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All Journal Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology Manilkara: Journal of Bioscience
Untari, Febriana
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Immunology & microbiology Medicine & Pharmacology Neuroscience Veterinary

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The Marine Actinobacterium Streptomyces sp. BTA 1-131 as a Potential Producer of Anti-Nontuberculous Mycobacterial (Anti-NTM) Paramita, Ni Luh Putu Vidya; Atikana, Akhirta; Sukmarini, Linda; Untari, Febriana; Prayoga, Muhammad Bagas; Maulidia, Faiqoh Nur; Ratnakomala, Shanti; Lisdiyanti, Puspita; Nuryastuti, Titik; Hertiani, Triana
Squalen, Buletin Pascapanen dan Bioteknologi Kelautan dan Perikanan Vol 19, No 3 (2024): December 2024
Publisher : :Agency for Marine and Fisheries Research and Human Resources, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15578/squalen.882

Abstract

Nontuberculous mycobacteria (NTM) are environmental microorganisms, also known as opportunistic pathogens, found in patients with pulmonary tuberculosis. The emergence of antibiotic resistance is increased by prolonged antibiotic treatment for NTM infections. Therefore, alternative sources of new antibiotics are essential for the treatment of NTM infections. A marine actinobacterium, Streptomyces sp. BTA 1-131, isolated from a marine sponge, Melophlus sarasinorum, has been reported as a potential source of antibacterials and anticancer agents. The present study aimed to investigate the potential of Streptomyces sp. BTA 1-131 against two NTMs: Mycobacterium smegmatis and Mycobacterium fortuitum. Streptomyces sp. BTA 1-131 was fermented in three cultivation media (SYP, ISP2, and YS), and the secondary metabolites were extracted using methanol. The bioactivity screening showed inhibition of all methanolic extracts against the growth of M. smegmatis and M. fortuitum. The methanolic extract, which could inhibit both mycobacteria, was a crude extract derived from SYP liquid medium fermentation. The isolated compounds in this study were preliminarily identified using thin-layer chromatography (TLC). The TLC results showed different potential compounds in the crude extracts of Streptomyces sp. BTA 1-131 also highlighted the impact of the fermentation medium on the production of metabolites from Streptomyces. This study also added knowledge about the importance of the Indonesian marine actinobacterium Streptomyces sp. BTA 1-131 as a promising producer of anti-NTM compounds.
Uji Aktivitas Antimikroba dari Ekstrak Metanol Teripang Asal Perairan Lampung Untari, Febriana; Rasyid, Abdullah; Murniasih, Tutik; Wibowo, Joko Tri
MANILKARA: Journal of Bioscience Vol 3 No 2 (2025): Februari
Publisher : LPPM Universitas Terbuka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33830/manilkara.v3i2.11162.2025

Abstract

Sea cucumbers possess various biological activities, including antihypertensive, antioxidant, anticoagulant, antimicrobial, hemolytic, cytotoxic, and immunomodulatory properties. These activities are attributed to the presence of primary and secondary metabolites in sea cucumbers, such as peptides, vitamins, minerals, fatty acids, saponins, steroids, carotenoids, collagen, gelatin, chondroitin sulfate, and amino acids. This study aims to evaluate the antimicrobial activity of methanol extracts from several sea cucumber species collected from Lampung waters. The agar disk diffusion method was used in the study. The results of methanol extracts from five sea cucumber species tested againts five microbial species showed varying outcomes. The highest yield of sea cucumber methanol extract was found in Bohadschia marmorata (3.88%), while the lowest was Metriatyla lessoni (2.68%). In the antibacterial potential test, no antibacterial activity was observed against the four tested bacteria. However, the fungus Candida albicans exhibited an inhibition zone. Four sea cucumber species demonstrated antifungal potential against C. albicans, with the following inhibition zone diameters: B. Marmorata (13.35 ± 2.76 mm), Holothuria lessoni (12.9 ± 0.71 mm), Stichopus quadrifasciatus (10.4 ± 0 mm), and Holothuria leucospilota (8.25 ± 0.07 mm).
Co-Authors Abdullah Rasyid Atikana, Akhirta Joko Tri Wibowo, Joko Tri LINDA SUKMARINI Maulidia, Faiqoh Nur Ni Luh Putu Vidya Paramita Prayoga, Muhammad Bagas PUSPITA LISDIYANTI SHANTI RATNAKOMALA Titik Nuryastuti Triana Hertiani Tutik Murniasih