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SINTESA 1,2-BIS(FOSFINO) ETANA UNTUK PREPARASI TETROFOSMIN DAN SENYAWA TURUNANNYA Purwoko, Purwoko; Pardede, Ratlan; Maskur, Maskur; Mutalib, Abdul; Hashimoto, K.
Jurnal Radioisotop dan Radiofarmaka Vol 9 (2006): jurnal PRR 2006
Publisher : Jurnal Radioisotop dan Radiofarmaka

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (200.886 KB)

Abstract

SINTESA 1,2-BIS(FOSFINO) ETANA UNTUK PREPARASI TETROFOSMIN DAN SENYAWA TURUNANNYA. Senyawa 1,2-bis (fosfino)etana adalah senyawa khelat bidentat sederhana dengan atom fosfor sebagai donor ligan. Telah dilakukan sintesa 1.2bis(fosfino)etana melalui dua tahap: reaksi trietil fosfit dengan 1,2 dibromo etana didapat senyawa tetra etil etilen difosfonat (fosforan), reduksi fosforan dengan LiAlH4 diperoleh senyawa fosfin 1.2- bis(fosfino)etana. Analisa hasil dari setiap tahap reaksi dilakukan dengan mengamati spektrum infra merah, spektrum massa serta kromatografi cairan dan telah diperoleh hasil senyawa fosfin 1,2 bis-(fosfino) etana sebagai starting material dalam sintesa tetrofosmin dan senyawa turunannya dengan kemurnian lebih 98 % dan rendemen sebesar 34%. Kata kunci: 1,2-bis (fosfino)etana, khelat bidentat, sintesa SYNTHESIS OF 1.2-BIS(PHOSPHINO)ETHANE FOR PREPARATION OF TETROFOSMINE AND DEREVATIVES. 1.2-bis(phosphino)ethane is a simple chelate bidentate based on phosphorous as a donor ligands . The 1.2-bis(phosphino)ethane was synthesized through two steps reaction: triethyl phosphite was coupled with dibromo ethane to give tetra ethyl ethylene diphosphonate (phosphorane), the reduction of phosphorane by LiAlH4 gave the phosphine compound 1.2-bis(fosfino)etana. Investigation of the product every steps reaction by observing infra red spectra, as well as mass spectrometric and high performance liquid chromatographic analysis showed that the product was pure phosphine 1,2 bis-(phosphino) ethane as starting material in the synthesis of tetrofosmine and derivatives, the purity more than 98% and yield was around 34 %. Key words: 1.2-bis(phosphino)ethane, chelate bidentate, synthesis.
UJI BIODISTRIBUSI DAN UJI PREKLINIS MIKROSFER GELAS-P-32 UNTUK PENGOBATAN KANKER Astuti, Laksmi Andri; Caniago, Djoharly; Pardede, Ratlan; Widjaksana, Widyastuti; Purwoko, Purwoko; Bagiawati, Sri; Setiyowati, Sri; Abidin, Abidin; Aguswarini, Sri
Jurnal Radioisotop dan Radiofarmaka Vol 6, No 2 (2003): Jurnal PRR 2003
Publisher : Jurnal Radioisotop dan Radiofarmaka

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ABSTRAKUJI BIODISTRIBUSI DAN UJI PREKLINIS MIKROSFER GELAS-P-32 UNTUK PENGOBATAN KANKER.Radiofarmaka telah  menunjukkan  manfaat lebih unggul dan spesiflk biladibandingkan dengan teknik pelayanan kesehatan lain, terutama untuk keperIuan diagnosis dan terapi beberapa penyakit  mematikan seperti kanker. Mikrosfer gelas-P-32 ( P-32 GMS ) adalah  salah  satu sediaan  baru  radiofarmaka untuk terapi  dengan cara  radiasi  interna beberapa penyakit  kanker ganas  seperti  penyakit  kanker  hati. Mikrosfer  gelas-P-32 ini  disiapkan  dengan  cara  mengira diasikan mikrosfer gelas-P31dengan neutron di reaktor nuklir, kemudian sediaan disuntikkan ke daerah yang terkena kanker Untukmemudahkan  penyuntikan  pada  sediaan  ini  perlu ditambahkan larutan pensuspensi, yaitu campuran dari PVP 16 %, dekstrose 50% dan salin. Mengingat ukuran mikrosfer ini spesiflk yaitu 40-60 J.Ull  maka pemilihan jamm suntik perIu dilakukan agar P-32 GMS yang diinjeksikan maksirnal bisa masuk ke daerah sasaran, dan mikrosfer tidak mengalami kerusakan karena gesekan dengan permukaan dalam  jarum. Ujibiodistribusi perIu dilakukan untuk melihat apakah P-32 GMS yang telah diinjeksikan terak1.lmulasike daerah penyuntikan  atau  terdistribusi  ke organ - organ lain yang  tidak dikehendaki, Hewan percobaan yang dipakai  adalah  mencit dengan penyuntikan dilakukan  pada otot  paha  kanan. Hasil biodistribusi pada I, 3dan  24 jam  setelah  injeksi  menunjukkan 100% aktivitas P-32 GMS terakumulasi di daerah penyuntikan.Hasil biodistribusi pada 5 jam setelah penyuntikan menunjukkan adanya penimbunan  aktivitas di organ lambung selain penimbunan aktivitas di daerah penyuntikan, namun hal ini diduga karena terjadi kontaminasi akibat kesalahan kerja .Kata Kunci : Radiofarmaka, , Mikrosfer gelas, P-32,  iradiasi, uji biodistribusi , kanker. ABSTRACTBIODISTRIBUTION AND PRECLINICAL TEST OF P-32 GLASS MICROSPHERESFOR CANCER THERAPY. The superiority of  radiophannaceutical compare to the  other  techniques off medical services, especially for diagnosis and  therapy  of  several deadly diseases such as cancer, shows that this technique is more specific and accurate. P-32-Glass microsphere (P-32 GMS) is one of theradiophannaceuticals developed reccntly for therapy using  interrnal  radiation  method  for several malignant cancers, such as hepatic canccr. 111cP-32 GMS was prcpared by irradiating P-31 GMS with neutron at a nuclear reactor, then the preparation was injected to the cancerous infected  area. To make easy  injection, it needs suspension agent that was including PVP, dextrose and saline with a composition of 16% PVP - 50%dextrose - saline as 2 : 3 : 3 (v/v/v). As microsphere size should be maintained at 40-60 11m, the injectionneedle was selected properly in order to remain the particle size of P-32 GMS unchanged  when  the frictionoccurs between microspheres and the inside surfaces of the needle. The injection  needle  used  was needle produced  by BD with a typical size of 20 GI Tw. Biodistribution  studies were carried out after I, 3, 5 and24 hour of injection. Experimental results  for 1, 3 and 24 hour post -injection studies showed  that 100%activity of  P-32 GMS was accumulated  at  the  injected  area. For 5 hour post-injection study, accumulation of  P-32 GMS activity was also found at stomach besides the injected area, but it was presured as working error. Keywords: Radiophannaceutical , glass microspheres ,P-32,  biodistribution, , cancer.    
Pengaruh Kepemimpinan, Komitmen Organisasi dan Lingkungan Kerja terhadap Prestasi Kerja melalui Kepuasan Kerja Karyawan Sebagai Variabel Intervening Pada PT. KSK Insurance Indonesia Ratlan Pardede
Journal of Business & Applied Management Vol 9, No 1 (2016)
Publisher : Universitas Bunda Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1062.136 KB) | DOI: 10.30813/jbam.v9i1.898

Abstract

This study aims to determine the influenceof leadership, organizational commitment, working environment towardemployeeperformance through working satisfaction as intervening variable. This research was conducted at PT KSK Insurance Indonesia by using total sample of 180 employees. Structural Equation Modeling (SEM) by AMOS program version 22 used to test the hypothesis. The study concludes : (1)leadership has positive effect but not significant on working satisfaction, (2)commitment has positive and significant effect on working satisfaction, (3)working environment has positive and significant effect on working satisfaction, (4)leadership has positive effect but not significant on employee performance, (5)commitment has positive and significant effect on employeeperformance, (6)working environment has positive and significant effect on workingperformance, (7)working satisfaction has positive and significant effecton employeeperformance;Key Words: Leadership, organizational commitment, working environment, working satisfaction and employee performance.
PENGARUH PERSEPSI HARGA DAN KUALITAS PRODUK TERHADAP KEPUTUSAN PEMBELIAN KONSUMEN YANG DIMEDIASI KEPUASAN KONSUMEN Ratlan Pardede; Tarcicius Yudi Haryadi
Journal of Business & Applied Management Vol 10, No 1 (2017)
Publisher : Universitas Bunda Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (845.148 KB) | DOI: 10.30813/jbam.v10i1.870

Abstract

This study aims to determine the influence of the perception of price and product quality on consumer purchasing decisions which is mediated by satisfaction on Indomaret mini market Rorotan North Jakarta. Indomaret mini market is engaged in the retail sale of goods which needs to pay attention to the behavior of consumers to make decisions.This research is a quantitative survey approach that seeks to know how the influence of the perception of price and product quality on consumer purchasing decisions with customer satisfaction as an intervening variable. Data collection techniques are by using questionaire. The test instrument is used for testing the validity and reliability. As for the technique of data analysis, SEM is used. The study concludes : 1) price perception has a positive and significant effect on customer satisfaction, 2)price perception has not positive and significant effect on consumer purchasing decisions, 3) product quality has a positive and significant effect on customer satisfaction, 4) product quality has not positive and significant effect on consumer purchasing decisions, 5). consumer satisfaction has a positive and significant effect on consumer purchasing decisions, 6). Consumer satisfaction has effect on consumer purchasing decision to mediate price perception and product quality.Keywords: price, product, consumer satisfaction, consumer purchasing
PENGARUH PERILAKU KONSUMEN GENERASI Y TERHADAP PEMBELIAN IMPULS DARING PADA E-DAGANG LAZADA INDONESIA Ratlan Pardede; Dwi Puteri
Jurnal Manajemen Kewirausahaan Vol 18, No 2 (2021): JMK EDISI DESEMBER 2021
Publisher : Sekolah Tinggi Ilmu Ekonimi IPWI Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33370/jmk.v18i2.691

Abstract

Penelitian ditujukan untuk menguji pengaruh perilaku konsumen generasi Y seperti atribut situs, keamanan privasi, layanan belanja daring, dan kenikmatan berbelanja, serta permediasi kenikmatan berbelanja terhadap pembelian impuls daring. Perkembangan e-dagang yang pesat disertai perilaku konsumen generasi Y cenderung melakukan pembelian secara tidak terencana atau pembelian impuls. Penelitian ini bersifat kuantitatif dengan data primer menggunakan metode purposive sampling. Jumlah responden sebanyak 161 dengan kriteria generasi Y di Indonesia yang berumur 16 – 33 tahun dan pernah berbelanja di situs Lazada Indonesia. Metode analisis data menggunakan Structural Equation Model (SEM) dengan aplikasi SmartPLS 3.0. Hasil penelitian menunjukkan bahwa atribut situs berpengaruh langsung terhadap perilaku pembelian impuls daring, tetapi keamanan privasi. Layanan belanja daring tidak berpengaruh langsung terhadap pembelian impuls daring. Atribut situs, keamanan privasi, dan layanan belanja daring berpengaruh terhadap kenikmatan berbelanja. Kenikmatan berbelanja berpengaruh terhadap perilaku pembelian impuls daring. Kata kunci: atribut situs, keamanan privasi, kenikmatan berbelanja, layanan belanja daring, pembelian impuls daring ABSTRACT This research aimed   to examine the effect of Y Generation consumer behavior such as site attributes, privacy security, online shopping services and shopping enjoyment, and mediation of shopping enjoyment on online impulse buying. The rapid development   of e-commerce and the behavior of Y Generation consumers tend to make unplanned purchases or impulse purchases. This research is quantitative with primary data using purposive sampling method. The number of respondents are 161 people using the criteria of Y Generation in Indonesia who aged 16-33 years and have ever shopped on the Lazada Indonesia site. The data analysis method used the Structural Equation Model (SEM) with the Smart-PLS 3.0 application. The results of this research indicate that the website attributes directly significant effect on the online impulse buying behavior, but security privacy and online shopping services does not directly significant to online impulse buying behavior. The website attributes, security privacy, online shopping services have significant effect to shopping enjoyment and shopping enjoyment has significant effect to online impulse buying behavior. Keywords: online impulse buying behavior, online shopping services, security privacy, shopping enjoyment, website attributes
The Influence of Trust and Perceived Usefulness on Purchase Intention with Price Mediation Fratama, Feri; Pardede, Ratlan; Samara, Aldi; Susanti, Metta
International Journal of Economics (IJEC) Vol. 2 No. 2 (2023): July-December
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijec.v2i2.660

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This research aims to determine the influence of trust and perceived usefulness on purchase intention which is mediated by price (empirical study: Shopee Indonesia users in Tangerang). Research data was obtained from distributing questionnaires via Google Forms. Samples were taken using purposive sampling technique. The sample used in this research was 256 respondents. This research uses quantitative analysis techniques and is processed using AMOS. The research results show that Trust and Perceived Usefulness have a positive and significant effect on price. This research can provide benefits in the form of knowledge to academics, practitioners and stakeholders. Besides that, this research can provide ideas for designing and developing marketing plans and sales strategies where Shopee companies can improve the welfare of the community through the benefits obtained through value by using Shopee.
THE INFLUENCE OF PRICE AND PRODUCT QUALITY ON PURCHASING DECISIONS WITH BRAND IMAGE AS MEDIATION IN BASEUS BRAND MOBILE PHONE ACCESSORIES PRODUCTS IN INDONESIA Christian, Mario Alvin; Pardede, Ratlan
International Journal of Social Service and Research Vol. 4 No. 8 (2024): International Journal of Social Service and Research
Publisher : Ridwan Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/ijssr.v4i8.891

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This study aims to analyze the influence of product price and product quality on purchase decisions, as well as the role of brand image as a mediating factor. The data was collected using a cross-sectional survey, where respondents were selected by purposive sampling from consumers of Baseus brand mobile phone accessories in various major cities in Indonesia. This study uses a quantitative method with a causal approach to examine the cause-and-effect relationship between price, product quality, and purchase decisions. The structural model and measurement model are then tested using the Partial Least Square (PLS) technique to test the hypothesis and feasibility of the model. The results of this study show that price has a significant influence on purchasing decisions, either directly or through brand image mediation. Moreover, the results of the study suggest that Baseus needs to consider product quality factors in the development of their brand image.
THE INFLUENCE OF MOTIVATION, PERCEPTIONS OF PROSPECTIVE STUDENTS, AND UNIVERSITY PROMOTIONS ON INTEREST IN STUDYING UNDERGRADUATE PROGRAMS MEDIATED BY ONLINE LECTURES (EMPIRICAL STUDY: INDONESIAN GO-JEK PARTNERS) Lizki, Abraham Charis; Pardede, Ratlan
International Journal of Social Service and Research Vol. 4 No. 8 (2024): International Journal of Social Service and Research
Publisher : Ridwan Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/ijssr.v4i8.899

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The purpose of this study is to investigate the influence of Motivation, Perception, and Promotion of higher education on interest in studying undergraduate programs among prospective students from Go-Jek Indonesia's partners, as well as the mediation role of online lectures in this relationship. Data were collected cross-sectionally from 264 prospective students using a questionnaire as the primary data collection method. The results of the study show that the perception of prospective students has a positive and significant effect on the interest in undergraduate programs. Higher education promotion to prospective students, including the quality of education, reputation, and job prospects of graduates, has proven to have a negative and significant impact on their interest in choosing online lectures. Online lectures mediate the effect of perception and promotion, both directly and through online lecture mediation. This study is expected to provide new insights into the role of Online Lectures in mediating the relationship between motivation, perception, and promotion and interest in study undergraduate programs in universities in Indonesia.
Peran kepuasan terhadap minat beli ulang dengan word-of-mouth sebagai mediator ada pelanggan Kopi Tuku di Jabodetabek Herdiyanto, Robertus; Pardede, Ratlan
Entrepreneurship Bisnis Manajemen Akuntansi (E-BISMA) Vol.5, No.2 (2024): December 2024
Publisher : Universitas Widya Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37631/ebisma.v5i2.1180

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Kopi Tuku is one of the modern café brands, specifically because it’s included in the Contemporary Coffee which uses Indonesian local coffee beans. The existence of Kopi Tuku makes researchist eager to know and analyze its customers behaviors specially in Jabodetabek area. This research aims to see the effect of customer satisfaction on repurchase intention with word-of-mouth as the intervening variable. This is a quantitative research with purposive sampling method to obtain the respondents. The research data was taken using g-form questionare which was processed and tested using Structural Equation Model analysis using AMOS 21 software. The population for this research is Kopi Tuku customers in Jabodetabek area with 214 respondents as its samples. After researchist conducting the hypothesis testing, the result are(1) Satisfaction has a positive and significant effect on Repurchase Intention, (2) Satisfaction has positive and significant effect on Word-of-Mouth, (3) Word-of-Mouth has no significant effect on Repurchase Intention and (4) Satisfaction has a positive and significant effect on Repurchase Intention with Word-of-Mouth as a mediating variable. This research also put the company’s policy regarding green policy as an indicator that reflects customer satisfaction
The Effect of Discount Price on Impulsive Buying Mediated by Utilitarian Browsing in TikTok Shop (Empirical Study of Gen Z and Millennials in Jakarta) Meylovsky, Rourentsia; Pardede, Ratlan
Edunity Kajian Ilmu Sosial dan Pendidikan Vol. 4 No. 8 (2025): Edunity: Social and Educational Studies
Publisher : PT Publikasiku Academic Solution

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57096/edunity.v4i8.434

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TikTok Shop, as a social commerce platform, is increasingly popular among Generation Z and millennial in Indonesia, particularly for skincare products. This phenomenon requires further investigation to understand the factors driving impulsive buying, especially considering utilitarian browsing as a mediating process. This study aims to analyze the influence of discount price on impulsive buying among TikTok Shop users while examining the mediating role of utilitarian browsing. This research adopts a quantitative approach, with data collected through online questionnaires distributed to 120 respondents from Generation Z and millennial residing in DKI Jakarta, who have purchased skincare products through TikTok Shop. The data analysis technique employed is Structural Equation Modeling (SEM) using SmartPLS 3.0 software, including testing the measurement model (outer model) and the structural model (inner model). The results of this study are expected to provide deeper insights into impulsive buying behavior and serve as a reference for social commerce industry players to optimize marketing strategies involving discount price to enhance consumer satisfaction and engagement.