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All Journal Medical Journal of Indonesia Narra J

Mohammad Z. Rahfiludin

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Author-ID : 355221

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The different levels of interferron gamma capacity production on several stages of leprosy Rahfiludin, Mohammad Z.; Kartasurya, Martha I.; Purwaningsih, Endang
Medical Journal of Indonesia Vol 16, No 4 (2007): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Informations concerning imunological activity in subclinical leprosy is still lacking. Therefore, the objective of this study was to find out the prevalence of subclinical leprosy and interferon- (IFN-) production at several stages of leprosy. This observational study using a cross sectional approach was conducted in Semarang, Central Java, Indonesia. Twenty-six leprosy patients and 62 relatives who lived together with the leprosy patients were included in the study. The venous blood samples were taken from all (88) of the subjects. All of the venous blood samples were measured for IFN- levels by Elisa method. Sixty two blood samples from the relatives who lived together with the leprosy patients were measured for IgM anti PGL-1 to determine the subclinical stage of leprosy. Thus, there were three groups in this study: leprosy patients (LP), subclinical leprosy (SL) and sero-negative subjects (SN). Thirty three of the 62 relatives (53.2%) were in subclinical stage of leprosy, while 29 others were not (sero-negative). There was a significant difference (P= 0.001) in IFN- production capacity among the three groups (LP,SL and SN). Among the three groups, the LP group had the lowest, while SL group had the highest IFN- production capacity. (Med J Indones 2007; 16:224-7) Keywords: subclinical leprosy, IgM anti PGL-1, sero negative

The difference of anti phenolic glycolipid-1 (PGL-1) immunoglobulin-M (IgM) level and nutritional intake in subclinical leprosy patients who reside at home and in the orphanage Rahfiludin, Mohammad Z.; Nugraheni, Sri A.; Ametati, Holy; Prihatin, Aniek; Purwaningsih, Endang
Medical Journal of Indonesia Vol 16, No 4 (2007): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Leprosy patients can be found in the orphanage, and ordinary house holds. The different living conditions in different places might cause differences in the environments, nutritional intake, and immunity, which in the end would affect the transmission of M. leprae. The aim of this study was to find out the difference in anti PGL-1 IgM level and nutritional intake between sub-clinical leprosy patients residing at home with their families and those living in the orphanage. This cross-section observational study was done in Semarang, Central Java, Indonesia. Thirty one sub-clinical leprosy patients living in an orphanage and 30 sub-clinical leprosy patients living at home were included in this study. Venous blood was taken from all of the subjects, the level of anti PGL-1 IgM was measured, and daily nutrient intake was analyzed. Differential test between the 2 groups was performed using independent t-test or Mann Whitney test, when the distribution was not normal. There was significant differences (P < 0.05) in the level of anti PGL-1 IgM, protein, zinc, and vitamin C intake between the 2 groups. (Med J Indones 2007;16:233-6)Keywords: nutrient intake, protein, zinc, vitamin C

Correlation of zinc plasma and IgM anti-PGL-1 levels among close contact of leprosy Rahfiludin, Mohammad Z.; Ginandjar, Praba; Pangestuti, Dina R.
Medical Journal of Indonesia Vol 21, No 3 (2012): August
Publisher : Faculty of Medicine Universitas Indonesia

Background: Previous study showed leprosy patients have low zinc status. Yet the status of zinc in close-contact, which indicated by IgM anti-PGL1 level, have not determined. The aim of the study was to determine the association of zinc plasma and IgM anti-PGL-1 levels among close contact of leprosy patients in Indonesia.Methods: This was an observational study. Subjects were 186 close-contact leprosy patients. Measurement of zinc plasma status used atomic absorption spectrophotometer while examination of IgM anti-PGL1 level used ELISA (Polyclonal rabbit anti human IgM/HRP/(DakoÂ®).Results: The average level of IgM anti-PGL1 and zinc plasma were 804 unit/mL (Â± 439.4) and 16.6 Î¼mol/L (Â± 3.5) consecutively. There was significant correlation between zinc plasma and IgM anti-PGL1 (r = - 0.230; p = 0.002).Conclusion: There is a significant correlation between zinc plasma and IgM anti-PGL1 in close contact of leprosy (Med J Indones. 2012;21:166-9)Keywords: IgM anti PGL-1, close contact of leprosy, zinc plasma

Zinc supplementation could modulate T cell to maintain interleukin-2 level in seropositive contact of leprosy patients Rahfiludin, Mohammad Z.; Wirjatmadi, Bambang; Agusni, Indropo; Dahlan, Yoes P.
Medical Journal of Indonesia Vol 20, No 3 (2011): August
Publisher : Faculty of Medicine Universitas Indonesia

Background: WHO classified the number of leprosy cases in Indonesia as number three in the world after India andÂ Brazil. The number of new leprosy patients tends to increase since there is a possibility that seropositive leprosy is turningÂ into manifest leprosy. The aim of this study was to analyze the influence of zinc supplementation on interleukin-2 (IL-2)Â level of seropositive contact of leprosy patients with marginal zinc deficiency.Methods: Twenty two subjects aged 20-40 years were recruited for this study. The zinc-supplemented group received 40Â mg elemental Zn/d orally for 3 months. Seropositive leprosy was determined by examining IgM anti Phenolic Glycolipidâ1Â level and concentration of IL-2 in lymphocyte cell culture supernatant fluid were measured by Elisa method.Results: The IL-2 concentration in the subject in the zinc group was relatively not changed (p= 0.721), whereas that inÂ placebo group tended to be significantly lower (p= 0.025) at the end of the study.Conclusion: There was a significant change of IL-2 level between both groups (p= 0.037). (Med J Indones 2011;20:201-4)Keyword: IgM anti phenolic glycolipid-1, seropositive leprosy

Co-Authors Aniek Prihatin Bambang Wirjatmadi Bina Kurniawan Dedek Sutinbuk Denny, Hanifa M. Dina R. Pangestuti Dwi Astuti Endang Purwaningsih Holy Ametati INDROPO AGUSNI Jayanti , Siswi Lestantyo , Daru Martha Irene Kartasurya Meidiana Dwidiyanti Novia Luthviatin Nurjazuli , Nurjazuli Onny Setiani Praba Ginandjar Setyaningsih , Yuliani Sri A. Nugraheni Widjarnarko, Bagoes Widjasena , Baju Yoes P. Dahlan Yuliani Setyaningsih

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