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All Journal FITOFARMAKA: Jurnal Ilmiah Farmasi Cendekia Journal of Pharmacy Parapemikir Jurnal Ilmiah Farmasi
Sri Fitrianingsih
ITEKES Cendekia Utama Kudus
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Physics

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Variations of Tween Surfactant and Propylene Glycol Cosurfactant in Topical Microemulsion Formulation on The Penetration of Ibuprofen Sri Fitrianingsih; Gunawan Pamudji Widodo; Dian Marlina
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 12, No 2 (2022): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v12i2.5785

Abstract

ABSTRACTIbuprofen is a derivative of propionic acid, a class of non-steroidal anti-inflammatory drugs (NSAIDs). Ibuprofen has side effects on the gastrointestinal tract. So that topical use can be a solution to reduce the side effects of oral use because of the release of topical drugs through the stratum corneum which makes it selective in certain places. The preparation chosen was a topical microemulsion because it is more thermodynamically stable and has no effect on the gastrointestinal tract. This study aims to determine the effect of the ratio of surfactant concentrations of various ratios of tween 20:tween 80 and cosurfactant propylene glycol to the penetration rate of ibuprofen across the membrane and to determine the physical characteristics of topical microemulsions. Selection of tween surfactant and propylene glycol cosurfactant because it has high physical stability. This research is an experimental study, namely by making four formulations with various ratios of surfactant and cosurfactant with a difference of 2.5% in each formulation of topical ibuprofen microemulsion with a concentration of 5% ibuprofen using variations of surfactant tween 20 and tween 80, cosurfactant propylene glycol with black cumin oil phase. Evaluation of the preparation by organoleptic test, pH test of the preparation, examination of the type of emulsion, particle size measurement, microemulsion release test in vitro using the Franz diffusion method. The results show that the concentration ratio of surfactant tween 20:tween 80 and cosurfactant propylene glycol can affect particle size, pH and penetration velocity (flux) in Franz diffusion. The results of the study showed that in F1 using surfactant tween 20:tween 80 with a concentration of 71.6% (6:4) had the smallest particle size of 11.5 nm and the largest flux value was 128.45 g.cm-2.H- 1. In conclusion, variations in surfactant and cosurfactant concentrations can affect the pH of the preparation, particle size, penetration speed (flux). The results obtained that the cumulative percent and penetration speed of all formulas had significant differences (p0.05).
Back Matter Cendekia Journal of Pharmacy Vol. 7 No. 1 Tahun 2023 Sri Fitrianingsih
Cendekia Journal of Pharmacy Vol 7, No 1 (2023): Cendekia Journal of Pharmacy
Publisher : STIKES Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v7i1.234

Abstract

Front Matter Cendekia Journal of Pharmacy vol. 7 No. 1 Tahun 2023 Sri Fitrianingsih
Cendekia Journal of Pharmacy Vol 7, No 1 (2023): Cendekia Journal of Pharmacy
Publisher : STIKES Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v7i1.233

Abstract

Optimasi Variasi Konsentrasi Palm Oil dan VCO Sabun Organik Kulit Biji Kopi Robusta (Coffea canephora Pierre ex A.Froehner) Menggunakan Metode Simplex Lattice Design Gendis Purno Yudanti; Siti Nur Hidayah; Sri Fitrianingsih
Parapemikir : Jurnal Ilmiah Farmasi Vol 15, No 1 (2026): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v15i1.9881

Abstract

Kulit biji kopi Robusta (Coffea canephora Pierre ex A.Froehner) memiliki kandungan bahan aktif sebagai flavonoid, tanin, alkaloid dan saponin yang cocok digunakan dalam pembuatan sabun organik. Sabun organik dengan bahan aktif kulit biji kopi yang dapat digunakan sebagai sabun esfoliasi yang aman untuk masyarakat dengan mekanisme kerja sebagai antioksidan pada kulit dan berbahan dasar palm oil dan VCO yang bagus untuk melembapkan kulit. Tujuan dari penelitian ini yaitu untuk mengetahui pengaruh dan mengetahui variasi konsentrasi palm oil dan VCO terhadap karasteristik jika ditinjau dari parameter kritis pH, kadar air, dan tinggi busa. Penelitian ini diawali determinasi tanaman yang akan digunakan, Kulit biji kopi Robusta (Coffea canephora Pierre ex A.Froehner) yang diperoleh diperoleh dari suatu daerah yaitu Rahtawu, Kabupaten Kudus, Jawa Tengah yang telah dilakukan penghalusan kemudian ditambahkan dalam sediaan sabun organik. Penelitian ini dilakukan dengan membuat perbedaan konsentrasi palm oil dan VCO yang telah ditentukan oleh metode Simplex Lattice Design dan diperoleh 10 formula. Hasil menentukan formula optimum menggunalan Simplex Lattice Design didapatkan formula 4 dan dilakukan pembuatan ulang pada formula 4. Formula dinyatakan tidak ada perbedaan signifikan pada hasil selisih prediksi dan sebenarnya, artinya metode Simplex Lattice Design dapat digunakan sebagai alat statistika dalam penelitian formula. Uji kelembapan dinyatakan ada perbedaan yang signifikan dari uji paired sample T-Test artinya ada peningkatan sebelum penggunaan sabun dan setelah penggunaan sabun. Kombinasi antara palm oil dan VCO memberikan efek terhadap sifat fisik yaitu uji organoleptis, uji pH, uji kadar air, uji tinggi busa dan uji kelembapan kulit.
Co-Authors Dian Marlina Gendis Purno Yudanti Gunawan Pamudji Widodo Siti Nur Hidayah