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All Journal Jurnal Natur Indonesia Jurnal Ilmu Kimia Universitas Brawijaya The Indonesian Green Technology Journal The Journal of Pure and Applied Chemistry Research JKPK (Jurnal Kimia dan Pendidikan Kimia) Acta Chimica Asiana
Danar Purwonugroho
Brawijaya University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Materials Science & Nanotechnology Medicine & Pharmacology Other

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Journal : The Indonesian Green Technology Journal

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Precipitation of Zn(II)-Pyrazinamide Complex from Ethanol Solution as an Antibacterial Candidate based on Transitional Metal Complex Compounds Adiba, Naila Azmi; Purwonugroho, Danar; Prananto, Yuniar Ponco
Indonesian Green Technology Journal Vol. 13 No. 1 (2024)
Publisher : Sekolah Pascasarjana, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.igtj.2024.013.01.01

Abstract

The Zn(II)-pyrazinamide complex compound is currently being developed as an antibacterial agent. To obtain the Zn(II)-pyrazinamide complex effectively, many factors must be considered, including the type of zinc(II) salt and the mole ratio. The aim of this research is to examine the influence of the type of zinc(II) salt and the mole ratio in the precipitation of the Zn(II)-pyrazinamide complex to obtain efficient results. The Zn(II)-pyrazinamide complex was synthesized using a direct mixing technique in ethanol solution with metal:ligand mole ratios of 1:2 and 1:4 and with types of zinc(II) salts, namely acetate, chloride, and nitrate. Based on the research results, the anion of the zinc(II) salt leads to the precipitation of the complex while the metal:ligand mole ratio leads to the resulting yield. An efficient synthesis condition to obtain the Zn(II)-pyrazinamide complex is to use ZnCl2 salt and a mole ratio of 1:4. Experimental data also shows that the Zn(II)-pyrazinamide complex precipitate melts at a temperature of 234oC, while infrared spectroscopy analysis shows the characteristic carbonyl and amide groups of pyrazinamide. Meanwhile, powder-XRD analysis showed that the resulting complex had a different structure than that previously reported.
Co-Authors A.A. Ketut Agung Cahyawan W Adiba, Naila Azmi Ani Mulyasuryani Arie Srihardyastutie Bambang Ismuyanto Damayanti, Christiana Adi Darjito Darjito Dzakwan, M. Naufal Tsaqif Falisca Amelinda Febrianti, Nufida Tri Felayati, Mifta Fauziah Ilham Pratomo Ira Mardiana Isnaini, Yulia Nur Karti'a, Galuh Wahyu Latifah Dwi Kartika Nurfitriningsih Mega Dona Indriana Mohammad Misbah Khunur Rachmat Triandi Tjahjanto Rosyida, Firdania Firdaus Rumiati Ningsih Sasmita Hanjaya Seruni Swasti Pundisari Sinaga, Ria Septiani Sri Wardhani Suhernadi, Arif Syarifah, Nidatul Tutik Setianingsih Wibisono, Gilang Kopa Yuniar Ponco Prananto