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All Journal Biology, Medicine, & Natural Product Chemistry Lantanida Journal Sains Natural: Journal of Biology and Chemistry Biologica Samudra Jurnal Pijar MIPA Jurnal Natural Journal Of Carbazon
Afifi, Muhammad Ridho
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Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Veterinary

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PENGARUH KONSENTRASI Na2CO3 TERHADAP RENDEMEN NATRIUM ALGINAT DAN KANDUNGAN PROKSIMAT ALGINAT DARI RUMPUT LAUT Sargassum sp. Srikandi Srikandi; Muhammad Ridho Afifi; RTM Sutamihardja
JURNAL SAINS NATURAL Vol. 3 No. 1 (2013): Sains Natural
Publisher : Universitas Nusa Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (853.193 KB) | DOI: 10.31938/jsn.v3i1.52

Abstract

Effect
Montmorillonite-Chitosan as a Biocomposite Encapsulation for Ibuprofen in Drug Release Afifi, Muhammad Ridho; Irwandi, Dodi; Safitri, Eka; Syafei, Dedri; Ngapa, Yulius Dala
Journal of Carbazon Vol 2, No 2 (2024): December 2024
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jocarbazon.v2i2.42149

Abstract

Ibuprofen is a type of anti-inflammatory drug. However, its use faces challenges in the medical field due to its rapid degradation, low bioavailability, limited solubility, and high permeability. One approach to address these issues is the encapsulation of ibuprofen by coating it with Montmorillonite (MMT) and Chitosan (CS) to control the released dosages of Ibuprofen. MMT and CS were used to coat ibuprofen using four methods. These methods were compared through dispersing MMT in water, mixing with chitosan, and combining ibuprofen under different conditions. Subsequently, tests were conducted on ibuprofen coated with MMT-CS, including morphology, efficiency, and release profile. The most effective method for controlling ibuprofen release was shown in the third method, where MMT-CS was first modified, and then ibuprofen was added to the modified MMT-CS. This method showed the highest encapsulation efficiency of 61.51%, the best release profile with 21.59% ibuprofen release within 90 minutes, and the most uniform encapsulation morphology. These studies indicated that the MMT-CS biocomposite effectively improves ibuprofen release efficiency, potentially enhancing therapeutic outcomes while reducing side effects of ibuprofen.
The validation of urea determination in saliva using optical urea biosensor with p-dimethylaminobenzaldehyde (DMAB) reagent ALDIANSYAH, TEUKU; SAFITRI, EKA; GINTING, BINAWATI; NAZARUDDIN, NAZARUDDIN; SUHUD, KHAIRI; SALEHA, SITTI; NURHAYATI, NURHAYATI; NAZARUDDIN, SALSABILLA LATANSA; AFIFI, MUHAMMAD RIDHO; NURHAIDA, NURHAIDA
Jurnal Natural Volume 25 Number 1, February 2025
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v25i1.41251

Abstract

The validation of urea determination in saliva using the biosensor method and the p-dimethylaminobenzaldehyde (DMAB) method has been successfully conducted. Anthocyanin compounds from Chatarantus roseus flowers were extracted using the maceration method with methanol as the solvent, yielding a total of 22.60% with a total concentration of 6.01 mg/L. The obtained extract was subjected to qualitative anthocyanin testing, showing a positive result was indicated by the formation of a reddish color and quantitative testing with the formation of a faded yellow color. The maximum wavelength ( max) of anthocyanin was 664 nm with an absorbance of 0.674. The saliva samples were obtained from three different ages i.e: children, teenagers, and adults. During the saliva collection procedure, participants were instructed to abstain from consuming any food or beverages, with the exception of water, for a minimum of 1 hour prior to sample collection. All samples were stored in a freezer at 4-8C until needed for analysis. Linearity test results were assessed using a calibration curve, yielding a coefficient of determination (R) of 0.978 with a sensitivity of 0.033 for the biosensor and an R of 0.975 with a sensitivity of 0.685 for DMAB. The limit of detection (LOD) values were determined as 7.203 10 M for the biosensor and 6.984 10 M for DMAB, while the limit of quantification (LOQ) values were 2.182 10 M and 2.116 10 M, respectively. Statistical analysis using a t-test showed tcalculated = 1.314, compared to ttable = 4.302, indicating that tcalculated ttable. This result suggests no statistically significant difference between the biosensor and DMAB methods, confirming that the biosensor method is comparable in performance to the DMAB method. Additionally, urea concentration measurements showed that adult samples exhibited the highest urea levels among the tested samples, which may indicate an association with potential health risks, including dental caries, kidney failure, and liver damage.
AKTIVITAS ANTIBAKTERI EKSTRAK DAN FRAKSI N-HEKSANA KULIT BUAH KAKAO (Theobroma cacao L.) Purnama, Agnia; Ginting, Binawati; Yahya, Mustanir; Afifi, Muhammad Ridho; Maghfirah, Ruhul; Farida, Mutia; Hamdiyati, Hamdiyati
Lantanida Journal Vol 13 No 1 (2025): January-June 2025
Publisher : UIN AR-RANIRY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/lj.v13i1.29989

Abstract

This study aims to evaluate the antibacterial activity of the n-hexane extract and fraction of cocoa pod husk against Staphylococcus aureus. The antibacterial was tested using the paper disc diffusion method. The results showed that the extract inhibited bacterial with inhibition zones of 7.13 ± 0.29; 8.58 ± 0.14; 9.60 ± 0.87; and 10.97 ± 0.08 mm at concentrations of 1%, 5%, 10%, and 20%, respectively. The fractionation process produced 9 fractions and the 9th fraction showed the greatest inhibitory activity with inhibition zone diameters of 7.42 ± 0.03; 9.22 ± 0.03; 10.43 ± 0.03; and 11.83 ± 0.03 mm at concentrations of 1%; 5%; 10%; and 20% respectively. Phytochemical analysis and thin-layer chromatography (TLC) showed the presence of terpenoid and steroid compounds. Based on the antibacterial activity exhibited by the extract and fraction, this plant shows potential to be developed as a source of natural antibacterials.
Superoxide Anion Radicals Biosensor Based on Protein Extract from Deinococcus Radiodurans Immobilization by Glutaraldehyde Cross-Linked Afifi, Muhammad Ridho; Iswantini, Dyah; Nurhidayat, Novik; Saprudin, Deden
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.153-160

Abstract

A common enzyme for superoxide anion radicals biosensors is superoxide dismutase (SOD). Deinococcus radiodurans protein extract can replace the use of pure SOD enzymes for superoxide anion radicals biosensors. The purpose of this research is to determine the analytical performance of the superoxide anion radicals biosensor with protein extract of Deinococcus radiodurans immobilized on carboxymethylcellulose-gelatin-zeolit (CMC-G-Z) that is crosslinked by glutaraldehyde. The response surface method showed that the optimum condition for the biosensor was pH 7, protein extract concentration of 1075 µg/ml, zeolite concentration of 5 mg/ml, and glutaraldehyde concentration of 0.0042 M. Stability of the biosensor retained 67% of its sensitivity after use for 24 hours. The biosensor exhibits good analytical performance with a linear range from 0.1 – 0.8 mM, a detection limit of 77.84 µM, and a limit of quantification of 259.5 µM with a correlation coefficient of 0.9905.
Quantitative Analysis of Sibutramine Hydrochloride in Slimming Herbal Medicines in Banda Aceh Using UV-Vis Spectrophotometry Ruhul Maghfirah; Farida, Mutia; Purnama, Agnia; Afifi, Muhammad Ridho; MZ, Kartika; Rahmawati, Erda
JURNAL BIOLOGICA SAMUDRA Vol 7 No 1 (2025): Biologica Samudra
Publisher : Program Studi Biologi, Fakultas Teknik, Universitas Samudra

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33059/jbs.v7i1.11763

Abstract

Sibutramine hydrochloride is a chemical compound that was once often used as a weight loss drug. This drug is hazardous if used illegally in herbal medicine because it can cause health problems such as kidney failure, heart attacks, and strokes. BPOM has banned its use in herbal medicine, but until now herbal medicine containing sibutramine hydrochloride is still on the market. This study aims to determine the levels of Sibutramine Hydrochloride contained in slimming herbal medicine. The samples used in this study consisted of four brands of slimming herbal medicine that are not registered with BPOM, coded A, B, C, and D, which were obtained from several shops in Baiturrahman District, Banda Aceh City. Sampling was carried out using the total sampling method and then analyzed quantitatively using UV-Vis spectrophotometry. The results of the analysis showed that the four samples were positive for containing Sibutramine Hydrochloride with an average level of 31.69% of herbal medicine sample A; 39.88% of herbal medicine sample B; 7.09% of herbal medicine sample C; and 36.60% of herbal medicine sample D. Therefore, stricter examination and supervision of the circulation of slimming herbal medicine products in the Banda Aceh city area are needed to protect public health.
Isolation and Characterization of Cellulose Whiskers from Lampung Sugarcane Bagasse, Indonesia Afifi, Muhammad Ridho; Aini, Zahratul; Irawadi, Tun Tedja; Purwaningsih, Henny
Jurnal Pijar Mipa Vol. 20 No. 5 (2025)
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i5.9371

Abstract

Sugarcane bagasse, the fibrous residue from sugar production, is an abundant agricultural waste in Indonesia, especially in Lampung, one of the country’s leading sugarcane-producing provinces. Its high lignocellulosic content makes it a promising alternative source of cellulose. However, effective extraction and conversion into high-value products such as cellulose whiskers require optimized chemical processes. This study aims to isolate cellulose from sugarcane bagasse using alkali and peroxide treatments and convert it into cellulose whiskers through hydrolysis using sulfuric acid (H₂SO₄) at varying concentrations (4–12 M). The objective is to evaluate the optimal acid concentration that produces cellulose whiskers with desirable morphology and crystallinity. Cellulose isolation was achieved through sequential NaOH and H₂O₂ treatments, significantly reducing lignin and hemicellulose content and yielding α-cellulose at 88.37%. Hydrolysis of the purified cellulose was then performed with H₂SO₄. The resulting materials were characterized using FTIR, SEM, XRD, and TGA. FTIR confirmed the removal of non-cellulosic components, while SEM showed that only 10 M H₂SO₄ produced well-defined whiskers with nanoscale dimensions (200–700 nm in length and 10–50 nm in diameter). Lower acid concentrations resulted in incomplete hydrolysis, while excessive degradation occurred at 12 M. XRD analysis revealed an increase in crystallinity to 86.7%, indicating the removal of amorphous regions and successful formation of crystalline whiskers. TGA analysis showed different thermal degradation patterns between isolated cellulose and whiskers, supporting structural transformation. Cellulose whiskers can subsequently be utilized as a reinforcing material in the fabrication of plastic films for water–oil separation and dye adsorption applications in laboratory experiments.
Co-Authors Aini, Zahratul ALDIANSYAH, TEUKU Binawati Ginting Deden Saprudin Dedri Syafei Dodi Irwandi, Dodi Dyah Iswantini Eka Safitri Hamdiyati, Hamdiyati Henny Purwaningsih Maghfirah, Ruhul Mutia Farida, Mutia MZ, Kartika N. Nazaruddin NAZARUDDIN, SALSABILLA LATANSA Novik Nurhidayat Nurhaida Nurhaida Nurhayati Nurhayati Purnama, Agnia Rahmawati, Erda RTM Sutamihardja Ruhul Maghfirah Sitti Saleha, Sitti Srikandi, Srikandi Suhud, Khairi Tun Tedja Irawadi Yahya, Mustanir Yulius Saprianus Dala Ngapa