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All Journal Majalah Kedokteran Sriwijaya SRIWIJAYA JOURNAL OF MEDICINE Bioscientia Medicina : Journal of Biomedicine and Translational Research International Journal of Nasopharyngeal Carcinoma Bioscientia Medicina : Journal of Biomedicine and Translational Research
Denny Satria Utama
Department Of Otorhinolaryngology Head And Neck Surgery Faculty Of Medicine Universitas Sriwijaya /RSUP Dr. Moehammad Hoesin Palembang
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : International Journal of Nasopharyngeal Carcinoma

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CORRELATION OF KI67 LEVEL TO METASTATIC EVENTS IN NASOPHARYNGEAL CARCINOMA Eriza; Kurnia, Ermalinda; Utama, Denny Satria
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i2.4276

Abstract

Introduction Nasopharyngeal carcinoma (KNF) is a malignant squamous cell tumor occurring in the nasopharyngeal epithelial region where the cuboid epithelium is transformed into squamous cells. One of the typical signs of malignancy is uncontrolled cell proliferation. K67 is an immunohistochemical (IHC) test to assess cell proliferation activity. Increased Ki67 expression is associated with increased mitotic activity in cell proliferation. Objective To determine the correlation of ki67 expression to regional and distant metastases events of nasopharyngeal carcinoma at KNF in Dr. Mohammad Hoesin Palembang. Methods This cross-sectional study was conducted on 31 subjects of KNF patients who had been diagnosed in Oncology Division of Department of Ear Nose and Throat Head Neck Surgery, then performed immunohistochemistry inspection of KI67 in Department of Anatomical Pathology of Dr. Mohammad Hoesin Palembang. The subjects were collected consecutive sampling from October to December 2017 and performed other tests for staging such as computer tomography, chest x ray and abdominal ultrasound. Results In the Ki67 level correlation analysis of the incidence of metastasis in nasopharyngeal carcinoma, the correlation coefficient was 0.98 with very strong correlation strength and the positive correlation was not statistically significant (p=0.599). However, in Ki67 level correlation analysis of histopathology result of nasopharyngeal carcinoma was found correlation coefficient of 0.385 and positive correlation which was statistically significant (p=0.032). Conclusion Ki67 levels of metastatic occurrence in nasopharyngeal carcinoma have no statistically significant correlation. However, Ki67 level on histopathological results of nasopharyngeal carcinoma and Ki67 immunoreactivity with primary tumor has a statistically significant correlation.
THE CHARACTERISTICS OF ADOLESCENTS NASOPHARYNGEAL CARCINOMA PATIENTS IN MOHAMMAD HOESIN GENERAL HOSPITAL PALEMBANG JANUARY 2013-DECEMBER 2017 Melania; Denny Satria Utama
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 01 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (655.031 KB) | DOI: 10.32734/ijnpc.v1i1.955

Abstract

Abstract Introduction: Nasopharyngeal carcinoma is (NPC) mostly found in men of productive age with a ratio of men and women 2,18: 1 and 60% of patients age between 25 and 60 years. NPCs are very rarely found in adolescents, namely age 11 to 21 years. Objective: To determine the characteristics of nasopharyngeal carcinoma in adolescent patients at ORL-HNS Department of Dr. Mohammad Hoesin General Hospital Palembang. Method: This is a descriptive retrospective study. The sample is all patients diagnosed with NPC in adolescence at ORL-HNS Department of Dr. Mohammad Hoesin General Hospital Palembang in January 2013 to December 2017 period. Results: In this study, the number of adolescent NPC patients from January 2013 to December 2017 was 12 patients. The majority of adolescent NPC patients were male (66,6%). The most common histopathological finding was WHO 2B (50%). Based on the T category, largely, the patients were T4 (41,6%). Most patients with Nodules were N3 (58,3%) and came to the ENT clinic were already in stage IV (41,6%). Conclusion: Adolescent nasopharyngeal carcinoma is more common in men than women (2: 1), and shows a response to proper therapy.
THE CHARACTERISTICS OF NASOPHARYNGEAL CARCINOMA PATIENTS IN MOEHAMMAD HOESIN GENERAL HOSPITAL PALEMBANG JANUARY 2013 - DECEMBER 2017 Denny Satria Utama
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 01 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (582.164 KB) | DOI: 10.32734/ijnpc.v1i1.960

Abstract

Introduction Nasopharyngeal carcinoma is a malignant tumor that grows in nasopharyngeal area with a predilection in fossa of Rossenmuller and roof of nasopharynx. Nasopharyngeal carcinoma is the most common malignant tumor in the neck and head area. This research is to determine the characteristics of nasopharyngeal carcinoma at Moehammad Hoesin General Hospital Palembang. Methods This study design is restrospective descriptive and took the sample from medical records in department of ORL-HNS Moehammad Hoesin General Hospital Palembang between January 2013 until December 2017. Results In this study, the number of nasopharyngeal carcinoma patients January 2013 to December 2017 was 284 patient. Most of them were male (72.86%). The age of most patients ranges from 41-50 years (33.20%). The highest histopathological description of patients was WHO 2B (54.9%). Most patients were T4 (36.29%). Most patients nodules were N3 (34.09%). As many as 93.88% of patients have not experienced distant metastasis. Most patients came to the department of ORL-HNS had already been in stage IV (63.84%). The most chemotherapy regimens given were carboplatin and docetaxel. Conclusions Nasopharyngeal carcinoma is still a problem in many countries. The main management is radiotherapy with or without chemotherapy.
ROLE OF DIETARY INTAKE AS RISK FACTOR FOR NASOPHARYNGEAL CARCINOMA IN MUHAMMADIYAH HOSPITAL PALEMBANG JUNE 2017-SEPTEMBER 2018 Norman Imansyah Rizal; Denny Satria Utama
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 03 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v1i03.2056

Abstract

Introduction Nasopharyngeal Carcinoma (NPC) are the most common malignancy of Ear, Nose, Throat, Head and Neck in Indonesia. Until now Epstein Barr virus as factor causing NPC, but nonviral cause like dietary intake and food can also cause an increase in the prevalence of NPC. Objective To evaluate the role of dietary intake as a risk factor in NPC patients in the department ORLHNS Muhammadiyah Hospital Palembang. Material and method Using medical record data in Muhammadiyah Hospital Palembang from June 2017 until September 2018, this is a descriptive crossectional study. The primary outcomes were patient medical history about their dietary intake, as well as examination for NPC like physical examination, CT Scan, and biopsy result. Result A total of 17 cases of NPC, 64.70% (11 patients) were man and 35.3% (6 patients) were women. From medical history we get dietary factor that as risk factor to cause NPC were salted fish 11 patient (64.7%), 4 salted meat (23.5%) and 2 alcohol consumption (5.9%). Conclusion Dietary intake or food are a non-viral factors that correlate in increasing the risk of NPC. The highest dietary factors are salted fish (64.7%).
FACTORS THAT HAVE PROGNOSTIC VALUES IN THE MANAGEMENT OF NASOPHARYNGEAL CARCINOMA PATIENTS Chandra Kangga; Denny Satria Utama
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 01 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i01.3454

Abstract

Introduction: The survival rate of Nasopharyngeal carcinoma (NPC) patients is influenced by several prognostic factors, Such aspatient factors, tumor factors and therapeutic interventions carried out as well as the quality of care. Tumor factors in the form of spread of local invasion, regional lymphatic involvementand metastasis that is reflected in the TNM stage (Tumor, Nodule and Metastatic) are the most important prognostic factors of NPC. Objective: To determine the Prognostic factors that effectedsurvival rate of nasopharyngeal carcinoma patients. Material and methods: Analytic observational studywith particular design of survival analysis. Data was taken from medical records and then performed survival analysis on the studiedfactors. Sample of this studywas all patients who were first diagnosed NPC From January 2013 until December 2013 and meetinclusion and exclusion criteria is52 patients. Results:From 52 patients in the fifth year, 50% died and 50% survive. Survival was worse in the 30-39 year age group (30.8%), male sex (47.2%), Stage IV (44.4%), T4 size (40%), N1 size (23,1%), Distant metastases (40%), WHO type III (48.5%), chemoradiation (48.9%). In multivariate analysis, it was found that the variables that most influenced the survival of NPC patients based on p <0.05 and based on hazard ratio strength were T-size, N-size categories and Metastasis with 95% CI. Conclusion: Prognostic factors that affect the survival of NPC patients in RSUP. Dr. Mohammad Hoesin Palembang is a category of size T, N, and Metastasis.
VISUAL IMPAIRMENT IN NASOPHARYNGEAL CARCINOMA Apryanza Akbar; Denny Satria Utama
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 01 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i01.3504

Abstract

Introduction: he most common complaint in almost half of nasopharyngeal carcinoma (NPC) patients is a lump in the neck. Neurological symptoms occur less frequently, whereas blindness occurs in only less than one percent of cases. Case report: A 47-year-old male had complained about headache, nasal voice, and blindness in the right eye since a month ago. An examination found a mass in the right nasal cavity, right neck lymph nodes enlargement, damage to the right oculomotor (III), trochlear (IV), and abducens (VI) nerve, and right optic nerve (II). On funduscopy, the right macular reflex decreased. On CT scan there was a right nasopharyngeal mass extending to intracranial and right intraorbital spaces. Conclusion: There was a direct infiltration of NPC into surrounding and intracranial structures. Unilateral blindness might be caused by expansion to middle cerebral fossa and orbita. It could also be caused by optic nerve compression from surrounding tumor tissue.
Carboplatin and Docetaxel Chemotherapy in Nasopharyngeal Carcinoma: A Case Report Denny Satria Utama
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 3 No. 01 (2021): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v3i01.5725

Abstract

Introduction: Nasopharyngeal Carcinoma (NPC) is a squamous cell malignant tumor that usually occurs in the lateral wall of the nasopharynx near the area of the eustachian tube. NPC is often found in southern Asia. In head and neck areas, NPC is one of the top five malignant which has the highest frequency tumours in Indonesia. Case report: We reported a case of a 57-year-old man with complaints of obstruction in both noses, accompanied by headache. Based on medical history, physical and Radiology examination, we concluded that he was diagnosed with Nasopharyngeal Carcinoma WHO II Stage III (T3N0M0). Histopathology revealed a differentiated non keratinizing squamous cell carcinoma in the nasopharynx. Six cycles of carboplatin and docetaxel regimen as an induction chemotherapy were planned for this patient. The patient then performed a nasoendoscopy followed by nasopharyngeal CT scan evaluation and showed a good response after Chemotherapy. Conclusion: Carboplatin and docetaxel chemotherapy management in this patient was given according to the management of nasopharyngeal carcinoma and has given a good response to the patient
Audiometry Finding in Nasopharyngeal Carcinoma Patients in ENT-HN Department of Mohammad Hoesin General Hospital Palembang 1 June 2016-1 June 2020 Denny Satria Utama; Sella Vanessa Lie
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 3 No. 02 (2021): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v3i02.6321

Abstract

Introduction: Nasopharyngeal Carcinoma (NPC) is a type of epithelial carcinoma that arises from the nasopharynx mucosal lining that usually develops in the fossa of Rosenmüller. One of NPC’s initial signs is hearing loss. Objective: This study aims to determine the audiometry of patients with nasopharyngeal carcinoma in the ENT-HN department of Mohammad Hoesin General Hospital Palembang 1 June 2016-1 June 2020. Methods: This research is a descriptive observational study with cross-sectional study design using medical records of patients with nasopharyngeal carcinoma at Mohammad Hoesin General Hospital Palembang 1 June 2016 – 1 June 2020 who met the inclusion criteria. Results: From 48 samples, 42 samples (87,5%) were male, and 14 samples (29,2%) were included in the age range of 47-52 years. There were 18 samples (37,5%) suffering from a moderate degree of deafness. NPC patients mostly had conductive hearing loss (72,9%). Most of the sample suffered from bilateral hearing loss (75%). The majority of NPC patients had already been in stage IV (70,8%). It was found that NPC patients with stage IV suffered the most from conductive hearing loss (79,4%). Conclusion: NPC patients from 1 June 2016 – 1 June 2020 at ENT-HN Department of Mohammad Hoesin General Hospital Palembang were mostly male with an age range of 47-52 years who suffered from bilateral moderate conductive hearing loss and had already been in stage IV. It was found that most patients with stage IV of NPC had conductive hearing loss
Co-Authors Abdiaman Putra Dawolo Adelien, Adelien Apryanza Akbar Bahrun Indawan kasim Belly Sutopo Wijaya Chandra Kangga Dwi Handayani Erial Bahar Erial Bahar Eriza Eriza Eriza Ermalinda Kurnia Kemas Muhammad Alwan Dwiputra Kurnia, Ermalinda M Arvin Arliand0 Melania Norman Imansyah Rizal Nurul Lintang Amelia Priscilla Ralahayu Puspa Zuleika, Puspa Sella Vanessa Lie Valencia, Valencia Widyasari, Fiona