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CORRELATION OF KI67 LEVEL TO METASTATIC EVENTS IN NASOPHARYNGEAL CARCINOMA Eriza; Kurnia, Ermalinda; Utama, Denny Satria
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i2.4276

Introduction Nasopharyngeal carcinoma (KNF) is a malignant squamous cell tumor occurring in the nasopharyngeal epithelial region where the cuboid epithelium is transformed into squamous cells. One of the typical signs of malignancy is uncontrolled cell proliferation. K67 is an immunohistochemical (IHC) test to assess cell proliferation activity. Increased Ki67 expression is associated with increased mitotic activity in cell proliferation. Objective To determine the correlation of ki67 expression to regional and distant metastases events of nasopharyngeal carcinoma at KNF in Dr. Mohammad Hoesin Palembang. Methods This cross-sectional study was conducted on 31 subjects of KNF patients who had been diagnosed in Oncology Division of Department of Ear Nose and Throat Head Neck Surgery, then performed immunohistochemistry inspection of KI67 in Department of Anatomical Pathology of Dr. Mohammad Hoesin Palembang. The subjects were collected consecutive sampling from October to December 2017 and performed other tests for staging such as computer tomography, chest x ray and abdominal ultrasound. Results In the Ki67 level correlation analysis of the incidence of metastasis in nasopharyngeal carcinoma, the correlation coefficient was 0.98 with very strong correlation strength and the positive correlation was not statistically significant (p=0.599). However, in Ki67 level correlation analysis of histopathology result of nasopharyngeal carcinoma was found correlation coefficient of 0.385 and positive correlation which was statistically significant (p=0.032). Conclusion Ki67 levels of metastatic occurrence in nasopharyngeal carcinoma have no statistically significant correlation. However, Ki67 level on histopathological results of nasopharyngeal carcinoma and Ki67 immunoreactivity with primary tumor has a statistically significant correlation.

Profil Klinis Karsinoma Nasofaring di Departemen THTKL RSUP Dr. Mohammad Hoesin Palembang Tahun 2014-2015 Abdiaman Putra Dawolo; Denny Satria Utama; Bahrun Indawan Kasim
Majalah Kedokteran Sriwijaya Vol 49, No 1 (2017): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v49i1.8318

Karsinoma nasofaring (KNF) adalah tumor ganas THTKL yang paling banyak dijumpai di Indonesia. Gejala dan tanda karsinoma nasofaring yang sering berupa benjolan di leher, obstruksi hidung, epistaksis dan diplopia.Penelitian ini bertujuan untuk mengetahui profil klinis karsinoma nasofaring di RSUP Dr. Mohammad Hoesin Palembang tahun 2014-2015.Penelitian ini merupakan penelitian deskriptif berupa serial kasus dengan menggunakan data sekunder dari rekam medis pasien di RSUP Dr. Mohammad Hoesin Palembang. Sampel penelitian ini adalah semua rekam medik pasien karsinoma nasofaring di RSUP Dr. Mohammad Hoesin Palembang tahun 2014-2015. Pada tahun 2014 terdapat sebanyak 60 kasus (16,85%) dan pada tahun 2015 terdapat 50 kasus (14,53%) dari total pasien KNF yang datang ke RSMH. Pasien KNF paling banyak (30,91%) terdapat pada kelompok usia 46-55 tahun. Sebanyak 72,73% pasien KNF adalah laki-laki. Gejala yang paling sering ditemui adalah hidung tersumbat (49,09%), benjolan di leher (43,64%), dan mimisan (36,36%). Sebanyak 81,82% kasus KNF adalah KNF WHO III, selebihnya adalah KNF WHO II (15,45%) KNF WHO I (2,73%). Mayoritas kasus KNF adalah KNF stadium IV (77,27%). Pasien KNF paling banyak terdapat pada kelompok usia 46-55 tahun. KNF lebih sering terjadi pada laki-laki daripada perempuan. Gejala klinik yang paling sering ditemui adalah hidung tersumbat, benjolan di leher dan mimisan. Mayoritas gambaran histopatologi KNF adalah KNF WHO III. Sebagian besar penderita KNF didiagnosis sebagai KNF stadium IV.

Prevalensi Abses Leher Dalam di RSUP dr. Mohammad Hoesin Palembang Periode 1 Januari 2012 – 31 Desember 2015 M Arvin Arliand0; Adelien Adelien; Denny Satria Utama
Majalah Kedokteran Sriwijaya Vol 49, No 3 (2017): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v49i3.8509

Abses leher dalam merupakan kumpulan nanah yang terdapat di dalam ruang-ruang yang terbentuk oleh fasia-fasia leher. Abses terjadi akibat komplikasi dari infeksi tonsil, infeksi saluran nafas, infeksi gigi dan periodontal dan diperparah oleh penyakit diabetes melitus dan imunodefisiensi. Gejala klinik yang dapat ditemukan pada pasien abses leher dalam juga beragam.Penelitian ini dilakukan untuk mengidentifikasi prevalensi abses leher dalam di RSUP dr. Mohammad Hoesin Palembang periode 1 Januari 2012-31 Desember 2015.Jenis penelitian ini adalah deskriptif observasional. Data sampel penelitian diambil dari rekam medik pasien abses leher dalam yang dirawat inap di RSUP dr. Mohammad Hoesin Palembang pada 1 Januari 2012-31 Desember 2015. Didapatkan 26 kasus yang memenuhi kriteria inklusi yang kemudian dideskripsikan menggunakantabel distribusi frekuensi.Dari 26 kasus yang diteliti, pasien abses leher dalam paling banyak (65,4%) adalah laki-laki, (26,9%)20-29 tahun, dengan tiga gejala klinik terbanyak (80,8%)adalah bengkak, (73,1%)odinofagia, dan(69,2%) demam. Abses leher dalam paling banyak(46,2%) terjadi di ruang submandibula dan (69,2%)disebabkan oleh infeksi odontogenik. Jarang dilakukan (15,3%)kultur pada abses leher dalam dengan hasil kultur paling banyak(75%) adalah Klabsiella pneumoniae. 23,1% kasus terdapat penyakit diabetes melitus dan tidak ada yang memiliki penyakit immunodefisiensi.Abses leher dalam paling banyak ditemukan pada laki-laki, usia 20-29 tahun, dengan gejala bengkak, demam, dan odinofagia, terjadi di ruang submandibula dan disebabkan oleh infeksi odontogenik.

Association of Smoking Habit With Nasopharyngeal Carcinoma Stage in ENT-HN Policlinic RSUP DR. Mohammad Hoesin Palembang Kemas Muhammad Alwan Dwiputra; Dwi Handayani; Denny Satria Utama
Majalah Kedokteran Sriwijaya Vol 51, No 2 (2019): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v51i2.8537

Karsinoma nasofaring (KNF) adalah tumor ganas yang berada dibagian mukosa rongga nasofaring yang disebabkan oleh banyak faktor, salah satu faktornya adalah merokok. Kebiasaan merokok meningkatkan kepekaan terhadap terjadinya KNF. Merokok menyebabkan terjadinya mutasi gen p53, gen p53 memegang peranan terhadap kerusakan DNA sel dengan jalan menghambat progresi sel. Hilangnya fungsi gen p53 menyebabkan hilangnya kontrol pada siklus sel, sehingga terjadi proliferasi sel-sel sehingga besar peluangnya untuk menjadi sel kanker. Penelitian ini bertujuan untuk menganalisis hubungan kebiasaan merokok dengan stadium karsinoma nasofaring.Penelitian ini adalah studi observasional analitik dengan rancangan cross sectional. Sampel adalah pasien poliklinik THT-KL dan rekam medik pasien karsinoma nasofaring di RSUP Dr. Mohammad Hoesin Palembang bulan Januari 2017-Desember 2018.Sampel penelitian ini berjumlah 70 kasus.Hasil penelitian ini akan disajikan dalam bentuk tabel dan narasi.Dari 70 kasus pasien KNF didapatkan semua penderita adalah laki-laki (100%), kelompok usia ?50 tahun (52,9%), pekerjaan non PNS (90%), alamat diluar Palembang (82,9%), keluhan utama benjolan pada leher (42,9%) dan stadium 4 (81,4%). Hasil uji Fisher’s Exact Test tidak terdapat hubungan yang bermakna antara jenis rokokdengan stadium KNFdinyatakan oleh p value=0,067, terdapat hubungan yang bermakna antara jumlah konsumsi rokokdengan stadium KNFdinyatakan oleh p value=0,042 dan tidak terdapat hubungan yang bermakna antara usia mulai merokokdengan stadium KNFdinyatakan oleh p value=1,000.Hasil uji korelasi pada pasien KNFmenunjukkan bahwa jumlah rokok (p= 0,043)merupakan faktor determinan terjadinya stadium KNFdanjenis rokok (p= 0,198) bukan merupakan faktor determinan terjadinya stadium KNF. Terdapat hubungan yang bermakna antara kebiasaan merokok dengan stadium KNF.

Prevalensi Rinosinusitis Kronik di RSUP Dr. Mohammad Hoesin Palembang Nurul Lintang Amelia; Puspa Zuleika; Denny Satria Utama
Majalah Kedokteran Sriwijaya Vol 49, No 2 (2017): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v49i2.8377

Rinosinusitis kronik merupakan penyakit yang ditandai dengan peradangan pada mukosa hidung dan sinus paranasal dengan durasi minimal 12 minggu. Diagnosis rinosinusitis kronik dapat ditegakkan dari adanya dua atau lebih keluhan. Berdasarkan anatomi sinus paranasal, rinosinusitis dikelompokkan menjadi rinosinusitis maksila, rinosinustis etmoid, rinosinusitis frontal dan rinosinusitis sfenoid. Faktor-faktor yang dapat menjadi penyebab meliputi faktor penjamu baik sistemik maupun lokal dan faktor lingkungan. Komplikasi yang dapat terjadi yaitu kelainan orbita dan intrakranial, osteomielitis dan kelainan paru. Penelitian ini bertujuan mengetahui prevalensi rinosinusitis kronik di RSUP Dr. Mohammad Hoesin Palembang.Penelitian ini merupakan penelitian observasional deskriptif. Data didapatkan melalui semua rekam medis pasien yang didiagnosis rinosinusitis kronik pada periode 01 Januari 2015 sampai dengan 31 Desember 2015 di RSUP Dr. Mohammad Hoesin Palembang yang memenuhi kriteria inklusi diambil sebagai sampel penelitian. Dari 140 pasien rinosinusitis, didapatkan 73 pasien rinosinusitis kronik, paling banyak (58,9%) pada laki-laki dan pada kelompok usia 46 – 52 (19,2%). Riwayat penyakit keluarga rinitis alergi paling banyak ditemukan (26%). Jenis rinosinusitis terbanyak adalah rinosinusitis maksila (28,8%). Gejala mayor paling sering dikeluhkan (69,9%) adalah hidung tersumbat dan gejala minor paling sering dikeluhkan (87,7%) adalah sakit kepala. Komplikasi yang sering terjadi adalah kelainan orbita (9,6%).Rinosinusitis kronik banyak ditemukan di bagian T.H.T.K.L RSUP Dr. Mohammad Hoesin Palembang. Kasus pada laki-laki lebih banyak dibanding pada perempuan dan banyak ditemukan pada usia 46-52 tahun.Gejala mayor yang sering dikeluhkan adalah hidung tersumbat dan gejala minor yang sering dikeluhkan ada sakit kepala.

Relationship between Primary Tumors of Nasopharyngeal Carcinoma with the Degree of Conductive Hearing Loss in Dr. Mohammad Hoesin Hospital Palembang Denny Satria Utama; Eriza; Priscilla Ralahayu; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 3 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i3.453

Background. Nasopharyngeal carcinoma is a malignant tumor that grows in the nasopharyngeal area with predilection in the fossa Rossenmuller and the nasopharyngeal roof adjacent to the Eustachian tube, so one of NPC’s early symptoms is ear symptoms. Hearing loss is a common symptom found in people with NPC due to dysfunction of the Eustachian tube, a continuing middle ear disorder that can result in conductive hearing loss.This study aims to find out the relationship between primary tumor of NPC and the degree of conductive hearing loss at dr. Mohammad Hoesin Hospital Palembang. Methods. This is a cross sectional study that obtained 42 samples from the medical records at Dr. Mohammad Hoesin Hospital Palembang that met the inclusion and exclusion criteria. The study subjects collected in total sampling have been conducted audiometry examinations at the ORLHNS clinic of Dr. Mohammad Hoesin Hospital Palembang during the period January 2019 - April 2021. Results. The proportion of hearing loss in NPC patients in this study was 30 subjects (71.4%) with the highest proportion of hearing loss complaints being 33.3%. The proportion of conductive hearing loss of nasopharyngeal carcinoma patients in the study was 33 subjects (78.5%) right ear and 28 subjects (66.7%) left ear. There was a significant association between the degree of the NPC primary tumor and the incidence of conductive deafness of the left ear, but there was no significant association in the right ear. There is a significant correlation between NPC primary tumors and left ear hearing thresholds at frequencies of 500 Hz and 4000 Hz, but there is no significant association between the degree of NPC primary tumor and right ear hearing loss. Conclusions. There is significant correlation between the primary tumor of NPC and the hearing threshold of the left ear but there was no significant association in the right ear.

Relationship between Primary Tumors of Nasopharyngeal Carcinoma with the Degree of Conductive Hearing Loss in Dr. Mohammad Hoesin Hospital Palembang Denny Satria Utama; Eriza; Priscilla Ralahayu; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 3 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i3.453

Background. Nasopharyngeal carcinoma is a malignant tumor that grows in the nasopharyngeal area with predilection in the fossa Rossenmuller and the nasopharyngeal roof adjacent to the Eustachian tube, so one of NPC’s early symptoms is ear symptoms. Hearing loss is a common symptom found in people with NPC due to dysfunction of the Eustachian tube, a continuing middle ear disorder that can result in conductive hearing loss.This study aims to find out the relationship between primary tumor of NPC and the degree of conductive hearing loss at dr. Mohammad Hoesin Hospital Palembang. Methods. This is a cross sectional study that obtained 42 samples from the medical records at Dr. Mohammad Hoesin Hospital Palembang that met the inclusion and exclusion criteria. The study subjects collected in total sampling have been conducted audiometry examinations at the ORLHNS clinic of Dr. Mohammad Hoesin Hospital Palembang during the period January 2019 - April 2021. Results. The proportion of hearing loss in NPC patients in this study was 30 subjects (71.4%) with the highest proportion of hearing loss complaints being 33.3%. The proportion of conductive hearing loss of nasopharyngeal carcinoma patients in the study was 33 subjects (78.5%) right ear and 28 subjects (66.7%) left ear. There was a significant association between the degree of the NPC primary tumor and the incidence of conductive deafness of the left ear, but there was no significant association in the right ear. There is a significant correlation between NPC primary tumors and left ear hearing thresholds at frequencies of 500 Hz and 4000 Hz, but there is no significant association between the degree of NPC primary tumor and right ear hearing loss. Conclusions. There is significant correlation between the primary tumor of NPC and the hearing threshold of the left ear but there was no significant association in the right ear.

THE CHARACTERISTICS OF ADOLESCENTS NASOPHARYNGEAL CARCINOMA PATIENTS IN MOHAMMAD HOESIN GENERAL HOSPITAL PALEMBANG JANUARY 2013-DECEMBER 2017 Melania; Denny Satria Utama
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 01 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Abstract Introduction: Nasopharyngeal carcinoma is (NPC) mostly found in men of productive age with a ratio of men and women 2,18: 1 and 60% of patients age between 25 and 60 years. NPCs are very rarely found in adolescents, namely age 11 to 21 years. Objective: To determine the characteristics of nasopharyngeal carcinoma in adolescent patients at ORL-HNS Department of Dr. Mohammad Hoesin General Hospital Palembang. Method: This is a descriptive retrospective study. The sample is all patients diagnosed with NPC in adolescence at ORL-HNS Department of Dr. Mohammad Hoesin General Hospital Palembang in January 2013 to December 2017 period. Results: In this study, the number of adolescent NPC patients from January 2013 to December 2017 was 12 patients. The majority of adolescent NPC patients were male (66,6%). The most common histopathological finding was WHO 2B (50%). Based on the T category, largely, the patients were T4 (41,6%). Most patients with Nodules were N3 (58,3%) and came to the ENT clinic were already in stage IV (41,6%). Conclusion: Adolescent nasopharyngeal carcinoma is more common in men than women (2: 1), and shows a response to proper therapy.

THE CHARACTERISTICS OF NASOPHARYNGEAL CARCINOMA PATIENTS IN MOEHAMMAD HOESIN GENERAL HOSPITAL PALEMBANG JANUARY 2013 - DECEMBER 2017 Denny Satria Utama
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 01 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Introduction Nasopharyngeal carcinoma is a malignant tumor that grows in nasopharyngeal area with a predilection in fossa of Rossenmuller and roof of nasopharynx. Nasopharyngeal carcinoma is the most common malignant tumor in the neck and head area. This research is to determine the characteristics of nasopharyngeal carcinoma at Moehammad Hoesin General Hospital Palembang. Methods This study design is restrospective descriptive and took the sample from medical records in department of ORL-HNS Moehammad Hoesin General Hospital Palembang between January 2013 until December 2017. Results In this study, the number of nasopharyngeal carcinoma patients January 2013 to December 2017 was 284 patient. Most of them were male (72.86%). The age of most patients ranges from 41-50 years (33.20%). The highest histopathological description of patients was WHO 2B (54.9%). Most patients were T4 (36.29%). Most patients nodules were N3 (34.09%). As many as 93.88% of patients have not experienced distant metastasis. Most patients came to the department of ORL-HNS had already been in stage IV (63.84%). The most chemotherapy regimens given were carboplatin and docetaxel. Conclusions Nasopharyngeal carcinoma is still a problem in many countries. The main management is radiotherapy with or without chemotherapy.

ROLE OF DIETARY INTAKE AS RISK FACTOR FOR NASOPHARYNGEAL CARCINOMA IN MUHAMMADIYAH HOSPITAL PALEMBANG JUNE 2017-SEPTEMBER 2018 Norman Imansyah Rizal; Denny Satria Utama
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 03 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v1i03.2056

Introduction Nasopharyngeal Carcinoma (NPC) are the most common malignancy of Ear, Nose, Throat, Head and Neck in Indonesia. Until now Epstein Barr virus as factor causing NPC, but nonviral cause like dietary intake and food can also cause an increase in the prevalence of NPC. Objective To evaluate the role of dietary intake as a risk factor in NPC patients in the department ORLHNS Muhammadiyah Hospital Palembang. Material and method Using medical record data in Muhammadiyah Hospital Palembang from June 2017 until September 2018, this is a descriptive crossectional study. The primary outcomes were patient medical history about their dietary intake, as well as examination for NPC like physical examination, CT Scan, and biopsy result. Result A total of 17 cases of NPC, 64.70% (11 patients) were man and 35.3% (6 patients) were women. From medical history we get dietary factor that as risk factor to cause NPC were salted fish 11 patient (64.7%), 4 salted meat (23.5%) and 2 alcohol consumption (5.9%). Conclusion Dietary intake or food are a non-viral factors that correlate in increasing the risk of NPC. The highest dietary factors are salted fish (64.7%).

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