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All Journal Journal Pharmasci (Journal of Pharmacy and Science) Journal of Science and Social Development Jurnal Sains dan Kesehatan
Galuh Gondo Kusumo
Akademi Farmasi Surabaya
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Identification of Secondary Metabolites of Onion Peels Extract (Allium cepa L.) of Various Solvent: Identifikasi Senyawa metabolit Sekunder Ekstrak Kulit Bawang Merah (Allium cepa L.) dari Berbagai Macam Pelarut Mercyska Suryandari; Galuh Gondo Kusumo
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 7 No. 2 (2022): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v7i2.289

Abstract

Onion peels (Allium cepa L.) is often disposed of without being used and ends up as waste in markets that can pollute the environment. Onion peels can potentially be developed for treatment as an anti-cancer because of its phytochemical compounds. Previous studies have shown that secondary metabolites found in onion peels using different solvents produce different secondary metabolites. So the purpose of this study was to find out the secondary metabolite compounds from onion peels extract (Allium cepa L.) qualitatively when extracted using 5 different solvents. This research was conducted using a phytochemical screening method on the onion peels extract (Allium cepa L.). n-Hexane, Ethyl Acetate, Acetone, Ethanol 96%, and Chloroform were used in the maceration extraction method separately. The results showed that the yield value was 0.96%; 2.66%; 3.90%; 4.80%; 1.62%. The results showed that acetone, ethanol, and chloroform extracts of onion peels extract (Allium cepa L.) contained alkaloids, flavonoids, saponins, steroids, terpenoids, and tannins. Meanwhile, the ethyl acetate extract of onion peels contains alkaloids, flavonoids, steroids, terpenoids, and tannins. Lastly, the n-hexane extract of the onion peels only contains steroids and terpenoids. So it can be concluded that secondary metabolites in onion peels extract contain alkaloids, flavonoids, saponins, steroids, terpenoids, and tannins.
Antioxidan Activity from Methanol Extract of Kratom Leaves (Mitragyna speciosa) Maseration Result Using The DPPH Method: Aktivitas Antioksidan Ekstrak Metanol Daun Kratom (Mitragyna speciosa) Hasil Maserasi Menggunakan Metode DPPH Andhika Dwi Aristyawan; Anggi Ayu Windari; Mercyska Suryandari; Galuh Gondo Kusumo
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 2 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i2.357

Abstract

Antioxidants are compounds that can prevent the formation of free radicals. Kratom is a typical plant from South Putussibau area, in West Kalimantan. The kratom plant contains alkaloids, triterpenoid-steroids, saponins, tannins and flavonoids. The main component of kratom leaves is an indole alkaloid that is efficacious as an antioxidant. The goal is to determine the antioxidant activity of kratom leaf extract (Mitragyna speciosa). The method used is the measurement of the reduced amount of DPPH from an antioxidant compound UV-Vis spectrophotometrically at a wavelength of 517nm using Vitamin C as a comparison. The extraction method used is maceration. The test was sampled 10 mg of kratom leaf extract (Mitragyna speciosa) with 10 ppm, 20 ppm, 30 ppm, 40 ppm, and 50ppm concentrations, then repeated 3 times. The results of the antioxidant activity of kratom leaves (Mitragyna speciosa) were expressed with IC50 values of 44,169 ± 0.5313 with an RSD value of 1.202%. Then it can be concluded that kratom leaf methanol extract (Mitragyna speciosa) has a very strong antioxidant activity with an IC50 value of 44,169 ± 0.5313 with an RSD value of 1.202%.
PENINGKATAN PEMAHAMAN MASYARAKAT DESA DRENGES KABUPATEN BOJONEGORO TENTANG PENGGUNAAN OBAT MELALUI PENYULUHAN PENGUNAAN OBAT YANG BENAR Ilil Maidatuz Zulfa; Prasetyo Handrianto; Ratih Kusuma Wardani; Galuh Gondo Kusumo
Journal of Science and Social Development Vol. 1 No. 2 (2018): Journal of Science and Social Development
Publisher : Universitas Nahdlatul Ulama Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55732/jossd.v1i2.169

Abstract

Irrational drug use usually happens in self medication practise without any supervision from health care providers. Self medication practise usually does not consider the potential of allergic reaction, pregnancy, breast feeding, diet, and medication history.The promotion of rational drug use through communication, information, and education still need to be conducted to the community. This event is purposed to improve perception, knowledge, and attitude of Desa Drenges residents in the term of drug usage. A total 23 person of Desa Drengeswere enrolled in this eventfacilitated by village administrators.The perception, knowledge, and attitude of the residents recruited were evaluate through questionnaire filled before and after the event. The result showed the increase of perception, knowledge, and attitude of the residents up to 2,69%. From the result, The community service event can improve the quality of health of residents in Desa Drenges through the improvement of perception, knowledge, and attitude in the term of rational drug use.
Formulasi dan Evaluasi Nano Partikel Ekstrak Etanol Daun Ubi Jalar Ungu (Ipomoea batatas L.) Varietas Antin-3: Formulation and Evaluation of Nano Particles Ethanol Extract of Purple Sweet Potato Leaves (Ipomoea batatas L.) Antin-3 Varieties Damaranie Dipahayu; Galuh Gondo Kusumo
Jurnal Sains dan Kesehatan Vol. 3 No. 6 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i6.818

Abstract

Ekstrak daun ubi jalar ungu (Ipomoea batatas Lamk) varietas Antin-3 (Ekstrak daun Antin-3) yang mengandung polifenol dan flavonoid yang memiliki kemampuan sebagai antioksidan. Polifenol dan Flavonoid memiliki bioavailabilitas yang rendah. Penelitian ini bertujuan untuk memperkecil ukuran partikel ekstrak menjadi nanopartikel sehingga penyerapan saluran cerna dapat meningkat serta evaluasi fisiknya untuk memastikan partikel nano seperti ukuran partikel (10-1.000 nm), indeks polidispersitas (PDI) ( < 0,5) dan nilai potensial zeta (±20mV sampai ±-30mV). Formulasi ekstrak nano dengan metode gelasi ionik menggunakan kitosan: NaTPP. Ada tiga Tiga sampel yang diteliti (F1:F2:F3) yaitu dengan perbandingan ekstrak daun Antin-3:kitosan:NaTPP (1:1:1 ); (1:5:1); (1:10:1). Evaluasi dilakukan dengan menggunakan PSA (Particle Size Analyzer). Hasil evaluasi sampel (F1:F2:F3) menggunakan PSA (Particle Size Analyzer) untuk ukuran partikel berturut-turut (1.482 nm; 564,38 nm; 734,36 nm); untuk PdI berturut-turut (0,3482; 0,4272; 0,381) dan untuk nilai potensial zeta masing-masing (5,19mV; 21,57mV; 33,4mV). F3 merupakan sampel yang memenuhi kriteria ukuran partikel, PdI dengan nilai zeta potensial
Co-Authors Anggi Ayu Windari Aristyawan, Andhika Dwi Damaranie Dipahayu Mercyska Suryandari Prasetyo Handrianto Ratih Kusuma Wardani Zulfa, Ilil Maidatuz