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All Journal Jurnal Pelayanan dan Pengabdian Masyarakat (Pamas) Journal Pharmasci (Journal of Pharmacy and Science) Jurnal Pengabdian Kepada Masyarakat Itekes Bali Prosiding Seminar Nasional Biologi Jurnal Komunitas Farmasi Nasional Journal of Science and Social Development Jurnal Sains dan Kesehatan IJENSET
Galuh Gondo Kusumo
Akademi Farmasi Surabaya
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Identifikasi Senyawa Tanin Pada Daun Kemuning (Murraya panicullata L. Jack) Dengan Berbagai Jenis Pelarut Pengekstraksi Kusumo, Galuh Gondo; Ferry Fernanda, M.A. Hanny; Asroriyah, Heppy
Journal of Pharmacy and Science Vol. 2 No. 1 (2017): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v2i1.63

Abstract

ABSTRAKKemuning (Murraya paniculata L. Jack) adalah salah satu kekayaan alam yang memiliki banyak manfaat bagi kehidupan manusia. Tanin merupakan salah satu metabolit sekunder dari kemuning yang dapat digunakan sebagai anti diare dan pelangsing. Ekstrak kemuning didapatkan dari maserasi menggunakan tiga pelarut berbeda, yaitu metanol, etanol dan etil asetat. Tannin kemudian dipisahan dari ekstrak dengan menggunakan kromatografi lapis tipis (KLT) dengan berbagai jenis pelarut. Hasil nalisis menunjukkan bahwa pelarut terbaik untuk mengekstraksi tanin adalah metanol dengan perolehan 23,6989 g (31,59%). Skrining fitokimia yang dilakukan menggunakan dua reagen yang berbeda menunjukkan hasil yang positif mengandung tanin. Eluenterbaik untuk analisa tanin pada penelitian ini adalah dengan n-heksan-etil asetat (6 : 4) dengan nilai Rf sebesar 0,62.Kata Kunci : kemuning (Murraya paniculata L. Jack), tannin, kromatografi lapis tipis (KLT)ABSTRACTOrange Jessamine (Murraya paniculata L. Jack) is one of the natural treasures which has many benefits for human life. Tannin is one of secondary metabolite of orange jessamine that can be used as antidiarrhoeal and body slimming. It was obtained by maceration using 3 different solvents, such as : methanol, ethanol, and ethyl acetate. Tannins was separated from crude extract using thin layer chromatography (TLC) in different type of eluent. The analysis showed that the best solvent to extract tannin is methanol that produce of 23.6989 g (31.59%). The phytochemical screening test of the two reagents shows positif result contain tannin compound. The best eluent in this study aimed is n-hexane: ethyl acetate (6 : 4) with tannin Rf value of 0.62.Keywords: Orange jessamine (Murraya paniculata L. Jack), tannin, maceration, thin layer chromatography
Anealisis Uji Pendahuluan Aktivitas Antikanker Ekstrak Biji Pepaya (Carica papaya L) dengan Metode BSLT Ulfa, Ninik Mas; Kusumo, Galuh Gondo; Zulfa, Ilil Maidatuz
Journal of Pharmacy and Science Vol. 4 No. 1 (2019): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v4i1.122

Abstract

ABSTRAKTumbuhan pepaya (carica papaya L) merupakan tumbuhan tropis yang banyak terdapat di Indonesia. Tumbuhan ini mempunyai banyak manfaatnya mulai dari buah, biji, hingga daunnya. Penelitian pendahuluan menyebutkan buah pepaya mengandung alkaloid dan flavonoid yang berkhasiat sebagai antikanker. Senyawa BenzylIsothiocyanat diketahui banyak terdapat pada biji dan buah pepaya yang sudah matang. Kandungan BenzylIsothiocyanat mempunyai khasiat sebagai antikanker. Pemanfaatan limbah biji pepaya pada penelitian ini untuk membuktikan aktivitas Benzyl-Isothiacyanat yang berkhasiat sebagai antikanker. Penelitian ini merupakan penelitian pendahuluan untuk menganalisis aktivitas antikanker dari Ekstrak kental biji pepaya dengan menggunakan metode BSLT. Konsentrasi ekstrak kentak yang digunakan yaitu 100 ppm, 200 ppm dan 300 ppm masing-masing diujikan pada 10 larva udang dalam air laut. Diperoleh hasil rata-rata kematian pada konsentrasi 100 ppm adalah 4,3, 200 ppm adalah 5,3 dan 300 ppm adalah 6,7. Hasil regresi linearitas menunjukkan aktivitas antikaker pada uji BSLT dari Ekstrak kental biji pepaya dengan LC50 sebesar 163,89 ppm. Dengan demikian ekstrak kental biji pepaya tersebut berpotensi untuk dikembangkan sebagai bahan antikanker alamiKata kunci: Aktivitas antikanker, Carica papaya, metode BSLT.ABSTRACTPapaya plant (carica papaya L) is a tropical plant that is widely found in Indonesian. This plant has many benefits ranging from fruit, seeds, to leaves. Preliminary research says papaya fruit contains alkaloids andflavonoids which are efficacious as anticancer. Benzyl-Isothiocyanat compounds are known to be widely found in ripe papaya seeds and fruit. The content of Benzyl-Isothiocyanat has properties as an anticancer. The use of papaya seed waste in this study is to prove the activity of Benzyl-Isothiacyanat which is efficacious as an anticancer. This research is a preliminary study to analyze the anticancer activity of thick papaya seeds using the BSLT method. The concentrations of used fart extracts were 100 ppm, 200 ppm and 300 ppm each tested on 10 shrimp larvae in seawater. The results of the average mortality at concentrations of 100 ppm were 4.3, 200 ppm were 5.3 and 300 ppm was 6.7. The linearity regression results showed the anticaker activity in the BSLT test from the thick extract of papaya seeds with LC50 of 163.89 ppm. Thus the thick extract of papaya seeds has the potential to be developed as a natural anticancer material.Key Words : Anticancer activity, BSLT method, Carica papaya.
Conjact Glucomannan Flour Extraction From Porang Tube (Amorphophallus muelleri Blume) with Differents Simplicia- Solvent Ratio (Subject were obtained from the Klagon Village of Saradan District): Ekstraksi Tepung Konyak Glukomanan dari Umbi Porang (Amorphophallus muelleri Blume) pada Berbagai Perbandingan Simplisia-Pelarut (sampel didapatkan dari desa Klangon Kabupaten Saradan) Kusumo, Galuh Gondo
Journal of Pharmacy and Science Vol. 6 No. 2 (2021): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i2.215

Abstract

This study aimed to determine the best simplicia-solvent comparison to extract Konyak Glucomannan (KGM) flour from porang tubers (Amorphophallus muelleri Blume) that obtained from Klangon Village, Saradan District. Extraction was carried out by water solvent with solvent-simplicia comparison of 1: 100; 1: 200; 1: 300; 1,5: 100; 1,5: 200; and 1,5: 300. The extraction was carried out at a temperature of 45oC and 55oC for 60 minutes. The results showed that the extraction of Konjac Glucomannan (CGM) flour, was optimally extracted with a 1: 300 simplicia-solvent ratio at 55oC for 60 minutes.
Identification of Secondary Metabolites of Onion Peels Extract (Allium cepa L.) of Various Solvent: Identifikasi Senyawa metabolit Sekunder Ekstrak Kulit Bawang Merah (Allium cepa L.) dari Berbagai Macam Pelarut Mercyska Suryandari; Galuh Gondo Kusumo
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 7 No. 2 (2022): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v7i2.289

Abstract

Onion peels (Allium cepa L.) is often disposed of without being used and ends up as waste in markets that can pollute the environment. Onion peels can potentially be developed for treatment as an anti-cancer because of its phytochemical compounds. Previous studies have shown that secondary metabolites found in onion peels using different solvents produce different secondary metabolites. So the purpose of this study was to find out the secondary metabolite compounds from onion peels extract (Allium cepa L.) qualitatively when extracted using 5 different solvents. This research was conducted using a phytochemical screening method on the onion peels extract (Allium cepa L.). n-Hexane, Ethyl Acetate, Acetone, Ethanol 96%, and Chloroform were used in the maceration extraction method separately. The results showed that the yield value was 0.96%; 2.66%; 3.90%; 4.80%; 1.62%. The results showed that acetone, ethanol, and chloroform extracts of onion peels extract (Allium cepa L.) contained alkaloids, flavonoids, saponins, steroids, terpenoids, and tannins. Meanwhile, the ethyl acetate extract of onion peels contains alkaloids, flavonoids, steroids, terpenoids, and tannins. Lastly, the n-hexane extract of the onion peels only contains steroids and terpenoids. So it can be concluded that secondary metabolites in onion peels extract contain alkaloids, flavonoids, saponins, steroids, terpenoids, and tannins.
Antioxidan Activity from Methanol Extract of Kratom Leaves (Mitragyna speciosa) Maseration Result Using The DPPH Method: Aktivitas Antioksidan Ekstrak Metanol Daun Kratom (Mitragyna speciosa) Hasil Maserasi Menggunakan Metode DPPH Andhika Dwi Aristyawan; Anggi Ayu Windari; Mercyska Suryandari; Galuh Gondo Kusumo
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 2 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i2.357

Abstract

Antioxidants are compounds that can prevent the formation of free radicals. Kratom is a typical plant from South Putussibau area, in West Kalimantan. The kratom plant contains alkaloids, triterpenoid-steroids, saponins, tannins and flavonoids. The main component of kratom leaves is an indole alkaloid that is efficacious as an antioxidant. The goal is to determine the antioxidant activity of kratom leaf extract (Mitragyna speciosa). The method used is the measurement of the reduced amount of DPPH from an antioxidant compound UV-Vis spectrophotometrically at a wavelength of 517nm using Vitamin C as a comparison. The extraction method used is maceration. The test was sampled 10 mg of kratom leaf extract (Mitragyna speciosa) with 10 ppm, 20 ppm, 30 ppm, 40 ppm, and 50ppm concentrations, then repeated 3 times. The results of the antioxidant activity of kratom leaves (Mitragyna speciosa) were expressed with IC50 values of 44,169 ± 0.5313 with an RSD value of 1.202%. Then it can be concluded that kratom leaf methanol extract (Mitragyna speciosa) has a very strong antioxidant activity with an IC50 value of 44,169 ± 0.5313 with an RSD value of 1.202%.
Identification of Secondary Metabolites of Garlic Peels Extract (Allium sativum) Mercyska Suryandari Mercyska; Galuh Gondo Kusumo; Ade Ferdinan
Jurnal Komunitas Farmasi Nasional Vol. 2 No. 2 (2022): Jurnal Komunitas Farmasi Nasional
Publisher : Akademi Farmasi Yarsi Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The use of garlic often only makes use of the root part, while the garlic skin is often thrown away without optimal utilization and ends up as waste. Garlic skin has the potential to be developed as a treatment, one of which is for cholesterol because it contains phytochemical compounds. Previous studies have shown that using different solvents during the extraction process will produce different secondary metabolites. So the purpose of this study was to find out the secondary metabolites of garlic skin extract (Allium sativum L.) qualitatively when extracted using 5 different solvents. In this research, the method used was phytochemical screening on garlic skin extract (Allium sativun L.). n-Hexane, Ethyl Acetate, Acetone, 96% Ethanol, and Chloroform using remaceration extraction method separately. The results showed that the yield value was 0.90%; 1.34%; 1.00%; 3.90%; 1.20%. The results showed that the n-Hexane extract of garlic (Allium sativum L.) peels contained steroids and terpenoids; ethyl acetate extract contains alkaloids, steroids and terpenoids; acetone extract contains saponins, steroids, terpenoids and tannins; 96% ethanol extract contains alkaloids, flavonoids, saponins, terpenoids, and tannins; and finally the chloroform extract of garlic skin contains alkaloids, steroids, terpenoids and tannins. So it can be concluded that the secondary metabolites in garlic peel extract contain alkaloids, flavonoids, saponins, steroids, terpenoids and tannins.the study, methods, results and conclusions, can describe qualitatiive and quantitative information.
PENINGKATAN PEMAHAMAN MASYARAKAT DESA DRENGES KABUPATEN BOJONEGORO TENTANG PENGGUNAAN OBAT MELALUI PENYULUHAN PENGUNAAN OBAT YANG BENAR Ilil Maidatuz Zulfa; Prasetyo Handrianto; Ratih Kusuma Wardani; Galuh Gondo Kusumo
Journal of Science and Social Development Vol. 1 No. 2 (2018): Journal of Science and Social Development
Publisher : Universitas Nahdlatul Ulama Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55732/jossd.v1i2.169

Abstract

Irrational drug use usually happens in self medication practise without any supervision from health care providers. Self medication practise usually does not consider the potential of allergic reaction, pregnancy, breast feeding, diet, and medication history.The promotion of rational drug use through communication, information, and education still need to be conducted to the community. This event is purposed to improve perception, knowledge, and attitude of Desa Drenges residents in the term of drug usage. A total 23 person of Desa Drengeswere enrolled in this eventfacilitated by village administrators.The perception, knowledge, and attitude of the residents recruited were evaluate through questionnaire filled before and after the event. The result showed the increase of perception, knowledge, and attitude of the residents up to 2,69%. From the result, The community service event can improve the quality of health of residents in Desa Drenges through the improvement of perception, knowledge, and attitude in the term of rational drug use.
Penyuluhan Peningkatan Pemahaman Masyarakat terhadap Beyond Use Date Sediaan Obat pada Swamedikasi Secara Daring Fernanda, M.A. Hanny Ferry; Kusumo, Galuh Gondo
Jurnal Pelayanan dan Pengabdian Masyarakat (Pamas) Vol 7, No 4 (2023): Jurnal Pelayanan dan Pengabdian Masyarakat (PAMAS)
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM Universitas Respati Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52643/pamas.v7i4.1491

Abstract

Beyond Use Date (BUD) can be defined as the time limit for a drug product that is safe for use after compounding or after the primary packaging has been opened. In contrast to the Expired Date (ED) or expiration date which is the limit on the use of drugs listed on the drug packaging. This BUD is not listed on the drug packaging so people need to know about this BUD. This BUD really determines the time limit for a drug product that is still of good quality and is in a stable condition. Ideally, the BUD is determined based on the results of the drug product stability test and is listed on the packaging. However, when doing self-medication or self-medication, people usually only use the expiration date as a reference for the safety of drug use. Therefore, there is a need for community service activities to provide education to the community about knowledge of drug damage after the packaging is opened and before ED. The purpose of this activity is to increase public knowledge about the safety of pharmaceutical preparations as long as they are stored with a time limit after the packaging is opened. This activity was carried out online through the zoom meeting application on Saturday, April 10, 2021. The results of this activity provided information that the public could understand the Beyond Use Date material on the use of self-medication drugs properly. Keywords : Beyond Use Date, Expired Date, Self Medication
UJI AKTIVITAS ANTIOKSIDAN TEH SEDUHAN DAUN ROSEMARY (Rosmarinus officinalis L.) DAN DAUN STEVIA (Stevia rebaudiana) DENGAN PERBANDINGAN (60:40) Mercyska, Mercyska Suryandari; Nur Indahwati, Sephia; Gondo Kusumo, , Galuh
Jurnal Komunitas Farmasi Nasional Vol. 3 No. 02 (2023): Jurnal Komunitas Farmasi Nasional
Publisher : Akademi Farmasi Yarsi Pontianak

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Abstract

Rosemary is an herbal plant whose content has compounds. Antioxidant that can prevent the occurrence of damage due to free addiction. This study wanted to find out the content of antioxidant that are obtained in steeping rosemary tea with using additional weetener stevia leaves. Antioxidant testing of leaf steeping tea. Rosemary and stevia leaves using the DPPH method observations were conducted at a wavelength of 522 nm, using a Vitamin C comparator. Replication was performed 3 times the treatment with a difference in brewing time of 5 minutes, 10 minutes and 15 minutes. From the results of the stury and observations obtained % Vitamin C concentration 1 ppm 15.45%, concentration 2 ppm 13.18%, concentration 3 ppm 26.52%, concentration 4 ppm 28.79%, concentration 5 ppm 38.33%. As for the result of % steeping rosemary leaf tea and stevia leaves on sample A brewed for 5 minutes on average % soaking 46.83%, sample B brewing for 10 minutes on average 32.01% dampening, and 15 minutes samle C brewing average % dampering 38.8%. The results of the antioxidant activity test of tea steeping rosemary leaves and stevia leaves in a ratio of (60:40) are that there is a strong antioxidant activity.
Formulasi dan Evaluasi Nano Partikel Ekstrak Etanol Daun Ubi Jalar Ungu (Ipomoea batatas L.) Varietas Antin-3: Formulation and Evaluation of Nano Particles Ethanol Extract of Purple Sweet Potato Leaves (Ipomoea batatas L.) Antin-3 Varieties Damaranie Dipahayu; Galuh Gondo Kusumo
Jurnal Sains dan Kesehatan Vol. 3 No. 6 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i6.818

Abstract

Ekstrak daun ubi jalar ungu (Ipomoea batatas Lamk) varietas Antin-3 (Ekstrak daun Antin-3) yang mengandung polifenol dan flavonoid yang memiliki kemampuan sebagai antioksidan. Polifenol dan Flavonoid memiliki bioavailabilitas yang rendah. Penelitian ini bertujuan untuk memperkecil ukuran partikel ekstrak menjadi nanopartikel sehingga penyerapan saluran cerna dapat meningkat serta evaluasi fisiknya untuk memastikan partikel nano seperti ukuran partikel (10-1.000 nm), indeks polidispersitas (PDI) ( < 0,5) dan nilai potensial zeta (±20mV sampai ±-30mV). Formulasi ekstrak nano dengan metode gelasi ionik menggunakan kitosan: NaTPP. Ada tiga Tiga sampel yang diteliti (F1:F2:F3) yaitu dengan perbandingan ekstrak daun Antin-3:kitosan:NaTPP (1:1:1 ); (1:5:1); (1:10:1). Evaluasi dilakukan dengan menggunakan PSA (Particle Size Analyzer). Hasil evaluasi sampel (F1:F2:F3) menggunakan PSA (Particle Size Analyzer) untuk ukuran partikel berturut-turut (1.482 nm; 564,38 nm; 734,36 nm); untuk PdI berturut-turut (0,3482; 0,4272; 0,381) dan untuk nilai potensial zeta masing-masing (5,19mV; 21,57mV; 33,4mV). F3 merupakan sampel yang memenuhi kriteria ukuran partikel, PdI dengan nilai zeta potensial
Co-Authors ., Syukrianto Ade Ferdinan Anggi Ayu Windari Anindya, Widya Dara Aristyawan, Andhika Dwi Asroriyah, Heppy Bawanda, Edward Melfin Damaranie Dipahayu Devianti, Vika Ayu Fernanda, M.A. Hanny Ferry Fernanda, MA Hanny Ferry Mercyska Suryandari Nur Indahwati, Sephia Octifany, Salsabila Pertiwi, Husadhani Dwi Prasetyo Handrianto Ramadhan Renaisansa Ratih Kusuma Wardani Renaisansa, Ramadhan Surahmaida, Surahmaida Suryadari, Mercyska Syukrianto Syukrianto, Syukrianto Ulfa, Ninik Mas Umar, Umarudin Umarudin Umarudin, Umarudin Wulansari, Silvi ayu Yuliarni, Floreta Fiska Zulfa, Ilil Maidatuz