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All Journal Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan Manilkara: Journal of Bioscience
Untari, Febriana
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Immunology & microbiology Medicine & Pharmacology Neuroscience Veterinary

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The Marine Actinobacterium Streptomyces sp. BTA 1-131 as a Potential Producer of Anti-Nontuberculous Mycobacterial (Anti-NTM) Paramita, Ni Luh Putu Vidya; Atikana, Akhirta; Sukmarini, Linda; Untari, Febriana; Prayoga, Muhammad Bagas; Maulidia, Faiqoh Nur; Ratnakomala, Shanti; Lisdiyanti, Puspita; Nuryastuti, Titik; Hertiani, Triana
Squalen, Buletin Pascapanen dan Bioteknologi Kelautan dan Perikanan Vol 19, No 3 (2024): December 2024
Publisher : :Agency for Marine and Fisheries Research and Human Resources, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15578/squalen.882

Abstract

Nontuberculous mycobacteria (NTM) are environmental microorganisms, also known as opportunistic pathogens, found in patients with pulmonary tuberculosis. The emergence of antibiotic resistance is increased by prolonged antibiotic treatment for NTM infections. Therefore, alternative sources of new antibiotics are essential for the treatment of NTM infections. A marine actinobacterium, Streptomyces sp. BTA 1-131, isolated from a marine sponge, Melophlus sarasinorum, has been reported as a potential source of antibacterials and anticancer agents. The present study aimed to investigate the potential of Streptomyces sp. BTA 1-131 against two NTMs: Mycobacterium smegmatis and Mycobacterium fortuitum. Streptomyces sp. BTA 1-131 was fermented in three cultivation media (SYP, ISP2, and YS), and the secondary metabolites were extracted using methanol. The bioactivity screening showed inhibition of all methanolic extracts against the growth of M. smegmatis and M. fortuitum. The methanolic extract, which could inhibit both mycobacteria, was a crude extract derived from SYP liquid medium fermentation. The isolated compounds in this study were preliminarily identified using thin-layer chromatography (TLC). The TLC results showed different potential compounds in the crude extracts of Streptomyces sp. BTA 1-131 also highlighted the impact of the fermentation medium on the production of metabolites from Streptomyces. This study also added knowledge about the importance of the Indonesian marine actinobacterium Streptomyces sp. BTA 1-131 as a promising producer of anti-NTM compounds.
Uji Aktivitas Antimikroba dari Ekstrak Metanol Teripang Asal Perairan Lampung Untari, Febriana; Rasyid, Abdullah; Murniasih, Tutik; Wibowo, Joko Tri
MANILKARA: Journal of Bioscience Vol 3 No 2 (2025): Februari
Publisher : LPPM Universitas Terbuka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33830/manilkara.v3i2.11162.2025

Abstract

Sea cucumbers possess various biological activities, including antihypertensive, antioxidant, anticoagulant, antimicrobial, hemolytic, cytotoxic, and immunomodulatory properties. These activities are attributed to the presence of primary and secondary metabolites in sea cucumbers, such as peptides, vitamins, minerals, fatty acids, saponins, steroids, carotenoids, collagen, gelatin, chondroitin sulfate, and amino acids. This study aims to evaluate the antimicrobial activity of methanol extracts from several sea cucumber species collected from Lampung waters. The agar disk diffusion method was used in the study. The results of methanol extracts from five sea cucumber species tested againts five microbial species showed varying outcomes. The highest yield of sea cucumber methanol extract was found in Bohadschia marmorata (3.88%), while the lowest was Metriatyla lessoni (2.68%). In the antibacterial potential test, no antibacterial activity was observed against the four tested bacteria. However, the fungus Candida albicans exhibited an inhibition zone. Four sea cucumber species demonstrated antifungal potential against C. albicans, with the following inhibition zone diameters: B. Marmorata (13.35 ± 2.76 mm), Holothuria lessoni (12.9 ± 0.71 mm), Stichopus quadrifasciatus (10.4 ± 0 mm), and Holothuria leucospilota (8.25 ± 0.07 mm).
Aktivitas Antioksidan Kapang Endofit asal Rumput Laut Caulerpa lentilifera Septiana, Eris; Hardhiyuna, Mutia; Untari, Febriana; Bustanussalam, Bustanussalam; Rahmawati, Siti Irma
Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan Vol 20, No 1 (2025): Juni 2025
Publisher : Politeknik - Ahli Usaha Perikanan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15578/jpbkp.v20i1.1040

Abstract

Aktivitas antioksidan dari ekstrak rumput laut telah banyak dilaporkan. Namun, belum banyak peneliti yang melaporkan aktivitas antioksidan dari kapang endofit asal rumput laut. Penelitian ini bertujuan untuk mengisolasi kapang endofit dari rumput laut C. lentilifera, mengevaluasi aktivitas antioksidan, serta profil senyawa kimia ekstrak terpilih. Isolasi kapang endofit dilakukan dengan metode sterilisasi permukaan dan ditanam pada media Potato Dextrose Agar (PDA). Uji antioksidan menggunakan metode 2,2-Diphenyl-1-picrylhydrazyl (DPPH), 2,2’-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS), dan ferric reducing antioxidant power (FRAP). Penentuan kadar fenolik dan flavonoid total masing-masing berdasarkan pada reaksi reagen Follin-Ciocalteu dan aluminium klorida. Ekstrak dengan aktivitas antioksidan terbaik dilakukan profiling senyawa kimianya menggunakan Kromatografi Gas-Spektroskopi Massa (KG-SM). Hasil isolasi didapatkan lima isolat kapang endofit yaitu Cl.Tka.S1, Cl.Tka.S2, Cl.Tka.S3, Cl.Tka.R1, dan Cl.Tka.R2. Ekstrak kapang endofit Cl.Tka.S3 memiliki aktivitas tertinggi dengan nilai IC50 sebesar 17,65 ± 1,88 dan 37,07 ± 2,16 mg/L pada metode ABTS dan DPPH,serta uji FRAP dengan kadar setara Fe(II) sebesar 1654,15 ± 32,95 µmol/mg ekstrak. Kadar fenolik total tertinggi didapatkan dari ekstrak kapang endofit Cl.Tka.S1 sebesar 75,05 ± 8,46 mg setara asam galat/g ekstrak. Kadar flavonoid total tertinggi didapatkan dari ekstrak kapang endofit Cl.Tka.S3 sebesar 38,50 ± 1,55 mg setara kuersetin/g ekstrak. Profiling senyawa kimia menunjukkan ekstrak isolat Cl.Tka.3 sebagai isolat terbaik mengandung senyawa antioksidan berupa senyawa golongan fenolik, asam lemak, alkana, dan alkohol. KATA KUNCI: ABSTRACTThe antioxidant activity of seaweed extracts has been widely reported. However, reports on the antioxidant activity of endophytic fungi derived from seaweed are still limited. This study aims to isolate endophytic fungi from C. lentilifera, determine antioxidant activity and chemical profiles of selected extracts. Endophytic fungi were isolated by the surface sterilization method and planted on Potato Dextrose Agar (PDA) media. Antioxidant test using 2,2-Diphenyl-1-picrylhydrazyl (DPPH), 2,2’-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS), dan ferric reducing antioxidant power (FRAP) methods. Total phenolic and flavonoid content was based on the reaction of Follin-Ciocalteu reagent and aluminium chloride, respectively. Extracts with the best antioxidant activity were profiled for their chemical compounds using Gas Chromatography-Mass Spectroscopy (GC-MS). The isolation results obtained five isolates of endophytic fungi, namely Cl.Tka.S1, Cl.Tka.S2, Cl.Tka.S3, Cl.Tka.R1, and Cl.Tka.R2. Cl.Tka.S3 extract had the highest activities with an IC50 value of 17.65 ± 1.88 and 37.07 ± 2.16 mg/L on the ABTS and DPPH methods, as well as FRAP test values with Fe(II) equivalent levels of 1654.15 ± 32.95 µmol/mg extract. Cl.Tka.S1 extract has the highest total phenolic content of 75.05 ± 8.46 mg gallic acid equivalent/g extract. Cl.Tka.S3 extract has the highest total flavonoid content of 38.50 ± 1.55 mg quercetin equivalent/g extract. Profiling of chemical compounds showed that the Cl.Tka.S3, as the best extract, contained antioxidant compounds such as phenolic compounds, fatty acids, alkane, and alcohol.
Co-Authors Abdullah Rasyid Atikana, Akhirta Bustanussalam Bustanussalam, Bustanussalam ERIS SEPTIANA Joko Tri Wibowo, Joko Tri LINDA SUKMARINI Maulidia, Faiqoh Nur Mutia Hardhiyuna, Mutia Ni Luh Putu Vidya Paramita Prayoga, Muhammad Bagas PUSPITA LISDIYANTI Rahmawati, Siti Irma SHANTI RATNAKOMALA Titik Nuryastuti Triana Hertiani Tutik Murniasih