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All Journal Majalah Obat Tradisional Media Farmasi Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming SANITAS: Jurnal Teknologi dan Seni Kesehatan Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Cartika, Harpolia
Politeknik Kesehatan Kemenkes Jakarta II
Automotive Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Environmental Science Health Professions Mechanical Engineering Medicine & Pharmacology Public Health

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Aktivitas Antioksidan Krim Ekstrak Etil Asetat Kulit Jeruk Nipis (Citrus aurantifolia) Yang Ditetapkan Dengan Metode DPPH Nurisyah, Nurisyah Nurisyah; Asyikin, Asyhari; Cartika, Harpolia
Media Farmasi XXX Vol 16, No 2 (2020): MEDIA FARMASI
Publisher : Jurusan Farmasi Politeknik Kesehatan Makassar, Kementerian Kesehatan RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v16i2.1818

Abstract

Lime peel (Citrus aurantifolia) contains flavonoids as antioxidants that prevent free radicals, and antioxidants are used to repair skin cells damaged by free radicals. Therefore, a research was conducted with the aim of formulating antioxidant cream preparations using lime peel extract. The extraction was carried out by maceration using ethanol 96% solvent, which was then fractionated with ethyl acetate as solvent. The ethyl acetate extract obtained was formulated into cream preparations with extract concentrations of 3%, 6%, and 9%. The formula obtained was tested for its physical and stability, and then for its antioxidant activity. The results showed that the physical properties of the cream preparation meet with requirements for the physical stability based on the organoleptic test parameters, homogeneity, pH and viscosity. Similarly, the antioxidant activity test of cream against the DPPH free radicals showed that formula 1 with an extract concentration of 3% gives an average IC50 value of 28.24 mg/ml; formula 2 with an extract concentration of 6% gives an average IC50 value of 22.97 mg/ml; and formula 3 with an extract concentration of 9% gives an average IC50 value of 14.80 mg/ml. Based on the results, it was concluded that the lime peel extract are formulated into a cream preparation with type M/A. Formula 3 with an extract concentration of 9% is the best formula with the greatest antioxidant activity.Keywords :antioxidant, ethyl acetate, extract, lime peel, creamKulit jeruk nipis (Citrus aurantifolia) mengandung flavonoid yang berfungsi sebagai antioksidan yang dapat menangkal radikal bebas. Antioksidan dapat dimanfaatkan untuk memperbaiki sel-sel kulit yang rusak akibat radikal bebas dan menangkal radikal bebas.Oleh karena itu dilakukan penelitian dengan tujuan untuk memformulasi sediaan krim antioksidan dengan menggunakan ekstrak kulit jeruk nipis. Ekstraksi dilakukan secara maserasi menggunakan pelarut etanol 96%, yang selanjutnya difraksinasi dengan pelarut etil asetat. Ekstrak etil asetat yang diperoleh diformulasi menjadi sediaan krim dengan konsentrasi ekstrak 3%, 6%, dan 9%. Formula yang diperoleh diuji fisik dan stabilitasnya, selanjutnya dilakukan uji aktivitas antioksidannya. Hasil penelitian menunjukkan bahwa sifat fisik sediaan krim yang dihasilkan memenuhi syarat kestabilan fisik berdasarkan parameter uji organoleptik, homogenitas, pH dan viskositas. Uji aktivitas antioksidan krim terhadap radikal bebas DPPH menunjukkan bahwa formula 1 dengan konsentrasi ekstrak 3% memberikan nilai IC50 rata-rata sebesar 28,24 mg/ml; formula 2 dengan konsentrasi ekstrak 6% memberikan nilai IC50 rata-rata sebesar 22,97 mg/ml; dan formula 3 dengan konsentrasi ekstrak 9% memberikan nilai IC50 rata-rata sebesar 14,80 mg/ml. Berdasarkan hasil penelitian ini maka dapat disimpulkan bahwa ekstrak kulit jeruk nipis dapat diformulasikan menjadi sediaan krim dengan tipe M/A, Formula 3 dengan konsentrasi ekstrak sebesar 9% adalah formula terbaik dengan aktivitas antioksidan paling besar. Kata kunci : antioksidan, etil asetat, ekstrak, kulit jeruk nipis, krim
Peningkatan Pengetahuan Terhadap Pengelolaan Dagusibu Obat Melalui Pelatihan Simulasi Kotak Simpan Obat di Kecamatan Johar Baru Tahun 2019 Adin Hakim Kurniawan; Harpolia Cartika; Yetri Elisya; Nanda Puspita; Wardiyah Wardiyah
Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Vol 4, No 1 (2021): Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstormin
Publisher : Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/japhb.v4i1.1727

Abstract

Pengetahuan mengenai pengelolaan dagusibu obat  merupakan faktor predisposisi dari perilaku kesehatan yang mengarah kepada timbulnya drug related problem. Bentuk kegiatan mencakup pemberdayaan masyarakat tentang pelatihan soft skill dan hard skill Pengelolaan Dagusibu Obat Melalui Simulasi Kotak simpan obat  di Wilayah Kecamatan Johar Baru Tahun 2019. Tujuan program pengabdian kepada masyarakat ingin terbentuknya tim pendampingan kader dagusibu obat di tiap-tiap wilayah. Metode pendekatan yang telah disepakati untuk menyelesaikan persoalan mitra yaitu dengan memberikan rangkaian kegiatan pelatihan yang dilakukan secara dua pendekatan pelatihan. Pendekatan Pertama metode pelatihan dengan teknik penyuluhan berbasis ceramah dan massal tanpa melalui simulasi kotak simpan obat, subjek atau sasaran responden terdapat pada masyarakat klurahan Tanah Tinggi Kecamatan Johar Baru. Kedua merupakan pendekatan metode pelatihan berbasis penyuluhan dan bersifat kelompok serta menggunakan simulasi kotak dagusibu. Subjek atau sasaran responden adalah kader kecamatan Johar Baru. Hasil pelaksanaan pengabdian kepada masyarakat yaitu terdapatnya responden perlakuan melalui pelatihan simulasi kotak simpan obat memberikan nilai pengetahuan yang baik 83,87% jika dibandingkan pelatihan penyuluhan tanpa simulasi kotak simpan obat hanya memperoleh cukup baik sebesar 48,27%. Terdapat perbedaan yang bermakna hubungan antara responden mengikuti pelatihan non simulasi dan menggunakan simulasi kotak simpan obat terhadap pengetahuan dagusibu  dengan nilai signifikansi  sebesar p=0,031 (p-Value lebih kecil 0,05).
Evaluation of Total Flavonoid, Total Phenolic, and Antioxidant Activity of Etlingera elatior (Jack) R.M.Sm Flower, Fruit, and Leaf Ulya Safrina; Wardiyah Wardiyah; Harpolia Cartika
Majalah Obat Tradisional Vol 27, No 1 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.72210

Abstract

Etlingera elatior (E. elatior) plant has long been used as a kitchen spice and daily food. E. elatior has potential as an antioxidant because it contains polyphenol and flavonoid compounds widely found in the leaves, fruit, and flowers. This study measures the total flavonoid content, total phenol content, and antioxidant activity using the ABTS method. Total phenol content was determined by the Follin-Ciocalteu method and total flavonoid content was determined by the Aluminium Chloride method. The results showed that the total flavonoid content from the highest to the lowest value from E. elatior was fruit extract, leaf extract, and flower extract, respectively. The value of total flavonoid content was 8.38 ± 0.15; 4.86 ± 0.10; and 2.60 ± 0.04 % w/w Catechin Equivalent (CE). The total phenol content from the highest to the lowest value from E. elatior was fruit extract, leaf extract, and flower extract, respectively. The total phenolic content values were 54.48 ± 1.89, 46.20 ± 0.83, and 4.80 ± 0.53 % w/w Gallic Acid Equivalent (GAE). The highest to lowest antioxidant activity values (IC50) were leaf extract at 58.82 ppm (strong activity), fruit extract at 103.05 ppm (moderate activity), and flower extract at 251.40 (weak activity), respectively.
UJI AKTIVITAS ANTI-AGING KRIM TABIR SURYA KOMBINASI EKSTRAK TONGKOL JAGUNG (Zea mays L.) DAN EKSTRAK BIJI KOPI ROBUSTA (Coffea canephora Pierre Ex. A. Froehner) Harpolia Cartika; Yetri Elisya; Fatwa Hasbi; Khairun Nida
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (501.535 KB) | DOI: 10.36387/jiis.v7i1.863

Abstract

Skin aging which is characterized by wrinkles and reduced skin moisture due to sun exposure can be prevented by using sunscreen preparations. The sunscreen cream combination of corn cob extract and robusta coffee bean extract has strong antioxidant activity and extra protection, so it has the potential as anti-aging. This study aims to determine the anti-aging activity of the test cream. Research using experimental methods. The sunscreen cream contains 10% corn cob extract and 15% robusta coffee bean extract. Physical testing and cream stability using the cycling test method. The anti-aging activity of the cream was tested in vivo using female Sprague-Dawley rats, the observations were continued by SEM, the parameter was wrinkles. The results of the evaluation of physical stability meet the requirements of the cream. Details of the average score of wrinkles on the skin of the feet of rats given a cream base of 2.5, a test cream of 1.5 and a comparison cream of 1. This indicates the test cream has the potential as an anti-aging.
Antioxidant Activity And Total Phenolic Content Of Date Palms Syrup (Phoenix Dactylifera L) Yetri Elisya; Harpolia Cartika; Anindita Rizkiana
SANITAS: Jurnal Teknologi dan Seni Kesehatan Vol 8 No 1 (2017): SANITAS Volume 8 Nomor 1 Tahun 2017
Publisher : Politeknik Kesehatan Kemenkes Jakarta II

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36525/sanitas.2017.10

Abstract

Palm date fruits (Phoenix dactylifera L) have been used for medical treatment, one of the medical purpose as antioxidant, which is the coumpound for free radical scavenging. In this study used palm juice makes with non sentrifuged method by grounds 200 grams of palm fruit with 20 ml of aquadest and store in room temperature. For date palm syrup used in this study were from certain brand distributed on the market. Antioxidant activity was testing by using DPPH method and determined by spectrophotometry Uv-Vis in wavelength 517nm, and Total Phenolic Content was testing by Folin Ciocalteu method and determined by spectrophotometry Uv-Vis in wavelength 774nm.11 sample of date palm syrup was sampling by purposive sampling methods and then got 2 sample to tested. Date Palm Juice were made by Non Cetrifuged methods. All sample were tested antioxidant activity using DPPH and Total Phenolic Content using Folin Ciocalteu. This study obtained that best operating time for all sample in antioxidant activity is 30 minutes with the highest point is Date Palm Juice 91,54%, Sample X for 86,93% and Sampel Y 89,92%. There was a linear correlation between with the result Total Phenolic Content for Date Palm Juice 9,25 mgGAE/g, Sample X 4,13 mgGAE/g and Sampel Y 4,28 mgGAE/g. Date Palm Juice and Date Palm Syrup could scavenge free radical DPPH in huge concentration and contain phenolic compound.
Profile of Prescribing COVID -19 Drug Therapy in Inpatients At Jakarta Haji Hospital harpolia cartika; Harpolia Cartika; Yusmaniar Yusmaniar; Adin Hakim Kurniawan; Fatwa Hasbi; Desi Suryani
SANITAS: Jurnal Teknologi dan Seni Kesehatan Vol 13 No 1 (2022): SANITAS Volume 13 Nomor 1 Tahun 2022
Publisher : Politeknik Kesehatan Kemenkes Jakarta II

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36525/sanitas.2022.1

Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-nCoV-2) the cause of Coronavirus Disease 2019 (COVID-19) was first discovered in Wuhan on December 2019, has spread throughout the world. Each country tries to develop treatment protocol guidelines following the latest research developments to increase the cure rate due to the absence of standard guidelines.The purpose of this research is to knowing the profile of prescribing COVID-19 drug therapy in inpatients at jakarta haji hospital the period September 2020-February 2021. This research is non-experimental with quantitative descriptive study design was taken retrospectively using secondary data in the form of prescription data history of COVID-19 patient visits recorded on the system with sampling techniques that is total sampling. The results showed that in total 387 COVID-19 patients the most were 46-65 years oldwith 198 patients and the mostly malewith 212 patients. The longest duration of treatment was 3-10 days as many as 246 patients and the highest degree of disease was mild to moderate as many as 363 patients The most widely prescribed drugs were Paracetamol (84.37%), Dexamethasone (78.4%), Osetalmivir (74.1%), Heparin (67.81%), Alprazolam (60.27%), Acetylsitein (58 ,12%), Insulin (54.93%), CTM (53.13%), Amlodipine 50.43%, Vitamin C (48.04%), Levofloxacin (35.48%), and Omeprazole (31.98 %). COVID-19 patients at the Jakarta Haji Hospital receive the main therapies, namely vitamins, antibiotics, antivirals, respiratory drugs, gastrointestinal drugs. The suitability of prescribing drug therapy classes based on the guidelines for the management of COVID-19 is 83% and those that are not in accordance with the guidelines are 27%.
Profile of Prescribing COVID -19 Drug Therapy in Inpatients At Jakarta Haji Hospital harpolia cartika; Harpolia Cartika; Yusmaniar Yusmaniar; Adin Hakim Kurniawan; Fatwa Hasbi; Desi Suryani
SANITAS: Jurnal Teknologi dan Seni Kesehatan Vol 13 No 1 (2022): SANITAS Volume 13 Nomor 1 Tahun 2022
Publisher : Politeknik Kesehatan Kemenkes Jakarta II

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36525/sanitas.2022.1

Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-nCoV-2) the cause of Coronavirus Disease 2019 (COVID-19) was first discovered in Wuhan on December 2019, has spread throughout the world. Each country tries to develop treatment protocol guidelines following the latest research developments to increase the cure rate due to the absence of standard guidelines.The purpose of this research is to knowing the profile of prescribing COVID-19 drug therapy in inpatients at jakarta haji hospital the period September 2020-February 2021. This research is non-experimental with quantitative descriptive study design was taken retrospectively using secondary data in the form of prescription data history of COVID-19 patient visits recorded on the system with sampling techniques that is total sampling. The results showed that in total 387 COVID-19 patients the most were 46-65 years oldwith 198 patients and the mostly malewith 212 patients. The longest duration of treatment was 3-10 days as many as 246 patients and the highest degree of disease was mild to moderate as many as 363 patients The most widely prescribed drugs were Paracetamol (84.37%), Dexamethasone (78.4%), Osetalmivir (74.1%), Heparin (67.81%), Alprazolam (60.27%), Acetylsitein (58 ,12%), Insulin (54.93%), CTM (53.13%), Amlodipine 50.43%, Vitamin C (48.04%), Levofloxacin (35.48%), and Omeprazole (31.98 %). COVID-19 patients at the Jakarta Haji Hospital receive the main therapies, namely vitamins, antibiotics, antivirals, respiratory drugs, gastrointestinal drugs. The suitability of prescribing drug therapy classes based on the guidelines for the management of COVID-19 is 83% and those that are not in accordance with the guidelines are 27%.
Co-Authors Adin Hakim Kurniawan Anindita Rizkiana Asyikin, Asyhari Desi Suryani Fatwa Hasbi Khairun Nida Nanda Puspita Nurisyah, Nurisyah Nurisyah Ulya Safrina Wardiyah, Wardiyah Yetri Elisya Yusmaniar Yusmaniar