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All Journal Jurnal Farmasi Indonesia International Journal of Contemporary Sciences (IJCS)
NURAINI HARMASTUTI
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Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Education Immunology & microbiology Medicine & Pharmacology

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Uji Sitotoksik Fraksi n-Heksana, Etil Asetat, Etanol dari Ekstrak Etanolik Daun Ende (Coccinia grandis (L.) Voigt) pada Sel HeLa NURAINI HARMASTUTI; GUNAWAN PAMUDJI WIDODO; MARIA E.D.O. HUREK MAKING; MARIA YANGSYE LENGGU; FEOLISTIN MIENCE POBAS
Jurnal Farmasi Indonesia Vol 9 No 1 (2012): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1009.178 KB) | DOI: 10.31001/jfi.v9i1.725

Abstract

Ende leaf (Coccinia grandis (L.) Voigt) is the one of plant that most popular in Nusa Tenggara Timur province. The study was aimed to know the cytotoxic effect of n-hexane, ethyl acetate, and ethanol fractions from ethanolic extract of ende leaf on hela cell and its IC50 value. Dried ende was macerated with 96 % ethanol solvent, then it was fractionated by n-hexane, ethyl acetate, and ethanol solvent. Then it was tested the cytotoxic by MTT (Microculture Tetrazolium Salt) method on HeLa cell The absorbance response was converted into abbreviation of cell viability. IC50 value was calculated with linear regression equation between logarithm of concentration samples versus percentage viability of HeLa cell. The result showed that the cytotoxic test of ende leaf against HeLa cell presented the IC50 value of ethanolic extract and n-hexane, ethyl acetate, and ethanol fractions were 415.719 ppm; 307.142 ppm; 50303.71 ppm; dan 50722.424 ppm, respectively.
Anchoring Analysis and Simulation of Molecular Dynamics of Dayak Onion Plant Compounds (Eleutherine bulbosa (Mill.) URB.) As an Antibacterial Candidate for Methicillin Resistant Staphylococcus aureus Pratamaa, Yuga; Rina Herowati; Nuraini Harmastuti; Andri Prasetiyo
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 3 (2024): January 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v2i1.8334

Abstract

MRSA infection that is growing and limited treatment is evidence that the handling and treatment of the disease is still inadequate so that appropriate drugs are needed as antibacterial against MRSA, the development of natural products, one of which is the dayak onion plant (Eleutherine bulbosa) which has the potential as antibacterial can be done with computational methods, one of which is molecular tethering, molecular dynamics and ADMET prediction. This study aims to predict the ability of natural compounds from dayak onions as antibacterial MRSA. Tethering and molecular dynamics are performed using AutoDock 4.2 and Yasara Dynamic software. The results showed that compounds with the greatest antibacterial potential were eleucanainones with binding energy of -11.91kcal / mol. The results of molecular tethering are then continued with molecular dynamics simulations. The results of molecular dynamics simulations show that the compound has a Root Mean Square Deviation (RMSD) value that is close to the native ligand. Conclusion: Dayak onion compounds (Eleutherine bulbosa) have potential as antibacterial MRSA
Uji Aktivitas Antioksidan Kombinasi Ekstrak Tanaman Daun Alpukat (Persea Americana Miller) Dan Daun Pucuk Merah (Syzygium Myrtifolium Walp) Dan Penetapan Kadar Flavonoid Total Ekstrak Tunggal Mei Adelia Sabrina; Nuraini Harmastuti; Ghani Nurfana Fadma Sari
Jurnal Farmasi Indonesia Vol 22 No 1 (2025): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v22i1.2657

Abstract

Antioxidants are compounds that can counteract free radicals. This study aims to test the antioxidant activity of avocado (Persea americana Mill.) and red shoot (Syzygium myrtifolium Walp.) leaf extracts, determine total flavonoid levels and compare with quercetin compounds. Extraction with 96% ethanol using maceration method. DPPH free radical activity test of avocado leaf and red shoot extract combination variation (1:3, 2:2, and 3:1) using UV-Vis spectrophotometry. The results of analysis were tested statistically using SPSS. Antioxidants are compounds that can counteract free radicals. The results of total flavonoid content of avocado leaf extract and red shoots are 45,20 and 14.46 mgQE/g. Combination of avocado leaf and red shoot extracts has strong antioxidant activity. The 3:1 ratio of extracts showed the highest antioxidant activity.
Co-Authors Andri Prasetiyo FEOLISTIN MIENCE POBAS Ghani Nurfana Fadma Sari Gunawan Pamudji Widodo MARIA E.D.O. HUREK MAKING MARIA YANGSYE LENGGU Mei Adelia Sabrina Pratamaa, Yuga R, Herowati