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All Journal Journal of Tropical Soils Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Biology, Medicine, & Natural Product Chemistry BERITA BIOLOGI Makara Journal of Science
Novik Nurhidayat
Puslit Biologi LIPI, Cibinong Science Center
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Medicine & Pharmacology Public Health

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Journal : BERITA BIOLOGI

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PENGARUH ANGKAK HASIL FERMENTASI BERAS OLEH Monascus purpureus JMBa TERHADAP AKTIVITAS ANTIOKSIDAN DAN GLUTATHION PEROKSIDASE (GPx) SERTA HISTOPATOLOGI HATI TIKUS GALUR SPRAGUE DAWLEY [The effect of Angkak from rice fermented by Monascus purpureus JMBa on antioxidant and glutathion peroxidase (GPx) activity and liver histopatology of Sprague Dawley Rats] Kasim, Ernawati; Triana, Evi; Yulinery, Titin; Nurhidayat, Novik
BERITA BIOLOGI Vol 11, No 2 (2012)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/beritabiologi.v11i2.487

Abstract

Free radicals released from metabolism processes in the body were reactive and toxic to cells and tissues because it cause protein, cell membrane and nucleic acid damages which lead to cancer. It could be overcame if antioxidant system in the body is in good function.Nevertheles antioxidant system could be destructed by variety of conditions. Modern lifestyle that frequently consumed of high saturated fat, additives, and low fiber content in foods were potential risk for cancer and hypercholesterolemia. To overcome that risks with specific drugs were high cost. Therefore this research was conducted to take advantages of natural sources which potential for antioxidant and antihypercholesterolemia activities that could be fast, easy and inexpensive processing. One of the natural sources that meet the criteria was angkak resulted from rice fermented by Monascus purpureus. The result revealed that angkak contained lovastatin showed antioxidant and antihypercholesterolemia activities and increased glutathion peroxidase activity of optimal dose 5 g/day. The histopathologi observation of rat’s liver showed that administered of angkak on rats feed high level of cholesterol inhibited accumulation of fat in rat’s liver.
IDENTIFIKASI GEN SELENOMETIL TRANSFERASE (smt) PADA ISOLAT Geobacillus sp. 20K YANG RESISTEN TERHADAP SELENIUM Triana, Evi; Nurhidayat, Novik; Yulinery, Titin; Kasim, Ernawati; Dewi, Ratih M
BERITA BIOLOGI Vol 10, No 3 (2010)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (329.562 KB) | DOI: 10.14203/beritabiologi.v10i3.747

Abstract

The trace element Selenium is toxic at high concentration.Most of organisms living in selenium rich environment are selenium resistant.One of the resistance mechanisms is methylation,in which selenium is methylated and transformed to non-toxic selenium compound.The methylation is catalyzed by seleno methyltransferase (SMT) coded by smt gene. The gene are expressed by selenium tolerant plants. However, there was no available report yet on such specific gene in the bacterial genome. This study was carried out to determine smt homologous gene on selected selenium accumulator bacteria, Geobacillus sp. 20k, The smt gene of was determined by amplifying target DNA and analyses its sequences through homology search (BLAST). The result showed that the DNA and its protein part of thermophilic enzyme involved selenium metabolisms.
IDENTIFIKASI GEN TERMOASIDOFILIK ALKOHOL 1 DEHIDROGENASE PADA BACILLUS SP-PJV MS, Yulia Atika; Artika, I Made; Nurhidayat, Novik
BERITA BIOLOGI Vol 14, No 1 (2015)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/beritabiologi.v14i1.1872

Abstract

One of the constrains in the conversion process of biomass to bioethanol is the unoptimum technology for the conversion process.One of the causes is the difference between optimum temperature for enzymatic hydrolytic saccharification and for fermentation.Enzymatic hydrolysis requires high temperature and acidic pH, while fermentation operates at mild condition.Hence, thermophilic fermentative microbes are needed so that simultaneous saccharification and fermentation processes can be carried out.Alcoholdehydrogenase(ADH), an enzyme functions in the final step of fermentation, catalyzes reduction of acetaldehydeto ethanol so that it being one of indicator fermentative microbial.Protium javanicum, a typical fruit from Lombok grow at high temperature and has sour taste so that it predicted has a thermo acidophilic ADH.This study was aimed toidentify gene encoding ADHin Protiumjavanicum(Pjv) microbial isolates.ADH gene identification was carried out by DNA amplification using spesific adh primers inqPCR machine. Results showed that all isolates tested had adh gene and that of Bacillus sp-Pjv was the most efficiently amplified. Results of fermentationtest also showed that the Bacillus sp-Pjv isolate was a better ethanol-producer than the others.
Co-Authors Afifi, Muhammad Ridho Deden Saprudin Dewi, Ratih M Dita Ariyanti Dori Kusuma Jaya Dyah Iswantini Evi Triana Ghozali, Ali Aulia Hefni Effendi I MADE ARTIKA Kasim, Ernawati Kurniawan, Yehezkiel Steven MS, Yulia Atika Purwantiningsih Sugita Rahayu, Sri Hartin Sarjiya Antonius Yulinery, Titin