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AKTIVITAS ANTIBAKTERI EKSTRAK BIJI LABU AIR (Lagenaria siceraria) TERHADAP Staphylococcus epidermidis, Staphylococcus aureus dan Escherichia coli Silvi Nurafni; Siti Mariam; Kasriati
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 2 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Lagenaria siceraria, known as water pumpkin seeds containing compounds alkaloids, phenolics, tannins, flavonoids and steroids. The above compounds are potentially as antibacterial. This research aims to know the effectiveness of the inhibition of the growth of the bacteria Staphylococcus epidermidis, Staphylococcus aureus and Escherichia coli. Based on the results of the research it is known that phytochemicals may be screening the content of water pumpkin seeds (Lagenaria siceraria) namely alkaloids, tannins, flavonoids, steroids and phenol. From the results of testing the effectiveness of antibacterial water pumpkin seed extract with ethyl acetate solvent, hexane and water is able to inhibit the growth of Staphylococcus epidermidis, Staphylococcus aureus and Escherichia coli. However the antibacterial activity of extracts of water pumpkin seeds using solvent hexane has a zone larger than drag the extract water pumpkin seeds using the solvent ethyl acetate and water. Comparison of antimicrobial activity of the solvent on the third with variation concentration of solvent shows a meaningful difference in inhibiting the growth of bacteria Staphylococcus epidermidis, Staphylococcus aureus and Escherichia coli. It can be seen from the p-value < 0.05 (p = 0.000).

AKTIVITAS ANTIHIPERGLIKEMIA EKSTRAK AIR DAN HEKSANA DAUN PANDAN WANGI (Pandanus amaryllifolius) TERHADAP TIKUS PUTIH (Rattus novergicus) Sitaresmi Yuningtyas; Siti Mariam; Auliatun Nisa
Jurnal Farmamedika (Pharmamedika Journal) Vol 2 No 2 (2017): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Diabetes mellitus is a disorder of carbohydrate metabolism characterized by high blood glucose levels, or hyperglycemia. Hyperglycemia is a condition where the amount of glucose in the blood exceeds normal limits. Many plants that have the potential as the lowering of blood glucose levels, one of which pandan leaves (Pandanus amaryllifolius). The purpose this study were to identified class of chemicals compounds contained in extracts of water and hexane pandan leaves. Beside that, this study was conducted to determine the activity extracts of water and hexane pandan leaves to decrease blood glucose levels of white rats (Rattus novergicus) with hyperglycemia. Simplicia of pandan leaves extracted by maceration method. Condensed extract contains compounds defined and tested in vivo in rats induced by alloxan. Water extract of pandan leaves (EADP) contained alkaloids, flavonoids, saponins and tannins. Hexane extract of pandan leaves (EHDP) contained alkaloids and steroids. Measurement of blood glucose levels were measured by using a glucometer for 15 days with intervals in every 3 days. Negative control treatment with Na-CMC 1% was increased in blood glucose levels to 137.50%. Metfomin as positive control treatment with 9 mg could decrease the blood glucose levels to 66.41%. Treatment with EADP 300, EADP 600, EHDP 300 and EHDP 600 could decrease glucose levels 42.38, 60.25, 26.99 and 24.81% respectively. Therefore, water and hexane extracts of pandan leaves (Pandanus amaryllifolius) could decrease the blood glucose levels with in vivo.

EVALUASI KEJADIAN INTERAKSI OBAT PADA PASIEN RAWAT INAP GERIATRI PENDERITA GAGAL JANTUNG Siti Mariam
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 1 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

An interaction occurs when the effects of a drug changed by the presence of other drugs, herbal medicine, food, drinks or other chemical agents in the environment. Drug interactions considered clinically important when the resulting increase or decrease the toxicity and effectiveness of the drugs that interact, especially when it comes to drugs with narrow safety margin (low terapheutic window). Genesis interactions may occur in patients taking two or more drugs. Interaction incident may occur in patients taking two or more drugs. The use of many drugs that often occur in geriatric patients, who suffer from degenerative diseases such as hypertension, diabetes mellitus, dyslipidemia, osteoarthritis and cardiovascular disease. Research conducted retrosfektif using medical records (MR) geriatric patients suffering from heart failure who are hospitalized in the Betha Medika Hospital in Sukabumi period March-April 2016. Retrieved 70 patients, 45% male and 54% female. Morbidities highest of 10 comorbidities with most patients is Hypertension Heart Disease (PJH). Drud interaction occur between: spironolactone, digoxin, amlodipine, bisoprolol with other drugs medicine drug classes heart failure and comorbid disease drug interactions with the number of events is different.

PERBANDINGAN PENURUNAN TEKANAN DARAH PASIEN BEDAH FRAKTUR DENGAN PREMEDIKASI ANESTESI PETIDIN DAN FENTANIL DI RSUD KOTA BOGOR Siti Mariam; Kiki Fitriana Dewi; Halimatussa’diyah
Jurnal Farmamedika (Pharmamedika Journal) Vol 4 No 1 (2019): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Premedication of intravenous anesthesia using the drugs petidine and fentanyl causes side effects of hypoventilation or decreased tidal volume and hypotension. This study aims to determine the decrease in blood pressure in fracture surgery patients at RSUD Kota Bogor. This study was conducted on 100 inpatients in the January-December 2018 period who were given the drugs petidine and fentanyl premedication. This type of non-experimental research with the retrospective data collection, research data were analyzed using the Kolmogorov-Sminorv test and the Mann Whitney test. Data taken included: Medical record number, age, sex, duration of surgery and blood pressure 5 minutes before premedication to 1 hour of surgery. The results found more surgical fracture patients occur in men (63%) with an age range of 40-50 years (29%). The duration of the most operations was 1 hour (62%). The most widely used premedication therapy as a narcotic analgesic drug is fentanyl (70%). The most common decrease in blood pressure is petidine (13.93 mmHg) compared to fentanyl (8.34 mm / Hg). Based on statistical results using the Kolmograv-Smirnov test and the Mann-Whitey test p-value (asymp sig. (2-tailed) showed a p-value of 0.05 (0,000) which means that there is a difference in blood pressure reduction between petidine and fentanyl.

AKTIVITAS EKSTRAK ETANOL KULIT BUAH NANGKA (Artocapus heterophyllus) MENGHAMBAT PERTUMBUHAN BAKTERI Escherichia coli dan Staphylococcus aureus Siti Mariam; Lia Rahmania; Lilik Sulastri
Jurnal Farmamedika (Pharmamedika Journal) Vol 5 No 2 (2020): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v5i2.109

Senyawa aktif yang terkadung dalam buah nangka (Artocapus heterophyllus Lamk.) diantaranya tannin dan polifenol yang diketahui memiliki efek antibakteri. Perlu dilakukan penelitian untuk mengetahui komposisi senyawa kimia dan aktifitas antibakteri pada bakteri Staphylococcus aureus (gram positif) dan bakteri Escherichia coli (gram negative) dari limbah kulit buah nangka Ekstraksi kulit buah dengan metode maserasi menggunakan pelarut etanol 96%. Metode difusi cakram digunakan untuk menguji aktivitas antibakteri dengan 3 kelompok perlakuan (terdiri dari kelompok konsentrasi 10%, 20%, dan 30%) serta 2 kelompok kontrol (chloramphenicol base sebagai control positif dan DMSO sebagai kontrol negative). Hasil penelitian menunjukkan bahwa 3 kelompok ekstrak kulit buah nangka mempunyai aktivitas antibakteri terhadap bakteri Staphylococcus aureus dan Escherichia coli. Aktivitas tertinggi terhadap bakteri Staphylococcus aureus pada konsentrasi 30% menghasilkan nilai diameter zona hambat rata-rata sebesar 10,76 mm termasuk kategori kuat dan pada bakteri Escherichia coli menghasilkan diameter zona hambat rata-rata sebesar 7,13 mm termasuk kategori sedang. Hasil Analisis data menggunakan ANOVA menunjukkan bahwa aktivitas antibakteri ekstrak kulit buah nangka berbeda nyata pada bakteri Staphylococcus aureus dan Escherichia coli. Hasil uji lanjut dengan Uji Duncan menunjukkan ekstrak kulit buah nangka mempunyai aktivitas antibakteri lebih tinggi pada bakteri Staphylococcus aureus dibanding bakteri Escherichia coli.

EVALUASI KEJADIAN INTERAKSI OBAT ANTIHIPERTENSI PADA PASIEN RAWAT JALAN DI PUSKESMAS TANAH SAREAL Siti Mariam; Anisa Salsabilila Y; Noneng Kurniasih
Jurnal Farmamedika (Pharmamedika Journal) Vol 7 No 2 (2022): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v7i2.189

Hipertensi merupakan salah satu penyakit sistem kardiovaskular yang paling banyak ditemukan dibandingkan dengan penyakit sistem kardiovaskular lainnya. Pada hipertensi pengobatan jangka panjang, dapat meningkatkan risiko terjadinya interaksi obat dengan obat penyakit penyerta yang diderita pasien. Penelitian ini bertujuan untuk mengevaluasi kejadian interaksi obat antihipertensi di Puskesmas Tanah Sareal periode Januari–Desember 2021. Jenis penelitian ini merupakan deskriptif observasional, pengambilan data secara retrospektif terhadap data sekunder rekam medis sebanyak 290 pasien terdiri dari perempuan 192 (66,21%) pasien dan laki-laki 98 (33,79%) pasien yang dipilih secara purposive sampling. Hasil penelitian menunjukkan pasien paling banyak usia 56–65 tahun sebanyak 117 pasien (40,34%), Penyakit penyerta terbanyak Dispepsia 92 pasien (31,72%%). Pasien mayoritas mendapatkan 2–4 obat sebanyak 272 pasien (93,79%). Obat antihipertensi yang paling banyak digunakan, yaitu amlodipin tunggal sebanyak 262 pasien (90,34%), obat penyakit penyerta paling banyak paracetamol 171 pasien (58,97%). Interaksi obat terjadi pada 49 (29,70%) pasien dari 165 pasien yang berpotensi mengalami interaksi obat dari obat antihipertensi dengan obat-obat penyakit penyerta. Obat yang berinteraksi adalah amlodipine dengan obat NSAIDs. Interaksi amlodipin dengan ibuprofen sebanyak 16 kasus (27%), amlodipin dengan natrium diklofenak sebanyak 26 kasus (38%), dan amlodipin dengan asam mefenamat sebanyak 7 kasus (44%) dari interaksi yang berpotensi berdasarkan literatur. Kejadian interaksi ditunjukkan dengan terjadinya peningkatan tekanan darah sistolik rata-rata 9,84 mm Hg dan tekanan darah diastolik rata-rata 5,92 mm Hg pada pasien.

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