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Effects of Oral Administration of Monosodium Glutamate (MSG) on Obesity in Male Wistar Rats (Rattus Norvegicus) Mulyati Sri Rahayu; Sri Wahyuni; Yuziani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 9 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i9.355

Introduction: Monosodium glutamate (MSG) is one of the most widely employed food enhancers. Although the umami compound, controversy persists regarding the effects of MSG intake on body weight. Chronic MSG intake may result in excessive body weight gain and obesity. Consumption of MSG result in organ damage, cardiovascular disease, oxidative stress, and also risk factors for obesity. This study aims to determine the effect of oral MSG on obesity in adult male Wistar rats (Rattus norvegicus).Methods: This true experimental study used the post-test control group design. Twenty-four adult male Wistar rats were randomly divided into four groups: control (received distilled water), Group 1 (MSG 0.378 mg/gr BW), Group 2 (0.756 mg/gr BW) and Group 3 (1.512 mg/gr BW). The obesity parameter was obtained by the Lee index. Kruskal-Wallis test follows by Mann-Whitney test were used to compare the Lee index between groups.Results: Lee’s index mean for each group was 358.4%, 314.1%, 287.8%, and 320.9%, respectively. The Kruskal Wallis test showed a significant difference in the Lee index between groups (p = 0.043). A follow-up test using Mann-Whitney found a significant difference between group 2 and the control group (p = 0.043, p <0.05). The mean of Lee index of group 2 was 70.51% lower than the control group.Conclusion: This study concluded that Lee index was not increased in MSG-treated rats than in the control group after oral MSG intervention for 21 days.

POLIMORFISME GEN PADA PENYAKIT MALARIA Sri Wahyuni
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Vol. 2: No. 1 (Mei, 2016)
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v2i1.411

Malaria adalah penyakit infeksi yang disebabkan oleh parasit Plasmodium yang hidup dan berkembang biak dalam sel darah merah manusia. Di Indonesia, malaria masih merupakan salah satu masalah kesehatan masyarakat yang dapat menyebabkan kematian terutama pada kelompok risiko tinggi yaitu bayi, anak balita, ibu hamil. Pengaruh genetik pejamu pada kerentanan terhadap malaria telah banyak diteliti beberapa tahun terakhir. Beberapa faktor genetik merupakan determinan utama bagi child survival di negara endemis malaria. Identifikasi gen yang terlibat dan pengaruhnya terhadap risiko penyakit malaria dapat memberikan suatu pengetahuan mengenai mekanisme untuk mempelajari hubungan pejamu-parasit malaria.

ITEM ANALYSIS BLOK IMUNOLOGI DAN NEOPLASMA TA 2015-2016 DI PROGRAM STUDI PENDIDIKAN DOKTER UNIVERSITAS MALIKUSSALEH Sri Wahyuni
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Vol. 1: No. 2 (November, 2015)
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v1i2.398

Multiple-choice questions (MCQs) atau soal pilihan berganda sering digunakan dalam penilaian mahasiswa. Item analysis secara luas digunakan untuk memperbaiki kualitas ujian. Indeks kesulitan soal (p) dan indeks diskriminasi soal (D) adalah dua indikator objektif untuk evaluasi soal MCQ. Penelitian ini bertujuan untuk menilai kualitas soal dan menjadikan soal yang berkualitas sebagai bank soal. Sebanyak 70 soal MCQ Blok Imunologi dan Neoplasma dianalisis dan dihitung nilai p dan nilai D masing-masing soal menggunakan Microsoft Excel. Korelasi antara p dan D dianalisis menggunakan korelasi Pearson. Hasil penelitian menunjukkan rerata nilai mahasiswa adalah 33,5 ± 10,3. Rerata nilai p adalah 0.48 ± 0.21 dan rerata nilai D adalah 0.37 ± 0.23. Sebanyak 13 (19%) soal termasuk mudah, 15 (21%) soal termasuk sulit dan 42 (60%) masih acceptable. Sebanyak masing-masing 3 (4%) soal mempunyai nilai indeks diskriminasi negatif dan rendah (poor). Total 79% soal memiliki indeks diskriminasi acceptable-excellent. Indeks diskriminasi menunjukkan korelasi positif lemah dengan indeks kesulitan soal (r = 0,357) dan bermakna signifikan (p=0,02). Penelitian ini menyimpulkan bahwa soal MCQ sudah mempunyai kualitas yang baik dan dapat dipergunakan pada ujian selanjutnya sehingga memperbaiki kualitas ujian secara keseluruhan.

PERAN IMUNITAS HUMORAL PADA PENYAKIT SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) Sri Wahyuni
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Vol. 3: No. 1 (Mei, 2017)
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v3i1.451

Systemic Lupus Erythematosus (SLE) adalah suatu kelainan autoimun multisistem kronik yang ditandai oleh autoantibodi dan kompleks imun yang berkaitan dengan manifestasi klinis dan kerusakan jaringan yang beragam dan luas. Beberapa defek dari komponen imunologi multipel berperan penting dalam patogenesis SLE. Abnormalitas imunologi pada SLE meliputi kemampuan untuk menghasilkan autoantibodi patogenik, hilangnya regulasi sel limfosit B dan T, serta defective clearance dari autoantigen dan kompleks imun. Faktor genetik, imunologik dan hormonal serta lingkungan diduga berperan dalam patofisiologi SLE. Tulisan ini mengkaji respon imun humoral sebagai salah satu patogenesis SLE.

Effects of Oral Administration of Monosodium Glutamate (MSG) on Obesity in Male Wistar Rats (Rattus Norvegicus) Mulyati Sri Rahayu; Sri Wahyuni; Yuziani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 9 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i9.355

Introduction: Monosodium glutamate (MSG) is one of the most widely employed food enhancers. Although the umami compound, controversy persists regarding the effects of MSG intake on body weight. Chronic MSG intake may result in excessive body weight gain and obesity. Consumption of MSG result in organ damage, cardiovascular disease, oxidative stress, and also risk factors for obesity. This study aims to determine the effect of oral MSG on obesity in adult male Wistar rats (Rattus norvegicus).Methods: This true experimental study used the post-test control group design. Twenty-four adult male Wistar rats were randomly divided into four groups: control (received distilled water), Group 1 (MSG 0.378 mg/gr BW), Group 2 (0.756 mg/gr BW) and Group 3 (1.512 mg/gr BW). The obesity parameter was obtained by the Lee index. Kruskal-Wallis test follows by Mann-Whitney test were used to compare the Lee index between groups.Results: Lee’s index mean for each group was 358.4%, 314.1%, 287.8%, and 320.9%, respectively. The Kruskal Wallis test showed a significant difference in the Lee index between groups (p = 0.043). A follow-up test using Mann-Whitney found a significant difference between group 2 and the control group (p = 0.043, p <0.05). The mean of Lee index of group 2 was 70.51% lower than the control group.Conclusion: This study concluded that Lee index was not increased in MSG-treated rats than in the control group after oral MSG intervention for 21 days.

Nomophobia (No MObile PHone PhoBIA) Among Medical Students: A Literature Review Sri Wahyuni
International Journal of Engineering, Science and Information Technology Vol 2, No 3 (2022)
Publisher : Master Program of Information Technology, Universitas Malikussaleh, Aceh Utara, Indonesia

Smartphones have become more popular due to advances in high-speed Internet connectivity. Smartphones are popular among young people, including medical students, as virtual devices. As a result, excessive use of smartphones has expressed concerns about its addictive potential, a condition known as nomophobia. Nomophobia (No MObile PHone PhoBIA) is the worry or fear people feel when they do not have their mobile phone or are unable to use it. The term was introduced in 2008 and is considered a modern phobia. Nomophobia is also a general pathology among students, particularly those in medicine. This literature review examines the prevalence of nomophobia, symptoms, causes of nomophobia among medical students, and the impact of nomophobia on student achievement. Existing literature on nomophobia in the PUBMED and Google Scholar databases was examined using the search terms ‘nomophobia’ OR ‘mobile phone use’ OR ‘mobile phone addiction’ AND 'medical students.' Several studies have found that medical students have nomophobia. More than 50% of medical students in this review have moderate nomophobia, while 5-20% have severe nomophobia. The most common symptoms of nomophobia were anxiety, agitation, tachycardia, inability to turn off the mobile phone, constantly checking the phone, charging the battery even when the phone is nearly fully charged, fear of not being able to connect to a data network, concerns about being removed from online status or identity, and avoid activities to spend time on a mobile device. Students with severe nomophobia reported poor academic performance; students with a higher level of nomophobia performed poorly academically and vice versa. Medical students had a greater incidence of addiction to mobile phones, which affected their health and academic achievement. More emphasis should be placed on early detection and intervention to overcome nomophobia.

POLIMORFISME GEN TRANSFERIN P570S TERHADAP KADAR HEMOGLOBIN (HB) PADA REMAJA PUTRI PONDOK PESANTREN DI YOGYAKARTA Siti Wahyuningsih; Sri Wahyuni; Arta Farmawati; Ahmad Hamim Sadewa; Zainal Arifin Nang Agus
Medika Respati : Jurnal Ilmiah Kesehatan Vol 16, No 3 (2021)
Publisher : Universitas Respati Yogyakarta

Transferrin P570s. Gene Polymorphism Against Hemoglobin (Hb) Levels in Adolescent Girls Islamic Boarding Schools In YogyakartaBackground: Anemia in adolescent girls is one of the nutrients problem. Transferin P570S gene polymorphism has an effect on glycosylated transferin so it can accelerate the degradation transferin. This can cause a decrease in transferrin function and interfere Fe homeostasis. The lack of Fe intake is one cause of the anemia. Objectives: To investigate correlation P570S transferrin gene polymorphisms with iron status as risk factor for iron deficiency anemia in adolescent girls. Methods: Desain of this study was case control. Eighty one adolescent girls living in the boarding school were included in this study. Blood samples used for biochemical examination of the blood and to detect the presence of P570S transferin polymorphism. Genotype frequencies between groups were analyzed using Chi square test and calculated the Odds Ratio (OR). Comparison of the mean rate of hemoglobin between genotype groups were analyzed statistically using One-way ANOVA test. Results: Transferin P570S polymorphism frequency in anemic girls with the CC was 68.4%, CT was 26.3%, TT was 5.3%, C allele frequency= 81.6% and T allele= 18.4%. The odds ratio (OR) P570S transferrin gene polymorphisms for polymorphic genotypes of 0.783 and for the T allele is 0.991. On the subject of anemia with polymorphic genotypes have hemoglobin levels 11.45 while wild type 11.6 (p= 0.000). On the subject of IDA with polymophic genotypes have hemoglobin levels 11.45 while wild type genotype 11.6 (p= 0.190). Conclusion: Genotype frequencies P570S transferring gene polymorphism in adolescent girls at the boarding school who suffer anemia of 31.6% and 35.7% of IDA. The mean hemoglobin levels in subjects with polymorphic genotype lower than the wild type.

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