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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Pengabdian Masyarakat AbdiMas Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Muhammadiyah Journal of Geriatric Muhammadiyah Medical Journal
Renovaldi, Dede
Universitas Muhammadiyah Jakarta
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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GERAKAN VAKSINASI COVID-19 DI BADAN KEAMANAN LAUT (BAKAMLA) REPUBLIK INDONESI (RI) Dewi, Ratna; Nurhayati, Ety; Sukarno, Anita; Mulyana, Budi; Fatmawati, Kiki Amanda; Estheria, Estheria; Puspitasari, Rista; Renovaldi, Dede
Jurnal Pengabdian Masyarakat AbdiMas Vol 8, No 01 (2021): Jurnal Pengabdian Masyarakat Abdimas
Publisher : Universitas Esa Unggul

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47007/abd.v8i01.4790

Abstract

The addition and spread of COVID-19 cases globally is happening quite quickly, not only in the Special Capital Region of Jakarta and other densely populated cities, but has spread to rural areas in remote areas. To overcome this, the government has intensively taken steps to break the chain of transmission of COVID-19 in a fast, precise, focused, integrated, and synergistic manner between ministries/agencies and local governments. Socialization efforts were carried out related to the prevention, promotion and management of COVID through the implementation of the COVID-19 Handling Health Protocol. Other efforts have been made by various countries, including Indonesia, to develop an ideal vaccine for the prevention of SARS-CoV-2 infection with various platforms. The COVID-19 vaccination aims to reduce the transmission/transmission of COVID-19, reduce morbidity and mortality due to COVID-19, achieve herd immunity and protect the community from COVID-19 in order to remain socially and economically productive. The implementation of the COVID-19 vaccination at the Indonesian Maritime Security Agency (BAKAMLA) is a form of community service aimed at helping the government in breaking the chain of transmission of Covid-19 and accelerating the implementation of vaccinations in government employees. The vaccination takes place for 1 day with 2 (two) dose stages (Dose I and II are 14 days apart) with the type of vaccine being given, namely Sars-cov II Biofarma (Sinovac). After the service activities, most of the employees of the Indonesian Maritime Security Agency (BAKAMLA) have received the COVID-19 vaccination. Keywords : vaccine, COVID-19, BAKAMLA RI
Expression of circulating miR-200c and vascular endothelial growth factor-A (VEGF-A) mRNA as potential biomarker in human hepatocellular carcinoma Nanda Qoriansas; Dede Renovaldi; Juwita Raditya; Puji Lestari; Nur Signa Gumilas; . Suharno; Didik Setyo Heriyanto; Neneng Ratnasari; Sofia Mubarika H
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 4 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (449.108 KB) | DOI: 10.19106/JMedScie/005004201805

Abstract

Hepatocellular carcinoma (HCC) is a common liver disease that causes significant publichealth problems throughout the world, including in Indonesia. The HCC is the six mostcommon cancers and second cancer-related deaths among men in the world. Recentlyit was reported that the microRNA is an important player in hepatocarcinogenesis. Theexpression of MiRNA-200c is often regulated in primary HCC and HCC cell lines. Vascularendothelial growth factor-A (VEGF-A) is a regulator of angiogenesis that has been reportedas miR-200c target gene. This study was conducted to measure expression levels in miR-200c and mRNAVEGF-A and their potential role as biomarkers at HCC. A total of 36HCC patients and 36 healthy subjects were included in this study. The relative expressionof miRNA-200c and mRNA VEGF-A was quantified using reverse transcription real timequantitative PCR (qRT PCR). Relative expression was calculated using . Unpaired t-testwas used to compare the expression levels of circulating miRNA-200c and mRNA VEGF-Ain HCC patients and healthy subjects. Pearson test was used to determine correlationbetween circulating miR-200c expression and mRNA VEGF-A expression levels. Theexpression levels of circulating miR-200c in HCC patients were lower compared to healthysubjects although it was not significant (p = 0.258). Conversely, the expression levelsof circulating mRNA VEGF-A in HCC patients were significantly higher compared tohealthy subjects (p = 0.001). The relative expression levels of circulating miR-200c werenegatively correlated with mRNA VEGF-A in HCC patients. In conclusion, the expressionlevels of mRNA VEGF-A in HCC patients are significantly deregulated in compared tothat in healthy subjects. Negative correlation between circulating miRN-200c and mRNAVEGF-A expression levels are reported in HCC patients.
Neurological Effect and Clinical Manifestations of COVID-19 in Elderly Population Ranita Rusydina Daroh; Dede Renovaldi
Muhammadiyah Journal of Geriatric Vol 1, No 2 (2020): Muhammadiyah Journal of Geriatric
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (600.62 KB) | DOI: 10.24853/mujg.1.2.58-67

Abstract

Background: Currently there is a new world health crisis which is urgent due to the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus. The elderly can be presented as a group of patients at high risk for developing covid-19 with progressive and rapid clinical deterioration including neurological manifestations. Many reports have emerged showing that SARS-CoV-2 infection has an impact on neurological function, and even causes serious neurological damage. Purposes: to investigate the possible correlation between aging process to the severity of neurological deterioration experienced in COVID-19 infection specifically by elderly people. Methods: literature searching was conducted through PubMed, MedLine and Embase. Results: Regardless of age, the infection of SARS-CoV-2 to both central and peripheral nervous system could lead into a range of neurological deteriorations, in which also ranging in forms and severity. Conclusion: In elderly patients, despite of comorbidities, the natural degeneration process is likely being a risk factor of more severe neurological symptoms of Covid-19 infection.
Analisis Hubungan Komposisi Tubuh dan Indeks Massa Tubuh Terhadap Status Fungsional Pada Lansia Ramadhanti, Syifa Aulia; Renovaldi, Dede
Muhammadiyah Journal of Geriatric Vol. 4 No. 2 (2023): Muhammadiyah Journal of Geriatric
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mujg.4.2.189-198

Abstract

Latar Belakang: Lansia (lanjut usia) didefinisikan sebagai seseorang yang berusia diatas 65 tahun. Perubahan komposisi tubuh yang terdiri dari massa lemak dan massa tanpa lemak serta indeks massa tubuh umum terjadi pada lansia. Terjadinya perubahan pada massa otot serta lemak akibat proses penuaan dikaitkan dengan terjadinya perubahan status fungsional atau tingkat kemandirian pada lansia. Tujuan: Diketahuinya hubungan komposisi tubuh dan indeks massa tubuh terhadap status fungsional lansia. Metode: Jenis penelitian ini adalah kuantitatif dengan rancangan penelitian analitik observasional melalui pendekatan cross-sectional menggunakan data primer pada lansia. Pengambilan data dilakukan menggunakan instrumen timbangan BIA (Bioelectrical Impedance Analysis) untuk komposisi tubuh serta kuesioner indeks Barthel untuk status fungsional. Hasil: Dari hasil analisis, didapatkan terdapat hubungan yang signifikan antara komposisi tubuh yang terdiri dari persentase massa lemak serta massa otot rangka terhadap status fungsional dengan p<0,05 (0,045 & 0,024). Sedangkan, tidak terdapat hubungan yang signifikan antara indeks massa tubuh terhadap status fungsional lansia (p>0,05). Simpulan: Komposisi tubuh lansia yang terdiri dari persentase massa lemak total dan otot rangka memiliki hubungan signifikan terhadap status fungsional. Jika terdapat peningkatan persentase massa lemak, maka status fungsional lansia akan menurun dan sebaliknya. Serta apabila persentase massa otot rangka mengalami peningkatan, maka status fungsional lansia akan mengalami peningkatan dan sebaliknya. Indeks massa tubuh tidak mempengaruhi status fungsional lansia.
Potential of Sweet Basil (Ocimum basilicum) as a Hepatoprotector Agent for Liver Injury Related to Drugs Renovaldi, Dede; Adam, Abdul Khalik
Muhammadiyah Medical Journal Vol 1, No 2 (2020): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (773.047 KB) | DOI: 10.24853/mmj.1.2.63-68

Abstract

The use of drugs is one of the most common causes of liver injury, because the liver is the main organ that metabolizes drugs. Little is currently done if there is a liver injury due to the hepatotoxic side effects of a drug. Herbal plants have active natural compounds that have pharmacological effects so they are widely used as alternative treatments. Sweet basil (Ocimum basilicum) is one of the most cultivated plants in Asia. Studies on the use of Ocimum basilicum in medicine have been carried out, one of which is the hepatoprotector effect. Studies indicate that Ocimum basilicum is rich in high antioxidant content (flavonoids, saponins, tannins, sterols, triterpenes, and rosmaniric acid) capable of providing hepatoprotector effects by helping the regeneration process of hepatocyte cells that are damaged by hepatotoxic agents and significantly decreasing liver damage biomarkers. The purpose of this review is to explain the potential of Ocimum basilicum as a hepatoprotective agent for liver injury associated with drugs. The conclusion of this review is Ocimum basilicum has high potential in its utilization as a hepatoprotector against liver injury mainly related to the consumption of drugs that have hepatotoxic effects.
Hubungan Indeks Massa Tubuh (IMT) dan Kualitas Tidur terhadap Irama Sirkadian pada Lansia di Panti Sosial Chintami, Alvita Shabilla; Renovaldi, Dede; Putra, Muhamad Dwi
Muhammadiyah Journal of Geriatric Vol 4, No 1 (2023): Muhammadiyah Journal of Geriatric
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mujg.4.1.35-43

Abstract

Latar Belakang: Pertambahan usia seseorang seiring dengan penurunan fungsi fisiologis tubuh dapat menyebabkan perubahan pada kualitas tidur. Jam tidur yang singkat dengan rata-rata 7 jam per hari dapat menyebabkan terjadinya kekurangan hormon leptin, kelebihan hormon ghrelin, dan kelebihan indeks massa tubuh (IMT). Pada lansia, keluhan gangguan tidur dan penurunan kualitas tidur diasumsikan mempengaruhi jam biologis tubuh atau irama sirkadian. Tujuan: Untuk mengetahui hubungan antara IMT dan kualitas tidur dengan irama sirkadian pada lansia di Panti Sosial. Metode: Studi ini adalah studi analitik observasional dengan pendekatan cross-sectional. Instrumen penelitian menggunakan antropometri (IMT), kuesioner PSQI (kualitas tidur) dan MEQ untuk mengevaluasi irama sirkadian. Analisis korelasi dilakukan menggunakan chi-square test dengan derajat kemaknaan 5%. Hasil: Sebanyak 60 responden didapatkan hasil mayoritas mempunyai kualitas tidur yang baik dan kategori irama sirkadian yaitu Morning type dengan IMT yang normal. Analisis korelasi chi square didapatkan nilai p-value 0,05 pada hubungan kualitas tidur dengan irama sirkadian, sementara p-value 0,05 didapatkan dari hubungan usia, jenis kelamin, dan IMT dengan irama sirkadian. Simpulan: Kualitas tidur yang baik pada lansia cenderung dimiliki oleh lansia dengan irama sirkadian morning type dengan hubungan yang secara statistik bermakna. Namun, IMT tidak memiliki hubungan yang signifikan terhadap irama sirkadian pada lansia di panti sosial.
Karakteristik Klinis dan Skor Ankle Brachial Index (ABI) Pada Lansia di Panti Sosial Tresna Werdha Budi Mulia 3 Jakarta Selatan Renovaldi, Dede; Afrijiyah, Raudatul Sifa
Muhammadiyah Journal of Geriatric Vol 3, No 1 (2022): Muhammadiyah Journal of Geriatric
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mujg.3.1.9-16

Abstract

Latar belakang: Lansia adalah seseorang yang sudah memasuki usia 60 tahun keatas. Lansia rentan mengalami beberapa masalah kesehatan vaskular seperti, hipertensi, stroke, diabetes melitus dan jantung koroner yang terpengaruh oleh keterlambatan regeneratif yaitu fisik, kognitif bahkan emosional. Salah satu metode untuk mendeteksi gangguan ini adalah Ankle Brachial Index (ABI). Ankle Brachial Index (ABI) adalah metode yang direkomendasikan untuk diagnosis penyakit arteri perifer (PAP), yakni penyakit yang menyebabkan gangguan aliran darah pada ekstremitas yang biasanya disebabkan oleh aterosklerosis. Tujuan: Penelitian. Diketahuinya karakteristik klinis dan skor Ankle Brachial Index (ABI) pada Lansia di Panti Sosial Tresna Werdha Budi Mulia 3. Metode: Penelitian ini merupakan penelitian kuantitatif yang bersifat observasional analitik dengan pendekatan cross sectional. Penelitian ini dilakukan untuk mengetahui hubungan karakteristik klinis dengan skor ABI pada lansia dengan jumlah sampel sebanyak 60 responden. Hasil: Hasil penelitian menyatakan bahwa terdapat hubungan bermakna antara indeks massa tubuh (IMT) dan riwayat komorbid terhadap skor ABI pada lansia dengan nilai p pada IMT (p=0.002) dan nilai p pada riwayat komorbid (p=0.000). namun tidak terdapat hubungan bermakna antara usia, jenis kelamin, dan riwayat merokok dengan skor Ankle Brachial Index (ABI) pada lansia dengan nilai (p= 0,05). Simpulan: Mayoritas lansia di Panti Sosial Tresna Budi Mulia 3 memiliki skor Ankle Brachial Index (ABI) yang normal. Tidak terdapat hubungan bermakna antara usia, jenis kelamin, dan riwayat merokok dengan skor Ankle Brachial Index (ABI), namun terdapat hubungan bermakna antara indeks massa tubuh (IMT) dan riwayat komorbid terhadap skor ABI. 
Comparison of Depression Levels between Medical and Engineering Students at Universitas Muhammadiyah Jakarta Nadila, Riska Indri; Renovaldi, Dede
Muhammadiyah Medical Journal Vol. 6 No. 1 (2025): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.6.1.50-58

Abstract

Background: Medicine and engineering faculties are noted for their vigorous learning intensity and high degree of academic difficulty, making them vulnerable to mental health illnesses such as depression. Purpose: To compare depression levels between medical and engineering students at Universitas Muhammadiyah Jakarta. Method: This study employed a cross-sectional design. Medical and Engineering students were given the Beck Depression Inventory II (BDI-II) questionnaire. The sample size consists of 152 people, collected through purposive sampling. The Mann-Whitney test was used for analysis (p = 0.05, 95% CI). Result: Age 21 (25.0%) was the most frequent age, while age 17 (2.6%) was the least frequent. Based on gender, the male respondents consisted of 87 people (57.2%), and the female respondents consisted of 65 (42.8%). The medical and engineering student groups each had 76 respondents (50.0%). Only 40.8% of medical students reported depression, compared to 63.1% of engineering students (p = 0.001). Conclusion: Engineering students experience more depression than medical students.
Dampak Kerja Shift dan Tingkat Stres terhadap Kadar Gen Brain-Derived Neurotrophic Factor (BDNF) pada Perawat Selama Pandemi Covid-19 Atthariq; Putri, Maria Eka; Fachri, Muhammad; Akaputra, Risky; Renovaldi, Dede
Majalah Kedokteran Indonesia Vol 75 No 3 (2025): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.75.3-2025-1583

Abstract

Introduction: The project aims to investigate how the Covid-19 epidemic influenced nurses’ stress levels, shift work, and BDNF mRNA expression. Hospitalized patient numbers in Indonesia were rising sharply during the outbreak. This illness has a major impact on nurses’ levels of weariness and stress, which follow each other. High-stress workers have lower serum levels of brain-derived neurotrophic factor (BDNF). Workload, job conflicts, and sleep difficulties are some of the causes that lead to this stress.Methods: The study was conducted at the Cempaka Putih Islamic Hospital in Central Jakarta, Indonesia, from July to September 2020. The study used an analytical observational approach and a cross-sectional design. The number of nurses who participated in this study was 89 people who were selected using This study included 89 nurses who were recruited using a purposive selection technique based on predetermined inclusion and exclusion criteria. Anthropometric measures and intravenous blood collection were used to gather data for real-time PCR analysis of the BDNF gene mRNA expression.Result: The mean BDNF mRNA expression level was 8.93 ng/mL. Nurses reported work-related stress, with a significant correlation (p less than 0.05) between BDNF mRNA expression, work shift, and stress levels. According to the findings, those with low, moderate, and high stress levels had mean BDNF levels of 11.69, 8.65, and 7.36, respectively. Statistical testing revealed a significant difference (p less than 0.001) in the mean mRNA expression of the BDNF gene across subjects with low, moderate, and high stress levels.Conclusion: During the Covid-19 pandemic, a statistical correlation was found between nurse stress levels, work shifts and low BDNF levels.
Co-Authors . Suharno ADAM, ABDUL KHALIK Afrijiyah, Raudatul Sifa Akaputra, Risky Atthariq Chintami, Alvita Shabilla Didik Setyo Heriyanto Estheria, Estheria Fatmawati, Kiki Amanda Juwita Raditya Muhammad Fachri Nadila, Riska Indri Nanda Qoriansas Neneng Ratnasari Nur Signa Gumilas Nurhayati, Ety Puji Lestari Puspitasari, Rista Putra, Muhamad Dwi Putri, Maria Eka Ramadhanti, Syifa Aulia Ranita Rusydina Daroh Ratna Dewi Sofia Mubarika Haryana Sukarno, Anita Yundari, Yundari