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All Journal Herb-Medicine Journal Jurnal Kesehatan Bina Generasi Jurnal Ilmu Kedokteran dan Kesehatan KOLONI MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation Promotor: Jurnal Mahasiswa Kesehatan Masyarakat Jurnal Abdimas Indonesia
Yanuarita Tursinawati
Universitas Muhammadiyah Semarang
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Pengaruh Hepatokuratif Ekstrak Daun Kenikir (Cosmos caudatus) terhadap Kadar SGPT Tikus Wistar yang Diinduksi Parasetamol Syaema Maulida; Yanuarita Tursinawati; Ardhea Jaludamascena
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 3, No 1 (2020): Herb-Medicine Journal April 2020
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v3i1.5599

Abstract

Penggunaan parasetamol dosis tinggi menjadi pemicu kerusakan hepar yang ditandai dengan peningkatan SGPT. Daun kenikir mengandung flavonoid, saponin, dan tanin yang berfungsi sebagai hepatokuratif. Tujuan penelitian ini adalah untuk mengetahui pengaruh ekstrak daun kenikir terhadap kadar SGPT darah tikus galur wistar yang diinduksi parasetamol. Penelitian ini merupakan studi eksperimen laboratorium dengan rancangan post test only control group design. Sampel sebanyak 30 ekor tikus jantan galur wistar yang dibagi dalam 5 kelompok secara random. Perlakuan dilakukan selama 15 hari, kelompok K- hanya diberi pakan standar selama masa perlakuan, kelompok KT diinduksi parasetamol dosis tunggal 270mg/200grBB tanpa diberikan intervensi, kelompok  K+, PI, dan PII diinduksi parasetamol, K+ diberi N-asetilsistein 2,52mg/kgBB, PI diberi ekstrak daun kenikir 62,5mg/kgBB, PII ekstrak daun kenikir 125mg/kgBB sampai hari ke-14 dan  hari ke-15 diperiksa kadar SGPT. Analisa data dengan uji one-way ANOVA dan dilanjutkan Post-hoc. Rerata kadar SGPT yaitu K- 47,0±0,82 IU/L, KT 78,0±0,97 IU/L, K+ 40,2±2,27 IU/L, PI 55,3±1,74 IU/L, dan PII 69,3±1,48 IU/L. Terdapat perbedaan signifikan rerata SGPT antar seluruh kelompok (p=0,000).Perbedaan signifikan juga ditemukan antar kelompok K- dengan KT (p=0,000), K- dengan K+ (p=0,023), K- dengan P1 (p=0,001), K- dengan P2 (p=0,000), KT dengan K+ (p=0,000), KT dengan P1 (p=0,000), KT dengan P2 (p=0,000), K+ dengan P1 (p=0,000), K+ dengan P2 (p=0,000), dan P1 dengan P2 (p=0,000). Ekstrak daun kenikir (Cosmos caudatus) dapat mempengaruhi kadar SGPT darah tikus galur wistar yang diinduksi parasetamol
HUBUNGAN ANTARA SELF REGULATED LEARNING DENGAN PROKRASTINASI PENYUSUNAN SKRIPSI MAHASISWA FK UNIMUS Ummu Syafa'ah; Mega Pandu Arfiyanti; Yanuarita Tursinawati
Jurnal Ilmu Kedokteran dan Kesehatan Vol 9, No 3 (2022): Volume 9 Nomor 3
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v9i3.5597

Abstract

Prokrastinasi akademik merupakan perilaku penundaan menyelesaikan suatu tugas atau pekerjaan oleh mahasiswa yang berkaitan dengan kegiatan akademik perkuliahan. Salah satu tugas akademik yang sering diprokrastinasi oleh mahasiswa adalah penyusunan skripsi, sebanyak 77,5% mahasiswa melakukan prokrastinasi akademik tinggi dalam penyusunan skripsi. Prokrastinasi akademik banyak menimbulkan dampak buruk bagi mahasiswa sehingga mahasiswa memerlukan kemampuan mengatur diri dalam belajar yang disebut dengan self regulated learning. Penelitian ini bertujuan untuk menganalisis hubungan antara self regulated learning dengan prokrastinasi penyusunan skripsi mahasiswa fk unimus. Jenis penelitian ini adalah observasional analitik dengan desain cross sectional. Sampel mahasiswa fakultas kedokteran Universitas Muhammadiyah Semarang sebanyak 100 orang dengan teknik total sampling. Responden diminta mengisi kuesioner Assesing self regulated learning untuk mengetahui kategori self regulated learning dan kuesioner PASS (Procrastination Assessment Scale for Students) digunakan untuk mengukur prokrastinasi akademik. Data yang diperoleh kemudian dianalisis menggunakan uji korelasi rank spearman. Hasil penelitian menunjukkan dari 100 mahasiswa kedokteran yang menjadi sampel penelitian, 74% melakukan prokrastinasi akademik kategori sedang dan 75% memiliki self regulated learning kategori tinggi. Berdasarkan hasil analisa didapatkan nilai signifikansi sebesar 0,320 (P>0,05). Kesimpulan dari penelitian ini adalah tidak terdapat korelasi antara self regulated learning dengan prokrastinasi penyusunan skripsi mahasiswa fk unimus.
KORELASI HbA1c DAN GULA DARAH PUASA TERHADAP RASIO TG/HDL-K PASIEN DIABETES MELLITUS TIPE 2 BERETNIS JAWA Yanuarita Tursinawati; Sakinah; Zulfachmi Wahab; Arum Kartikadewi
Bina Generasi : Jurnal Kesehatan Vol 15 No 1 (2023): Bina Generasi : Jurnal Kesehatan
Publisher : LPPM STIKES BINA GENERASI POLEWALI MANDAR

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35907/bgjk.v15i1.259

Abstract

Background : Most of the causes of death in type 2 Diabetes Mellitus (T2DM) are coronary heart disease (CHD) with dyslipidemia as one of its risk factors. The best marker for early detection of dyslipidemia is the ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-C). In T2DM patients, glycemic control in the form of Fasting Blood Sugar (GDP) and HbA1c can be done to avoid the risk of CHD. This study aims to identify the correlation of Hba1c and GDP with the ratio of TG/HDL-K in T2DM patients with Javanese ethnicity.Methods : This research was a cross sectional study involving 107 respondents from several health centers in Semarang City with consecutive sampling method. GDP, HbA1c, and TG/HDL-K ratio were obtained from medical records. Spearman correlation statistical test was used with a significance value of p <0.05. Results: The average HbA1c (7.86 ±1.97%), GDP (160.36± 76.82gr/dL), and the TG/HDL-K ratio (3.50± 2.22) exceeded the normal number. There was a weak significant correlation between GDP and the TG/HDL-K ratio (p=0.020; r=0.224) and there was no correlation between HbA1c and the TG/HDL-K ratio (p=0.549; r=0.059) in T2DM patients with Javanese ethnicity.Conclusion: The GDP of Javanese T2DM patients is weakly correlated with the TG/HDL-K ratio but not with HbA1c. Glycemic control is needed as an early marker of CHD risk in T2DM.
PENINGKATAN PEMAHAMAN STUNTING DAN KESEHATAN GIGI MULUT PADA IBU HAMIL Etny Dyah Harniati; Ageng Wicaksono; Yanuarita Tursinawati
Jurnal Abdimas Indonesia Vol 7, No 1 (2025): JURNAL ABDIMAS INDONESIA
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/jai.v7i1.2862

Abstract

Kesehatan ibu hamil mempengaruhi kondisi kesehatan bayi, termasuk risiko stunting atau kondisi gagal tumbuh akibat kekurangan gizi kronis. Salah satu faktor yang mempengaruhi stunting adalah kesehatan gigi dan mulut ibu selama kehamilan. Peningkatan pengetahuan dan pemahaman tentang stunting dan kesehatan gigi mulut dapat ditingkatkan melalui upaya promotif seperti penyuluhan. Penyuluhan mengenai stunting dan kesehatan gigi mulut bagi ibu hamil di Desa Tlahap, Temanggung, bertujuan meningkatkan pemahaman tentang pentingnya menjaga kesehatan gigi dan mulut ibu selama kehamilan guna mencegah stunting pada anak. Metode penyuluhan mencakup ceramah, demonstrasi perawatan, pemberian buku saku, dan sesi tanya jawab. Hasil penyuluhan menunjukkan peningkatan pengetahuan ibu hamil tentang kesehatan gigi mulut dan risiko stunting. Edukasi yang berkelanjutan bagi ibu hamil di komunitas terbukti efektif dalam upaya preventif mencegah stunting.
Extract Melatonin and Phytochemicals Identification and α-glucosidase Inhibitory Activities of Local Indonesian Legumes Ardita Nadia Zahirah; Yanuarita Tursinawati; Gharini Sumbaga Nahardina
PROMOTOR Vol. 9 No. 3 (2026): JUNI
Publisher : Universitas Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/pro.v9i3.2347

Abstract

Nuts have the potential to lower blood sugar levels and increase insulin sensitivity in people with diabetes mellitus through antioxidant, anti-inflammatory, and α-glucosidase enzyme inhibition activities due to their phytochemical and melatonin content. Melatonin is known to lower blood sugar through the mechanism of inhibiting the α-glucosidase enzyme, but there has been no research related to the melatonin content in local Indonesian nuts. This study aims to identify phytochemicals and melatonin and test the α-glucosidase enzyme inhibitory activity in extracts of red beans, peanuts, soybeans, tolo beans, and mung beans. Samples were prepared in the form of simples, then extracted by maceration method. Qualitative identification of phytochemicals (flavonoids, phenolics, alkaloids, tannins, and saponins) was carried out using specific reagents, while total flavonoid and total phenolic levels were determined quantitatively by UV-Vis spectrophotometry. Melatonin content was tested using Thin Layer Chromatography (TLC), and α-glucosidase enzyme inhibitory activity was tested in vitro. Data analysis was performed using linear regression and One-Way ANOVA. The results showed that all extracts contained flavonoids, phenolics, and alkaloids, with saponins found only in soybeans. The highest flavonoid and phenolic content was found in peanuts, while the best α-glucosidase inhibitory activity was demonstrated by red beans with an IC50 value of 0.4057 mg/mL.
COMPARISON OF THE EFFECTIVENESS OF ONDANSETRON IN BREAST CANCER PATIENTS AFTER CHEMOTHERAPY FAC (Fluorouracil, Doxorubicin Cyclophosphamide) AND TC (Taxane Cyclophosphamide) Azka Akhmad Fauzi; Titin Setyowati; Yanuarita Tursinawati; Muslimah
MEDALION Journal: Medical Research, Nursing, Health and Midwife Participation Vol. 7 No. 2 (2026): June
Publisher : PT. Radja Intercontinental Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Breast cancer is one of the leading causes of morbidity and mortality in women worldwide. Chemotherapy with the regimens of FAC (Fluorouracil, Doxorubicin, Cyclophosphamide) and TC (Taxane Cyclophosphamide) is often used in the treatment of breast cancer, but side effects such as Chemotherapy-Induced Nausea and Vomiting (CINV) can impact the patient's quality of life. Ondansetron, a 5-HT3 serotonin receptor antagonist, has been widely used as an antiemetic therapy. This study aims to compare the effectiveness of Ondansetron in overcoming CINV in breast cancer patients receiving FAC and TC regimen chemotherapy. The research design used Quasi-Experimental with Two Group Pretest-Posttest, involving 36 patients selected by purposive sampling at Ken Saras Hospital in December 2024 – January 2025. Data were collected using the Rhodes Index of Nausea, Vomiting, and Retching (RINVR) and analyzed by paired-sample t-test and independent-sample t-test. The results showed that Ondansetron effectively lowered the RINVR score significantly in both groups (p = 0.00). However, there was no significant difference in the effectiveness of Ondansetron between the FAC and TC regimens, either before (p = 0.065) or after (p = 0.118) chemotherapy. The conclusions of this study showed that Ondansetron had good effectiveness in reducing CINV in both groups of patients, although there was no significant difference between the regimens.
Perbandingan Efektivitas Kombinasi OHO (Obat Hipoglikemik Oral) Terhadap Gula Darah Puasa Pasien Diabetes Melitus Tipe 2 Comparison of the Effectiveness of Oral Hypoglycemic Agents (OHO) on Fasting Blood Glucose Levels in Type 2 Diabetes Mellitus Patients Talitha Elliora Salsabilla; Zulfachmi Wahab; Yanuarita Tursinawati
KOLONI Vol. 5 No. 2 (2026): JUNI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/koloni.v5i2.966

Abstract

Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disease characterized by insulin resistance and impaired insulin secretion, leading to increased blood glucose levels. Optimal blood glucose control is necessary to prevent long-term complications. One of the parameters used to assess glycemic control is Fasting Blood Glucose (FBS). This study aims to compare the effectiveness of the combination of metformin-glimepiride and metformin-gliclazide on FBS levels in T2DM patients. This study is a quantitative, observational, and analytical study using a cross-sectional approach. Data were obtained from the medical records of outpatients with T2DM at K.R.M.T. Wongsonegoro Regional General Hospital from January 2022 to December 2023. The study sample consisted of 50 patients selected using a purposive sampling technique, consisting of 25 patients receiving metformin-glimepiride therapy and 25 patients receiving metformin-gliclazide therapy. Data analysis was performed using the Paired T-Test, Mann–Whitney, and Independent T-Test. The results showed that both therapy combinations resulted in significant reductions in GDP after three months of therapy. The Mann–Whitney test showed no significant difference in GDP reduction between the two groups. However, the Independent T-Test showed a significant difference in final GDP levels, with the metformin-gliclazide group having a lower mean final GDP than the metformin-glimepiride group. Therefore, the metformin-gliclazide combination is superior in controlling GDP levels in patients with type 2 diabetes compared to the metformin-glimepiride combination.
Co-Authors Ageng Wicaksono Ardhea Jaludamascena Ardita Nadia Zahirah Arum Kartikadewi Azka Akhmad Fauzi Etny Dyah Harniati Gharini Sumbaga Nahardina Mega Pandu Arfiyanti Muslimah Sakinah Syaema Maulida Talitha Elliora Salsabilla Titin Setyowati Ummu Syafa&#039;ah Wahab, Zulfachmi