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REVIEW: POTENSI BOREH USADA BALI BERBASIS KEARIFAN LOKAL DENGAN BAHAN UTAMA MELATI PUTIH SEBAGAI ANTIBAKTERI PROPIONIBACTERIUM ACNES Giri, Gede Sugiartha; Paramita, Ni Luh Putu Vidya
Kartika : Jurnal Ilmiah Farmasi Vol 8 No 2 (2023)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v8i2.643

Abstract

Boreh Usada Bali merupakan sarana pengobatan masyarakat Hindu Bali terbuat dari kombinasi tumbuh-tumbuhan yang memiliki khasiat obat. Berdasarkan Usada Taru Pramana tanaman melati putih (Jasminum sambac) memiliki potensi untuk mengurangi jerawat. Boreh Usada Bali dibuat dengan bahan utama khasiat daun melati putih dikombinasikan dengan bahan pendukung khasiat seperti beras, kulit batang kayu manis, kayu cendana, rimpang lempuyang, rimpang kunyit, buah pala, dan garam. Review dilakukan terhadap sediaan boreh dengan komposisi bahan melati putih dan bahan alam lainnya sebagai pendukung khasiat antibakteri terhadap Propionibacterium acnes. Penyusunan artikel ini menggunakan metode studi literatur yang tergolong dalam penelitian deskriptif kualitatif secara sistematis. Potensi boreh Usada Bali melati putih didukung oleh beberapa penelitian tentang antibakteri dari komponen di dalam boreh. Hal ini karena, melati putih dilaporkan memiliki senyawa tanin dan flavonoid dan untuk bahan pendukung khasiat boreh lainnya mengandung senyawa aktif utama seperti kulit batang kayu manis (sinamaldehid dan eugenol), kayu cendana (alfa-santalol, beta-santalol, dan epi-beta-santalen), lempuyang (zerumbon), kunyit (kurkuminoid), dan pala (monoterpen) dengan mekanisme masing-masing yang berperan sebagai antibakteri terhadap bakteri Propionibacterium acnes. Sediaan boreh dengan bahan utama khasiat melati putih dan bahan pendukung khasiat boreh (kulit batang kayu manis, kayu cendana, rimpang lempuyang, rimpang kunyit, buah pala) berpotensi sebagai antibakteri terhadap Propionibacterium acnes.   Kata kunci: Antibakteri, boreh, jasminum sambac, propionibacterium acnes, usada bali.   Abstract Boreh Usada Bali is a Balinese Hindu community healing tool made from a combination of plants that have medical efficacy. White jasmine (Jasminum sambac), is a plant in Usada Taru Pramana, that potentially reduces acne. Boreh Usada Bali is made by leaf white jasmine’s efficacy combined with supporting ingredients such as rice, cinnamon, sandalwood, bitter ginger, turmeric, nutmeg, and salt. Review boreh preparations with a composition of white jasmine’s and other natural ingredients as supporting antibacterial properties against Propionibacterium acnes. Review article was conducted with a literature review method which is classified as a systematic qualitative descriptive study. Potentially of boreh Usada Bali white jasmine’s is supported by several studies on the antibacterial properties of the components in boreh. This is because, white jasmine is reported to have tannins and flavonoids compounds and supporting efficacy ingredients boreh contain active compounds with cinnamon (cinnamaldehyde and eugenol), sandalwood (alpha-santalol, beta-santalol, and epi-beta-santalen), bitter ginger (zerumbon), turmeric (curcuminoid), and nutmeg (monoterpen) with their respective mechanisms which act as antibacterial agents against bacteria Propionibacterium acnes. Boreh with the main ingredient of white jasmine and combined with supporting ingredients (cinnamon, sandalwood, bitter ginger, turmeric, nutmeg) potentially to antibacterial activity of Propionibacterium acnes.   Keywords: Antibacterial, boreh, jasminum sambac, propionibacterium acnes, usada bali  
The Marine Actinobacterium Streptomyces sp. BTA 1-131 as a Potential Producer of Anti-Nontuberculous Mycobacterial (Anti-NTM) Paramita, Ni Luh Putu Vidya; Atikana, Akhirta; Sukmarini, Linda; Untari, Febriana; Prayoga, Muhammad Bagas; Maulidia, Faiqoh Nur; Ratnakomala, Shanti; Lisdiyanti, Puspita; Nuryastuti, Titik; Hertiani, Triana
Squalen, Buletin Pascapanen dan Bioteknologi Kelautan dan Perikanan Vol 19, No 3 (2024): December 2024
Publisher : :Agency for Marine and Fisheries Research and Human Resources, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15578/squalen.882

Abstract

Nontuberculous mycobacteria (NTM) are environmental microorganisms, also known as opportunistic pathogens, found in patients with pulmonary tuberculosis. The emergence of antibiotic resistance is increased by prolonged antibiotic treatment for NTM infections. Therefore, alternative sources of new antibiotics are essential for the treatment of NTM infections. A marine actinobacterium, Streptomyces sp. BTA 1-131, isolated from a marine sponge, Melophlus sarasinorum, has been reported as a potential source of antibacterials and anticancer agents. The present study aimed to investigate the potential of Streptomyces sp. BTA 1-131 against two NTMs: Mycobacterium smegmatis and Mycobacterium fortuitum. Streptomyces sp. BTA 1-131 was fermented in three cultivation media (SYP, ISP2, and YS), and the secondary metabolites were extracted using methanol. The bioactivity screening showed inhibition of all methanolic extracts against the growth of M. smegmatis and M. fortuitum. The methanolic extract, which could inhibit both mycobacteria, was a crude extract derived from SYP liquid medium fermentation. The isolated compounds in this study were preliminarily identified using thin-layer chromatography (TLC). The TLC results showed different potential compounds in the crude extracts of Streptomyces sp. BTA 1-131 also highlighted the impact of the fermentation medium on the production of metabolites from Streptomyces. This study also added knowledge about the importance of the Indonesian marine actinobacterium Streptomyces sp. BTA 1-131 as a promising producer of anti-NTM compounds.