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Forced Degradation Study Of Paracetamol Levels Using Uv-Vis Spechtrophotometry: Studi Degradasi Paksa Terhadap Kadar Paracetamol Menggunakan Spektrofotometri UV-Vis M.A. Hanny Ferry Fernanda; Maulidia Ningsih
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 1 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i1.312

Abstract

Paracetamol or acetaminophen is a class of over-the-counter drugs widely used by the general public to treat fever and mild pain. The study aimed to determine the effect of forced degradation by hydrolysis on paracetamol levels using Uv-Vis Spectrophotometry. This type of research is experimental with the method used is Uv-Vis Spectrophotometry which is carried out at a wavelength of 200-400 nm. The results obtained from the study in the form of a linear regression equation y=0,0652x + 0,0269 with a value of R2 = 0,9938. Furthermore, paracetamol without degradation was 90,40%, while paracetamol with degradation was 87,98%. It was concluded that there was a decrease in the levels of paracetamol treated with degradation, so it was stated that there was an indication of the effect of forced degradation by hydrolysis of paracetamol. The advice given by the researcher is to develop further research related to validation methods and degradation studies in determining the levels of paracetamol tablets.
Analysis of Proximate Level of Porang Tubers (Amorphophallus muerelli Blume) After Drying with Oven and Sun: Analisis Kadar Proksimat Umbi Porang (Amorphophallus muerelli Blume) Setelah Pengeringan dengan Oven dan Sinar Matahari Ratih Kusuma Wardani; M.A. Hanny Ferry Fernanda
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 1 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i1.315

Abstract

Porang tubers are one of the tubers that have special features compared to other tubers. Porang tubers contain glucomannan which has many health benefits. Glucomannan is a polysaccharide compound and contains high fiber. People have not been able to consume porang tubers directly because they contain high concentration of calcium oxalate. Soaking porang tubers in lime solution can help lower calcium oxalate levels. In addition to the content of glucomannan and calcium oxalate, proximate levels in porang tubers also need to be analyzed to determine the quality of processed porang tubers. In this study, an analysis of proximate levels in porang tubers was carried out before and after soaking in lime solution. The proximate levels of porang tubers before and after soaking with lime solution did not differ much. Porang tubers that have been dried for 6 days have a lower water content and higher carbohydrate content than tubers that have been dried for 4 days. Likewise, porang tubers that have been dried at 70 °C have a lower moisture content and higher carbohydrate content than tubers dried at 60 °C.
Perbedaan Kandungan Asam Askorbat Buah Nanas dan Keripik Nanas yang Beredar di Pasar Wonokusumo Menggunakan Metode Spektrofotometri Ultra Violet Dinda Alya Hasan; M.A. Hanny Ferry Fernanda
BORNEO JOURNAL OF PHARMASCIENTECH Vol 6 No 2 (2022): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v6i2.430

Abstract

Vitamin C is one of the vitamins needed by the body that acts as an antioxidant to form a defense against free radicals. One of the fruits that contain vitamin C is pineapple. Pineapple is one of the most popular types of fruit. One of the most popular processed pineapple fruit is pineapple chips. This study aimed to determine the differences in the content of vitamin C in pineapple fruit and chips. The analytical method used to determine vitamin C levels is UV-Vis Spectrophotometry because this method is quite accurate and more efficient and produces high accuracy and precision. The results of this study are the linearity test obtained a linear regression equation, namely y = 0.0363x + 0.0687 with a value of R² = 0.993. Successively obtained the average level of pineapple fruit is 0.191 %w/w, brand A pineapple chip is 0.099 %w/w, and pineapple chips brand B is 0.111 %w/w. Based on the results of statistical tests, it is known that there are differences in vitamin C levels in pineapple and pineapple chips.
EDUKASI PEMANFAATAN DAUN BINAHONG SEBAGAI PESTISIDA NABATI DI KELURAHAN KALI KEDINDING SURABAYA Surahmaida Surahmaida; Cicik Herlina Yulianti; M.A. Hanny Ferry Fernanda
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 4 No. 2 (2023): Volume 4 Nomor 2 Tahun 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v4i2.15988

Abstract

Kampung Tanah Kali Kedinding Surabaya dikenal sebagai Kampung Si Ahong dan Kampung Sayur. Setiap rumah warga di perkampungan ini memiliki tanaman hias, tanaman obat serta penggalakan budidaya tanaman binahong yang terkenal akan manfaat kesehatannya. Dalam budidaya tanaman, serangan serangga hama seringkali menjadi masalah yang sering dihadapi. Masyarakat biasanya mengandalkan penggunaan pestisida kimia untuk mengatasi hama dan penyakit yang merusak pertanaman. Namun, pestisida kimia memiliki dampak negatif terhadap kesehatan dan lingkungan. Kegiatan Pengabdian kepada Masyarakat ini bertujuan untuk meningkatkan keterampilan warga dalam pembuatan pestisida nabati berbahan dasar daun binahong sebagai alternatif pengendalian hama yang ramah lingkungan. Metode Pengmas yang dilakukan antara lain metode pemaparan, demonstrasi, sesi diskusi, serta pengisian pretest dan postest. Hasil Pengmas menunjukkan bahwa terdapat peningkatan pemahaman warga dari 24% menjadi 100%. Harapan dari hasil kegiatan Pengmas ini dapat meningkatkan pemahaman dan pengetahuan warga dalam mengadopsi inovasi teknologi dalam pengendalian hama tanaman dengan membuat pestisida nabati yang ramah lingkungan.
ANALISIS KADAR TIMBAL PADA EYELINER DENGAN METODE SPEKTROFOTOMETRI SERAPAN ATOM (SSA) Dwi Handayani; M.A. Hanny Ferry Fernanda; Djamilah Arifiyana
Jurnal Komunitas Farmasi Nasional Vol. 2 No. 1 (2022): Jurnal Komunitas Farmasi Nasional
Publisher : Akademi Farmasi Yarsi Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study aims to determine the level of lead concentration in eyeliner cosmetics in Surabaya city. Eyeliner is one of the cosmetics that is applied to the eye line, therefore the ingredients contained in it must be safe. Cosmetic eyeliner totaled 6 samples with different trademarks were collected by purposive sampling method. The cosmetic eyeliner samples were digested wet with aqua regia and heavy metal analysis of lead was performed using Atomic Absorption Spectrophotometry (AAS) at a wavelength of 283.3 nm. BPOM of Indonesian Republic decides the limit of heavy metals allowed in cosmetics is 20 mg/kg. All samples in this study were found to contain lead metal exceeding the specified limits. The highest lead levels were found in sample E, which was 180.1188 ppm. The results show that cosmetic eyeliner products are exposed to dangerous heavy metals and may have a risk to the health of users because metals can accumulate in the body.
Penyuluhan Peningkatan Pemahaman Masyarakat terhadap Beyond Use Date Sediaan Obat pada Swamedikasi Secara Daring M.A. Hanny Ferry Fernanda; Galuh Gondo Kusumo
Jurnal Pelayanan dan Pengabdian Masyarakat (Pamas) Vol 7, No 4 (2023): Jurnal Pelayanan dan Pengabdian Masyarakat (PAMAS)
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM Universitas Respati Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52643/pamas.v7i4.1491

Abstract

Beyond Use Date (BUD) can be defined as the time limit for a drug product that is safe for use after compounding or after the primary packaging has been opened. In contrast to the Expired Date (ED) or expiration date which is the limit on the use of drugs listed on the drug packaging. This BUD is not listed on the drug packaging so people need to know about this BUD. This BUD really determines the time limit for a drug product that is still of good quality and is in a stable condition. Ideally, the BUD is determined based on the results of the drug product stability test and is listed on the packaging. However, when doing self-medication or self-medication, people usually only use the expiration date as a reference for the safety of drug use. Therefore, there is a need for community service activities to provide education to the community about knowledge of drug damage after the packaging is opened and before ED. The purpose of this activity is to increase public knowledge about the safety of pharmaceutical preparations as long as they are stored with a time limit after the packaging is opened. This activity was carried out online through the zoom meeting application on Saturday, April 10, 2021. The results of this activity provided information that the public could understand the Beyond Use Date material on the use of self-medication drugs properly. Keywords : Beyond Use Date, Expired Date, Self Medication
Analisa Kadar Timbal (Pb) pada Lipstik di Wilayah Kota Surabaya yang Teregistrasi dan Tidak Teregistrasi Menggunakan Spektofotometri Serapan Atom (SSA) M.A. Hanny Ferry Fernanda; Devi Elidya; Novianti Ayu Manaheda; Nurul Qomaryah; Muhammad Khotibul Umam; Anisa Riski Amalia; Djamilah Arifiyana
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 4 No. 1 (2019): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v4i1.130

Abstract

ABSTRAKLipstik merupakan salah satu kosmetik yang paling banyak dan hampir setiap hari digunakan oleh wanita. Timbal adalah salah satu cemaran logam berat yang terdapat dalam lipstik. Penelitian ini bertujuan untukmengetahui kandungan logam berat timbal dalam lipstik yang teregistrasi dan tidak teregistrasi mengguanakan Spektrofotometer Serapan Atom (SSA). Preparasi sampel menggunakan destruksi basah dengan aqua regia. Sampel lipstik yang digunakan sebanyak 24 sampel lipstik yang diambil di wilayah Kota Surabaya, dimana 12 sampel memiliki nomor registrasi BPOM dan 12 sampel tidak memiliki nomor registrasi BPOM. Hasil penelitian menunjukkan adanya kandungan logam berat yang melebihi persyaratan BPOM pada semua sampel lipstikdengan rata-rata kadar 108.9517 ppm untuk lipstik yang teregistrasi dan 102.7183 ppm untuk lipstik yang tidak teregistrasi. Berdasarkan uji Mann-Whitney U diketahui bahwa tidak ada beda antara kadar Pb pada lipstik yang teregistrasi dengan lipstik yang tidak teregistrasi dengan nilai α= 0,05.Kata kunci: Timbal (Pb), Lipstik, Surabaya, Registrasi, Spektrofotometri Serapan Atom. ABSTRACTLipstick is one of the most widely used cosmetics every day by women. Lead is one of the heavy metal contaminants found in lipstick. This study aims to determine the heavy metal content of lead in registered lipstickand not registered using Atomic Absorption Spectrophotometer (AAS). Sample preparation using wet destruction with aqua regia. Lipstick samples were used as many as 24 lipstick samples taken in the Surabaya area, where 12 samples had BPOM registration numbers and 12 samples did not have BPOM registration numbers. The results showed that there was a heavy metal content that exceeded BPOM requirements for all lipstick samples with an average level of 108.9517 ppm for registered lipstick and 102.7183 ppm for unregistered lipstick. Basedon the Mann-Whitney U test it is known that there is no difference between Pb levels on lipstick registered with lipstick which was not registered with a value of α = 0.05.Keywords: Lead (Pb), Lipstick, Surabaya, Registration, Atomic Absorption Spectrophotometry..
Study of Tetracycline HCl Residue in Broiler Chicken Meat and Liver at Several Farms in Lamongan District Using Ultraviolet Spectrophotometry Method: Kajian Residu Tetrasiklin HCl dalam Daging dan Hati Ayam Broiler pada Beberapa Peternakan di Kabupaten Lamongan Menggunakan Metode Spektrofotometri Ultraviolet M.A. Hanny Ferry Fernanda; Rosita Dwi Chrisnandari
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 6 No. 1 (2021): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i1.206

Abstract

Tetracycline HCl is one of the most commonly used antibiotics in animal feed additives to control disease caused by bacteria. The dosage of antibiotics added to animal feed is sometimes not in accordance with existing regulations, causing residues in the body to be left behind. The purpose of this study was to determine the presence and levels of tetracycline HCl antibiotic residues in the meat and liver of broiler chickens on farms in Lamongan City by using the spectrophotometric method by selecting the maximum wavelength which was carried out by making the absorbance relationship curve and the wavelength of the standard solution at a certain concentration. The results of tetracycline antibiotic residues in boiler chicken meat and liver on the first farm showed that the residual levels of tetracycline HCl were 3,969.10 ± 392.32 ppm and 14,247.74 ± 2,632.63 ppm, on the second farm showed residual levels of tetracycline HCl. 5,470.03 ± 512.76 ppm and 20,464.60 ± 5,985.63 ppm, respectively, and the third farm showed that the remaining levels of tetracycline HCl were 7,032.37 ± 971.99 ppm and 19,232.71 ± 6,404.63 ppm. The results showed that the residual content of tetracycline HCl in broiler meat and liver exceeds the maximum residual content of tetracycline class of antibiotics in meat and milk based on SNI 01-6366-2000 which limits the residue to not more than 0.1 ppm.
Antimicrobial Activity of Ganoderma lucidum Ethanol Extracts using Bioautography Method against Escherichia coli and Bacillus subtillis: Potensi Antimikroba Ekstrak Ethanol Ganoderma lucidum Menggunakan Metode Bioautografi terhadap Bakteri Escherichia coli dan Bacillus subtillis Tri Puji Lestari Sudarwati; M.A. Hanny Ferry Fernanda
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 6 No. 1 (2021): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i1.212

Abstract

This study was aimed to determine the antibacterial potency of ethanol extract of lingzhi mushroom(Ganoderma lucidum) using bioautographic TLC method against Escherichia coli and Bacillus subtillis.Soxhletation method was chosen to extract the bioactive compound using the ethanol solvent. Following theextraction, the obtained extract was diluted to make a serial concentration which are 2%, 4%, 6%, 8% and10% with five replication each. Bioautographic TLC used n-butanol: glacial acetic acid: water (4: 1: 5) as adeveloping solvent. After complete development, the TLC plate was dried and observed for the spots whichare yellow spot with Retention factor (Rf) value of 0.3, blue spot with Rf 0.87, and brown spot with Rf 0.93.Based on the reference Rf value, this third detected spot is considered as triterpene compound. The spot wasthen tested for the inhibition zone. In the E. coli culture medium, the average value of the inhibition zone was5.45 mm (weak category) for the concentration of 2%, 5.14 mm for the 4%, 5.48 mm for the 6%, 5.94 mm forthe 8%, and 6.98 mm (medium category) for the 10%. Meanwhile in the Bacillus subtillis culture medium, aconcentration of 2% yielded 5.9 mm, 4% yielded 6.34 mm, 6% yielded 6.68 mm, 8% yielded 7.88 mm, and10% yielded 8.6 mm (medium category). In conclusion, the lingzhi mushroom ethanol extract hasantibacterial activity against both Escherichia coli and Bacillus subtillis with concentration-dependentmanner.