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All Journal Pharmacoscript Lumbung Farmasi : Jurnal Ilmu Kefarmasian Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran Jurnal Mahasiswa Ilmu Kesehatan Jurnal Anestesi: Jurnal Ilmu Kesehatan dan Kedokteran
Gina Septiani Agustien
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Chemistry Dentistry Health Professions Medicine & Pharmacology Nursing Physics Public Health

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UJI AKTIVITAS PERTUMBUHAN RAMBUT KOMBINASI EKSTRAK ETANOL DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb.) DAN DAUN LIDAH MERTUA (Sansevieria trifasciata Prain.) Gina Septiani Agustien
Pharmacoscript Vol. 1 No. 2 (2018): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v1i2.103

Abstract

ABSTRACT The frequency and quantity of hair loss problems increases which eventually leads to baldness. The use of medicinal plants today is very popular and increasingly favored by the community. Plants are efficacious as a hair grower such as pandanus leaves (Pandanus amaryllifolius Roxb.) and sansevieria leaves (Sansevieria trifasciata Prain.). The purpose of this study to determine the hair growth activity of a combination of pandanus leaves extract and sansevieria leaves. Test preparation was made by combining both extracts at 5% concentration with comparison of pandanus leaves extract and sansevieria leaves 1: 1, 2: 3 and 3: 2. The results showed that the combination of 3: 2 has the best hair growth activity. Testing of this hair growth activity is a combination extract compared to normal control, 96% ethanol and minoxidil. The result of hair growth activity showed that the combination extract had better activity than the sole extract. Key word : hair growth activity, pandanus leaves, sansevieria leaves, extract combination.
Uji Aktivitas Antidiare Ekstrak Etanol Daun Katuk (Breynia androgyna (L.)) pada Mencit Putih dengan Metode Transit Intestinal Nitya Nurul Fadilah; Gina Septiani Agustien; Lina Rahmawati Rizkuloh
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 3, No 2 (2022): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v3i2.9791

Abstract

ABSTRAKDiare merupakan suatu masalah gangguan pada saluran pencernaan yang ditandai dengan pengeluaran feses cair berulang kali atau lebih dari 3 (tiga) kali sehari atau diare adalah frekuensi terjadinya defekasi lebih sering dari keadaan normal. Tanaman katuk mengandung senyawa-senyawa kimia meliputi flavonoid, saponin dan tanin. Tanin merupakan salah satu zat yang berkhasiat sebagai adstringensia sehingga diduga mampu memberikan efek antidiare.Tujuan penelitian ini adalah untuk melihat aktivitas antidiare dari tanaman katuk (Breynia androgyna).   Metode yang digunakan untuk menguji efek antidiare ekstrak etanol daun katuk yakni menggunakan metode transit intestinal. Dosis yang digunakan berturut-turut adalah (dosis I) 40 mg (dosis II) 80 mg dan (dosis III) 160 mg/20g BB. Berdasarkan hasil yang didapatkan pada uji aktivitas antidiare ekstrak etanol daun katuk dapat diketahui bahwa ekstrak daun katuk memiliki efek sebagai antidiare yang ditunjukkan dengan nilai rasio transit intestinal terbaik sebesar 0.39 pada dosis III sebesar 160mg/20gBB dan secara statistik siginifikan (p<0.05)   terhadap kontrol negatif. Kata kunci : Diare; Daun Katuk; Transit Intestinal; Tanin.ABSTRACTDiarrhea is a problem in the digestive tract, which is characterized by repeated discharge of liquid stools or more than 3 (three) times a day or diarrhea is the frequency of defecation more often than normal. Katuk plant contains chemical compounds including flavonoids, saponins and tannins. Tannins are one of the substances that are efficacious as an adstringensia so that they are thought to have an antidiarrheal effect. The purpose of this study was to see the antidiarrheal activity of the katuk (Breynia androgyna) plant. The method used to test the antidiarrheal effect of the ethanolic extract of katuk leaves is using the intestinal transit method. The doses used were (dose I) 40 mg (dose II) 80 mg and (dose III) 160 mg/20g BW. Based on the results obtained in the antidiarrheal activity test of the ethanol extract of katuk leaves, it can be seen that the katuk leaf extract has an antidiarrheal effect as indicated by the best intestinal transit ratio value of 0.39 at dose III of 160mg/20gBW and statistically significant (p<0.05) against the control negative. Keywords : Diarrhea; Katuk Leaves; Intestinal Transit; Tannins
Formulasi Dan Uji Stabilitas Fisik Sediaan Masker Gel Peel-Off Ekstrak Etanol Umbi Porang (Amorphophallus Muelleri) Sebagai Antioksidan Wahyu Firmansyah; Gina Septiani Agustien; Nitya Nurul Fadilah
Jurnal Anestesi Vol. 1 No. 4 (2023): Oktober : Jurnal Anestesi
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/anestesi.v1i4.510

Abstract

A peel-off gel mask is a cosmetic used for facial skin care in the form of a gel. Porang tuber extract peel-off gel mask (Amorphophallus muelleri) contains polyphenolic tannins which are efficacious as antioxidants. This study aims to determine the formulation of peel-off gel mask preparations of porang tuber extract and to determine the physical evaluation and antioxidant test of peel-off gel mask preparations of porang tuber extract using the DPPH method. Experimental formulation method with 7% polyvinyl alcohol (PVA) base. The active ingredient used is porang tuber extract with a concentration of 0.5% (F1), 1% (F2), and 1.5% (F3). Evaluation of the preparations carried out were organoleptic test, homogeneity test, pH test, drying preparation test, spreadability test, hedonic test and stability test. Based on the results of the stability test, it was shown that the peel-off gel mask preparation of porang tuber ethanol extract at various concentrations met the requirements for each test parameter. The antioxidant test results showed that F1 had an IC50 value of 48.75 ppm, F2 had an IC50 value of 43.18 ppm, and F3 had an IC50 value of 11.15 ppm which means that the three formulas have very strong antioxidant activity.
Formulasi Dan Uji Aktivitas Antioksidan Sediaan Facemist Ekstrak Umbi Wortel (Daucus Carota L) Alin Marlina; Gina Septiani Agustien; Susanti Susanti
Jurnal Mahasiswa Ilmu Kesehatan Vol. 1 No. 4 (2023): Oktober: Jurnal Mahasiswa Ilmu Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/jumkes.v1i4.255

Abstract

Excessive exposure to sunlight is a source of free radicals that cause damage to the skin such as redness, dullness, and aging, so skincare containing antioxidants is needed, one of which is a face mist made from carrot root extract. The carrot (Daucus carota L) is a plant rich in antioxidants such as β-carotene and vitamin C which can counteract free radicals. This research aims to determine whether carrot tuber extract can be formulated in a face mist preparation and to determine the value of antioxidant activity in the carrot tuber extract face mist preparation. The method used in this study is the experimental method. Preparation of carrot root extract was carried out using the maceration method with 70% ethanol solvent. Facemist carrot root extracts was made with various concentrations of FI 1%, FII 3%, and FIII 5%. All preparations were subjected to physical stability (organoleptic, pH, spray spreadability, dry time, and homogeneity) and antioxidant activity tests using the DPPH method. The results of physical stability stated that all formulas met the physical quality requirements. The antioxidant activity value of carrot tuber extracts facemist at concentrations of 1%, 3%, and 5% has an IC₅₀ value of 41.31ppm, 34.64ppm, and 28.80ppm respectively. This value is in the very strong category. The conclusion of this study is that carrot root extract can be formulated as a face mist preparation and has a very strong antioxidant value.
Formulasi Dan Evaluasi Sediaan Fisik Krim Antioskidan Ekstrak Pelepah Pohon Aren (Arenga Pinnata Merr.) Iqbal Abdul Raup; Gina Septiani Agustien; Nitya Nurul Fadilah
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 1 No. 4 (2023): Oktober : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v1i4.2447

Abstract

Aren (Arenga pinnata Merr.) is a biological resource that is thought to have antioxidant abilities and is easily found in all regions of Indonesia. The stem is used for traditional medicine to relieve itching and scars on the skin. The aim of this study was to find out whether palm frond extract (Arenga pinnata Merr.) can be formulated into a cream and has good quality. The research method used is experimental in nature by formulating the extract into three formulations namely extract concentrations of 1%, 2%, 3%. Data analysis was carried out using qualitative analysis including organoleptic tests, homogeneity tests, and quantitative analysis including pH tests, spreadability tests, adhesion tests, viscosity and using One Away ANOVA statistics. The results of the analysis showed that there was no significant difference in the concentration of palm frond cream on pH with a sig. value of 0.279 (sig. > 0.05), adhesion of 0.544 (sig. > 0.05) and viscosity that met the standard of good cream viscosity, namely between (2000 - 50000 cps). Analysis of the research data shows that the three variations of the extract can be formulated in cream preparations and have standard quality cream preparations that meet the requirements, there is no effect of variations in the concentration of palm fronds extract. The test results of the antioxidant activity of palm tree fronds that have been carried out show that in Formulas I, II, and III the IC50 values ​​were 8.88 µg/mL, 9.89 µg/mL, 6.83 µg/mL and vitamin C had a IC50 of 0.726 µg/mL. The best antioxidant content was found in formulation III with an IC50 value of 6.83 µg/mL.
Co-Authors Alin Marlina Iqbal Abdul Raup Lina Rahmawati Rizkuloh Nitya Nurul Fadilah Susanti Susanti WAHYU FIRMANSYAH