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All Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Mega Efrilia
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Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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PENINGKATAN FOTOSTABILITAS PIGMEN BETA KAROTEN DENGAN PEMBUATAN MIKROEMULSI Ika Agustina; Mega Efrilia
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (186.109 KB) | DOI: 10.36387/jiis.v7i1.823

Abstract

Sepanjang tahun 2018 BPOM menemukan berbagai macam kosmetik illegal yang mengandung bahan dilarang/bahan berbahaya. Salah satu bahan berbahaya yang ditemukan adalah pewarna tekstil Merah K3 pada lipstick. Solusi yang diperlukan adalah dengan membuat pewarna alami yang memiliki kestabilan yang baik terhadap cahaya. Tujuan penelitian ini adalah untuk meningkatkan kestabilan pigmen beta karotenoid terhadap cahaya dengan membuat sediaan mikroemulsi. Sumber senyawa beta karoten berasal dari Daucus carota L. Teknik ekstraksi menggunakan maserasi dengan pelarut etanol:heksana (4:3). Untuk mendapatkan formulasi mikroemulsi terbaik dibuat variasi konsentrasi PEG 40 HCO:gliserol:ekstrak. Formulasi mikroemulsi terbaik adalah kode FW3 dengan komposisi 2:2:1 (PEG 40 HCO:gliserol:ekstrak). Kemudian ekstrak Daucus carota L dan mikroemulsi FW3 diuji fotostabilitas. Hasil pengujian fotostabilitas menunjukkan penurunan kadar ekstrak Daucus carota L. sebesar 2.84%, sedangkan mikroemulsi Daucus carota L mengalami penurunan kadar sebanyak 1.33%. Kedua sediaan tetap dikategorikan sebagai substansi yang fotosensitif.
EKSPLORASI KANDUNGAN FENOLIK TOTAL BUAH OKRA (Abelmoschus esculentus L.) SEBAGAI KANDIDAT PRODUK HERBAL Mega Efrilia; Evan, Yulius Evan Christian; Pra Panca Bayu Chandra; Ema Hermawati
Jurnal Ilmiah Manuntung Vol 11 No 1 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i1.903

Abstract

Okra fruit (Abelmoschus esculentus L.) is a plant that contains phenolic and flavonoid compounds that have the potential as natural antioxidants and can be utilized in pharmaceutical formulations and health products. This study aims to determine the total phenolic content in 70% ethanol extract of okra fruit and evaluate its physical characteristics. The method used in this study consists of several stages. Extraction was done using the maceration method, with 1,005.88 grams of simplistic powder soaked in 10 liters of 70% ethanol for 5 days, stirring every 24 hours. After maceration, the filtrate from the extraction is filtered using Whatman No.1 filter paper, then evaporated using a rotary vacuum evaporator at 40°C until a thick extract is obtained. The extract obtained was tested for physical characteristics through organoleptic testing, including color, odor, and taste. Furthermore, total phenolic content was determined using the Folin-Ciocalteu method, with gallic acid (GAE) as a standard. Absorbance measurements were taken using a UV-Vis spectrophotometer at a wavelength of 765 nm. The results showed that the thick extract yielded 9.47%, with a DER-native value of 10.56. Organoleptic tests showed that the extract had a blackish-brown color, a distinctive odor of okra fruit, and a bitter taste with a slight tartness, indicating the presence of phenolic compounds and tannins. Determination of total phenolic content showed that okra fruit extract had a phenolic content of 921.21 mg GAE/g extract, which showed potential as a natural antioxidant. The 70% ethanol extract of okra fruit has high phenolic content, so it has the potential to be used as a natural antioxidant in pharmaceutical formulations and natural ingredient-based health products.
Co-Authors Ema Hermawati Evan, Yulius Evan Christian Ika Agustina Pra Panca Bayu Chandra