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All Journal Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) SANITAS: Jurnal Teknologi dan Seni Kesehatan Pharmacoscript Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Katalisator
Fatwa Hasbi
Politeknik Kesehatan Kementerian Kesehatan Jakarta II
Agriculture, Biological Sciences & Forestry Chemistry Environmental Science Health Professions Medicine & Pharmacology Public Health

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UJI AKTIVITAS ANTI-AGING KRIM TABIR SURYA KOMBINASI EKSTRAK TONGKOL JAGUNG (Zea mays L.) DAN EKSTRAK BIJI KOPI ROBUSTA (Coffea canephora Pierre Ex. A. Froehner) Harpolia Cartika; Yetri Elisya; Fatwa Hasbi; Khairun Nida
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (501.535 KB) | DOI: 10.36387/jiis.v7i1.863

Abstract

Skin aging which is characterized by wrinkles and reduced skin moisture due to sun exposure can be prevented by using sunscreen preparations. The sunscreen cream combination of corn cob extract and robusta coffee bean extract has strong antioxidant activity and extra protection, so it has the potential as anti-aging. This study aims to determine the anti-aging activity of the test cream. Research using experimental methods. The sunscreen cream contains 10% corn cob extract and 15% robusta coffee bean extract. Physical testing and cream stability using the cycling test method. The anti-aging activity of the cream was tested in vivo using female Sprague-Dawley rats, the observations were continued by SEM, the parameter was wrinkles. The results of the evaluation of physical stability meet the requirements of the cream. Details of the average score of wrinkles on the skin of the feet of rats given a cream base of 2.5, a test cream of 1.5 and a comparison cream of 1. This indicates the test cream has the potential as an anti-aging.
PENAMBATAN SENYAWA KOMPONEN TANAMAN KUMIS KUCING (Orthosiphon stamineus Benth) SEBAGAI DIURETIK MENGGUNAKAN METODE DOCKING Fatwa Hasbi; Saeful Amin; Tita Nofianti
Pharmacoscript Vol. 1 No. 2 (2018): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v1i2.100

Abstract

Orthosiphon Benth Stamineus is an herbal remedy that has a diuretic effect empirically. The 98’s chemical compounds from orthosiphon has been docking into some receptors ; 1Z9Y receptor with Furosemide as comparator ligand (native), 3HS4 receptor with Acetazolamide as comparator ligand (native) and 3VHU receptor with Spironolactone as comparator ligand (native). The results showed that litospermat acid 1 has -120,0670 kcal of energy which is the lowest bond energy to the receptor 1Z9Y, Dikafeoil tartaric has -107,0110 kcal of energy which is the lowest bond energy to the receptor 3HS4, but for 3VHU receptors did not get any lowest bond energy from 98’candidates compared with the energy of spironolactone is -114,5740 kcal. Ortosifonon C as component of chemical compound java’s tea which according to the literature has a diuretic effect, evidanced the data it has -91,2897 kcal to bind with 1Z9Y and -79,4270 kcal to bind with 3HS4, thus energy are lower than the native ligand (Acetazolamide). Lower energy to bind with the receptor it can makes more stable for the binding. The results of visualization showed thus are has similarities of the hydrogen bonds between the compound Litospermat acid I, Dikafeoil tartaric and Ortosifonon C with native ligand. So that 3 of chemical compounds is predicted to have the highest potential as a diuretic.
PROFIL MONOUNSATURATED DAN POLYUNSATURATED FATTY ACIDS DALAM PLASMA DARAH WANITA YANG MENGONSUMSI JAMU Fatwa Hasbi; Endang Darmawan; Akrom Akrom
Pharmacoscript Vol. 3 No. 1 (2020): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v3i1.396

Abstract

Latar Belakang : Masyarakat Indonesia diketahui gemar mengonsumsi jamu. Pada riskesdas tahun 2010 diketahui bahwa 59,12% masyarakat Indonesia mengonsumsi jamu. Jamu merupakan minuman asli Indonesia yang terbuat dari tumbuh-tumbuhan untuk tujuan pengobatan. MUFA dan PUFA banyak di temukan pada tumbuh-tumbuhan.   MUFA (Mono Unsaturated Fatty Acid) & PUFA (Poly Unsaturated Fatty Acid) merupakan golongan lemak tak jenuh yang dapat menurunkan kadar LDL serta menaikkan kadar HDL dalam darah.Tujuan : Untuk mengetahui profil monounsaturated dan polyunsaturated fatty acids dalam plasma darah wanita yang mengonsumsi jamuMetode : Penelitian ini menggunakan rancangan observasional dengan pendekatan cross sectional. Jumlah relawan dalam penelitian adalah 127 orang. Kadar MUFA & PUFA dalam plasma darah diukur menggunakan GC-MS. Hasil pengukuran kemudian dianalisis secara statistik dengan menggunakan uji distribusi frekuensi dan one-way ANOVA dengan taraf kepercayaan 95%.Hasil : Rata-rata kadar asam lemak pada  relawan yang minum jamu adalah MUFA 0,176% dan PUFA 0,012% . Jenis MUFA dan PUFA yang teridentifikasi di dalam darah relawan wanita yang mengonsumsi jamu di Kabupaten Bantul adalah Palmitoleic acid, Oleic acid (MUFA) dan Linolenic acid (PUFA). Relawan dengan nilai BMI < 18,5 (kurus) memiliki kadar MUFA yang paling tinggi dibandingkan relawan dengan nilai BMI ≥ 18,5.Kesimpulan : Ditemukan kadar MUFA yang lebih banyak dibandingkan dengan PUFA pada plasma darah relawan wanita yang mengonsumsi Jamu.  Terdapat hubungan antara kadar MUFA dengan nilai BMI.Kata kunci: MUFA, Mono Unsaturated Fatty Acid, PUFA, Poly Unsaturated Fatty Acid, Jamu.
Profile of Prescribing COVID -19 Drug Therapy in Inpatients At Jakarta Haji Hospital harpolia cartika; Harpolia Cartika; Yusmaniar Yusmaniar; Adin Hakim Kurniawan; Fatwa Hasbi; Desi Suryani
SANITAS: Jurnal Teknologi dan Seni Kesehatan Vol 13 No 1 (2022): SANITAS Volume 13 Nomor 1 Tahun 2022
Publisher : Politeknik Kesehatan Kemenkes Jakarta II

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36525/sanitas.2022.1

Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-nCoV-2) the cause of Coronavirus Disease 2019 (COVID-19) was first discovered in Wuhan on December 2019, has spread throughout the world. Each country tries to develop treatment protocol guidelines following the latest research developments to increase the cure rate due to the absence of standard guidelines.The purpose of this research is to knowing the profile of prescribing COVID-19 drug therapy in inpatients at jakarta haji hospital the period September 2020-February 2021. This research is non-experimental with quantitative descriptive study design was taken retrospectively using secondary data in the form of prescription data history of COVID-19 patient visits recorded on the system with sampling techniques that is total sampling. The results showed that in total 387 COVID-19 patients the most were 46-65 years oldwith 198 patients and the mostly malewith 212 patients. The longest duration of treatment was 3-10 days as many as 246 patients and the highest degree of disease was mild to moderate as many as 363 patients The most widely prescribed drugs were Paracetamol (84.37%), Dexamethasone (78.4%), Osetalmivir (74.1%), Heparin (67.81%), Alprazolam (60.27%), Acetylsitein (58 ,12%), Insulin (54.93%), CTM (53.13%), Amlodipine 50.43%, Vitamin C (48.04%), Levofloxacin (35.48%), and Omeprazole (31.98 %). COVID-19 patients at the Jakarta Haji Hospital receive the main therapies, namely vitamins, antibiotics, antivirals, respiratory drugs, gastrointestinal drugs. The suitability of prescribing drug therapy classes based on the guidelines for the management of COVID-19 is 83% and those that are not in accordance with the guidelines are 27%.
AKTIVITAS DIURETIK EKSTRAK ETANOL BIJI ALPUKAT (Persea americana Mill.) Khairun Nida; Purnama Fajri; Harpolia Cartika; Fatwa Hasbi
JURNAL KATALISATOR Vol. 7 No. 1 (2022): Jurnal Katalisator Volume 7 Nomor 1, April 2022
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (664.85 KB) | DOI: 10.22216/katalisator.v7i1.691

Abstract

Previous research conducted by Omodamiro and Jimoh showed that the ethanol seed extract of Persea americana , known as avocado had a diuretic activity of urine volume and electrolytes Na+, Cl- and K+ which increased significantly compare to the normal control group. Thus it is necessary to conduct further research on the ethanol seed extract of avocado to determine wether increasing dose of the extract can increase the diuretic activity. The aim of the study was to determine diuretic profile of the ethanol seed extract of avocado against furosemide as appositive control. Testing of diuretic activity uses the parameter of urine volume excreted every 30 minutes for 6 hours and 24 hours. Three treatment groups containing extracts of 7 mg, 14 mg, 28 mg were compared to furosemide.     The three doses of this extract had a diuretic profile that was not identical to that of furosemide, but had the same diuretic activity with the significant value (p> 0,05). A dose of 28 mg has a better diuretic effect than furosemide, which is characterized by the accumulation of a higher volume of urine produced. This means that the higher the dose, the better the diuretic activity
PENGKAJIAN PENGETAHUAN SIKAP DAN DETERMINASI PENGELOLAAN BEYOND USE DATE OBAT DI RUMAH TANGGA WILAYAH KECAMATAN MENTENG JAKARTA PUSAT Adin Hakim Kurniawan; Fatwa Hasbi; Muhammad Rizky Arafah
Majalah Farmasi dan Farmakologi Vol. 27 No. 3 (2023): MFF SPECIAL ISSUE
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v27i01.30037

Abstract

Latar Belakang: Pengelolaan beyond use date obat merupakan sebuah keharusan untuk dicantumkan pada etiket wadah obat. Di Indonesia pencantuman beyond use date pada etiket wadah obat masih sangat minim. Tujuan: Penelitian ini dilakukan untuk mengetahui tingkat pengetahuan dan sikap masyarakat tentang pengelolaan beyond use date obat di rumah tangga. Metode: Jenis penelitian menggunakan desain cross-sectional. Jumlah sampel penelitian ini sebanyak 110 orang.  Penelitian berlokasi di Kecamatan Menteng pada periode Januari sampai dengan Mei 2022. Teknik pengambilan sampel penelitian ini adalah purposive sampling. Teknik analisis statistik bivariat menggunakan analisis chi-square. Hasil: Dari hasil penelitian diperoleh sebagaian besar responden mampu mengelola BUD dengan sikap positif sebanyak 78,18%. Nilai pengetahuan masyarakat tentang beyond use date di rumah tangga dikategorikan kurang baik sebanyak 62 orang (56,36%) dan sebagian besar responden menjawab sediaan obat dry syrup yang diencerkan dengan air setelah membuka kemasan dapat digunakan selama 30 hari sebanyak 38,18%. Dari analisis Chisquare terdapat hubungan signifikan dengan pengelolaan beyond use date obat dirumah tangga yaitu Media informasi BUD melalui brosur/label kemasan obat  (p=0,004; OR3,143) dan Sikap pengelolaan BUD (p= 0,001;OR 4,091). Kesimpulan : Pengetahuan masyakat wilayah Menteng Jakarta Pusat mengenai tindakan pengelolaan BUD memiliki pengetahuan cukup baik dan memiliki pemahaman sikap pengelolaan BUD obat yang positif. Namun dari ketiga variabel pengetahuan, sikap dan media informasi yang paling dominan dan berpengaruh adalah sikap pemahaman masyarakat  yang masih kurang dalam mengelola Beyond Use Date Obat.
Co-Authors Adin Hakim Kurniawan Akrom, Akrom Cartika, Harpolia Desi Suryani Endang Darmawan Harpolia Cartika Khairun Nida Khairun Nida Muhammad Rizky Arafah Purnama Fajri Saeful Amin Tita Nofianti Yetri Elisya Yusmaniar Yusmaniar