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All Journal Journal of Midwifery Jurnal Ners Jurnal Ilmu Kesehatan Indonesia (JIKSI) ARMADA : Jurnal Penelitian Multidisiplin Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI)

Gestina Aliska

Fakultas Kedokteran Universitas Andalas

Author-ID : 4165600

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Kandungan Timbal pada Sala Lauak yang Dijual di Pasar Raya Padang Akibat Penggunaan Kertas Ketikan sebagai Pembungkus Habifa Mulya Cita; Asterina Asterina; Gestina Aliska
Jurnal Ilmu Kesehatan Indonesia Vol 1 No 1 (2020): Maret 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Latar Belakang. Timbal merupakan logam berat yang dapat memberikan efek buruk terhadap kesehatan manusia. Timbal masuk ke dalam tubuh manusia melalui saluran pernafasan, saluran cerna, dan kulit. Makanan dapat terkontaminasi oleh timbal apabila pengemasan tidak tepat, misalnya pada sala lauak yang dibungkus menggunakan kertas ketikan dapat masuk ke dalam tubuh. Objektif. Penelitian ini bertujuan untuk membuktikan adanya kandungan timbal pada sala lauak yang dijual di Pasar Raya akibat penggunaan kertas ketikan sebagai pembungkus. Metode. Penelitian ini bersifat deskriptif dan dilakukan di Laboratorium Air Fakultas Teknik Lingkungan Universitas Andalas pada Mei 2018 – November 2018. Jumlah sampel sebanyak 34 sampel terdiri 17 sampel sala lauak yang dibungkus kertas ketikan dan 17 sampel yang tidak dibungkus kertas ketikan dengan menggunakan teknik total sampling. Pemeriksaan sampel menggunakan alat ICP (Inductively Coupled Plasma). Hasil. Hasil penelitian didapatkan seluruh sala lauak yang dijual pedagang di Pasar Raya Padang positif mengandung timbal, baik yang dibungkus kertas ketikan maupun yang tidak dibungkus. Rata-rata kadar timbal pada sala lauak yang dibungkus sebesar 0,172 ppm dan sala lauak yang tidak dibungkus sebesar 0,167 ppm. Kesimpulan. seluruh sampel sala lauak mengandung logam timbal dan terdapat peningkatan kadar timbal akibat pembungkusan. Kata kunci: logam timbal, sala lauak, kertas ketikan

Prevalensi Gen OXA-23 pada Isolat Klinis Bakter Acinetobacter baumanii di RSUP Dr. M. Djamil Padang Mhd. Alzaref; Linosefa Linosefa; Gestina Aliska
Jurnal Ilmu Kesehatan Indonesia Vol 1 No 3 (2020): November 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Acinetobacter baumannii is such a big challenge in this modern era because of their multi-drug resistance (MDR) through their resistance mechanism, namely the production of beta lactamase enzymes, one of them is oxacillinases. Several studies have revealed that the OXA-23 gene has an important role in the production of the beta lactamase enzyme so that these bacteria are resistant to antibiotics, especially carbapenem. This study was conducted to determine the description of the resistance of the Acinetobacter baumannii by looking at the prevalence of the OXA-23 gene in clinical isolates of these bacteria at RSUP Dr. M. Djamil Padang. This study was a descriptive observational study and used a cross-sectional design using polymerase chain reactions (PCR) and electrophoresis techniques. The samples were clinical isolates of Acinetobacter baumannii bacteria stored in the Microbiology Laboratory of the Faculty of Medicine, Andalas University with inclusion and exclusion criteria. Of the 150 clinical isolates of Acinetobacter baumannii studied, most of the bacteria were still sensitive to the antibiotics of Amikacin (84%), Tigecycline (78.76%), and Trimethoprim / Sulfamethoxazole (76.77%). Meanwhile, all of the Acinetobacter baumannii isolates were resistant to cefazolin. In PCR and electrophoresis tests, 50 clinical isolates were positive for the OXA-23 gene. 46 of them were carbapenem resistant, while the other 4 isolates were sensitive to carbapenem. From these results it can be concluded that the prevalence of the OXA-23 gene in Acinetobacter baumannii isolates in RSUP Dr. M. Djamil Padang was 85.18% for carbapenem resistant isolates and 4.30% for carbapenem sensitive isolates. Keywords : Acinetobacter baumannii, carbapenem, OXA-23 gene

Correlation of ApoE Gene Polymorphism with Coronary Heart Disease Severity in Patients with Acute Coronary Syndrome Who Receive Statin Therapy, Padang, Indonesia Elly Usman; Gestina Aliska; Masrul Syafri
Journal of Midwifery Vol 7, No 1 (2022): Published on June 2022
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jom.7.1.1-7.2022

Coronary Heart Disease (CHD) is still the most common cause of death. Ischemic heart disease causes more than 7 million (12.8%) deaths worldwide. It is estimated that 3,750,000 Indonesians have CHD. CHD is a disease with many risk factors. ApoE gene polymorphism is associated with atherosclerosis and plays a role in lipid metabolism, which is 2-16% affecting variability in LDL levels. This study aims to look at the relationship between ApoE gene polymorphism and the severity of coronary heart disease. Data regarding ApoE gene polymorphism was obtained using polymerase chain reaction (PCR). DNA was isolated from white blood cells using DNA purification kit. ApoE2, ApoE3, ApoE4 alleles were detected by DNA sequencing. Data on the severity of coronary heart disease were obtained from angiography and were calculated based on SYNTAX scores. In this study, ApoE was obtained with e2 allele frequencies (4.63%), e3 (78.70%), and e4 (16.67%) with E2 / 2 (0%), E2 / 3 (3.70%), E2 / 4 (5.56%), E3 / 3 (64.81%), E3 / 4 (24.07%), and E4 / 4 (1.85%). The relationship between the SYNTAX score and the ApoE genotype has no significant difference. ApoE3 / 4 genotype has the highest SYNTAX score and the e4 allele has the most influence on CHD despite the influence of statin therapy.

Pengaruh Peer Education Terhadap Pengetahuan Dan Sikap Remaja Putri Yang Mengalami Anemia Ulfa Badri; Defrin Defrin; Afdal Afdal; Firdawati Firdawati; Zelly Dia Rofinda; Gestina Aliska
Jurnal Ners Vol. 10 No. 3 (2026): JULI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i3.60696

Iron deficiency anemia is a common nutritional problem among adolescent girls in Indonesia. According to the World Health Organization (WHO), the prevalence of anemia among adolescents worldwide was 32.5% in 2020. UNICEF data (2021) reported that in Indonesia, the highest prevalence of anemia was found among adolescents aged 13–15 years, at 22.7%. Providing health education about anemia and balanced nutrition is necessary to minimize the incidence of anemia among adolescent girls. This study aims to determine the effect of peer education on changes in knowledge and attitudes among adolescent girls with anemia at MTsN 6 Kota Padang. The study, using a pre-experimental design, was conducted at MTsN 6 Kota Padang from February to August 2025. The sample consisted of 52 adolescent girls with anemia, selected using consecutive sampling. Data were analyzed using univariate and bivariate methods, with the Wilcoxon test (p≤0.05). The results showed that 83% of the female students experienced an increase in knowledge (p=0.001), while 69% experienced an increase in positive attitudes (p=0.001). Statistically, there was a significant difference in knowledge and attitudes among anemic female adolescents after receiving peer education.

The Effect of Dragon Tail Leaf Extract (Epipremnum pinnatum (L.) Engl) on Blood Glucose in Rats with Diabetes Mellitus Feby Larasati; Rauza Sukma Rita; Gestina Aliska
ARMADA : Jurnal Penelitian Multidisiplin Vol. 4 No. 4 (2026): ARMADA : Jurnal Penelitian Multidisplin, April 2026
Publisher : LPPM Sekolah Tinggi Ilmu Ekonomi 45 Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/armada.v4i4.1977

Diabetes mellitus is a metabolic disorder characterized by elevated blood glucose levels exceeding normal limits (hyperglycemia) due to impaired insulin secretion by the pancreas. One alternative treatment being developed is the use of medicinal plants with antidiabetic activity. Dragon's tail leaf (Epipremnum pinnatum (L.) Engl.) is known to contain secondary metabolites such as flavonoids, alkaloids, saponins, and phenolics that have the potential to lower blood glucose levels. The purpose of this study was to determine the effect of dragon's tail leaf extract on blood glucose levels in rats with diabetes mellitus. This experimental study used a pre-test-post-test control group design. Thirty-six rats were divided into six groups: K(-) as normal controls, K(+) as diabetic controls induced by alloxan at 100 mg/kgBW, Kmet as a comparison group induced by metformin at 250 mg/kgBW, and treatment groups P1, P2, and P3, which were administered dragon's tail leaf extract at varying doses of 125, 250, and 375 mg/kgBW. Diabetes induction was performed using alloxan to induce hyperglycemia. Blood glucose levels were measured using the POCT method. The results showed that administration of dragon's tail leaf extract (Epipremnum pinnatum (L.) Engl.) reduced blood glucose levels in diabetic rats (p=0.001). Thus, dragon's tail leaf extract has potential as a natural antihyperglycemic agent in the management of diabetes mellitus.

Hubungan Unmet Need Dengan Kualitas Hidup Pasien Kanker Ginekologi yang Membutuhkan Perawatan Paliatif di RSUP Dr. M. Djamil Padang Mainiati Mainiati; Syamel Muhammad; Arina Widya Murni; Roza Sriyanti; Gestina Aliska; Tuti Lestari
Jurnal Ners Vol. 10 No. 3 (2026): JULI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i3.59990

Kanker ginekologi merupakan penyakit kronis yang memerlukan perawatan holistik, termasuk perawatan paliatif. Pelayanan kesehatan yang masih berfokus pada aspek kuratif menyebabkan beberapa kebutuhan belum terpenuhi. Kebutuhan yang tidak terpenuhi (unmet need) berpotensi menurunkan kualitas hidup pasien. Penelitian ini bertujuan untuk menganalisis hubungan antara unmet need dengan kualitas hidup pasien kanker ginekologi yang membutuhkan perawatan paliatif di RSUP Dr. M. Djamil Padang. Jenis penelitian ini adalah penelitian kuantitatif dengan desain penelitian cross sectional. Penelitian dilakukan pada Mei 2025-Juni 2026 dengan jumlah sampel 55 responden yang dipilih menggunakan teknik purposive sampling. Data dikumpulkan melalui kuesioner SCNS-SF34 dan EORTC QLQ-C30 dan dianalisis dengan uji Pearson dan Spearman. Hasil univariat menunjukkan dari lima domain, unmet need ditemukan pada domain kebutuhan psikologis, serta fisik dan aktivitas sehari-hari. Sedangkan pada domain kebutuhan sistem dan informasi kesehatan, dukungan dan perawatan serta seksual kebutuhan sudah terpenuhi. Kualitas hidup buruk ditemukan pada skala fungsional dan status kesehatan umum, sedangkan pada skala gejala kualitas hidup baik. Hasil bivariat menunjukkan ada hubungan unmet need domain kebutuhan psikologis dengan kualitas hidup pada skala fungsional (r = -0,527), skala gejala (r = 0,442), dan status kesehatan umum (r = -0,508). Selain itu, unmet need domain kebutuhan fisik dan aktivitas sehari-hari juga ada hubungan dengan kualitas hidup pada skala fungsional (r = -0,577), skala gejala (r = 0,546), dan status kesehatan umum (r = -0,522). Namun, tidak ada hubungan antara unmet need domain sistem dan informasi kesehatan, domain kebutuhan dukungan dan perawatan, serta domain seksual dengan kualitas hidup (p > 0,05). Kesimpulan penelitian ini, ada hubungan unmet need domain kebutuhan psikologis serta fisik dan aktivitas sehari-hari dengan kualitas hidup pasien kanker yang membutuhkan perawatan paliatif. Kata Kunci: kanker ginekologi, perawatan paliatif, unmet need, kualitas hidup.

Korelasi Perubahan Kadar Enzim Superoxide Dismutase dan Ambang Dengar pada Penderita Tumor Ganas Kepala Leher yang Mendapat Kemoterapi Cisplatin Rini Yoanita; Rossy Rosalinda; Sukri Rahman; Gestina Aliska; Husna Yetti
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 4 No. 1 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v4i1.92

Latar Belakang: Cisplatin dapat digunakan sebagai terapi tunggal atau kombinasi untuk induksi atau terapi neoadjuvan pada tumor ganas kepala leher, memiliki berbagai toksisitas yang membatasi dosis dan bersifat kumulatif, bahwa stria vaskularis merupakan awal cedera yang diinduksi oleh Cisplatin. Cisplatin meningkatkan pembentukan reactive oxygen species (ROS) di koklea. Superoksida diubah menjadi hidrogen peroksida baik secara spontan maupun melalui superoxide dismutase (SOD). Tujuan penelitian untuk mengetahui korelasi antara perubahan konsentrasi enzim antioksidan SOD dan perubahan ambang dengar penderita kemoterapi dengan Cisplatin pada tumor ganas kepala leher. Metode: Penelitian ini menggunakan pretest-posttest one group design pada penderita tumor ganas kepala leher yang mendapat kemoterapi cisplatin dengan dosis 75 mg/m2. Sebelum dilakukan kemoterapi dilakukan pemeriksaan audiometri nada murni dan pengambilan sampel darah sebagai data awal. Dua minggu sesudah kemoterapi, dilakukan pemeriksaan audiometri nada murni dan pengambilan sampel darah kembali. Data dianalisis secara statistik dengan program komputer dan dinyatakan bermakna jika p<0,05. Hasil: Pada penelitian ini didapatkan peningkatan kadar SOD sesudah diberikan kemoterapi cisplatin dengan signifikansi p<0,05. Terdapat peningkatan nilai ambang dengar hantaran tulang pada frekuensi 250, 500, dan 8000 Hz sesudah kemoterapi dengan signifikansi p<0,05. Terdapat korelasi lemah antara kadar SOD dan ambang dengar hantaran tulang pada frekuensi 250, 2000, dan 4000 Hz, dan korelasi sedang pada frekuensi 500, 1000, dan 8000 Hz. Kesimpulan: Pemeriksaan kadar SOD berkorelasi lemah dan sedang terhadap ambang dengar penderita tumor ganas kepala leher yang mendapat kemoterapi cisplatin. Pemeriksaan kadar SOD dapat dijadikan prediktor untuk menilai kondisi stres oksidatif pada kejadian ototoksik sebagai pertimbangan pemberian antioksidan.

Perbedaan Nilai Fibrosis Hati Sebelum dan Setelah Terapi Antivirus Tenofovir pada Pasien Hepatitis B Kronik di RSUP M.Djamil Padang Miftahuz Zahrah; Saptino Miro; Yusticia Katar; Fadrian; Gestina Aliska; Malinda Meinapuri
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 2 (2026): Juni 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i2.1529

Hepatitis B virus infection is a global health problem. Long-term exposure to hepatitis B virus can cause inflammation in hepatocytes leading to liver fibrosis. Liver fibrosis is a predictor of serious complications such as liver cirrhosis and hepatocellular carcinoma. One of the targets of antiviral therapy is to reduce the degree of liver fibrosis which is associated with clinical improvement in patients with chronic hepatitis B. The aim of this study is knowing the difference in liver fibrosis values before and after tenofovir antiviral therapy in chronic hepatitis B patients at M.Djamil Padang Hospital. This study was an observational analytic study using medical record data of 43 chronic hepatitis B patients who had received tenofovir antiviral therapy for 1 year. Data were analyzed with Wilcoxon test. 93% of chronic hepatitis B patients experienced a decrease in liver fibrosis values after tenofovir antiviral therapy for one year with the difference in median values before and after tenofovir antiviral therapy was 10.8 vs 6.4 kPa. There was a significant difference between liver fibrosis values before and after tenofovir antiviral therapy.

Co-Authors Afdal, Afdal Arina Widya Murni Asterina Defrin Defrin Dia Rofinda, Zelly Dia Elly Usman Fadrian Feby Larasati Firdawati Firdawati Habifa Mulya Cita Husna Yetti Linosefa Linosefa Mainiati Mainiati Malinda Meinapuri Masrul Syafri Mhd. Alzaref Miftahuz Zahrah Rauza Sukma Rita Rini Yoanita Rossy Rosalinda Saptino Miro Sukri Rahman Syamel Muhammad Tuti Lestari Ulfa Badri Yanti, Roza Sri Yusticia Katar

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