Article Per Year (5 Year)
p-Index From 2020 - 2025
3.369
P-Index
This Author published in this journals
All Journal The Indonesian Biomedical Journal Jurnal SainHealth JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Journal of Stem Cell Research and Tissue Engineering CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology Vision Science and Eye Health Journal Ophthalmologica Indonesiana IPSSJ
Zuhria, Ismi
Department Of Ophthalmology, Faculty Of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Public Health Social Sciences Veterinary

Published : 21 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 21 Documents
Search

 1   2   3 
Mechanism of Corneal Epithelial Cells Death by Infection of pseudomonas Aeruginosathrough Analysis Expression of Caspase-1, TNF, RIPK1, RIPK3, Caspase-3 in Rats Model Ismi Zuhria; Nurwasis; Eddy Bagus Wasito; Winarto; I Ketut Sudiana; Reny I’tishom; Nyilo Purnami
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15802

Abstract

Ba
Cryotherapy Has No Significant Effect on MMP-9 and TGF-β1 Expression in Fungal Corneal Ulcer Dwita Permatasari; Hendrian Dwikoloso Soebagjo; Ismi Zuhria; Nila Kurniasari; Hari Basuki Notobroto; Cinintha Nandini
The Indonesian Biomedical Journal Vol 13, No 3 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i3.1516

Abstract

BACKGROUND: Usually, surgical intervention is needed to eradicate the fungal microorganism that cause fungal corneal ulcers. However, since surgical intervention is invasive, the latest technology uses cryotherapy in treating it. Cryotherapy plays a vital role in the wound healing process. We aimed to evaluate is to study the decreased expression of matrix metalloproteinase 9 (MMP-9) and transforming growth factor β1 (TGF-β1) in fungal corneal ulcers after the administration of cryotherapy.METHODS: Aspergillus flavus fungus was injected to the intrastromal corneas of all Sprague Dawley rats. The rats were divided into four groups, the first group was not given any therapy, the second group was given topical natamycin therapy, the third group was given cryotherapy, and the fourth group was given a combination between cryotherapy and topical natamycin therapy. Therapy was given after five days of follow up on the formation of a corneal ulcer. After four days of therapy, the eyes were enucleated to determine MMP-9 and TGF-β1 expression.RESULTS: The result in the third group showed lower MMP-9 expression (20.0±10.0% cells per field of view) compared to the second group (40.0±20.0% cells per field of view) and the fourth group (30.0±25.0% cells per field of view), but had the same MMP-9 expression value as the first group. There was no significant difference in MMP-9 expression between the four groups (p=0.356). The third group reduced more TGF-β1 expression (10.0±12.50% cells per field of view) compared to the fourth group (30±27.5% cells per field of view) and the first group (30±32.5% cells per field of view). There was also no significant difference in TGF-β1 between the four groups (p=0.315).CONCLUSION: There is no significant difference in the expression of TGF-β1 and MMP-9 after the cryotherapy treatment.KEYWORDS: corneal ulcer, cryotherapy, MMP-9, TGF-β1
CASE REPORT AWARENESS TO PROLAPSE OF THE EYE IN BABY Athi Purnasari; Ratna Doemilah; Ismi Zuhria
Jurnal SainHealth Vol 4, No 1 (2020): Maret 2020
Publisher : Faculty of Health Sciences Universitas Maarif Hasyim Latif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51804/jsh.v4i1.702.1-7

Abstract

Corneal perforation may be associated with prolapse of ocular tissue. We present a rare case reportan11 months-old female presented prolapsed of right eye. She was earlier diagnosedwithright corneal ulcer anddescemetocele. Physicalexamination revealed perforatedcornea.On ultrasound examination showedvitreous hazzinessand membranous opacity assumed due to inflammation. Based on examinationswe suspectedmalignancy process and performed enucleation withautogenous Dermis Fat Graft (DFG) which harvested onthigh region.Histopathology examination revealed chronic inflammation process.Hence, determining the causative factors of the prolapsed eye is the key for better management and prognosis.
Matrix Metalloproteinase-3 Down Regulation and Cell Migration Inhibition in Human Pterygium Fibroblasts by Mitomycin-C, Curcumin and Fibrin Glue Ferdian Ramadhan; Jamaluddin Jamaluddin; Ismi Zuhria; Luki Indriaswati; Evelyn Komaratih
The Indonesian Biomedical Journal Vol 14, No 2 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i2.1825

Abstract

BACKGROUND: Pterygium is an ocular surface disease that often occurs in tropical countries with a high recurrence rate. Matrix metalloproteinase-3 (MMP-3) play a key role in the inflammatory process of pterygium. This study aims to investigate the ability of curcumin and fibrin glue (FG) in suppressing the expression of MMP-3, and whether can be expected as adjuvant therapy to reduce pterygium recurrence.METHODS: Human pterygium fibroblasts (HPF) obtained from primary cultured of pterygium were treated with no treatment, curcumin, mitomycin-C (MMC), and FG. MMP-3 expression was analyzed using immunocytochemistry and the intensity measurement was done using ImageJ software. Cell migration was measured by scratching and stratification of fibroblast culture after cell confluence, and assessed for 48 hours.RESULTS: The expression of MMP-3 were lower in the HPF treated with 100 mol/mL curcumin, 200 mol/mL, and FG (2205.84±86.1 pg/mL, 1002.51±25.22 pg/mL, 1131.55±17.71 pg/mL, respectively) in comparison with untreated HPF (4703.49±108.9 pg/mL). The expression of MMP-3 were significantly different between groups (p<0.001). Cell migration of HPF after scratching with curcumin intervention at 200 mol/mL decrease from 178.67±2.85 (24 hours) to 88.83±1.48 (48 hours). Meanwhile the migration in FG group also decrease from 180.4±2.56 (24 hours) to 72.45±1.25 (48 hours).CONCLUSION: Curcumin and FG able to reduce the expression of MMP-3 and inhibit the migration of HPF cells.KEYWORDS: curcumin, mitomycin C, fibrin glue, human pterygium fibroblast, MMP-3
Good Visual Acuity Outcome from an Ocular Blast Injury with Proper Management in Dr. Soetomo General Hospital Surabaya, Indonesia Rifat Nurfahri; Delfitri Lutfi; Ismi Zuhria
Vision Science and Eye Health Journal Vol. 1 No. 1 (2021): Vision Science and Eye Health Journal
Publisher : Department of Ophthalmology, Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (866.774 KB) | DOI: 10.20473/vsehj.v1i1.2021.1-5

Abstract

Introduction: Ocular blast injury related to fireworks most often causing corneal erosion (29%), conjunctival erosion (11%), and conjunctival foreign body (10%) with children are more often than adults (65.9%:34.1%), and males far more often than female (71.9%:28.1%). Knowing proper management is very important to achieve the best result. Case presentation: We describe an ocular blast injury that experienced broad erosion and multiple foreign bodies on the corneal and pericorneal surface in the left eye and visual acuity decreased. The foreign body was scattered, and the fluorescein test was positive. We did proper foreign body extraction, irrigation, and ocular bandage. It was treated with chloramphenicol 0.5% eye ointment and homatropine eye drop. In two months, the patient’s left eye had clear cornea with a small scar formation near the visual axis. The visual acuity was 6/7 and BCVA was 6/6 with S-0.5 C-0.5 A 50° correction. Conclusions: Patients with ocular blast injury limited to superficial cornea erosion and and conjunctival erosion have a reasonable probability of achieving the best visual acuity. Foreign body extraction, proper irrigation, and topical medication show promising results. Scar formation near the visual axis can disrupt visual acuity however can be corrected in this case it can be corrected with glasses. Furthermore, public promotion and regulation to control firework using are very important.
Blast Eye Injury After Mobile Phone Battery Explosion: How to Manage it? Ratih Justitia Kartika; Ismi Zuhria
Vision Science and Eye Health Journal Vol. 1 No. 2 (2022): Vision Science and Eye Health Journal
Publisher : Department of Ophthalmology, Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (584.286 KB) | DOI: 10.20473/vsehj.v1i2.2022.28-34

Abstract

Introduction: Injuries from mobile phone blasts have been on the rise in recent years. Lithium-ion batteries are the most common type found in cellphones and devices. In 2016 around 100 of the 2.5 million phone cell units have been recorded to have exploded. Mobile battery burst is a significantly underappreciated cause of serious ocular morbidity and could be a combination of mechanical, thermal, and chemical effects. Knowing proper management is very important to achieve the best result. Case presentation: We describe an ocular blast injury due to mobile phone battery explosion when plugged in to charge that experienced spasm and burned cilia, limbal ischemia, broad corneal haziness on both eyes, and visual acuity decreased. The fluorescein test was positive. We did proper irrigation and debris extraction around the ocular surface and periorbital tissue. It was treated with quinolone antibiotics eyedrop, atropine sulfate eyedrop, prednisolone eyedrop, and NSAID orally. In four days, the patient’s eye showed good clinical improvement with decreased corneal haziness with minimal epithelial defect. The visual acuity was improved on both eyes. Conclusions: Lithium-ion batteries are used in almost all smartphones and electronics. Lithium explosions can result in chemical and thermal burns on the ocular surface. Ocular alkali chemical injury combined with thermal and mechanical is an emergency case. The vision can be saved if the ocular surface burns are treated promptly and properly. These cases are required to raise public awareness about the potential risks of smartphone use, adopt safe practices as recommendations from the manufacturers, and avoid counterfeit products and such accidents.
Comprehensive Management of Preseptal Cellulitis with Massive Palpebral Abscess in 72-year-old Man Ruth Anastasia; Ismi Zuhria; Susy Fatmariyanti
Vision Science and Eye Health Journal Vol. 2 No. 1 (2022): Vision Science and Eye Health Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/vsehj.v2i1.2022.1-5

Abstract

Introduction: Infectious inflammation of the periorbital and orbital soft tissue can be classified as preseptal (periorbital) or postseptal (orbital) cellulitis. Eyelid abscess, an accumulation of pus in the palpebral tissue, can occur in isolation or in association with preseptal cellulitis. Preseptal cellulitis is nearly three times more common than orbital cellulitis. Case Presentation: The patient, in this case, was admitted with a complaint of swollen left eyelid ten days before being admitted. Swollen eyelid with the inability to open the left eye was accompanied by pus discharge five days before coming to the hospital. Current complaints include eyelid pain, swelling, and discharge of thick yellow fluid. Massive abscess with active pus and crust was present in the left superior and inferior eyelid and frontotemporal area. A head CT scan revealed a soft tissue mass in the left sub galea soft tissue, left frontal region, left orbit, and left temporal region. Multi-department consultations and several workups were done to reveal the etiology and plan the appropriate management of this condition. Conclusion: A comprehensive assessment must be done to distinguish preseptal and orbital cellulitis. Ophthalmology examination and imaging are crucial to detect any extension of the palpebral abscess beyond the orbital septum. Examining an immunocompromised state and focal infection is crucial in determining proper treatment.
Conjunctivitis Patients in the Ophthalmology Outpatient Clinic Dr. Soetomo General Academic Hospital, Surabaya, in 2017 Angeline Hartadhi; Ismi Zuhria; Bambang Hermanto
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 14 No. 1 (2023): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V14I12023.17-20

Abstract

Highlights:1. Ginger (Zingiber officinale) has antimicrobial activity against UPEC which commonly causes UTI in women.2. The MIC and MBC of ginger against UPEC in this study was 1000 mg/ml. AbstractIntroduction: Conjunctivitis is a self-limiting disease. It can be diagnosed through clinical signs found in the eye examination. The purpose of this study was to define the characteristics of conjunctivitis patients in the ophthalmology outpatient clinic Dr. Soetomo General Academic Hospital, Surabaya, in 2017.Methods: This was a retrospective descriptive observational study of all conjunctivitis patients from the medical history in the ophthalmology outpatient clinic Dr. Soetomo General Academic Hospital, Surabaya, in 2017.Results: There were 497 patients included in this study. Most patients with conjunctivitis were 0-9 years old (19.32%). The most common sign of conjunctivitis was conjunctival hyperemia (80.89%), followed by eye discharge (24.14%), eyelid edema (8.05%), blepharospasm (5.63%), and papillary hypertrophy (5.03%). Most cases of conjunctivitis were bilateral (58.75%). Conclusion: The majority of conjunctivitis was bilateral conjunctivitis. It commonly affects children under ten years old. The most typical finding was conjunctival hyperemia.
AN ACTIVE, SIGHT-THREATENING GRAVES’ ORBITOPATHY: A CHALLENGING CASE REPORT Muhammad Fariz; Delfitri Lutfi; Ismi Zuhria; Susy Fatmariyanti; Hendrian Dwikoloso Soebagjo
Majalah Oftalmologi Indonesia Vol 49 No 1 (2023): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v49i1.100634

Abstract

Introduction: Graves’ Orbitopathy is a self-limiting autoimmune process associated with dysthyroid states, and if left untreated can lead to a number of complications, ranging from mild to sight-threatening. Corneal ulcer is one of the sight-threatening complications of Graves’ Orbitopathy. Case Report: A 22-year-old woman came with a complaint of blurred vision and retrobulbar pain on both eyes that happened gradually for 2 months, preceded by protrusion on both eyes. She had history of untreated hyperthyroid disease for 7 years. Her visual acuity was 1/60 and hand movement on the right and left eye, respectively. Anterior segment examination on both eyes revealed eyelids redness and swelling, redness and chemosis of conjunctiva, and corneal ulcer with descemetocele on her right eye. All of these clinical findings support the diagnosis of an active, sight-threatening Graves’ Orbitopathy. Discussion: The management of this patient involves; 1) thyroid function control due to the high level of thyroid function, 2) active, sight-threatening Graves’ orbitopathy management using high doses of intravenous methylprednisolon as guided by the 2016 European Group on Graves’ Orbitopathy (EUGOGO) guidelines protocol, 3) Application of amniotic membrane transplant to prevent the prolapse of intraocular tissue. Conclusion: By following EUGOGO guideline protocol, the clinical condition of this patient improved, but the management of an active, sight-threatening Graves’ Orbitopathy remains challenging and should be covered by multidisciplinary approach.  
Uncovering the Uncommon Nocardia Keratitis: Early Recognition of Its Pathognomonic Characteristic to Save Vision: Poster Presentation - Case Report - Resident Maria Astrid Claudia; Ismi Zuhria
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/5hf58024

Abstract

Introduction : Nocardia keratitis is a rare bacterial infection. Global prevalence is below 2%. Mimicking a fungal infection and slow-growth bacteria in culture leads to improper management and an increased risk of permanent vision loss. This case highlights the pathognomonic infiltrate seen in Nocardia keratitis. Case Illustration : A 41-year-old male presented with a four-week history of redness of the left eye, associated with ocular pain, tearing, photophobic, and decreased vision following an injury caused by a grasshopper while riding a motorcycle two weeks before. Visual acuity was hand movement. Conjunctival and ciliary injection, mid-periphery corneal “wreath-pattern” infiltrate with satellite lesions, corneal thinning, and hypopyon were found. Topical antibiotics and antifungals were given empirically earlier with little to no effect. Progressive hypopyon necessitated paracentesis. After seven days of inoculation, a culture test showed slow-growing Nocardia sensitive to amikacin and tobramycin. Treatment then changed to an amikacin subconjunctival injection and tobramycin eye drops. The epithelial defect was resolved, but leukoma and neovascularization were found; thus, keratoplasty was planned. Discussion : Corneal involvement of Nocardia may occur in several forms. Slowly progressive symptoms, satellite lesions, and cotton-wool-like infiltrate can mimic fungal infection. However, it has a pathognomonic characteristic, a pinhead-sized infiltrate forming a “wreath-pattern” in the mid-periphery cornea. Familiarity with this classical pattern could prevent neovascularization, endophthalmitis, corneal perforation, and that cause vision loss. Conclusion : Due to slow-growth inoculation of Nocardia, clinicians should be aware of this pathognomonic presentation to aid in early diagnosis and proper treatment that leads to favorable outcomes and salvage vision in most cases.
Co-Authors Alphania Rahniayu Angeline Hartadhi Asti, Annisa Kinanti Athi Purnasari Bambang Hermanto Bening, Daya Banyu Cinintha Nandini Devi Sarah Intan Permatasari Doemilah, Ratna Dwita Permatasari Eddy Bagus Wasito Fadia Ghaisani Ferdian Ramadhan Firmansjah, Muhammad Hari Basuki Notobroto Hendrian Dwikoloso Soebagjo Hidayat, Shofa Annesa I'tishom, Reny Indriaswati, Dyah Kusworini Jamaluddin Jamaluddin Komaratih, Evelyn Lutfi, Delfitri Maria Astrid Claudia Monica Rizky Wigianita Muhammad Fariz Muhammad Vitanata Arfijanto, Muhammad Vitanata Nila Kurniasari Nurwasis Nurwasis Nyilo Purnami Prakoeswa, Camilla A. Prastyani, Reni Rahmawati, Lita Diah Ramadhani, Amelia Safitri Ratih Justitia Kartika Rifat Nurfahri Ruth Anastasia S.Pd. M Kes I Ketut Sudiana . Sarasati, Fani Septian Dwi Prabowo Soebagjo, Hendrian Dwikoloso Susy Fatmariyanti Widjaja, Sauli Ari WINARTO Yustiarini, Ima