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All Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Borneo Journal of Pharmacy
Asra Al Fauzi
Universitas Airlangga
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Profile of Clinical and Radiological Factors of Intracerebral Hemorrhage Stroke Patients in Dr. Soetomo Hospital Farizal Rizky Muharram; Asra Al Fauzi; Paulus Rahardjo; Pudji Lestari
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 10 No. 1 (2019): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (544.936 KB) | DOI: 10.20473/juxta.V10I12019.15-19

Abstract

Introduction: ICH (intracerebral hemorrhage) is a medical emergency with high mortality and morbidity that occurs in 15-20% of stroke cases. However, in the Multicenter Surgical Trial in Lobar ICH (STICH) study no benefit was found from the initial operative handler in Lobar ICH patients. Many clinical and radiological factors that affect outcomes of patients.Methods: The design of this study was a cross-sectional study. Clinical and radiological factors were analyzed by chi-square test and Kruskal-Wallis test. Then significant results were sought Relative RiskResults: This research was conducted from January 2017 to September 2018 starting from sampling to processing data. Sampling was carried out at the medical record center of Dr. Hospital. Soetomo Surabaya. Data collection is done by using secondary data in the form of patient medical records. All of the collected intracerebral hemorrhage patients were 302 and the total patients who met the inclusion and exclusion criteria were included in the study as the study subjects. Patients who met the criteria obtained 247 research subjects.Conclusion: There are several factors that influence the outcome of ICH stroke patients. Radiological factors and clinical factors both have an impact on outcomes. Further research is needed to find out which factors can be a diagnosis for choosing treatments that provide better outcomes. Statistically more than 1 variable is needed to determine an action that results in a more significant outcome of living patients. This shows that the choice of treatment for patients with different characteristics requires different treatments. Further analysis is needed to look for indications of the use of Operative or Conservative actions16.
Epidemiology of Intra-Cerebral Hemorrhage in Young Adult Patients Melisa Melisa; Asra Al Fauzi; Anggraini Dwi Sensusiati
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 11 No. 2 (2020): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V11I22020.65-68

Abstract

Introduction: This study aimed to define the CT scan imaging of young adult intracerebral hemorrhage (ICH) patients in Dr. Soetomo General Hospital, Surabaya.Methods: This was an observational descriptive study. The data were collected retrospectively with medical records of 18 to 45 years old ICH patients who were treated in Dr. Soetomo General Hospital, Surabaya between 2014 and 2017. The collected data were then presented into tables.Results: 207 patients were identified in this study. The locations of the ICH were basal ganglia (45.89%), lobar (41.55%), thalamus (10.63%), brainstem (8.7%), cerebellum (4.83%), and others (3.86%). The volume of ICH varied from less than 30 cc (66.67%), 30 to 59 cc (27.54%), and more than 60 cc (5.8%).  Conclusion: The CT scan imaging of young adults ICH mainly had hematoma volume less than 30 cc and was mostly located in basal ganglia area then followed by lobar area. 
The Effect of Thymoquinone on Progressive Brain Damage: An Experimental Study in a Wistar Rat Model of Intracerebral Hemorrhage Khamim Thohari; Asra Al Fauzi; Djoko Agus Purwanto
Borneo Journal of Pharmacy Vol. 9 No. 2 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i2.10849

Abstract

Intracerebral hemorrhage (ICH) accounts for 20% of stroke cases and is associated with a 40–50% mortality rate, yet effective neuroprotective therapies remain lacking. This study evaluated the therapeutic efficacy and molecular mechanisms of thymoquinone (TQ), the primary bioactive constituent of Nigella sativa, in a Wistar rat model of ICH. Male Wistar rats (n = 55, 200–220 g) were randomized into five groups: untreated control, untreated ICH, vehicle-treated ICH (corn oil for 7 days), and ICH treated orally with TQ at 150 mg/kg or 250 mg/kg body weight daily for 7 days. ICH was induced via autologous blood injection (0.12 mL) into the brain parenchyma. Biomarkers for neuroinflammation (NLRP3, TNF-α, IL-6, IL-1β), oxidative stress (SOD, MDA), tissue remodeling (MMP-9), and neuronal necrosis were quantified using ELISA, immunohistochemistry, and histological staining. TQ administration significantly elevated MMP-9 levels (p = 0.000) compared with untreated ICH controls and markedly suppressed NLRP3, TNF-α, and IL-1β expression. Furthermore, TQ increased SOD antioxidant activity, whereas MDA levels remained elevated. These neuroprotective effects were dose-dependent, with maximal modulation observed at 250 mg/kg TQ. In conclusion, TQ modulates critical inflammatory and oxidative pathways in experimental ICH while unexpectedly upregulating MMP-9, suggesting a complex dual function in early neuroprotection and subsequent tissue remodeling. These findings demonstrate that TQ holds promising potential as a natural neuroprotective agent for hemorrhagic stroke management.
Co-Authors Djoko Agus Purwanto Farizal Rizky Muharram Khamim Thohari Melisa Melisa Paulus Rahardjo, Paulus Pudji Lestari Sensusiati, Anggraini Dwi