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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Tropical and Infectious Disease Care : Jurnal Ilmiah Ilmu Kesehatan Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Muhammad Vitanata Arfijanto, Muhammad Vitanata
Division Of Tropical & Infectious Disease, Department Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga/Dr. Soetomo General Hospital, Surabaya
Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Malaria Hepatopathy and Thrombocytopenia in Severe Falciparum Malaria Arfijanto, Muhammad Vitanata; Wahyudi, Mohammad Imam
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 2 (2023): VOLUME 24, NUMBER 2, August, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2422023172-175

Abstract

Jaundice commonly occurs in severe malaria, seen in approximately 2,5% patients with falciparum malaria infection. Jaundice in malaria can be caused by intravascular hemolysis, disseminated intravascular coagulation (DIC) or malaria-related liver disorders. Malaria hepatopathy is a term that is often used to describe hepatocytic dysfunction in severe malaria, although inflammation does not occur in the liver parenchyma.  Malaria hepatopathy also characterized by a rise in serum bilirubin along with the rise in serum glutamate pyruvate trasnaminase levels. This two condition are similar but must be distinguished because of different treatment required.
ANALYSIS FACTORS AFFECTING OPPORTUNISTIC INFECTIONS IN WOMEN HIV IN DR SOETOMO HOSPITAL Trisnashanti, Dea Praditya; Romdhoni, Achmad Chusnu; Arfijanto, Muhammad Vitanata
Indonesian Midwifery and Health Sciences Journal Vol. 9 No. 1 (2025): Indonesian Midwifery and Health Sciences Journal, January 2025
Publisher : UNIVERSITAS AIRLANGGA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/imhsj.v9i1.2025.88-97

Abstract

Background: Human Immunodeficiency Virus (HIV) remains a major global health concern. In Indonesia, women account for 35.1% of HIV cases. In East Java alone, 1,062 new cases were reported between January and March 2023, with Surabaya recording the highest number at 663 cases. Opportunistic infections frequently affect HIV patients due to weakened immune systems. Tuberculosis is the most prevalent OI among HIV patients in Indonesia, accounting for 62.1% of cases, and is commonly found in women, posing a risk of vertical transmission. This study aims to analyze the factors influencing of opportunistic infections in women living with HIV. Methods: A quantitative approach with an observational analytic design and retrospective method. Used a total sampling technique involving all female HIV patients diagnosed with opportunistic infections at HIV clinic of Dr. Soetomo Hospital from January-December 2023, meet the inclusion criteria. The research was conducted from December 2023-October 2024. The dependent variable is opportunistic infections, while the independent variables are duration of HIV infection, adherence to antiretroviral therapy, CD4 cell count, and viral load. Data were analyzed using univariate and bivariate methods, with the Chi-Square test. Results: The results, duration of HIV infection was not significantly associated with opportunistic infections (p = 0.402). However, ARV adherence (p = 0.003), CD4 count (p < 0.001), and viral load (p = 0.001) were significantly associated with increased risk of opportunistic infections. Conclusion: In conclusion, ARV adherence, CD4 count, and viral load significantly influence the occurrence of opportunistic infections among HIV-positive women at Dr. Soetomo Hospital
The CD4 Count and Viral Load Differences in HIV Patients with and without Infectious Posterior Uveitis at a Tertiary Hospital in Indonesia Hidayat, Shofa Annesa; Zuhria, Ismi; Arfijanto, Muhammad Vitanata; Prastyani, Reni
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 2 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i2.65918

Abstract

Introduction: The human immunodeficiency virus (HIV) compromises the immune system, making the monitoring of cluster of differentiation (CD4) counts and viral loads critical for assessing disease progression and opportunistic infection risks. Eye-related manifestations, such as uveitis, are common among HIV patients. The purpose of this study was to investigate the differences in CD4 count and viral load between HIV patients with infectious posterior uveitis and those without at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Methods: A retrospective study with an analytical observational design was conducted using the medical records of 75 HIV patients. The examined variables included CD4 count and viral load as independent variables, alongside the incidence and absence of infectious posterior uveitis as dependent variables. The inclusion criteria were HIV patients with regular follow-ups, thereby excluding those with irregular follow-ups. The analysis used the Mann-Whitney test, with p<0.05 indicating a statistically significant difference. Results: All 75 samples met the inclusion criteria for analysis. The majority of the patients were male (64%) and within the age range of 31 to 40 years (44%). Patients with infectious posterior uveitis had significantly lower CD4 counts (p<0.05) compared to those without the disease. However, no significant differences in viral loads (p>0.05) were observed between patients with posterior uveitis and those without. Conclusion: CD4 counts differ significantly between patients with infectious posterior uveitis and those without, while viral loads show no considerable differences.   Highlights: 1. This study highlights the differences in cluster of differentiation (CD4) lymphocyte count and viral load between HIV patients with infectious posterior uveitis and those without. 2. The findings may provide new insights into the immunological mechanisms underlying infectious posterior uveitis in persons living with HIV. 3. This work contributes to determining the factors that affect the development of infectious posterior uveitis and explores the potential use of CD4 lymphocyte count and viral load as biomarkers for the diagnosis and management of the disease.
PROFIL RASIO NEUTROFIL TERHADAP LIMFOSIT PADA PASIEN DENGAN DUGAAN DEMAM TIFOID DI RSUD DR. SOETOMO SURABAYA Nurhidayah, Meiwinda Rizky; Arfijanto, Muhammad Vitanata; Widodo, Agung Dwi Wahyu; Kholili, Ulfa
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 9, No 1 (2021): EDITION MARCH 2021
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v9i1.2042

Abstract

Demam tifoid merupakan penyakit multisistem akut yang disebabkan oleh Salmonella typhi dan bersifat endemis. Rendahnya sensitivitas alat diagnostik menyebabkan under diagnosed maupun over diagnosed. Beberapa studi menggunakan rasio neutrofil limfosit sebagai parameter status inflamasi. Studi ini untuk mengetahui gambaran rasio neutrofil limfosit pada pasien dengan dugaan demam tifoid. Sebuah studi deskriptif observasional dengan desain lintang potong menggunakan data sekunder dari rekam medis di Rumah Sakit Umum Daerah Dr. Soetomo Surabaya tahun 2016-2018. Teknik pengambilan sampel adalah total sampling dan diperoleh 64 sampel. Jumlah pasien dengan jenis kelamin laki-laki sebanyak 53,1% dan perempuan sebanyak 46,9% Perbandingan pasien laki-laki dan perempuan 1,3:1 dengan rentang usia terbanyak 17-25 tahun. Gambaran klinis rerata lama demam yaitu 6,95 hari dengan rentang lama demam terbanyak 1-7 hari. Demam ditunjukkan pada semua pasien (100%). Pemeriksaan hematologi kadar hemoglobin, leukosit dan trombosit dalam batas normal. Hasil neutrofil dan limfosit dalam batas normal. Gambaran rasio neutrofil limfosit memiliki median 3,97 dengan rentang nilai dalam batas normal.
Clinical Characteristics and Microbiological Profile of Oral Candidiasis among HIV-Positive Patients in Indonesia: A Literature Review Prameshvari, Putu Lovina Indra; Permana, Putu Bagus Dharma; Hidayati, Afif Nurul; Murtiastutik, Dwi; Arfijanto, Muhammad Vitanata
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 3 (2025): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V37.3.2025.209-217

Abstract

Background: As the country with the highest identified active cases of HIV/AIDS across Southeast Asia, Indonesia faces a massive challenge in providing adequate antiretroviral therapy (ART) coverage to prevent disease progression and mortality.  Oral candidiasis (OC) is the most frequently identified oral manifestation of HIV infection and represents the degree of immunosuppression, treatment failure, and prognosis among people living with HIV/AIDS. Demographic characteristics, clinical types, and causative pathogens of OC vary between different geographical and socioeconomic settings. Hence, the role of oral candidiasis is crucial in developing effective strategies to address the HIV-related burden in Indonesia. Review: This literature review evaluated 11 descriptive studies conducted across eight major cities in Indonesia, comprising 764 HIV-positive patients diagnosed with OC. Most affected individuals were male and exhibited advanced immunosuppression, with the majority presenting CD4+ counts below 200 cells/mm³. Six clinical variants of OC were identified, with pseudomembranous candidiasis being the predominant form, followed by angular cheilitis, erythematous candidiasis, hyperplastic candidiasis, and sporadic cases of atrophic candidiasis and denture stomatitis. Microbiological findings showed Candida albicans as the leading etiologic species; however, non-albicans Candida (NAC)—particularly C. krusei, C. glabrata, and C. tropicalis—demonstrated notable prevalence, including mixed colonization with C. albicans. The rise of NAC species highlights concerns regarding antifungal resistance in the ART era. Conclusion: Oral candidiasis serves as an important clinical finding among patients living with HIV/AIDS, and its appropriate management is necessary not only to prevent further complications but also to mitigate the recent development of antifungal resistance.
Co-Authors Afif Nurul Hidayati, Afif Nurul Agung Dwi Wahyu Widodo Aryati Aryati Asmarawati, Tri Pudy Bayu Abhiyoga Bramanton Bramantono Bramantono, Bramantono Dominicus Husada Dwi Murtiastutik Heri Krisnata Ginting Hidayat, Shofa Annesa Ilham Munandar Jihan Kalishah Lusida, Maria Lucia Inge M Thohirin Ramadhani Moh. Hamzah Raka Pratama Musofa Rusli Nasronudin Nasronudin Nenci Siagian Nurhidayah, Meiwinda Rizky Permana, Putu Bagus Dharma Prameshvari, Putu Lovina Indra Prastyani, Reni Prihartini Widiyanti Rachman, Brian Eka Romdhoni, Achmad Chusnu S. Ugroseno Yudho Bintoro Siti Irma Mashitah, Siti Irma Siti Nurul Jannah Trisnashanti, Dea Praditya Ulfa Kholili Usman Hadi Wahyudi, Mohammad Imam Zuhria, Ismi