herbal ingredient for increasing hemoglobin levels in female adolescents. Methods: This study used a systematic review which was processed using the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) technique. The articles included in this study were from electronic databases that published between 2013 and 2023 in Google Scholar, Science Direct, and PubMed. The articles then extracted with due regard to the title and abstract to see their suitability for the topics discussed. Results: Out of the six papers chosen, it determined that honey increased hemoglobin levels in female adolescents. Honey contains very good nutrients to increase hemoglobin levels such as iron. The iron content contained in honey is needed to increase erythropoietin as a stimulus for erythrocyte production so that hemoglobin levels can increase. Conclusion: Consuming honey can increase hemoglobin levels in female adolescents because it contains a lot of iron, thereby minimizing the occurrence of anemia.

Utilization of Frying Water to Increase Phenolic and Flavonoid Content in Brassica Vegetables As Antioxidant Agents for The Body Dilla Ambar Dewi; Salsabila Mahia Nadia; Saryono Saryono
International Journal of Biomedical Nursing Review Vol 2 No 3 (2023): International Journal of Biomedical Nursing Review (IJBNR)
Publisher : Fakultas Ilmu-ilmu Kesehatan Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.ijbnr.2023.2.3.8649

Background: Brassica vegetables are a type of vegetable that is easy to find and widely consumed by people in Indonesia because of their high variety and relatively cheap prices. Brassica vegetables such as cauliflower, broccoli, kale, and sprouts have a high antioxidant content due to their phenolic compounds. In general, Brassica vegetables are not consumed raw but through processing. The antioxidant compounds contained in brassica can be known depending on the processing method used. Various processing methods, one of which is the processing method using Air Frying. Objective: The purpose of this Systematic Review study was to examine the use of Air Frying in Brassica vegetables to increase the content of phenolic compounds and flavonoids. Method: The design used in this study is a systematic literature review (SLR) using the preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) method by searching journals in electronic databases published on Google Scholar, Pubmed, and Science Direct, which have been published since from 2013 to 2023. These articles were then extracted by paying attention to the titles and abstracts to see their suitability for the topics discussed. Results: The 5 selected articles show that hot air frying technology makes the nutritional quality of food higher than conventional frying, and becomes a practical alternative for getting healthier fried foods because of the possibility of reducing fat, lipid degradation, and oxidation. Air frying is becoming a more suitable processing method for processing brassica vegetables. Frying with high-temperature air for a short time will prevent the nutritional content of vegetables during processing. Air fryers are capable of significantly increasing the TFC and TPC of brassica vegetables regardless of the variety. Conclusion: The application of Air Frying improves the phenolic and flavonoid status and antioxidant potential of selected Brassica Vegetables.

Co-Authors Aan Febriani Arif Imam Hidayat Bella Christa Desiyani Nani Devi Etivia Purlinda Diah Dwi Astuti Dilla Ambar Dewi Dwi Adi Nugroho Dyla Annisa Putri Fahmi Romdhoni Hanifa Intan Khairunnisa Hernayanti Hernayanti Joko Setyono Lantip Rujito Latifah Jehloh Mustofa Mustofa Puji Lestari Reko Alya Gita Prawadya Salsabila Mahia Nadia Satrio Budi Utomo Sharah Ayuni Sorta Basar Ida Simanjuntak Sri Lestari Titis Wening Setyoharsih Yollanda Ardhitya Putri

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