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Pengaruh pemberian Monosodium glutamat peroral terhadap gambaran histopatologi jantung pada tikus putih (Rattus norvegicus) jantan galur Wistar Mulyati Sri Sri Rahayu; Yuziani Yuziani; Cut Sidrah Nadira
Jurnal Kedokteran Syiah Kuala Vol 21, No 1 (2021): Volume 21 Nomor 1 April 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v21i1.20725

Abstrak. Monosodium glutamat (MSG) diketahui mempunyai pengaruh yang cukup besar bagi kesehatan jika dikonsumsi secara berlebihan. Pemberian MSG dalam dosis tertentu dapat menyebabkan stres oksidatif yang berujung pada kerusakan seluler. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian MSG peroral terhadap gambaran histopatologis jantung pada tikus putih (Rattus norvegicus) jantan galur wistar. Penelitian ini merupakan true experimental laboratory dengan rancangan Post test control group design dengan sampel tikus putih (Rattus norvegicus) jantan galur wistar yang dibagi dalam 4 kelompok. Sampel diberi larutan MSG dengan 3 dosis berbeda selama 21 hari. Organ jantung kemudian diambil, ditimbang dan dibuatkan preparat histologi dengan pewarnaan Hematoxilin-Eosin. Data persentase nekrosis sel dianalisis menggunakan uji Kruskal-Wallis dan dilanjutkan dengan Mann-Whitney Post-Hoc Test. Hasil penelitian menunjukkan rerata persentase kerusakan histologi jantung pada masing-masing kelompok K, P1, P2 dan P3 berturut-turut sebesar 10,27%, 15.93%, 23,91 % dan 27,68 %, dengan p value 0,000 untuk uji Kruskal Wallis dan p value 0,004 untuk Mann Whitney baik antara kelompok kontrol dengan kelompok P1, P2, maupun P3. Kesimpulan: pemberian MSG peroral pada ketiga kelompok perlakuan secara bermakna mempengaruhi tingkat kerusakan histologi jantung tikus putih (Rattus novegicus) jantan galur wistar. Kata kunci: Monosodium glutamat, stres oksidatif, berat jantung, histopatologi jantung, nekrosis jantung Abstract. Monosodium glutamate (MSG) is known to have a considerable effect on health if excessively consumed. Administering MSG in certain doses can cause oxidative stress which leads to cellular damage. This study aims to determine the MSG oral administration effect on the histopathological features of male white rats (Rattus norvegicus) Wistar strain’s heart. This research is a true experimental laboratory with a post-test control group design. The samples were divided into 4 groups and given MSG solution with 3 different doses for 21 days. The heart organs were then harvested, weighed and processed into histological preparations by Hematoxylin-Eosin staining. The percentage of cell necrosis data were analyzed using the Kruskal-Wallis test and followed by the Mann-Whitney Post-Hoc Test. The result showed that mean percentage of heart histological damage in each group K, P1, P2 and P3 were 10.27%, 15.93%, 23.91% and 27.68% respectively, with a p value of 0.000 for the Kruskal Wallis test and p value. 0.004 for Mann Whitney both between the control group and the P1, P2, and P3 groups. Conclusion: The administration of MSG orally to the three treatment groups of male white rats (Rattus novegicus) Wistar strain significantly affected the histological damage level of the heart. Keywords: Monosodium glutamate, oxydative stress, heart weight, cardiac histopathology, cardiac necrosis

THE RELATIONSHIP OF COGNITIVE FUNCTION AND INDEPENDENCE ACTIVITIES OF DAILY LIVING (ADL) IN ELDERLY AT PANTI DARUSSA'ADAH AND AN-NUR LHOKSEUMAWE Cut Sidrah Nadira; Mulyati Sri Rahayu
JURNAL KEDOKTERAN DAN KESEHATAN Vol 7, No 3 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V7I3.10690

Aging causes a lot of changes in elderly’s physiologic function. It could be physical, mental or functional changes, including cognitive function. Cognitive function needed for performing ADL tend to decrease in elderly. Decreasing in cognitive function will cause disturbance in fulfil daily requirements so that increasing the dependency on others to help performing ADL. This study purpose to analyze relationship between cognitive function and independent level in performing ADL in elderly at panti Darussa’adah and An-Nur lhokseumawe using analytical cross-sectional design with purposive sampling technique. The data was analyzed by chi-square for the statistical test. Population for this study was elderly who lives in panti Darussa’adah and An-Nur by September 2017. Data obtained from 30 participants based on inclusion and exclusion criteria. Variables of this study are cognitive function and independent level in performing ADL. The result showed that half participants (50%) had a severe cognitive impairment. Most of them (53,3%) need helps to perform ADL. There is no significant relationship between cognitive function and independent level in performing ADL in elderly at Panti Darussa’adah and An-Nur lhokseumawe (p = 0,209). However, it is suggested that elderly should have a mental activity for maintaining their cognitive function.

POSYANDU LANSIA SEBAGAI ALTERNATIF PROGRAM PELAYANAN KESEHATAN DI PANTI JOMPO DARUSSA’ADAH DAN AN-NUR DI KOTA LHOKSEUMAWE Mulyati Sri Rahayu; Meutia Maulina; Yuziani Yuziani
JURNAL PENGABDIAN KEPADA MASYARAKAT Vol 23, No 3 (2017): JULI - SEPTEMBER
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jpkm.v23i3.7469

Abstrak Penduduk lansia terus meningkat dari tahun ke tahun sehingga dibutuhkan optimalisasi wahana pelayanan bagi kaum lansia seperti posyandu lansia (poslan). Tujuan pengabdian masyarakat ini adalah untuk mengatasi permasalahan program pelayanan kesehatan poslandi Panti Jompo Darussa’adah dan Panti Jompo An-Nur yang dinilai belum optimal. Selain program pelayanan poslan yang belum optimal, keterbatasan fasilitas kesehatan yang menunjang program tersebut juga masih menjadi kedala. Metode penyelesaian permasalahan dilakukan dengan membentuk kader poslan,sosialisasi poslan, pelatihan tentang tugas 5 meja (pemeriksaan fisik dan kemandirian lansia, pengisian KMS dan keterampilan laboratorium sederhana), praktek pelaksanaan poslan, penyediaan fasilitas alat kesehatan dan laboratorium sederhana serta melaksanakan kegiatan penunjang kesehatan lansia seperti senam lansia. Hasil kegiatan Iptek Bagi Masyarakat (IbM) yang dilaksanakan pada kedua mitra adalah tersedianya sistem pelayanan kesehatan 5 meja pada kedua poslan dan tersedianya kader lansia terlatih serta tersedianya sarana alat kesehatan untuk melakukan pemeriksaan kesehatan fisik dan mental emosional, tersedianya laboratorium sederhana sebagai fasilitas yang digunakan untuk deteksi dini penyakit pada lansia. Kesimpulan dari kegiatan IbM dapat meningkatkan jangkauan pelayanan kesehatan lansia dan terbentuk pelayanan kesehatan yang sesuai dengan kebutuhan lansia sehingga dapat meningkatkan derajat kesehatan lansia. Kata kunci: Posyandu Lansia, Panti Jompo, Pelayanan Kesehatan Lima Meja Abstract The elderly population continues to increase from year to year, so it is necessary to optimize the health care program for the elderly such as the elderly posyandu (poslan). The purpose of the project community service is to overcome the problem of health care program poslan at Panti Jompo Darussa'adah and Panti Jompo An-Nur which considered not optimal yet. In addition to the poslan service program that has not been optimal, the limited health facilities that support the program is also still a flame. The problem solving method is done by establishing poslan cadres, poslan socialization, training on 5 table tasks (physical examination and elderly independence, KMS completion and simple laboratory skills), simulation of poslan, provision of simple medical and laboratory facilities and carrying out elderly health support activities such as Elderly gymnastics. The results of the project community activities on both partners are the availability of a five-table health care system in both posyandu and the availability of trained elderly cadres as well as the availability of health-care equipment to perform physical and emotional mental health examination, the availability of simple laboratories as facilities used for early detection of disease in the elderly. The conclusion of the project community activities can increase the reach of elderly health service and formed health service in accordance with elderly needs so as to improve elderly health degree. Keywords: Elderly Posyandu, Nursing Home, FiveDesk Health Service.

Effects of Oral Administration of Monosodium Glutamate (MSG) on Obesity in Male Wistar Rats (Rattus Norvegicus) Mulyati Sri Rahayu; Sri Wahyuni; Yuziani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 9 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i9.355

Introduction: Monosodium glutamate (MSG) is one of the most widely employed food enhancers. Although the umami compound, controversy persists regarding the effects of MSG intake on body weight. Chronic MSG intake may result in excessive body weight gain and obesity. Consumption of MSG result in organ damage, cardiovascular disease, oxidative stress, and also risk factors for obesity. This study aims to determine the effect of oral MSG on obesity in adult male Wistar rats (Rattus norvegicus).Methods: This true experimental study used the post-test control group design. Twenty-four adult male Wistar rats were randomly divided into four groups: control (received distilled water), Group 1 (MSG 0.378 mg/gr BW), Group 2 (0.756 mg/gr BW) and Group 3 (1.512 mg/gr BW). The obesity parameter was obtained by the Lee index. Kruskal-Wallis test follows by Mann-Whitney test were used to compare the Lee index between groups.Results: Lee’s index mean for each group was 358.4%, 314.1%, 287.8%, and 320.9%, respectively. The Kruskal Wallis test showed a significant difference in the Lee index between groups (p = 0.043). A follow-up test using Mann-Whitney found a significant difference between group 2 and the control group (p = 0.043, p <0.05). The mean of Lee index of group 2 was 70.51% lower than the control group.Conclusion: This study concluded that Lee index was not increased in MSG-treated rats than in the control group after oral MSG intervention for 21 days.

GAMBARAN PERFORMA INSTRUKTUR KETERAMPILAN KLINIK PROGRAM STUDI PENDIDIKAN DOKTER FAKULTAS KEDOKTERAN UNIVERSITAS MALIKUSSALEH mulyati sri rahayu; Yuziani Yuziani
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Vol. 6: No. 2 (November, 2020)
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v6i2.2399

Performa seorang instruktur skill lab sangat berpengaruh terhadap pencapaian sasaran pembelajaran skill lab. Tujuan penelitian ini adalah untuk mengetahui gambaran performa instruktur skill lab Program Studi Kedokteran di FK Unimal. Jenis penelitian ini adalah deskriptif-analitik menggunakan rancangan cross sectional. Responden adalah 213 mahasiswa. Instrumen yang digunakan adalah “Instrument for Evaluating Clinical Skills lab Teacher’s Didactical Performance”. Hasil penelitian menunjukkan performa keterampilan mengajar, keterampilan interpersonal dan komunikasi dan performa kondisi/strategi pelatihan intruktur keterampila klinik didinilai baik oleh mahasiswa dengan persentase kategori baik sampai sangat baik lebih dari 90 %. Kesimpulan penelitian ini menunjukkan bahwa secara umum performa instruktur keterampilan klinik di Program Studi Kedokteran FK Unimal sudah baik berdasarkan persepsi mahasiswa. Kata kunci : keterampilan klinis, instruktur, perfoma mengajar, instrumen

HUBUNGAN INDEKS MASSA TUBUH DENGAN PENYAKIT JANTUNG KORONER DI RUMAH SAKIT UMUM CUT MEUTIA KABUPATEN ACEH UTARA Mulyati Sri Rahayu
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Vol. 2: No. 1 (Mei, 2016)
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v2i1.400

Penyakit jantung koroner (PJK) merupakan penyakit kardiovaskular yang menyebabkan kematian nomor satu di Indonesia. Salah satu faktor risiko yang sering dijumpai pada penderita PJK adalah obesitas sentral. Lingkar leher dan lingkar pinggang saat ini dianggap sebagai salah satu cara pengukuran antropometri yang lebih sensitif, murah, dan mudah dalam menilai obesitas sentral. Penelitian ini bertujuan untuk mengetahui hubungan indeks massa tubuh dengan PJK di RSU Cut Meutia Kabupaten Aceh Utara tahun 2014. Penelitian ini menggunakan metode analitik dengan pendekatan cross sectional yang dilaksanakan pada bulan September 2014 sampai Januari 2015. Pengambilan sampel penelitian menggunakan cara convenient sampling dengan jumlah sampel yang memenuhi kriteria inklusi dan eksklusi sebanyak 56 orang. Analisis hubungan indeks massa tubuh dengan PJK menggunakan uji statistik Chi Square dengan derajat signifikan (α) 0,05. Berdasarkan hasil analisis bivariat tidak terdapat hubungan antara indeks massa tubuh dengan PJK (p value = 0,197).

Effects of Oral Administration of Monosodium Glutamate (MSG) on Obesity in Male Wistar Rats (Rattus Norvegicus) Mulyati Sri Rahayu; Sri Wahyuni; Yuziani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 9 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i9.355

Introduction: Monosodium glutamate (MSG) is one of the most widely employed food enhancers. Although the umami compound, controversy persists regarding the effects of MSG intake on body weight. Chronic MSG intake may result in excessive body weight gain and obesity. Consumption of MSG result in organ damage, cardiovascular disease, oxidative stress, and also risk factors for obesity. This study aims to determine the effect of oral MSG on obesity in adult male Wistar rats (Rattus norvegicus).Methods: This true experimental study used the post-test control group design. Twenty-four adult male Wistar rats were randomly divided into four groups: control (received distilled water), Group 1 (MSG 0.378 mg/gr BW), Group 2 (0.756 mg/gr BW) and Group 3 (1.512 mg/gr BW). The obesity parameter was obtained by the Lee index. Kruskal-Wallis test follows by Mann-Whitney test were used to compare the Lee index between groups.Results: Lee’s index mean for each group was 358.4%, 314.1%, 287.8%, and 320.9%, respectively. The Kruskal Wallis test showed a significant difference in the Lee index between groups (p = 0.043). A follow-up test using Mann-Whitney found a significant difference between group 2 and the control group (p = 0.043, p <0.05). The mean of Lee index of group 2 was 70.51% lower than the control group.Conclusion: This study concluded that Lee index was not increased in MSG-treated rats than in the control group after oral MSG intervention for 21 days.

Korelasi Tekanan Darah dengan Fungsi Kognitif pada Pasien Hipertensi di Puskesmas Kota Lhokseumawe Rani Aprilita; Mulyati Sri Rahayu; Anna Millizia; Yuziani Yuziani
Jurnal Kesehatan Terpadu (Integrated Health Journal) Vol 13 No 1 (2022): Jurnal Kesehatan Terpadu (Integrated Health Journal) Mei 2022
Publisher : Poltekkes Kemenkes Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32695/jkt.v13i1.183

Hypertension, or an elevation of blood pressure, is often asymptomatic and called the “silent disease.” Hypertension is associated with impaired cognitive function that interferes with the patient’s activities. This study aimed to analyze the correlation between blood pressure and cognitive function in patients with hypertension at Community Health Center in Lhokseumawe City. This analytic study with a cross-sectional method employed the consecutive sampling approach from March 17 to April 16, 2021. Cognitive function was examined with Mini-Mental State Examination (MMSE) questionnaire. Spearman rank test was performed to analyze the data. Among sixty patients who participated in this study, thirty-five patients (58.3%) had stage 1 hypertension, whereas 25 (41.7%) had stage 2 hypertension. There were 25 patients (41.7%) with normal cognitive function, 28 patients (46.7%) with mild cognitive impairment, and seven patients (11.7%) with moderate cognitive impairment. Correlation coefficient demonstrated a positive correlation between blood pressure and cognitive function (r=+0.31, p-value=0.016). Uncontrolled hypertension will be a risk factor for cognitive decline. This study concluded that blood pressure is positively correlated with cognitive decline in hypertensive patients at Community Health Center in Lhokseumawe.

UJI AKTIVITAS EKSTRAK ETANOL DAUN SUKUN (ARTOCARPUS ALTILIS) TERHADAP BAKTERI ESCHERICHIA COLI Khafifah Ali; Yuziani; Mulyati Sri Rahayu
Jurnal Ilmiah Manusia Dan Kesehatan Vol 5 No 2 (2022): Jurnal Ilmiah Manusia Dan Kesehatan
Publisher : FAKULTAS ILMU KESEHATAN UNIVERSITAS MUHAMMADIYAH PAREPARE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31850/makes.v6i2.1561

Escherichia coli merupakan salah satu jenis utama bakteri Gram-negatif. Penyakit infeksi yang diakibatkan oleh bakteri Escherichia coli merupakan penyebab utama morbiditas dan mortalitas di dunia. Salah satu alternatif yang dapat dilakukan untuk mengatasi hal tersebut adalah dengan memanfaatkan senyawa yang terkandung dalam daun sukun. Daun sukun (Artocarpus altilis) mengandung senyawa seperti flavonoid, saponin, tanin, triterpen/steroid dan glikosida yang berfungsi sebagai antibakteri. Tujuan penelitian ini adalah untuk menguji apakah ekstrak etanol daun sukun (Artocarpus altilis) dapat mengahambat pertumbuhan bakteri Escherichia coli. Metode penelitian yang digunakan adalah metode posttest only control group design. Uji pengaruh ekstrak etanol daun sukun dilakukan dengan metode difusi dengan konsentrasi 10%, 20% dan 40% dengan kontrol positif amoxicillin dan kontrol negatif Dimethylsulfoxide (DMSO). Hasil penelitian ini didapatkan bahwa konsentrasi 10%, 20%, dan 40% menghasilkan rata-rata zona hambat sebesar 13,88 mm, 14,5 mm dan 14,3 mm. Data dianalisis menggunakan uji Kruskal-Wallis dengan p value 0,001 dan dilanjutkan dengan uji Mann-Whitney dengan adanya perbedaan yang bermakna p1 dan p2 (p : 0,035). Kesimpulan yang didapatkan dari penelitian ini adalah ekstrak etanol daun sukun (Artocarpus altilis) dengan konsentrasi 10%, 20%, dan 40% memiliki daya aktivitas antibakteri yang lemah terhadap Escherichia coli. Kata kunci : Antibakteri, ekstrak daun sukun, Escherichia coli

Hubungan Pemberian ASI Eksklusif dengan Kejadian Dermatitis Atopik pada Balita di Rumah Sakit Umum Cut Meutia Aceh Utara Mulyati Sri Rahayu; Wizar Putri Mellaratna; Ghina Nurul Tasha
Jurnal Ilmiah Manusia Dan Kesehatan Vol 5 No 3 (2022): Jurnal Ilmiah Manusia dan Kesehatan
Publisher : FAKULTAS ILMU KESEHATAN UNIVERSITAS MUHAMMADIYAH PAREPARE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31850/makes.v5i3.1836

Dermatitis atopik (DA) adalah penyakit kulit inflamasi yang khas, bersifat kronis dan sering terjadi kekambuhan (eksaserbasi) terutama mengenai bayi dan anak-anak, namun dapat pula terjadi pada orang dewasa. Penyakit ini biasanya disertai dengan peningkatan kadar IgE dalam serum serta adanya riwayat rhinitis alergik dan asma pada keluarga maupun penderita. Penyakit alergi seperti dermatitis atopik pada anak-anak harus dicegah sedini mungkin karena anak memerlukan tumbuh dan kembang yang optimal. Faktor pencegah tersebut diantaranya dengan memberikan ASI eksklusif dimana selain memberikan nutrisi diduga mampu melindungi bayi terhadap penyakit alergi seperti dermatitis atopik. Penelitian ini bertujuan untuk mengetahui hubungan antara pemberian ASI eksklusif dengan kejadian dermatitis atopik pada balita di Rumah Sakit Umum Cut Meutia Aceh Utara. Metode penelitian yang digunakan adalah observasional analitik dengan pendekatan potong lintang (cross sectional) dengan teknik purposive sampling. Hasil penelitian menunjukkan terdapat 46 sampel yang terdiri dari balita perempuan 23 orang (50%) dan balita laki-laki 23 orang (50%) dengan usia terbanyak yaitu pada rentang usia 7-24 bulan (50%). Responden yang menderita dermatitis atopik lebih banyak tidak mendapatkan ASI eksklusif yaitu 14 orang (63,6%). Berdasarkan analisis uji Chi Square, didapatkan nilai OR 0,484 (95%=0,148-1,578) dan nilai p yaitu 0,226 (p>0,05). Kesimpulan dari penelitian ini adalah tidak terdapat hubungan yang signifikan antara pemberian ASI eksklusif terhadap kejadian dermatitis atopik pada balita di Rumah Sakit Umum Cut Meutia Aceh Utara.

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