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All Journal e-CliniC JURNAL BIOMEDIK Medical Scope Journal (MSJ)
Agnes L. Panda
Universitas Sam Ratulangi Manado
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Nursing Public Health

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PROFILE OF ATRIAL FIBRILATION IN PROF. R.D. KANDOU HOSPITAL MANADO FROM SEPTEMBER 2012 – FEBRUARY 2013 Kawilarang, Michael S.; Suhartono, Iman Y.; Moeljono, Elfan; Wangko, Loretta C.; Panda, Agnes L.; Lefrandt, Reginald L.
Jurnal Biomedik : JBM Vol 5, No 2 (2013): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.5.2.2013.2595

Abstract

Abstrak: Fibrilasi atrial merupakan gangguan irama jantung menetap yang paling sering dijumpai di praktek sehari-hari, ditandai oleh adanya aktivasi atrium yang tidak terorganisasi dan kontraksi atrium dan ventrikel yang tidak terkoodinasi. Meskipun banyak laporan mengenai fibrilasi atrial di Indonesia, tetapi hal ini belum pernah dilaporkan di Sulawesi Utara. Penelitian ini bertujuan untuk mendapatkan profil fibrilasi atrial di Manado. Data diambil dari pasien fibrilasi atrial di Bagian Jantung dan Pembuluh Darah, Prof R D Kandou, Manado, sejak September 2012-Februari 2013. Variabel yang diamati ialah jenis kelamin, usia, penyakit penyerta, ekokardiografi, dan terapi. Sebanyak 84 pasien diikutsertakan dalam penelitian ini, terdiri dari 42 laki-laki dan 42 perempuan dengan usia 21-84 tahun dengan rincian 53 pasien berusia ≥60 tahun dan 30 pasien <60 tahun. Pada 59 pasien yang dilakukan ekokardiografi, 39 pasien (66,1%) mempunyai fraksi ejeksi ≥55%; dan 20 pasien (33,9%) <55% (rerata 55,8%). Pembesaran atrium kiri ditemukan pada 33 pasien (55,9%) dan trombus pada 13 pasien (22%). Penyakit penyerta yang ditemukan ialah: hipertensi pada 35 pasien (41,7%); gagal jantung 40 pasien (40,76%); penyakit jantung koroner 20 pasien (23,8%); penyakit jantung katub 21 pasien (25%); penyakit paru 6 pasien (7%); hipertiroid 5 pasien (6%); dan tanpa penyakit penyerta 1 pasien (1,2%). Pada 70 pasien (83,3%) diberikan terapi bisoprolol; 2 pasien (2,4%) digoksin; 3 pasien (3,5%) amiodaron; 7 pasien (8,4%) bisoprolol dan digoksin; dan 2 (2,4%) bisoprolol dan amiodaron. Obat antikoagulan oral diberikan pada 28 pasien (33,03%), dan aspirin pada 40 pasien (47,6%). Stroke ditemukan pada 4 pasien (4,8%); satu orang diantaranya meninggal akibat stroke. Simpulan: Fibrilasi atrial lebih sering ditemukan pada usia lanjut. Gagal jantung dan hipertensi merupakan penyakit penyerta yang tersering, sehingga perlu diwaspadai. Bisoprolol merupakan pilihan terapi yang tersering diberikan, dan angka komplikasi dan kematiannya rendah. Kata kunci: fibrilasi atrial, penyakit penyerta, terapi.   Abstract: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia encountered in clinical practice characterized by disorganized atrial activation and uncoordinated contraction of the atria and ventricle. Although there are many reports regarding the profile of atrial fibrillation (AF) in Indonesia, none have been published in North Sulawesi. This study aimed to provide epidemiological data regarding atrial fibrillation profile in Manado. We reviewed medical records of outpatients diagnosed with AF in the Department of Cardiology and Vascular Medicine, Prof. Dr. R.D. Kandou Hospital, Manado, from September 2012-February 2013. Relevant variables such as gender, age, co-morbids, echocardiography, and medical therapy were documented. The results showed that a total of 84 patients with AF were enrolled in the study. There were 42 males (50%) and 42 females (50%) with age ranges from 21 to 84 years (mean 60.74 years), of these 53 patients (63%) were ≥60 years and 31 patients (37%) <60 years. From the total 84 patients, 59 patients underwent echocardiography examinations: 39 patients (66.1%) had ejection fraction (EF) ≥55%; and 20 patients (33.9%) had EF <55% (mean 55.8%). Left atrial enlargement was found in 33 patients (55.9%) and thrombus was found in 13 patients (22%). Besides suffering from AF, 35 patients (41.7%) had hypertension, 40 (40.76%) had congestive heart failure, 20 (23.8%) had coronary artery disease, 21 (25%) had valvular heart diseases, 6 (7%) had pulmonary diseases, 5 (6%) had hyperthyroidism, and 1 (1.2%)  had no comorbid. Seventy patients (83.3%) were treated with bisoprolol, 2 (2.4%) with digoxin, 3 (3.5%) with amiodarone, 7 (8.4%) with bisoprolol and digoxin, and 2 (2.4%) with bisoprolol and amiodarone. Oral anticoagulant was used in 28 patients (33.3%), and aspirin in 40 patients (47.6%). Strokes were found in four patients (4.8%); one died due to stroke. Conclusion: The prevalence of AF was higher in the elderly. Congestive heart failure and hypertension were the most common co-morbids found, thus, greater awareness is needed. Bisoprolol was used as the highest proportion of treatment in AF patients, and the complication and mortality rates were low. Keywords: atrial fibrillation, comorbids, therapy.
Gambaran Fungsi Ginjal Pasien PJK dengan Oklusi Total Kronik yang Menjalani IKP di RSUP Prof. Dr. R. D. Kandou Manado Periode Januari-Desember 2022 Anjani, Ni Made; Panda, Agnes L.; Jim, Edmond L.
Medical Scope Journal Vol. 7 No. 1 (2025): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v7i1.54929

Abstract

Abstract: Accumulation of fat on the walls of blood vessels can affect blood flow to the heart muscles which has an impact on heart and kidney functions. This study aimed to obtain the description of kidney function in patients with coronary artery disease (CAD) with chronic total occlusion (CTO) who underwent percutaneous coronary intervention (PCI). This was a retrospective and descriptive study with a cross-sectional design. Samples were CAD patients with CTO registered in medical records of Prof. Dr. R. D. Kandou Hospital from January to December 2022. The results showed that there were 95 cases of CTO who underwent PCI. There were 36 (37.9%) patients with increased creatinine levels and decreased eGFR including 33 (34.7%) males, 20 (43.5%) aged 45-59 years, seven (7.4%) with hypertension. There were six patients (16.7%) with contrast induced nephropathy (CIN) including five (13.9%) males, three (8.3%) aged ≥70 years, and two (5.6%) with dyslipidemia. In conclusion, elevated creatinine levels and decreased eGFR are more common in males, pre-elderly, and with hypertension, meanwhile contrast induced nephropathy is more common in males, high-risk elderly, and with dyslipidemia as comorbid. Keywords: kidney function; coronary heart disease; chronic total occlusion; percutaneous coronary intervention   Abstrak: Penumpukan lemak pada dinding pembuluh darah dapat memengaruhi aliran darah ke otot jantung yang berdampak pada fungsi jantung dan ginjal. Penelitian ini bertujuan untuk mengetahui gambaran fungsi ginjal pasien penyakit jantung coroner (PJK) dengan oklusi total kronik (OTK) yang menjalani intervensi koroner perkutan (IKP). Jenis penelitian ialah deskriptif retrospektif dengan desain potong lintang. Sampel penelitian ialah pasien PJK dengan OTK yang tercatat di Rekam Medik RSUP Prof. Dr. R. D. Kandou Manado periode Januari-Desember 2022. Hasil penelitian mendapatkan 95 kasus OTK yang menjalani IKP. Terdapat 36 (37,9%) mengalami peningkatan kadar kreatinin dan penurunan eGFR di antaranya 33 (34,7%) laki-laki, 20 (43,5%) berusia 45-59 tahun, tujuh (7,4%) dengan hipertensi. Terdapat enam pasien (16,7%) yang mengalami contrast induced nephropathy (CIN) diantaranya lima (13,9%) laki-laki, tiga (8,3%) berusia ≥70 tahun, dan dua (5,6%) dengan dislipidemia. Simpulan penelitian ini ialah peningkatan kadar kreatinin dan penurunan eGFR sering terjadi pada laki-laki, kelompok pra lanjut, dengan hipertensi sedangkan contrast induced nephropathy sering terjadi pada pasien laki-laki, usia lanjut berisiko tinggi dan penyakit penyerta dislipidemia. Kata kunci: fungsi ginjal; penyakit jantung koroner; oklusi total kronik; intervensi koroner perkutan
Gambaran Komplikasi Terapi Intervensi Koroner Perkutan dengan Akses Transradial pada Pasien Penyakit Jantung Koroner Setiono, Richella M. W.; Pangemanan, Janry; Panda, Agnes L.
e-CliniC Vol. 13 No. 1 (2025): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v13i1.60181

Abstract

Abstract: Coronary heart disease (CHD) is a serious health problem worldwide. Currently, the most common procedure for removing atherosclerotic plaque is percutaneous coronary intervention (PCI). This study aimed to describe the complications of PCI therapy with transradial access in patients with CHD at Prof. Dr. R. D. Kandou Hospital Manado. This was a retrospective and descriptive study with a cross-sectional approach. Samples were medical records of CHD patients undergoing PCI with transradial access during the period January-December 2022. The results showed that the percentage of complications from percutaneous coronary intervention with transradial access was 4.3% with the highest complication was radial artery spasm (35.3%). The characteristics of those that experienced the most complications were age range 61-75 years (53.5%), males (53.5%), and body mass index 18.5-24.9 kg/m2. In conclusion, the rate of transradial access complication at Prof. Dr. R. D. Kandou Hospital Manado was low. Complications were more common in males of older age and had normal body mass index. This might be influenced by the number of coronary heart disease patients who underwent percutaneous coronary intervention with transradial access was dominated by males. Keywords: transradial access; coronary heart disease; percutaneous coronary intervention    Abstrak: Penyakit jantung koroner (PJK) masih merupakan masalah kesehatan serius dunia. Saat ini prosedur paling umum untuk menghilangkan plak aterosklerosis tersebut dengan intervensi koroner perkutan (IKP). Penelitian ini bertujuan untuk mengetahui gambaran komplikasi terapi intervensi koroner perkutan dengan akses transradial pada pasien PJK di RSUP Prof. Dr. R. D. Kandou Manado selama periode Januari-Desember 2022. Jenis penelitian ialah deskriptif retrospektif dengan desain potong lintang. Sampel penelitian ialah rekam medis pasien PJK yang menjalani IKP akses transradial. Hasil penelitian mendapatkan persentase terjadi komplikasi IKP dengan akses transradial sebesar 4,3%, dengan komplikasi terbanyak yakni spasme arteri radial (35,3%). Karakteristik pasien yang mengalami komplikasi terbanyak ialah rentang usia 61-75 tahun (53,5%), laki-laki (53,5%), dan indeks massa tubuh 18,5-24,9 kg/m2. Simpulan penelitian ini ialah tingkat komplikasi terkait akses transradial di RSUP Prof. Dr. R. D. Kandou Manado tergolong rendah. Komplikasi lebih banyak ditemukan pada laki-laki dengan rentang usia lebih tua dan memiliki indeks massa tubuh normal. Hal ini dapat dipengaruhi oleh total sampel pasien penyakit jantung koroner yang menjalani intervensi koroner perkutan dengan akses transradial didominasi oleh laki-laki. Kata kunci: akses transradial; penyakit jantung koroner; intervensi koroner perkutan
Pengaruh Rehabilitasi Kardiovaskular terhadap Kapasitas Fisik pada Pasien Gagal Jantung Santoso, Richard L.; Joseph, Victor F. F.; Panda, Agnes L.
Medical Scope Journal Vol. 7 No. 2 (2025): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v7i2.60821

Abstract

Abstract: Cardiovascular rehabilitation is one of the essential management strategies recommended to enhance functional capacity of patients with heart failure. This study aimed to determine the effect of cardiovascular rehabilitation on physical capacity in heart failure patients at Prof. Dr. R. D. Kandou Hospital Manado. This was a descriptive and analytical method with a retrospective and cross-sectional design. This study involved 145 heart failure patients undergoing cardiovascular rehabilitation, of whom 48 fulfilled the inclusion criteria, while 97 were excluded. The results showed that majority of participants were male, aged 45–59 years, and had a body mass index (BMI) in the obesity I category. Most patients had hypertension, dyslipidaemia, and were prescribed ACE-I/ARB and statin therapies. Most participants' ejection fractions were classified as reduced (<40%) or mildly reduced (40–49%). Statistical analysis using the paired t-test showed significant improvements in 6-minute walk test distance, VO2 Max, and METs after cardiovascular rehabilitation (p-value <0.05 for each variable). In conclusion, cardiovascular rehabilitation significantly improved physical capacity in heart failure patients, as evidenced by increased 6-minute walk test distance, VO2 Max, and METs. These findings indicate a positive effect of cardiovascular rehabilitation on the physical capacity of heart failure patients at Prof. Dr. R. D. Kandou Hospital Manado. Keywords: cardiovascular rehabilitation; physical capacity; heart failure   Abstrak:Rehabilitasi kardiovaskular merupakan salah satu strategi penatalaksanaan penting yang direkomendasikan untuk meningkatkan kapasitas fungsional pasien gagal jantung. Penelitian ini bertujuan untuk menganalisis pengaruh rehabilitasi kardiovaskular terhadap kapasitas fisik pada pasien gagal jantung di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif analitik dengan desain potong lintang retrospektif. Sampel penelitian ialah 145 pasien gagal jantung yang menjalani rehabilitasi kardiovaskular; 48 pasien memenuhi kriteria inklusi dan 97 pasien dieksklusi. Hasil penelitian mendapatkan mayoritas pasien ialah laki-laki, berusia 45–59 tahun, dengan indeks massa tubuh (IMT) kategori obesitas I. Sebagian besar pasien memiliki hipertensi, dislipidemia, dan mendapatkan terapi ACE-I/ARB serta statin. Sebagian besar fraksi ejeksi pasien dikategorikan sebagai reduced ejection fraction (<40%) atau mildly reduced ejection fraction (40–49%). Analisis statistik menggunakan uji paired t-test menunjukkan peningkatan bermakna pada jarak tempuh uji jalan 6 menit, VO2 Max, dan METs setelah rehabilitasi kardiovaskular (nilai p<0,05 untuk setiap variabel). Simpulan penelitian ini ialah rehabilitasi kardiovaskular secara bermakna meningkatkan kapasitas fisik pasien gagal jantung, yang ditunjukkan oleh peningkatan jarak tempuh uji jalan 6 menit, VO2 Max, dan METs. Temuan ini mengindikasikan adanya pengaruh positif rehabilitasi kardiovaskular terhadap kapasitas fisik pasien gagal jantung di RSUP Prof. Dr. R. D. Kandou Manado. Kata kunci: rehabilitasi kardiovaskular; kapasitas fisik; gagal jantung
Co-Authors Aaron Ch. Rambi Alia, Jaka K. Anjani, Ni Made Christin Tatukude, Christin Desire Sutrisno Dewanti, Lidia A. D. Dewi U. Djafar, Dewi U. Edmond L. Jim Elfan Moeljono Emor, Engelin E. Fitri Jumalang Fonny M. Tedjo Ike Adriana, Ike Iman Y. Suhartono Ira Posangi Jacqueline A. Fuzairi, Jacqueline A. Jan H. Awaloei Janry A. Pangemanan Janry Pangemanan Jeffrey Ongkowijaya Linda W. A. Rotty Loretta C. Wangko Masola, Adhytia B. C. P. Michael S. Kawilarang Monique Rotty, Monique Parera, Ferdinand I. Polii, Natalia C. I. Polii, Natalia Ch. Reginald L. Lefrandt Ronaldi ., Ronaldi Santoso, Richard L. Setiono, Richella M. W. Sihombing, David H. P. Sitepu, Ade M. Starry H. Rampengan Tambuwun, Christa F.D. Terrance Ransun Tumbel, Mawarni I.S. Ventje Kawengian Victor F. F. Joseph, Victor F. F. Wagiu, Mutiara B. Wenas, Mercilia F.