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All Journal Medicina Sari Pediatri Paediatrica Indonesiana ISM (Intisari Sains Medis) : Jurnal Kedokteran
Putu Junara Putra
Bagian Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Udayana/RSUP Sanglah,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology

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Journal : Paediatrica Indonesiana

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Characteristics and outcomes of low birth weight infants in Bali Putu Junara Putra
Paediatrica Indonesiana Vol 52 No 5 (2012): September 2012
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (104.602 KB) | DOI: 10.14238/pi52.5.2012.300-3

Abstract

Background The prevalence and the mortality of low birthweight infants are still high. Low birth weight (LBW) births areresponsible for newborn death. LBW infants are easier to sufferserious health problems and death. Lower infant body weightand younger gestational age are determinants of greater risk ofmortality.Objective To determine the characteristics of LBW infants andtheir outcomes in Sanglah Hospital, Denpasar.Methods This prospective study was conducted on all LBWinfants in the nursery from their time of admission until dischargefor the year of 20 11..Results There were 120 LBW infants admitted to SanglahHospital fromJanuary 2011 to December 2011. The prevalenceofLBW was 8.9%. The birth weight group of 1500􀁰2499 gramshad the highest number of infants (79.2%). The gestational agegroup of 33􀁰36 weeks had 53.3% of the infants, while 68.3% ofthe LBW infants were of the appropriate gestational age. Themost common method of delivery was normal spontaneousdelivery (70%). Moderate asphyxia was observed in 25% of thesubjects, while severe asphyxia was observed in 22.5% of subjects.The mortality rate was 24.2%.Conclusions The prevalence of LBW of all newborns in ourhospital was 8.9%. Severe asphyxia was observed in 22.5% ofsubjects. The mortality rate of the LBW infants was 24.2%. OurLBW infants were most cormnonly in the categories of birth weightof 1500􀁰2499 grams, gestational age was between 33􀁰36 weeks,appropriate for gestational age, as well as delivered spontaneously.[Paediatr lndanes. 2012,52:30003].
Oxidative stress in neonates with hyperbilirubinemia before and after phototherapy: malondialdehyde and catalase activity Putu Junara Putra; Rinawati Rohsiswatmo; Pustika Amalia Wahidiyat
Paediatrica Indonesiana Vol 58 No 6 (2018): November 2018
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (214.323 KB) | DOI: 10.14238/pi58.6.2018.269-73

Abstract

Background Phototherapy is used to treat neonatal hyperbilirubinemia, but is currently thought to cause photodynamic stress and can induce lipid peroxidation. There is increasing evidence that many severe diseases of the neonates are caused by oxidative injury and lipid peroxidation. In the present communique, we review the oxidative succeptibility of the neonate and the evidence now available that phototherapy induces oxidative stress. Malondialdehyde (MDA) is a metabolic product of free radicals. Catalase is a antioxidant that binds free radicals. Objective To compare the levels of oxidants and antioxidants before and after phototherapy in neonates with hyperbilirubinemia. Methods This pretest-posttest control group study was conducted in Sanglah Hospital, Bali from November 2016 to April 2017. Thirty babies with gestational age ≥35 weeks and hyperbilirubinemia with total bilirubin levels requiring phototherapy were included in this study. The MDA levels and catalase activity were measured before and after 24 hours of phototherapy. Results Comparative analysis using paired T-test showed a significant increase of malondialdehyde level, with mean MDA 23.73 (SD 8.20) nmol/mL before and 53.05 (SD 10.18) nmol/mL after phototherapy (P<0.001). However, catalase activity significantly decreased from of 72.33 (SD 10.63) kU/L before phototherapy to 44.85 (SD 14.79) kU/L after phototherapy (P<0.001). The MDA level had a significant, negative association with catalase activity after phototherapy (r =-0.4; P=0.028). Conclusion Neonates with hyperbilirubinemia are found to have increased oxidative stress after phototherapy, as indicated by increased MDA levels and decreased CAT activity after 24 hours of phototherapy.
Co-Authors Ayu Setyorini Mestika Mayangsari Bagus Ngurah Putu Arhana Franky Luhulima Gusti Ayu Putu Nilawati I Gusti Agung Trisna Windiani I Komang Kari I Made Kardana I Wayan Darma Artana I Wayan Dharma Artana I Wayan Gustawan Ida Bagus Subanda IK. Suandi IM Dharmajaya Julitasari S Kadek Deddy Ariyanta Kadek Deddy Ariyanta Kadek Hartini Ketut Ariawati Made Darmajaya Made Sukmawati Ni Made Sukewanti Ni Putu Siadi Purniti Novilia Sjafri Bachtiar Novita Purnamasari Assa Nyoman Gina Henny Kristianti Pustika Amalia Wahidiyat Rinawati Rohsiswatmo Rini Mulia Sari Sudaryat S Wayan Sulaksmana Sandhi Parwata Wega Upendra Sindhughosa Yoga Putra