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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Tropical and Infectious Disease Care : Jurnal Ilmiah Ilmu Kesehatan Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Muhammad Vitanata Arfijanto, Muhammad Vitanata
Division Of Tropical & Infectious Disease, Department Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga/Dr. Soetomo General Hospital, Surabaya
Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Case Report: A Rare Case of Glioblastoma in Patient with HIV-AIDS Ilham Munandar; M. Vitanata Arfijanto
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16916

Abstract

Patients with HIV_AIDS have an increased risk to develop neurological disorders include a complicationof intracerebral mass. Primary CNS tumors in this condition are rare and difficult to diagnose because it hasuncommon presentation, unusual tumor growth and manifests at a young age in a patient with HIV-AIDS.Advanced imaging techniques with contrast-enhanced magnetic resonance scans should be used to guidediagnosis in this condition. in a patient with HIV-AIDS, biopsy should be carried out if standard imagingshowed atypical features or in a patient who has a poor response to empirical treatment for neurotoxoplasmosis.In this case, we reported a case of A 26 years old male with HIV-AIDS with neurological deficits who laterdiagnosed with glioblastoma.
Relationship between Neutrophil-Lymphocyte Ratio and Disease Severity in COVID-19 Patients in Isolation Ward of Dr. Soetomo General Teaching Hospital Heri Krisnata Ginting; M. Vitanata Arfijanto; Tri Pudy Asmarawati; S. Ugroseno Yudho Bintoro
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17558

Abstract

This study was conducted to prove the relationship between the neutrophil-lymphocyte ratio and theseverity of COVID-19. A retrospective cohort study using medical record data of inpatients from Juneto July 2020. Analysis of the NLR relationship and the degree of severity using the Mann Whitney testif the data had an abnormal distribution. Significant if p<0.05 and 95% confidence interval. If there weresignificant results, we try to measure the cut-off of NLR value to predict severe and non-severe clinicalsymptoms. Total study subjects were 110 patients, with a male as many as 65 (59.1%), the median agewas 53.5 years (range 20-88). Most of the comorbidities were diabetes mellitus (35.5%), followed byhypertension (30%). The severity of clinical symptoms was 50% in the non-severe and severe groups,respectively. The NLR value was higher in the severe group. Mann-Whitney test showed significantdifferences in the value of NLR between the severe group and the not severe group with the p-value<0.001. Receiver operating characteristic (ROC) curve analysis area under the curve (AUC) of NLRon day-1 was 0.716 (CI 95%: 0.605 - 0.826), and the cut-off point of the prediction severity diseaseat day-7 was ≥ 6.14 with a sensitivity of 71% and a specificity of 69.1%. The neutrophil-lymphocyteratio value with severe symptoms was higher than the neutrophil ratio value for lymphocytes with nonseveresymptoms in patients with COVID-19.
Predictor of Mortality COVID-19 in Two Referral Hospital in Surabaya, Indonesia Usman Hadi; Bramanton; Tri Pudy Asmarawati; Musofa Rusli; Nasronudin; Brian Eka Rachman; M. Vitanata Arfijanto
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17659

Abstract

Introduction: World Health Organization had identified COVID-19 in January 2019. This disease is caused by SARS-CoV-2, which spread throughout the world and became a pandemic on March 20, 2020. COVID-19 is still a health problem because it has not clear whether the patients will be cured and survive from the disease or not. This study aims to determine the predictors of mortality from COVID-19 at Dr. Soetomo General Academic Hospital and Universitas Airlangga Hospital in Surabaya, Indonesia.Method: This study was conducted in Dr. Soetomo General Academic Hospital (referral hospital for COVID-19, 1500 beds) and Universitas Airlangga Hospital (Referal Hospital for COVID-19, 600 beds). The study used data on patients with confirmed COVID-19 who were hospitalized at these two referral hospitals. Predictors of mortality were analyzed using logistic regressions.Result: There were 247 COVID-19 patients enrolled in this study, all patients were tested positive PCR SARS-CoV-2. The main complaints were cough, nasal congestion, dyspnea, and fever. Significant predictor mortality in this study were age >60 years old (OR: 3.24, 95% CI, 1.36 - 7.70), chronic kidney disease (OR: 5.71, 95% CI, 2.05 - 15.89), obesity (OR: 8.22, 95% CI,1.5 - 54.17), malignancy (OR: 6.025, 95% CI, 1.1- 33.00), coronary heart disease (OR: 5.31, 95% CI, 1.28 - 21.98) , and C-reactive protein >10 mg/L (OR 4.603, 95% CI, 2.03 - 10.44).Conclusions: Obesity and the presence of malignancy, chronic kidney disease, heart disease and age >60 yearsold are the strongest predictors of mortality in people with COVID-19, despite high CRP results.
Diagnostic Challenge Of Peritoneal Tuberculosis In Woman With Ascites Nenci Siagian; Muhammad Vitanata Arfijanto
Biomolecular and Health Science Journal Vol. 3 No. 1 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i1.19131

Abstract

Tuberculosis (TB) is a major health global issue including extrapulmonary tuberculosis (EPTB). The one of manifestation of EPTB is peritoneal TB that constitutes 2% from all cases of pulmonary TB around the world. The diagnosis of peritoneal TB is quite challenging because many cases have symptom that similar to other diseases and those often necessary need further specific examinations such as PCR, culture and radiologic examination. We reported a case report of peritoneal tuberculosis in woman with ascites.
Sepsis: Antibiotic Resistances of Gram-Positive and Gram-Negative Bacterial in a Tertiary Care Hospital Siti Nurul Jannah; Muhammad Vitanata Arfijanto; Musofa Rusli; Agung Dwi Wahyu Widodo
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 12 No. 1 (2021): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V12I12021.29-37

Abstract

Introduction: Sepsis is a systemic infection that causes multiorgan failure and death. The death rate that is caused by sepsis is increasing. This high value of death has a correlation with the resistance of antibiotics. However, increased antibiotic resistance is not balanced with new research about antibiotics. As a consequence, it causes difficulties in handling sepsis patients who need antibiotic 1-2 hours after diagnosis is enforced. Methods: This was a descriptive study with case study design to analyze medical records of the patients, evaluating the pattern of bacterial resistance to antibiotic in 221 patients with sepsis with 240 blood isolates to identify. Results: From 221 patients identified as sepsis, there were 97 male patients (43.9%) and 124 female patients (56.1%), mostly between 18-59 years old (63.8%), with the highest level in female (54.8 %) and elderly (66.3%). The bacteria that caused the most sepsis were gram-positive. The most species in gram-positive are Staphylococcus haemolyticus (16.3%) and Staphylococcus aureus (12.5%), and the most species in gram-negative is Escheriichia coli (13.3%). The most sensitive antibiotics in gram-positive bacteria were Piperacillin-Tazobactam (100%), Daptomycin (99.2%), and Clindamycin (99.2%). The sensitive antibiotics in gram-negative bacteria were Amikacin (85.9%), Cefoperazone (84.6%), and Piperacillin-Tazobactam (84.1%). Conclusion: The most sensitive antibiotics in gram-positive bacteria were Piperacillin-Tazobactam, Daptomycin, and Clindamycin. The sensitive antibitics in gram-negative bacteria were Amikacin, Cefoperazone, and Piperacillin-Tazobactam. 
IgA ANTI-DENGUE PROFILE IN SAMPLES WITH POSITIVE DENGUE PCR OR NS1 M Thohirin Ramadhani; Aryati Aryati; M Vitanata Arfijanto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 1 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i1.1483

Abstract

Dengue Virus Infection (DVI) causes several clinical manifestations and requires varied diagnostic instruments. IgA anti-dengue as one of the diagnostic markers of DVI is suspected to have a shorter lifespan and greater sensitivity in detecting secondary infections compared to IgM anti-dengue. This study was conducted using 34 sera with positive RT-PCR or NS1 dengue virus. Samples were examined by a reverse flowimmunochromatographic method using AIM Dengue IgA Assure Rapid Test and will be analyzed its profile toward the day of fever, serotype, severity, platelet count, and type of infection. The overall sensitivity of IgA anti-dengue was 61.76% (n=34); in which IgA anti-dengue detected 14.29% primary and 66.67% secondary cases. IgA anti-dengue detected DEN1, DEN2, DEN3, and Mixed DEN1 – DEN3 virus serotype respectively 55.56%, 22.22%, 16.67%, and 5.56% (n=20). The day of fever was dominated by day-4 and day-5 respectively 28.57% (n=21). IgA anti-dengue was detected in DD, DHF grade I, II, and III 42,86%, 28.57%, 19.05%, and 9.52% (n=21) respectively. IgA anti-dengue detected in all levels of platelet count, it detected 60% in < 50,000 cell/mm3, 30% in 50,000 - 100.000 cell/mm3 and 10% in > 100,000 cell/mm3 platelet count sample (n=20). In conclusion, IgA anti-dengue showed a good performance, applicable as a diagnostic marker of DVI.
BIOFILM FORMATION AND ANTIMICROBIAL RESISTANCE OF ESCHERICHIA COLI IN VITRO TOWARDS CEFTRIAXONE AND CEFIXIME Jihan Kalishah; Dominicus Husada; M Vitanata Arfijanto; Agung Dwi Wahyu Widodo
Current Internal Medicine Research and Practice Surabaya Journal Vol. 3 No. 1 (2022): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v3i1.32549

Abstract

Introduction: Escherichia coli is a Gram-negative bacteria and a most cause of nosocomial infections. Bacteria has the ability to form biofilm that may cause antimicrobe resistance. This biofilm protects the microbes from environmental conditions which make it the most cause of nosocomial infections including urinary tract infection and the infections resulted from the use of medical instruments. The aim of this experiment is to observe the presence of cefotaxime and ceftriaxone antimicrobial resistance in E. coli as a cause of biofilm formation. Method: This study conducted three experiments of E. coli sensitivity test on cefotaxime and ceftriaxone, E. coli resistance test after a 48 hours incubation, and optical density measurement using iMark™ ELISA Microplate Reader. Result: The results of sensitivity experiment with antibiotic cefotaxime and ceftriaxone disk showed sensitive result in wild-type E. coli and E. coli ATCC while after 48 hours incubation E. coli ATCC remains sensitive and in wild-type E. coli result are three intermediates, one sensitive and other than that it’s all change to resistance. The third experiment results were obtained from ELISA then classified into three categories. In E. coli ATCC 1 and 2, the results are mostly in high category (OD >0.240). The OD in E. coli 1 is mostly high, while results from E. coli 2 consists of one bacterium in weak category (OD <0.120), four in moderate category (OD 1.20 – 0.240), and three in high category. Conclusion: It can be concluded that E. coli resistance test in cefotaxime and ceftriaxone after 48 hours’ incubation are mostly resistant in wild-type E. coli but sensitive in E. coli ATCC.
Cholangiocarcinoma With Sepsis Associated With Percutaneous Transhepatic Biliary Drainage (PTBD) Muhammad Vitanata Arfijanto; Bayu Abhiyoga
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 22, No 3 (2021): VOLUME 22, NUMBER 3, December 2021
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3831.584 KB) | DOI: 10.24871/2232021240-248

Abstract

Percutaneous transhepatic biliary drainage (PTBD) can be an alternative palliative treatment in resectable cholangiocarcinoma. One of the most common complications of PTBD is infection, with a prevalence of 3.6 – 67.4% in patients undergoing PTBD procedure, with mortality rate of 0.05-7%. We report a case of a 46-year old male with a history of fever 14 days after undergoing PTBD procedure. Physical examination revealed tachycardia, tachypnea, febris, jaundice, and decreased urine output. Laboratory results revealed hypochromic-microcytic anemia, leukocytosis, decreased renal function, elevated liver enzymes, obstructive icterus, hypoalbuminemia, and hyperkalemia. Blood and gall culture revealed a growth of Eschericia coli. The patient was given fluid resuscitation and antibiotic suitable to microbial sensitivity test, and treatment of acute kidney injury and hyperkalemia, including hemodialysis. The patient’s general condition improved after ten days of care, and was discharged on the twentieth day.  Cholangitis is one of the most infectious complications following PTBD procedure. The prevalence of sepsis in biliary drainage procedures was reported 2.5-2.7%, with enteral bacteria gram-negative bacilli being the most common pathogen found in blood and bile. The administration of prophylactic antibiotics was not proven to decrease prevalence of infection. Bacterial translocation via portal vein due to loss of mucosal integrity in the intestines may contribute to bacteremia following PTBD procedure.
CD4 Association with Mortality in HIV Patients with Dyspnea in Dr Seotomo General Academic Hospital Surabaya Moh. Hamzah Raka Pratama; Muhammad Vitanata Arfijanto; Maria Lucia Inge Lusida
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 1 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i1.42609

Abstract

Introduction: HIV AIDS patients who have a CD4 count < 200 cells/uL often complain of respiratory symptoms (Wallace, 1993). The complaint was shortness of breath (62%). Opportunistic infections (IO) in HIV patients are also brought on by a decreased CD4 count of 200 cells/uL (Peters, 2007). HIV/AIDS patients with CD4 < 200 cells/uL have a risk of death of 10.399 (Kusumaadhi, 2021). This study aims to determine the association between CD4 cell count with mortality in HIV patients with shortness of breath at Cendana, Dr. Soetomo General Academic Hospital Surabaya, during the period of January–December 2020.Methods: This study used a cross-sectional retrospective design. The population in this study were patients diagnosed with HIV at Cendana, Dr. Soetomo General Academic Hospital, using a total sampling technique. The variables studied were the CD4 counts as the independent variable, and the mortality of HIV patients with dyspnea as the dependent variable. The sample in this study must meet the inclusion criteria, namely, the sample must have a history of CD4 counts in their medical record in the last 2 to 3 months while in Cendana, Dr. Soetomo General Academic Hospital. Secondary data from medical record data in Cendana, Dr. Soetomo General Academic Hospital, was used for the research from January to December 2020. Results: A total of 128 HIV patients with dyspnea and a history of CD4 counts in the previous 3 to 4 months were included in the study: 79 (61.7%) males and 49 (38.3%) females. The most common age groups were 31–40 years (33.6%), 20–30 years (32.0%), 41–50 years (23.4%), and > 60 years (2.4%), with no patients under the age of 20. The distribution of the most opportunistic infections were: pneumocystis pneumonia (n = 62), tuberculosis (n = 49), and bacterial pneumonia (n = 17). Patients lived (n = 79) and died (n = 49) in total.Conclusion: There was no significant association between CD4 count and mortality in HIV patients with dyspnea (p-value 0.084 > 0.05).
A Patient with Suspected Diphtheria Arfijanto, Muhammad Vitanata; Mashitah, Siti Irma; Widiyanti, Prihartini; Bramantono, Bramantono
Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 2 (2010)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (718.818 KB) | DOI: 10.20473/ijtid.v1i2.2169

Abstract

It was reported that a mature woman, Mrs. S, 42 years old with several complaints and symptoms such as fever, swallowing painweak body, swollen tonsil with beslag, dirty uvula of mouth cavity and tongue, and bullneck. The final diagnosis indicated that thepatient was suspected diphtheria, candidiasis oris, sepsis, and pneumonia. The sudden death of the patient was probably caused bymyocarditis.
Co-Authors Afif Nurul Hidayati, Afif Nurul Agung Dwi Wahyu Widodo Aryati Aryati Asmarawati, Tri Pudy Bayu Abhiyoga Bramanton Bramantono Bramantono, Bramantono Dominicus Husada Dwi Murtiastutik Heri Krisnata Ginting Hidayat, Shofa Annesa Ilham Munandar Jihan Kalishah Lusida, Maria Lucia Inge M Thohirin Ramadhani Moh. Hamzah Raka Pratama Musofa Rusli Nasronudin Nasronudin Nenci Siagian Nurhidayah, Meiwinda Rizky Permana, Putu Bagus Dharma Prameshvari, Putu Lovina Indra Prastyani, Reni Prihartini Widiyanti Rachman, Brian Eka Romdhoni, Achmad Chusnu S. Ugroseno Yudho Bintoro Siti Irma Mashitah, Siti Irma Siti Nurul Jannah Trisnashanti, Dea Praditya Ulfa Kholili Usman Hadi Wahyudi, Mohammad Imam Zuhria, Ismi