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All Journal JPK: Jurnal Proteksi Kesehatan Borneo Journal of Pharmacy
Dian Mayasari
Universitas Abdurrab
Health Professions Medicine & Pharmacology Nursing Public Health

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Antibacterial Activity Test of Ethanol Extract of Mangkokan Leaves (Polyscias scutallarium (Burm.f.) Fosberg) against Escherichia coli and Staphylococcus aureus Deri Islami; Vonny Kurnia Utama; Dian Mayasari; Yan Hendrika
JURNAL PROTEKSI KESEHATAN Vol 10 No 2 (2021): JPK: Jurnal Proteksi Kesehatan
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Poltekkes Kemenkes Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36929/jpk.v10i2.374

Abstract

Mangkokan is one of traditional medicinal plants that has many benefits in restoring health, such as preventing hair loss, treating wounds, antibacterial agent, improving blood circulation and as an antioxidant agent. This study aimed to examine the activity of the ethanol extract of the mangkokan leaf (Polyscias scutellarium (Burm.f.) Fosberg) against Escherichia coli and Staphylococcus aureus. The extraction process was carried out by gradual maceration through three solvents including n-hexane, ethyl acetate, and ethanol. The antibacterial activity test was carried out by agar diffusion method by calculating diameter of the inhibition zone from ethanol extract of mangkokan leaf with four variation concentrations: 20%, 40%, 60%, and 80%. The antibacterial activity of the ethanolic extract of the mangkokan leaf against Escherichia coli resulted in the average diameter od the inhibition zone at the following concentrations: 20% (5,9 mm), 40% (5,2 mm), 60% (5,9 mm), dan 80% (7,03 mm. While antibacterial test against Staphylococcus aures resulted in the average diameter of the inhibition zone at the following concentrations: 20% (9,66 mm), 40% (10,71 mm), 60% (11,27 mm), 80% (12,42 mm).
Antibacterial Activity and TLC-Densitometric Analysis of Secondary Metabolites in the Leaves of the Traditional Herb, Melastoma malabathricum L. Dian Mayasari; Yosi Bayu Murti; Sylvia Utami Tunjung Pratiwi; Sudarsono Sudarsono
Borneo Journal of Pharmacy Vol. 5 No. 4 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i4.3818

Abstract

Indonesia is rich in the biodiversity of medicinal plants used traditionally for healing several ailments. Melastoma malabathricum L. is one of the traditional herbs used to treat many diseases. A TLC-densitometric method was developed for determining secondary metabolites such as phenolic compounds and their related compounds, M. malabathricum leaves from Riau, Indonesia. This study investigated the secondary metabolites of M. malabathricum extract by spraying reagent: FeCl3, p-anisaldehyde, and cerium (IV) sulfate and followed by antibacterial assay through broth macro dilution method. Densitometric qualitative analysis of phenolic compounds and their related compounds was employed to examine peaks of the M. malabathricum extract through winCATS software. After spraying with particular reagents, the three extracts showed various spots/bands with several colors and exhibited peaks in TLC densitogram profiles. Three extracts were tested for antibacterial activity against Staphylococcus aureus and Escherichia coli. The result showed that ethyl acetate extract revealed excellent antibacterial activity against S. aureus and E. coli with MIC values of 3.125±0.6 mg/mL and 6.25±0.5 mg/mL, respectively. Owing to the presence of a wide variety of secondary metabolites, the leaf extract of M. malabathricum is expected to exhibit and help develop as a therapeutic agent.
Co-Authors Islami, Deri Sudarsono Sudarsono Sylvia Utami Tunjung Pratiwi Vonny Kurnia Utama Yan Hendrika Yosi Bayu Murti